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Topic: Cathepsin

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	Cathepsin - Wikipedia, the free encyclopedia
		A cathepsin is one of a family of proteases, a type of protein that breaks apart other proteins, found in many types of cells including those in all animals.
		Cathepsin B seems to actually break down the proteins which cause amyloid plaquethe root of Alzheimer's symptoms, and may even be a pivotal part of the natural defense against this disease used by people who do not get it[2].
		Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells.
	en.wikipedia.org /wiki/Cathepsin (288 words)

	tutorial text
		Cathepsin K is a recently discovered protease that belongs to the papain family of cysteine proteases.
		The presence of cathepsin K in chondroclasts and RA-synoviocytes also suggests that it is involved in the normal turnover of cartilage (Bromme et al., 1999).
		With these functions of cathepsin K, mutations in the cathepsin K gene have been shown to cause pycnodysostosis, which is a rare autosomal recessive skeletal dysplasia characterized by short stature, osteosclerosis, bone fragility, and abnormal bone and tooth development (Chapman et al., 1997).
	srv2.lycoming.edu /~newman/courses/bio44400/cathepsin/right.htm (2380 words)

	Comparative Localization of Cathepsin B Protein and Activity in Colorectal Cancer -- Hazen et al. 48 (10): 1421 -- ...
		Cathepsin B activity was present in all specimens (Fig 1a).
		Digital photomicrographs of adjacent sections showing (a) activity and (b) protein of cathepsin B in colon adenoma, (c) activity and (d) protein of cathepsin B in well-differentiated colorectal carcinoma, (e,f) activity of cathepsin B in moderately differentiated colorectal carcinoma, and (g) activity and (h) protein of cathepsin B in poorly differentiated carcinoma.
		Werle B, Julke B, Lah T, Spiess E, Ebert W (1997) Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
	www.jhc.org /cgi/content/full/48/10/1421 (4954 words)

	Surface Cathepsin B Protects Cytotoxic Lymphocytes from Self-destruction after Degranulation -- Balaji et al. 196 (4): ...
		Perforin cleavage by cathepsin B. (A) Perforin from CTL extracts was treated with 258 ng/ml purified cathepsin B for various times and analyzed by blotting with anti-perforin antibody.
		Extracellular cathepsin B is implicated by the data in Fig.
		Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.
	www.jem.org /cgi/content/full/196/4/493 (6888 words)

	Cathepsin G, a Neutrophil-Derived Serine Protease, Increases Susceptibility of Macrophages to Acute Human ...
		Chemotactic activity or effect of cathepsin G on HIV-1 infection of macrophages is dependent on its catalytic activity and Gi protein signal transduction.
		Chemotactic activity and effect of cathepsin G (CatG) on HIV-1 infection of macrophages is dependent on its catalytic activity and Gi protein signal transduction.
		Cathepsin G was washed out after the indicated period (30 min or 24 h) of incubation or continuously supplied by replacing approximately half of the medium containing the same amount of cathepsin G every 4 days.
	jvi.asm.org /cgi/content/full/74/15/6849 (4479 words)

	Normal Neutrophil Function in Cathepsin G-Deficient Mice -- MacIvor et al. 94 (12): 4282 -- Blood
		Cathepsin G is a neutral serine protease that is highly expressed at the promyelocyte stage of myeloid development.
		Cathepsin G and neutrophil elastase activities in cathepsin G-deficient mice.
		The activity of cathepsin G and neutrophil elastase was determined by the ability of total bone marrow protein extracts to cleave colorometric peptide substrates in vitro, as described in Materials and Methods.
	www.bloodjournal.org /cgi/content/full/94/12/4282 (6879 words)

