| Genomics|HuGENet|Case Study|Parkinson's|Overview |
 | | Approximately two-thirds of Parkinson's disease cases are sporadic while the remainder are familial; a small subset appears to follow autosomal dominant inheritance, whereas the vast majority have no clear inheritance pattern. |
 | | In one study (Scott et al., 1999), the SNCA gene was tested for the A53T mutation in 356 affected persons from 186 multiplex families with Parkinson disease; one Greek-American family segregated this mutation as an autosomal dominant trait, giving a frequency for this mutation of less than 1 in 186, or 0.5%. |
 | | In a study for mutations in the SNCAIP gene, Marx et al. |
| www.cdc.gov /genomics/hugenet/CaseStudy/PARKINSON/PARKview.htm (604 words) |