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Topic: Catecholamine

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  Catecholamines: Test Sample
Catecholamines are a group of similar hormones produced in the medulla (central portion) of the adrenal glands.
The primary catecholamines are dopamine, epinephrine (adrenaline), and norepinephrine.
Normally, catecholamines and their metabolites are present in the body in small, fluctuating amounts that only increase appreciably during and shortly after a bout of stress.
www.labtestsonline.org /understanding/analytes/catecholamine/sample.html   (771 words)

 Catecholamine Synthesis is Mediated by Tyrosinase in the Absence of Tyrosine Hydroxylase -- Rios et al. 19 (9): 3519 -- ...
Catecholamine Synthesis is Mediated by Tyrosinase in the Absence of Tyrosine Hydroxylase
Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to
Catecholamine histofluorescence in the peripheral and CNS of pigmented postnatal TH-null mice
www.jneurosci.org /cgi/content/full/19/9/3519   (5342 words)

 Catecholamine Summary
Catecholamines are produced by the enzymatic conversion of tyrosine, sharing the chemical root of 3, 4-dihydroxyphenylethanolamine.
High catecholamine levels in blood are associated with stress, which can be induced from psychological reaction or environmental stressors such as elevated sound levels or intense light.
Catecholamines have the distinct structure of a benzene ring with two hydroxyl groups, an intermediate ethyl chain and a terminal amine group.
www.bookrags.com /Catecholamine   (337 words)

 Catecholamines: The Test
Catecholamine testing is ordered when a doctor either suspects that a patient has a pheochromocytoma or wants to rule out the possibility.
Since the catecholamine test is sensitive to many outside influences and pheochromocytomas are rare, a doctor may see more false positives with this test than true positives.
While plasma and urine catecholamine testing can help detect and diagnose pheochromocytomas, they cannot tell the doctor where the tumor is, whether there is more than one, or whether or not the tumor is benign (although most are).
www.labtestsonline.org /understanding/analytes/catecholamine/test.html   (924 words)

 Highbeam Encyclopedia - Search Results for catecholamine
A biogenic amine and one of the catecholamine hormones, chemically related to adrenalin and crucial to the maintenance of alertness, drive, and motivation, synthesized from tyrosine in the presence of the cofactor vitamin C, and secreted by the chromaffin cells of the adrenal...
Epinephrine, a catecholamine, together with norepinephrine, is secreted principally by the medulla of the adrenal gland.
Any of a number of nitrogenous bases that can be formed from catecholamines and indoleamines and that, when treated with formaldehyde gas, fluoresce under ultraviolet light, the wavelength of the emitted light depending on the specific catecholamine or indoleamine involved,...
www.encyclopedia.com /SearchResults.aspx?Q=catecholamine   (923 words)

 Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs -- Nagayama et al. 275 (4): 1075 -- AJP - ...
Increases in catecholamine output in response to SNS and ACh.
The 3-Hz SNS- and ACh-induced increases in catecholamine
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
ajpregu.physiology.org /cgi/content/full/275/4/R1075   (3297 words)

 Correlation of Real-time Catecholamine Release and Cytosolic Ca[IMAGE] at Single Bovine Chromaffin Cells -- Finnegan ...
In the present study, the simultaneous detection of intracellular Ca, with the fluorescent probe fura-2, and catecholamine release, using a carbon-fiber microelectrode, are examined at single chromaffin cells in culture.
Cytosolic free Ca and catecholamine responses to caffeine in the presence and absence of external Ca 10 mM and 40 mM caffeine was alternately applied to cells (A) in the presence of 2 mM extracellular Ca n = 5) and (B) in medium containing 0.2 mM EGTA (n = 7).
Caffeine induces catecholamine secretion from perfused adrenal glands in both the presence and absence of extracellular Ca This is in contrast to the depolarizing agents and has lead to the concept that mobilization of internal Ca stores can independently induce exocytosis(29, 51).
www.jbc.org /cgi/content/full/270/10/5353   (5686 words)

 Catecholamine - Wikipedia, the free encyclopedia
Catecholamines are chemical compounds derived from the amino acid tyrosine.
Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response).
Monoamine oxidase (MAO) is the main enzyme responsible for degradation of catecholamines.
en.wikipedia.org /wiki/Catecholamine   (294 words)

 Catecholamine-Synthesizing Enzymes in Carcinoid Tumors and Pheochromocytomas -- Meijer et al. 49 (4): 586 -- Clinical ...
of catecholamines and metabolites was observed in 10 (48%) carcinoid
and platelet serotonin) and urinary excretion of catecholamines
Catecholamines and metabolites were not measured in each patient; therefore, the numbers do not equal 21 for each measurement.
www.clinchem.org /cgi/content/full/49/4/586   (3043 words)

 catecholamine - HighBeam Encyclopedia
catecholamine, any of several compounds occurring naturally in the body that serve as hormones or as neutrotransmitters in the sympathetic nervous system.
The catecholamines include such compounds as epinephrine, or adrenaline, norepinephrine, and dopamine.
They resemble one another chemically in having an aromatic portion (catechol) to which is attached an amine, or nitrogen-containing group.
www.encyclopedia.com /html/c1/catechol.asp   (204 words)