	Regulation of Elastinolytic Cysteine Proteinase Activity in Normal and Cathepsin K-deficient Human Macrophages -- ...
		Cathepsin K secretion into the cell-free supernatants was assessed by Western blot analysis in A, B, and C, and cathepsin B in D. The pro- (white arrowheads) and mature (arrows) forms of the enzymes are indicated.
		Cystatin C or cathepsin K–cystatin complexes were immunoprecipitated using rabbit preimmune sera (lanes 1, 3, 5, and 7) or a specific anti–cystatin C Ab (lanes 2, 4, 6, and 8).
		The elastinolytic activity of cells derived from a healthy donor (lanes 1 and 2), an unaffected heterozygous individual (lanes 3 and 4), or an affected subject (lanes 5 and 6) was evaluated in the absence (lanes 1, 3, and 5) or presence (lanes 2, 4, and 6) of 100 µM E-64.
	www.jem.org /cgi/content/full/192/6/789 (6847 words)

	Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma ...
		Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
		Variable expression of cathepsin B and D correlates with high invasive and metastatic phenotype of oral cancer.
		The role of cathepsin D in the invasiveness of human breast cancer cells.
	jcp.bmj.com /cgi/content/full/55/2/121 (3607 words)

	Human Endothelial Cell Damage by Neutrophil-Derived Cathepsin G : Role of Cytoskeleton Rearrangement and Matrix-Bound ...
		E and F, Cathepsin G (0.2 µmol/L, 1 hour): formation of intercellular gaps (E); microfilaments are diffused in the cell cytoplasm; decrease in stress fibers (F).
		Cathepsin G (0.04 µmol/L, 2 hours) was inhibited by washing cells with serum-containing medium.
		Human leukocyte elastase, cathepsin G and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor.
	atvb.ahajournals.org /cgi/content/full/15/11/2037 (5371 words)

	Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome -- Hart et al. 36 (12): 881 -- Journal ... (Site not responding. Last check: 2007-10-08)
		Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome -- Hart et al.
		Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome
		The wild type cathepsin C with 463 amino acids is shown at the top, as predicted from the coding region of cloned CTSC NCBI Accession No The three residues of the active site are indicated by arrows.
	jmg.bmj.com /cgi/content/full/36/12/881 (3288 words)

	Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair ...
		Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling -- ROTH et al.
		Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
		Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin.
	www.fasebj.org /cgi/content/full/14/13/2075 (6903 words)

	Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription ...
		Cathepsin K is a cysteine protease from the papain family
		Cathepsin K Is a Transcriptional Target of Mitf and TFE3 via Three Consensus Elements in the Cathepsin K Promoter.
		928 bp to +2 (25, 26), mutant cathepsin K constructs with individual E-boxes mutated, and a deletion construct without the upstream three E-boxes were transfected into MCF-7 cells in the presence of Mitf, TFE3, or vector controls.
	www.pnas.org /cgi/content/full/98/10/5798 (4866 words)

	Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor -- Thurmond et al. 308 (1): 268 -- Journal ...
		Cathepsin S is a cysteine protease found in the lysosome of
		The main substrate of cathepsin S in vivo is the invariant chain.
		Cathepsin S was incubated for 15 min with DMSO, JNJ 10329670, LHVS, or E-64 each at 100 µM. Afterwards the compounds were dialyzed overnight at 4°C. Enzyme activity was determined before dialysis (gray bar), after dialysis (open bar), and after addition of compounds diluted because they would be during dialysis (fl bar).
	jpet.aspetjournals.org /cgi/content/full/308/1/268 (5989 words)

	Cathepsin L Gene Expression and Promoter Activation in Rodent Granulosa Cells -- Sriraman and Richards 145 (2): 582 -- ...
		Spatiotemporal expression of cathepsin L in the mouse and rat ovary.
		Using a probe generated to mouse cathepsin, cathepsin L mRNA was detected in the granulosa cells of growing and ovulating follicles.
		In these ovaries, cathepsin L message was observed not only in the granulosa cells of preovulatory follicles but also in granulosa cell and theca of follicles stimulated by hCG for 2 and 8 h, respectively.
	endo.endojournals.org /cgi/content/full/145/2/582 (5730 words)

	Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell ...
		Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins -- Warner et al.
		Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins
		CLAP, either free or as a complex with cathepsin L, was resistant
	content.febsjournal.org /cgi/content/abstract/271/20/4014 (400 words)

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