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Topic: Cathepsin B

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	RedNova News - Science - HaCaT Keratinocytes Secrete Lysosomal Cysteine Proteinases During Migration (Site not responding. Last check: 2007-10-14)
		Cell surface- association of active cathepsin B was observed during spontaneous and induced migration, suggesting a contribution of cathepsin B to dissociation of cellular contacts and to ECM remodelling to enable keratinocytes to populate free surface areas during growth, and to facilitate keratinocyte migration during wound healing.
		Cathepsin B activity is detected in association with perinuclear vesicles corresponding to lysosomes, or extracellularly at the plasma membrane of keratinocytes at the wound margins (c', f', arrowheads, punctate lines denote the cell surfaces).
		Cathepsin B was already suggested as an important enzyme for proteolysis of ECM constituents during the propagation of streptococcal infections of mouse skin (Lukomski et al., 1999).
	www.rednova.com /news/display?id=131196 (8830 words)

	Abstract: Relationship Between Cathepsin B and Thrombin in Rheumatoid Arthritis
		The effect of thrombin on the release of IL-8 and cathepsin B from SFC was investigated.
		The effect of recombinant IL-8 on the activation of cathepsin B was examined using the knee joints of rabbits.
		Cathepsin B activity was also significantly higher in SF cells and synovial tissue extracts from RA patients than in those from OA patients.
	www.jrheum.com /abstracts/abstracts04/1265.html (405 words)

	An Intracellular Form of Cathepsin B Contributes to Invasiveness in Cancer -- Szpaderska and Frankfater 61 (8): 3493 -- ...
		Cathepsin B was measured with the fluorogenic substrate
		Time-dependent inhibition of intracellular cathepsin B by 10 µ
		B in a peripheral lymph node by 20–30%.
	cancerres.aacrjournals.org /cgi/content/full/61/8/3493 (6612 words)

	Cathepsin B antibody (ab7670) datasheet (Site not responding. Last check: 2007-10-14)
		This antibody recognises human precursor and mature forms of Cathepsin B. The antibody also recognises Cathepsin B enzyme/inhibitor complexes.Cathepsin B is a cysteine endopeptidase which is synthesised as a 40kD inactive glycoprotein and processed into the mature form.
		If Cathepsin B antibody (ab7670) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Cathepsin L is a potent lysosomal cysteine proteinase reported to be involved in several pathological processes, including rheumatoid arthritis, muscular dystrophy, Alzheimers and cancer.
	www.abcam.com /?datasheet=7670 (369 words)

	Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor -- ...
		B activity is expressed as arbitrary units of luciferase activity relative to ß-galactosidase activity.
		Cathepsin B is a key mediator in TNF-induced caspase-dependent apoptosis of tumor cells.
		B protein and activity in the cytosol (Fig 8A and Fig B).
	www.jcb.org /cgi/content/full/153/5/999 (6967 words)

	Thyroid functions of mouse cathepsins B, K, and L -- Friedrichs et al. 111 (11): 1733 -- Journal of Clinical ...
		Cathepsin D was absent from the inner portions of enlarged lysosomes of thyroid epithelial cells with a deficiency in cathepsin L (d, arrows).
		Tg persistence in thyroids of mice with deficiencies in cathepsin B or L. Lysates of thyroids from mice of the indicated genotypes were normalized to equal amounts of protein, separated on 10% SDS gels, and transferred to nitrocellulose for subsequent incubation of the blots with antibodies against Tg.
		Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
	www.jci.org /cgi/content/full/111/11/1733 (7926 words)

	The Cathepsin B Inhibitor z-FA.fmk Inhibits Cytokine Production in Macrophages Stimulated by Lipopolysaccharide -- ...
		B exists as a dimer of a p50 and p65 subunit that is
		B complexes indicates that they are both composed of p50 and p65.
		Cathepsin B is a cysteine protease implicated in a number of inflammatory diseases and pathological conditions, such as bronchitis,
	www.jbc.org /cgi/content/full/276/24/21153 (3736 words)