 Thomas Jefferson University - Anesthesiology
Circulating catecholamine levels is an important indicator of cardiovascular homeostasis and fluctuates is response to surgical stress, pain related stress and other sympathoadrenal-mediated events.
The separation of plasma catecholamines by HPLC is dependent upon the individual physical properties of each catecholamine in relationship to the stationary phase and the mobile phase.
Plasma Catecholamine values (pg/ml) are calculated for individual samples by means of a linear regression analysis, based upon a triplicate injection of a single-point external reference standard.
www.tju.edu /anesthesiology/research/proj-catecholamines.cfm   (254 words)

 Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland -- Fukushima et al. 281 (5): 1562 -- AJP ...
Perfusate was sampled before and during the stimulation to determine catecholamine output.
The increases in catecholamine output induced by the stimulation
Whereas the ES-induced catecholamine output responses in the rat adrenal gland are mainly mediated by nicotinic receptors
ajpregu.physiology.org /cgi/content/full/281/5/R1562   (4000 words)

 Catecholamine treatment of ocular hypertension - Patent 4275074
The method in accordance with claim 1 wherein the applied amount of said catecholamine is about 0.01 to about 5 milligrams and the concentration of the catecholamine in said ophthalmic vehicle is no more than about 0.5 percent, weight by volume.
The method in accordance with claim 1 wherein the applied amount of said catecholamine is about 0.02 to about 2 milligrams and the concentration of the catecholamine in said ophthalmic vehicle is about 0.001 to about 0.15 percent, weight by volume.
The method in accordance with claim 1 wherein the catecholamine is an acid addition salt of.alpha.-methyl epinephrine.
www.freepatentsonline.com /4275074.html   (3468 words)

 Morning Preprandial Plasma Ghrelin and Catecholamine Concentrations in Patients with Phenylketonuria and Normal ...
interfering with the conversion of Tyr to the catecholamine
Correlation coefficients between ghrelin and plasma amino acids or catecholamines and 24-h nutrient intake or BMI in PKU patients and controls
Quigada M, Illner P, Krulich L, McCann S 1974 The effect of catecholamines on hormone release from anterior pituitaries and ventral hypothalamus incubated in vitro.
jcem.endojournals.org /cgi/content/full/89/8/3983   (2665 words)

 Activation of Angiotensin II Subtype 2 Receptor Induces Catecholamine Release in an Extracellular Ca2+-Dependent Manner ...
induced catecholamine release from the adrenal medulla (23).
The medium was subsequently examined with a catecholamine analyzer as described in the text.
Catecholamine release evoked by AngII was assessed to be about 80% AT mediated and 20% AT mediated in cultured porcine chromaffin cells.
endo.endojournals.org /cgi/content/full/142/7/3075   (5496 words)

 Signal Transduction Pathways for Catecholamine Receptors
However, in addition to these rapid effects, catecholamines exert many other actions on their target neurons that produce short- and long-term modulatory effects on neuronal function (see Figure 1).
Catecholamine receptors that result in alterations in the cAMP or Ca pathways would be expected to result in altered CREB phosphorylation and altered transcriptional activity (22).
It is likely that catecholamines influence cell growth, differentiation, and movement (including axoplasmic transport and sprouting of dendrites and axons) in their target cells, although the details of the mechanisms involved remain obscure.
www.acnp.org /G4/GN401000028/CH.html   (7925 words)

 ARDB Receptor Ligand Information
Thus, there is a high concentration of catecholamines in synaptic vesicles and a relatively low concentration of catecholamines in the cytosol of catecholaminergic cells.
Almost all of the catecholamine content of a sympathetically innervated tissue is contained in the synaptic vesicles inside the catecholaminergic nerves.
The low concentration of catecholamines in the cytosol of catecholaminergic nerves is maintained in part by the vesicular amine uptake pump and in part by the mitochondrial enzyme, monoamine oxidase (MAO).
ardb.bjmu.edu.cn /ligand/storage_release.htm   (636 words)

 Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion -- Parmer et ...
peptides that inhibit release of catecholamines from adrenal
Restoration of catecholamine secretion by anticatalytic antiplasminogen mAb in PC12 cells overexpressing t-PA. PC12 CS1F9 cells were treated with 60 µM nicotine or buffer (basal) in the presence of 2 µM plasminogen and 300 nM of either an anticatalytic antiplasminogen mAb (open bars) or normal mouse IgG (closed bars).
Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway: catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J.
www.jci.org /cgi/content/full/106/7/907   (5062 words)

