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Topic: Carotenodermia

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	Carotenodermia - Wikipedia, the free encyclopedia
		Carotenodermia (also carotenaemia, carotenemia or hypercarotenemia) is a yellowish/orange discoloration of the skin, most often occurring in the palms of the hands and soles of the feet as a result of high levels of carotene in the body.
		Carotenodermia has been observed to occur upon chronic doses in excess of 30 mg of carotenoid per day, most often caused by eating an overabundance of carrots.
		Carotenodermia is most commonly associated with overconsumption of food containing carotene, but it can be a medical sign of other conditions, including:
	en.wikipedia.org /wiki/Carotenodermia (422 words)

	Carotenemia -
		Carotenodermia or carotenaemia, is a yellowish discoloration of the skin, most often occurring in the palms of the hands and soles of the feet as a result of high levels of beta-carotene.
		Carotenodermia has been observed to occur upon chronic doses in excess of 30 mg of carotenoid per day.
		The broader body of knowledge about diseases and their treatments is medicine.
	www.medicalgeo.com /Med-Diseases-C---Ch/Carotenemia.html (157 words)

	Beta-Carotene
		Doses of 30 milligrams/day or greater of beta-carotene taken for prolonged periods may cause carotenodermia.
		Carotenodermia is characterized by yellowish discoloration of the skin and is distinguished from jaundice by the absence of yellowed ocular sclerae, which are found in those with jaundice.
		Carotenodermia is considered harmless and reversible with the discontinuation of beta-carotene.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/bet_0032.shtml (5202 words)

	Carotenoids, Linus Pauling Institute's Micronutrient Information Center
		Although the reasons for these findings are not yet clear, many experts feel that the risks of high-dose beta-carotene supplementation outweigh any potential benefits for chronic disease prevention, especially in smokers or other high-risk populations (28,29).
		Carotenodermia: High doses of beta-carotene supplements (30 mg/day or more) and the consumption of large amounts of carotene-rich foods have resulted in a yellow discoloration of the skin known as carotenodermia.
		Carotenodermia is not associated with any underlying health problems and resolves when beta-carotene supplements are discontinued or dietary carotene intake is reduced.
	lpi.oregonstate.edu /infocenter/phytochemicals/carotenoids (4333 words)

	FDA/CFSAN: Agency Response Letter: GRAS Notice No. GRN 000110
		In contrast, Cognis notes that carotenodermia was not observed in an ongoing study in which subjects consumed supplements containing up to 40 mg/person/day of Cognis' lutein esters product for more than 90 days.
		As part of its notice, Cognis includes the report of a panel of individuals (Cognis' GRAS panel) who evaluated the data and information that are the basis for Cognis' GRAS determination.
		In its notice, Cognis informs FDA that one intended use of lutein esters is use in medical foods intended as the sole item of the diet.
	vm.cfsan.fda.gov /~rdb/opa-g110.html (1624 words)

	Vitamin A Information (Site not responding. Last check: 2007-10-12)
		It is recommended that women who are pregnant or may become pregnant do not exceed the tolerable Upper Limits.
		Chronic doses of 30 mg/day or higher of beta-carotene may cause carotenodermia.
		Carotenodermia is characterized by yellowish discolorization of the skin and is considered harmless and reversible with the discontinuation of beta-carotene supplementation.
	www.vitaminherbuniversity.com /topic.asp?categoryid=1&topicid=1000 (2309 words)

	Nat' Academies Press, Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000)
		Carotenodermia is characterized by yellowish discoloration of the skin that results from an elevation of plasma carotene concentrations.
		This condition has been reported in adults taking supplements containing 30 mg/day or more of β-carotene for long periods of time or consuming high levels of carotenoid-rich foods such as carrots (Bendich, 1988) and is the primary effect of excess carotenoid intake noted in infants, toddlers, and young children (Lascari, 1981).
		Lycopenodermia results from high intakes of lycopene-rich foods such as tomatoes and is characterized by a deep orange discoloration of the skin.
	www.nap.edu /openbook/0309069351/html/368.html (787 words)

	Vitamin A and Carotenoids in the Reptile and Amphibian diet
		A herbivores diet lacking vitamin A may be in for some life-treating tribulations when carotenoids become impaired and cannot function because levels of proteins and trace minerals are inadequate, therefore resulting in respiratory disturbances, slowed gene expression, viral infections, xerophthalmia, ect.; vitamin A deficient symptoms.
		Ectodermal storage of carotenoids results in a condition called carotenodermia.
		So if your herbivore (usually carnivores have adequate protein, thyroid hormones, and zinc from complete, whole animal, food sources) is experiencing carotenodermia on a limited diet of the basic food sources and without protein and vitamin supplements {+ZINC} added to their diet -this will result in a vitamin A deficient diet as well.
	sdnvaranus.tripod.com /vitaminA.html (2291 words)