	Surface Cathepsin B Protects Cytotoxic Lymphocytes from Self-destruction after Degranulation -- Balaji et al. 196 (4): ...
		Activation-induced suicide of cytotoxic effectors in the presence of membrane-impermeant cathepsin B inhibitors.
		Perforin cleavage by cathepsin B. (A) Perforin from CTL extracts was treated with 258 ng/ml purified cathepsin B for various times and analyzed by blotting with anti-perforin antibody.
		Extracellular cathepsin B is implicated by the data in Fig.
	www.jem.org /cgi/content/full/196/4/493 (6785 words)

	Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues -- Crabb et al. 11 (4): 831 ... (Site not responding. Last check: 2007-10-14)
		The three-dimensional structure of cathepsin B. The structure of bovine spleen procathepsin B (Yamamoto et al.
		B was activated by incubating the proenzyme for 15 min at 37°C
		Jessup, W., Mander, E.L., and Dean, R.L. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages.
	www.proteinscience.org /cgi/content/full/11/4/831 (4184 words)

	Cysteine Protease Activity Is Required for Surfactant Protein B Processing and Lamellar Body Genesis -- Guttentag et ...
		B is a composite of photomicrographs from immunohistochemistry of cells using the organelle markers BiP (ER), p230 (Golgi), early endosomes (Eea1), and lamellar bodies/multivesicular bodies (Lamp1).
		Expression of single chain 28-kD Cathepsin H (CTSH, upper arrowhead) increased during in vitro differentiation in both the presence and absence of E-64, whereas expression of the 22-kD heavy chain fragment accumulates to a greater degree in the presence of E-64 (n = 3).
		Cathepsin H activity assay performed on freshly isolated undifferentiated alveolar epithelial cells (no DCI) and cells cultured for 3 and 5 d in DCI ± 10, 50, or 100 µM E-64.
	ajrcmb.atsjournals.org /cgi/content/full/28/1/69 (7214 words)

	Venomous protease of aphid soldier for colony defense -- Kutsukake et al. 101 (31): 11338 -- Proceedings of the ...
		B protein was purified from the culture medium by using the
		(B) Semiquantitative RT-PCR of soldier-specific and nonspecific cathepsin B genes.
		B protein was also produced in a soldier-specific manner (Fig.
	www.pnas.org /cgi/content/full/101/31/11338 (4035 words)

	OUTPUT from blastx for A5-0002 (Site not responding. Last check: 2007-10-14)
		(Y18460) cathepsin B [Homo sapiens] 90 1e-19 spP07688CATB_BOVIN CATHEPSIN B PRECURSOR 92 2e-19 pdb1QDQA Chain A, X-Ray Crystal Structure Of Bovine Cathe...
		cathepsin B [Mus musculus] spP10605CATB_MOUSE CATHEPSIN B PRECURSOR (CATHEPSIN B1) pirKHMSB cathepsin B (EC 3.4.22.1) precursor - mouse gbAAB20536.1
		cathepsin B [Rattus norvegicus] spP00787CATB_RAT CATHEPSIN B PRECURSOR (CATHEPSIN B1) (RSG-2) pirKHRTB cathepsin B (EC 3.4.22.1) precursor - rat embCAA57792.1
	cbr-rbc.nrc-cnrc.gc.ca /reith/tetra/tetra4/A5-0002.html (1109 words)

	Upstate - Protein Products - Cathepsin - Cathepsin B
		Active Cathepsins are involved in proteolysis of proteoglycans and collagens of cartilage, bone resorption, and in the activation of TGFα and TGFβ.
		Cathepsin B (a cysteine protease) may be part of a Secretase complex involved in cleavage of APP to form Aβ in Alzheimer's disease (AD).
		Cathepsin D (an aspartyl protease) has also been linked to AD.
	www.upstate.com /browse/proteinproducts.asp?ProteinID=398 (86 words)

	Cathepsin B contributes to TNF-{alpha}-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c ...
		Cathepsin B contributes to TNF-{alpha}-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c -- Guicciardi et al.
		Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
		Cathepsin L and Cathepsin B Mediate Reovirus Disassembly in Murine Fibroblast Cells
	www.jci.org /cgi/content/abstract/106/9/1127 (2489 words)

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