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Cataplexy - Wikipedia, the free encyclopedia Cataplexy is a medical condition which often affects people who have narcolepsy, a disorder whose principal signs are EDS (Excessive Daytime Sleepiness), sleep attacks, and disturbed nighttime sleep. Cataplexy manifests itself as muscular weakness which may range from a barely perceptible slackening of the facial muscles to the dropping of the jaw or head, weakness at the knees, or a total collapse. Cataplexy is also sometimes confused with epilepsy, where a series of flashes or other stimulus cause similar seizures. en.wikipedia.org /wiki/Cataplexy   (260 words)

Cataplexy | Cataplexy Definition | Cataplexy Symptoms | Cataplexy Treatment Cataplexy is a strange neurologic situation, which is sometimes confused with epilepsy. Cataplexy may be most severe when the subject is tired rather than completely alert and can lead to considerable anxiety although anxiety itself is not a trigger. Cataplexy may be partial or complete, affecting a range of muscle groups, from those controlling facial features to (less commonly) those controlling the entire body. www.sleepdisordersguide.com /topics/cataplexy.html   (517 words)

Cataplexy Analysis Cataplexy, a sudden loss of voluntary muscle control, is a hallmark symptom of narcolepsy, a sleep disorder believed to affect 1 in 1000. Cataplexy is usually triggered by emotions such as laughter, surprise, fear or anger, and is more common in times of stress. Reliably inducing cataplexy in a clinical setting is hampered by the social and ethical concerns surrounding purposeful evocation of strong emotions as well as defense mechanisms patients commonly develop to resist such emotions. www.mayo.edu /bir/Projects/Cataplexy/Cataplexy.html   (359 words)

FAQs Cataplexy (the other hallmark symptom of narcolepsy) is a sudden loss of voluntary muscle control, usually triggered by emotions such as laughter, surprise, fear or anger. Cataplexy for others can be so instantaneous that there is no time to prepare for safety and serious injury can occur. Cataplexy may interfere with physical activities, and cause efforts to avoid emotions, which may lead to social withdrawal. www.cataplexic.com /faqs.html   (1380 words)

Narcolepsy - Symptoms - SleepChannel Cataplexy is the most common auxiliary symptom of narcolepsy, afflicting roughly 70 percent of patients. Cataplexy, the most prevalent secondary symptom of narcolepsy, is almost exclusive to narcolepsy. Indeed, excessive daytime sleepiness and cataplexy are sufficient for a diagnosis of narcolepsy. www.sleepdisorderchannel.com /narcolepsy/symptom.shtml   (844 words)

APSS Abstracts Search Results   (Site not responding. Last check: 2007-10-17) Cataplexy occurs suddenly from active wake and is triggered by emotional excitation while REM sleep occurs in the middle of sleep. During cataplexy, phasic phenomena of REM sleep, such as rapid eye movements (REMs) are less frequently observed than during natural REM sleep (see, [2]). Cataplexy was quantified using the Food Elicited Cataplexy Test [3] in six narcoleptic Dobermans. www.websciences.org /cftemplate/apss97/indiv.dbm?ID=19979512   (837 words)

Narcolepsy Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS) Cataplexy is a sudden loss of muscle tone that leads to feelings of weakness and a loss of voluntary muscle control. But in about 10 percent of all cases, cataplexy is the first symptom to appear and can be misdiagnosed as a manifestation of a seizure disorder. Although cataplexy can occur spontaneously, it is more often triggered by sudden, strong emotions such as fear, anger, stress, excitement, or humor. www.ninds.nih.gov /disorders/narcolepsy/detail_narcolepsy.htm   (4086 words)

Sleep, symptoms of narcolepsy, #3, cataplexy, what is cataplexy, sleep disorders, narcolepsy Cataplexy is the partial or complete loss of bilateral muscle tone in response to strong emotion. Reduced muscle tone may be minimal, occur in a few muscle groups, and cause head drooping, slurred speech, or dropping things from the hand; or it may be so severe that total body paralysis occurs, resulting in complete collapse wherein the person is unable even to open his or her eyes. The onset of cataplexy is most frequently simultaneous with the onset of excessive daytime sleepiness, but cataplexy may not develop until many years after initial onset of excessive day- time sleepiness. www.holistic-online.com /REMEDIES/Sleep/sleep_narc_symptoms_3.htm   (294 words)