	[No title]
		The formulations per capsule of study dietary supplements are: 13 mg of beta-carotene, 2 mg of lycopene, 5 mg of vitamine E and 30 mg of vitamine C (B13/L2) or 3 mg of beta-carotene, 3 mg of lycopene, 5 mg of vitamine E and 30 mg of vitamine C (B3/L3).
		A 8-week B13/L2-supplementation lead to a detectable carotenodermia whereas the B3/L3-supplementation not.
		Signicative increase of melanin concentrations in skin were found after 4, 5, 6 and 8 weeks of dietary antioxidant intake in both groups (p
	www.lycopene.org /documents/doc/3962Skin1995-2002.doc (552 words)

	Lutein (Site not responding. Last check: 2007-10-12)
		While no recommended daily allowance currently exists for lutein as for other nutrients, positive effects have been seen at levels of 6 mg/day.
		The only definitive side effect of excess lutein consumption is the same observed for β-carotene overdose, namely bronzing of the skin (Carotenodermia).
		The functional difference between the benefits of lutein and lutein esters is not entirely known.
	pda.molinu.com /wiki/en/lu/Lutein.htm (535 words)

	On Target - Weekly Journal, Issue January 1, 2001 (Site not responding. Last check: 2007-10-12)
		The difference between the two groups was significant during the course of the study.
		None of the patients developed signs of carotenodermia or retinol toxicity.
		According to the authors, usual supplementation with retinol, alpha-tocopherol and ascorbate given to patients with CF does not sufficiently reduce the increased lipid peroxidation found in CF.
	www.targethealth.com /ontarget/2001/01012001.htm (1976 words)

	Vitamin A
		Occasionally, patients complain of "loose stools," but this usually clears up spontaneously and does not necessitate stopping treatment.
		Elevated carotene levels in the blood do not lead to vitamin A toxicity, nor do they lead to any other significant disturbance besides a yellowing of the skin (carotenodermia).
		The ingestion of large amounts of carrots or carrot juice (.45 to 1.0 kilograms of fresh carrots per day for several years) can, however, cause a neutropenia ads well as menstrual disorders.
	www.sengchiropractic.com /id28.html (1832 words)

	UniCare - Antioxidants -
		Carotenoids are naturally occurring antioxidants and levels of carotenoids in the skin can frequently be detected with the naked eye - even more so with a blue laser light, particularly on the palms of the hands.
		Increased consumption of carotenoids may cause the skin to turn orange or yellow, a condition known as "carotenodermia." This occurrence is completely benign and is unrelated to jaundice, the yellowing of the skin that can result from liver disease or other causes.
		There is no published literature in the National Library of Medicine regarding any medical indications for detection of carotenoids in the skin.
	www.biosyntrx.com /Article.htm?ArticleID=239 (496 words)

	vitamins overdose- vitamin e overdose-vitamin a overdose and vitamin toxicity
		Another important point:Women must avoid vitamin A supplementation during pregnancy.Dosage as low as 5,000-10,000 IU are believed to have caused birth defects.
		Beta-carotene overdose or toxicity: During years,beta-carotene has been used in high doses without a single reported adverse effect.A few people develop carotenodermia which is a benign yellowing of the skin that reverses completely once the beta-carotene is reduced or discontinued.
		Vitamin E overdose or toxicity: Clinical trials of vitamin E supplementation as high as 3200 IU per day have not shown any adverse effects.In addition,studies have shown that vitamin E inhibits platelet aggregation and decreases the risk of blood clots in much the same way as aspirin.
	www.vitamin-supplement-reference.com /vitamins-overdose.html (731 words)

	Bird Yellow Eyes Australia Facts, Articles And Resource (Site not responding. Last check: 2007-10-12)
		Survival rates, based on tumor stage, range from 2 to 85 percent.
		Carotenodermia an erroneous diagnosis of jaundice in Italian.
		Gallbladder cancer classically presents with jaundice, hepatomegaly, and a mass in the right upper quadrant Courvoisier's sign.
	www.jaundice-answers.info /bird-yellow-eyes-australia.html (1009 words)

	N101 \| Carotenoids (Site not responding. Last check: 2007-10-12)
		Carotenoids are generally regarded as safe, based primarily on studies with beta-carotene.
		Increased consumption of carotenoids may cause to the skin to turn orange or yellow—a condition known as “carotenodermia.” This occurrence is completely benign and is unrelated to jaundice—the yellowing of the skin that can result from liver disease or other causes.
		Until more is known, people especially smokers should not supplement with synthetic beta-carotene.
	www.n101.com /Static/HNs/Supp/Carotenes.htm (1778 words)