 Catecholamine definition - Medical Dictionary definitions of popular medical terms
The catecholamine metabolites vanillylmandelic acid and homovanillic acid can be measured quantitatively in the urine as a test for the disease.
Pheochromocytoma is a benign tumor derived from the adrenal medulla or sympathetic paraganglia.
These catecholamines cause attacks of hypertension, headache, nausea and vomiting, sweating, pallor and severe apprehension.
www.medterms.com /script/main/art.asp?articlekey=20210   (388 words)

 Improving the Catecholamine System in Parkinson's Disease
These three play a role in motor control, so enhancing the catecholamine system is a method to reduce Parkinson's symptoms and improve overall health.
In this article, the attempt to improve receptor sites for the catecholamines is one aspect of anti-aging and helping to improve overall health in Parkinson's Disease.
A low level of catecholamines, such as abnormal low levels of dopamine, as in Parkinson's Disease, is stress to the body.
www.restoreunity.org /improving_catecholamine.htm   (1468 words)

 What is the best diagnostic approach when pheochromocytoma is suspected?
Taken individually, plasma catecholamine and total urinary meta-nephrine assays have a false-negative rate of 7%, urinary norepinephrine and epinephrine assays a rate of 14%, and the urinary vanillyl-mandelic acid assay a rate of 41%.
Patients with plasma catecholamine levels between 1,000 and 2,000 pg/mL and urinary metanephrine levels between 1.3 and 1.8 mg/24 hours may have neurogenically mediated catecholamine release and will require a suppression test (eg, with oral clonidine).
Patients who are highly suspected of having pheochromocytoma and who have plasma catecholamine levels of 1,000 pg/mL or less and urinary metanephrine levels of 1.3 mg/24 hours or less require a provocative test (eg, with glucagon injection).
www.clevelandclinicmeded.com /ccjm/march2002/bravo.htm   (671 words)

 Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine -- Eisenhofer et al. 56 ...
The deaminated aldehyde metabolites of catecholamines are short-lived
To maintain vesicular stores of catecholamines constant, the rate of catecholamine turnover (i.e., loss of catecholamine due to metabolism or escape to the bloodstream) must be balanced by an equal rate of synthesis.
The sympathoneuronal pathway (white) is the major pathway of catecholamine metabolism and involves intraneuronal deamination of norepinephrine leaking from storage granules or of norepinephrine recaptured after release by sympathetic nerves.
pharmrev.aspetjournals.org /cgi/content/full/56/3/331   (7157 words)

 Catecholamine Secretory Vesicle Stimulus-Transcription Coupling in Vivo: DEMONSTRATION BY A NOVEL TRANSGENIC ...
and chromogranin A, the precursor of the catecholamine release-inhibitory,
and chromogranin A, precursor of the catecholamine release
Influx of calcium induces both catecholamine release by exocytosis (all-or-none secretion) and chromogranin A gene transcription through a pathway (62–64) involving activation of protein kinase C (PKC) and mitogen activated protein kinase (MAPK).
www.jbc.org /cgi/content/full/278/34/32058   (5527 words)

 Primary Structure and Function of the Catecholamine Release Inhibitory Peptide Catestatin (Chromogranin A344-364): ...
) on inhibition of desensitization of catecholamine release.
A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Wakade AR 1981 Studies on secretion of catecholamines evoked by acetylcholine or transmural stimulation of the rat adrenal gland.
mend.endojournals.org /cgi/content/full/14/10/1525   (3761 words)

 The role of angiotensin II in regulating catecholamine secretion during hypoxia in rainbow trout Oncorhynchus mykiss -- ...
The role of angiotensin II in regulating catecholamine secretion during hypoxia in rainbow trout Oncorhynchus mykiss -- Lapner and Perry 204 (23): 4169 -- Journal of Experimental Biology
Plasma catecholamine levels were measured at ‘Pre’, 10 min and 60 min of infusion and during acute hypoxia.
The involvement of the RAS in eliciting catecholamine release from non-desensitised chromaffin cells
jeb.biologists.org /cgi/content/full/204/23/4169   (4069 words)

 Neomycin Inhibits Catecholamine Secretion by Blocking Nicotinic Acetylcholine Receptors in Bovine Adrenal Chromaffin ...
Catecholamine secretion from chromaffin cells was measured in 24-well plates following the method described by Park et al.
Orsulakova A, Stockhorst E and Schacht J (1976) Effect of neomycin on phosphoinositide labelling and calcium binding in guinea-pig inner ear tissues in vivo and in vitro.
Purifoy JA and Holz RW (1984) The effects of ketamine, phencyclidine and lidocaine on catecholamine secretion from cultured bovine adrenal chromaffin cells.
jpet.aspetjournals.org /cgi/content/full/288/1/73   (4652 words)

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