Narcolepsy - Sleep Disorders including, Sleep Apnea, Narcolepsy, Insomnia, Snoring and Nightmares Cataplexy is a sudden, temporary (reversible) loss of muscle tone (the normal firmness of a muscle) in a person with narcolepsy. An attack of cataplexy usually is triggered by emotional stimuli such as laughter, excitement, surprise, or anger. Cataplexy is present in 65% to 70% of patients with narcolepsy. www.medicinenet.com /narcolepsy/page3.htm   (526 words)

Cataplexy Cataplexy rates as one of the strangest things I have ever felt, right up there with sticking your finger in a light socket, except at the opposite end of the scale. Cataplexy is a form of SP, the difference being that it doesn't have to involve your whole body, it can affect any group of muscles or even just one muscle. It is said that emotions are what causes a cataplexy attack to be triggered, this is true but I have found that many times an emotion is triggered by some event that in turn then triggers the cataplexy. home.insightbb.com /~narcolepsy_indiana/Cataplexy.htm   (3933 words)

Cataplexy - WrongDiagnosis.com Cataplexy is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Cataplexy, or a subtype of Cataplexy, affects less than 200,000 people in the US population. Cataplexy is also sometimes confused with epilepsy, where a series of flashes or other stimulus may cause coma. www.wrongdiagnosis.com /c/cataplexy/intro.htm   (799 words)

Sleep Disorders Cataplexy, which represents the atonia of REM sleep, is a sudden loss of muscle tone and strength which may be localized to a region of the body such as the legs or the head and neck or can be generalized and affect the whole body. In the past, tricyclic anti-depressants were very helpful in treating the cataplexy, but they had significant side effects such as drowsiness. The mode of action in treating the cataplexy is not well known, but it has been the most effective treatment for the cataplexy yet. www.uoahouston.org /article2.htm   (1793 words)

Specialty Laboratories ::: we help doctors help patients Cataplexy is a striking, sudden episode of muscle weakness triggered by sudden strong emotions, such as laughter and impulsive anger, that cause the knees to buckle. This HLA haplotype is found in approximately 95% of narcoleptic patients with severe cataplexy, 85% of narcoleptic patients with "clear-cut" cataplexy, 54% of narcoleptic patients with mildest cataplexy, and ~ 40% of narcoleptic patients with atypical or no cataplexy, compared with 12-38% in control populations of various ethnic groups. Cataplexy is either atypical or absent in 8-42% of "narcoleptic" cases. www.specialtylabs.com /books/display.asp?id=949   (922 words)

Orphan Medical Cataplexy is a debilitating symptom of narcolepsy usually triggered by strong emotions such as laughter, anger, or surprise. Cataplexy is a debilitating symptom characterized by loss of muscle control in response to strong emotional reactions such as laughter, anger, or surprise. During the first trial, the median number of weekly cataplexy attacks in patients who received the 9 gram dose of Xyrem decreased by a median of 68.6% in comparison to the baseline. www.projectghb.org /orphan_medical.htm   (2564 words)

Narcolepsy from Neurology / Sleep Related Diseases   (Site not responding. Last check: 2007-10-17) Cataplexy (Latin, "to strike down with fear") is an abrupt attack of muscle weakness. Cataplexy is seen in about 70% of patients with narcolepsy, and its presence with EDS strongly suggests the diagnosis of narcolepsy. Vossler DG, Wyler AR, Wilkus RJ: Cataplexy and monoamine oxidase deficiency in Norrie disease. users3.ev1.net /~drtony/narcolep.htm   (4051 words)

NNPDF Parent to Parent: Seizures   (Site not responding. Last check: 2007-10-17) Cataplexy is an abrupt temporary loss of voluntary muscular function and tone, evoked by an emotional stimulus such as laughter, pleasure, anger, or excitement. Cataplexy occurs when a person experiences an emotional stimulation - hearing a good joke (laughter), taking a trip (excitement), having an argument (anger), being in a crowded store (stress), etc. The stimulation leads to a very rapid loss of voluntary muscle control - often the person will immediately collapse as a result. Cataplexy can be confused with seizures, especially if you are not familiar with the differing symptoms. www.nnpdf.org /parent6.htm   (306 words)

cataplexy exist independently of narcolepsy Cataplexy is a rapidly occurring loss of voluntary... Cataplexy, a sudden loss of muscle tone ranging from slight weakness to complete collapse, is another major symptom of narcolepsy... The cause of narcolepsy with cataplexy appears to be... www.about-doctors.com /305/cataplexy-exist-independently-of-narcolepsy.html   (397 words)

Cataplexy [2] Cataplexy (the other hallmark symptom of narcolepsy) is a sudden loss of voluntary muscle control, usually triggered by emotions such as laughter, surprise, fear or anger. Cataplexy often develops several years after the onset of daytime sleepiness... Cataplexy can also be more dramatic, and the individual may drop objects being... insomnia.growing-good-health.info /cataplexy   (242 words)