	U.S. FDA/CFSAN: Agency Response Letter: GRAS Notice No. GRN 000119
		BASF reports that results of these studies showed no adverse effects on the absorption of other carotenoids.
		BASF notes, however, that excessive intake of food or dietary supplements high in carotenoids or lycopene has been associated with carotenodermia
		In its notice, BASF notes that synthetic lycopene imparts color to food.
	vm.cfsan.fda.gov /~rdb/opa-g119.html (2130 words)

	[Brainlife] CASSILETH B et al (2002) - Lutein
		No adverse effects have been reported at normal doses.
		Toxicity: Carotenodermia is a harmless biological effect of high carotenoid intake.
		Characterized by a yellowish discoloration of the skin, it results from chronically elevated serum concentrations of carotenes.
	www.brainlife.org /abstract/cassileth_lutein2002.htm (679 words)

	Nat' Academies Press, Diet and Health: Implications for Reducing Chronic Disease Risk (1989)
		These potent antioxidant effects of carotenoids may protect cells against oxidative damage to DNA, thereby exerting a chemopreventive effect against cancer (Dimitrov, 1986).
		-carotene can result in elevated plasma carotene levels (hypercarotenemia) and a yellow-orange pigmentation of the skin (carotenodermia).
		Furthermore, abnormally elevated plasma levels of vitamin A and clinical evidence of hypervitaminosis A do not result from the consumption of high doses of
	www.nap.edu /openbook/0309039940/html/314.html (1008 words)

	Taking Enough Lutein? - Kemin Health (Site not responding. Last check: 2007-10-12)
		There are no known toxicity or overdose concerns regarding lutein consumption.
		Extremely high consumption of lutein may result in the skin taking on an orange or yellow color, known as carotenodermia.
		You can find products containing FloraGLO Lutein in most health food stores, major supermarkets, drugstores and department store chains.
	www.floraglolutein.com /enough_lutein (271 words)

	50% OFF Twinlab Carotene - TwinLab
		Contraindications Carotenes are generally regarded as safe, based primarily on studies with beta-carotene.
		Increased consumption of carotenes may lead to the skin turning orange or yellow—a condition known as “carotenodermia.” This occurrence is completely benign and is totally unrelated to jaundice—the yellowing of the skin caused by liver damage.
		Until more is known, smokers should not supplement with synthetic beta-carotene.
	www.valuenutritioncenter.com /twincarprod.html (1442 words)

	Self-Service Science Forum Message (Site not responding. Last check: 2007-10-12)
		The ABC reserves the right to remove offensive or inappropriate messages.
		You can read an abstract about a case study of the condition (known as carotenodermia) here
		search for 'carotenodermia' and you should come p with a few hits...
	www2.abc.net.au /science/k2/stn/october2000/posts/topic145352.shtm (1350 words)

	Carotenoids
		No other drug interactions have been identified in relation to carotenoids.
		Carotenoids may cause a condition referred to as carotenodermia, which is characterized by a yellow or orange pigmentation of the skin.
		The condition can be corrected when the use of carotenoids is discontinued.
	www.webvitamins.com /Nutrient.aspx?id=425 (282 words)

	Transcutaneous Bilirubin Measurements and Serum Total Bilirubin Levels in Indigenous African Infants -- Slusher et al. ...
		This case demonstrates that carotenodermia can also affect the
		Red palm oil in the maternal diet increases provitamin A carotenoids in breastmilk and serum of the mother-infant dyad.
		Pinto F, Mognol D, Garbelotto G, Dannhauser D, Grava G, Sanzuol F. [Carotenodermia: an erroneous diagnosis of jaundice].
	pediatrics.aappublications.org /cgi/content/full/113/6/1636 (3412 words)

	[No title]
		Ophthalmological evaluation showed an average increment in visual acuity of 0.4, and glare sensitivity also improved.
		No significant side effects such as hypercarotenemia, carotenodermia or changes in biochemical or haematological profile were observed.
		Thus, lutein supplementation at achievable dietary levels increased and maintained serum lutein levels, which were associated with an improvement in the visual function of the patients.
	www-u.life.uiuc.edu /labs/crofts/arc-lit/200108/01083025 (17012 words)

	ClearSkin.net :: View topic - Information and Articles about Vitamin A
		Care must be taken with the use of vitamin A supplements.
		Hypercarotenosis - is usually seen with excessive intakes of carrot or tomato juice, which results in hypercarotaemia (increased blood carotene levels) and carotenodermia (yellow-orange skin colouration).
		This does not progress to hypervitaminosis A. Hypervitaminosis A - occurs at recurrent intakes of 10 times RDI.
	www.clearskin.net /viewtopic.php?t=3030 (14428 words)

	Lutein Vitamin Supplements and Information (Site not responding. Last check: 2007-10-12)
		No side effects have been reported at normal doses
		Toxicity from high lutein intake can cause carotenodermia, a yellowish discoloration of the skin.
		Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical profession.
	www.buyvitaminsupplements.net /nutritional_supplements/lutein.htm (608 words)

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