Xyrem: Some Questions and Misperceptions Although patients who enrolled in the clinical trials were required to withdraw from their cataplexy medications in order to comply with the study protocol it certainly is not necessary for one to stop their existing cataplexy medication in order to start taking Xyrem. In the initial clinical trials patients were withdrawn from their cataplexy medications in order to compare a person's cataplexy at "baseline" verses while on the new medication or placebo. A person may still experience some mild rebound cataplexy while slowly weaning from the old medications (it is hard to avoid entirely due to the nature of anti-depressants), but generally this rebound cataplexy will be mild and less severe as the Xyrem works to help lessen the rebound. www.talkaboutsleep.com /sleep-disorders/2005/05/narcolepsy-xyrem-questions.htm   (1586 words)

Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. The disease is characterized by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep, such as sleep paralysis and hypnagogic hallucinations. Of the 116 cases, 10 are associated with multiple sclerosis, one case of acute disseminated encephalomyelitis, and relatively rare cases were reported with vascular disorders (n=6), encephalitis (n=4) and degeneration (n=1), and hererodegenerative disorder (three cases in a family). In contrast to idiopathic narcolepsy cases, an occurrence of cataplexy is not tightly associated with hypocretin ligand deficiency in symptomatic cases. www.galenicom.com /medline/article/16006155/mt:Coffin-Lowry%252520Syndrome   (627 words)

Narcolepsy Network, Inc. In the past six years, two medications have received FDA approval specifically to treat narcolepsy symptoms, and are considered by leading narcolepsy experts to be the first-line treatments for the symptoms of narcolepsy. For treatment of REM-related symptoms -- cataplexy, hallucinations and sleep paralysis -- tricyclic antidepressants such as imipramine, clomipramine and protriptyline were found decades ago to be helpful in reducing episodes of cataplexy. Some cataplexy medications are not recommended in the presence of certain other medical conditions or in combination with certain other medications. www.narcolepsynetwork.org /meds.php   (738 words)

APSS Abstracts Search Results   (Site not responding. Last check: 2007-10-17) Data were then analyzed in relation to the presence or absence of cataplexy and in relation to the severity of cataplexy. The analysis of the Stanford cataplexy questionnaires, completed by 113 subjects, and reviewed by a clinician (C.G.) allowed subjects to be subdivided into three groups: patients with no cataplexy (n=7), with doubtful or possible cataplexy (n=16), and with definite cataplexy (n=90). The importance of DQB1*0602 positivity in relation to cataplexy was further examined in terms of severity of cataplexy. www.websciences.org /cftemplate/apss97/indiv.dbm?ID=19979399   (958 words)

PRESS RELEASE Xyrem(R) is Launched in Germany for the Treatment of Cataplexy in Adults with Narcolepsy   (Site not responding. Last check: 2007-10-17) Narcolepsy is a debilitating, life-long neurological disorder that is characterised by excessive daytime sleepiness and sleep attacks[1]. Cataplexy is a typical symptom of narcolepsy and is present in 65-70% of patients with narcolepsy. A follow-up, 12-month open-label study showed that Xyrem®; (3-9 g) was well-tolerated and produced significant and long-term clinical improvement in the frequency of cataplexy attacks and diminished day-time sleepiness[3]. www.marketwire.com /mw/release_html_b1?release_id=103520   (719 words)

[No title] In experiments with narcoleptic dobermans and canines, narcoleptic cataplexy is found to be closely associated with the cholinergic pathway in the basal forebrain. Narcolepsy is a chronic, incurable central nervous system disorder characterized by excessive and overwhelming daytime sleepiness, frequent sleep attacks, cataplexy, and abnormal REM (rapid eye movement, a sleeping state in which dreaming occurs) latency. Neurochemical and electrophysiological studies have shown that narcolepsy is associated with an abnormal cholinergic supersensitivity and a monoaminergic (dopamine and norepinephrine) hypoactivity. sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_267.html   (2263 words)

View topic - Cataplexy..newly diagnosed Cataplexy is actually related to and is a kind of REM sleep, triggered by emotions. The seizures and cataplexy are very different...cataplexy is marked by total weakness of the muscles. I am struck by the fact that you were able to hold on to the pizza...with cataplexy, you normally would not be able to hold on to anything if your hands were involved in a catapletic episode. www.talkaboutsleep.com /message-boards/viewtopic.php?t=17333   (2050 words)

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