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Sue Golding Graduate Division @ AECOM - Lisanti, Michael   (Site not responding. Last check: 2007-10-21) Caveolin, an integral membrane protein, is a principal component of caveolae membranes. Caveolin appears to function as a multi-valent scaffolding protein that interacts with different classes of signal tranducers. Caveolins, a family of scaffolding proteins for organizing "pre-assembled signaling complexes" at the plasma membrane. www.aecom.yu.edu /phd/faculty/lisanti.htm   (403 words)

caveolin   (Site not responding. Last check: 2007-10-21) The caveolin family of small transmembrane proteins includes caveolin-1/VIP21, caveolin-2, and a muscle-specific isoform caveolin-3. Caveolin-1 spans the plasma membrane twice forming a hairpin structure on the surface and forms homo- and hetero-oligomers with caveolin-2. Caveolins are the principle constituents of caveolae (small non-clathrin coated invaginations in plasma membrane). wrpx00.bioch.virginia.edu /cellmig_mol/get_cellmig_one.cgi?acc=caveolin   (119 words)

Cellular apoptosis is associated with increased caveolin-1 expression in macrophages -- Gargalovic and Dory 44 (9): ... After treatment, caveolin expression in whole-cell lysates was measured by immunoblotting (A), and DNA fragmentation was assessed by agarose-gel electrophoresis (B), as described in Experimental Procedures. The expression of caveolins and ß-actin was assessed by immunoblotting (A), DNA fragmentation by agarose gel electrophoresis (B), and apoptosis by PS externalization (C). Caveolin is an inhibitor of platelet-derived growth factor receptor signaling. www.jlr.org /cgi/content/full/44/9/1622   (5740 words)

Pfam 17.0 : Caveolin   (Site not responding. Last check: 2007-10-21) Caveolins MEDLINE:8567687, MEDLINE:8552590 are a family of integral membrane proteins which are the principal components of caveolae membranes. Caveolins may act as scaffolding proteins within caveolar membranes. Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. pfam.wustl.edu /cgi-bin/getdesc?name=Caveolin   (102 words)

Caveolin-3 homepage Caveolins are believed to play a role in the formation of the caveolae membranes, acting as scaffolding proteins organizing and concentrating caveolin-interacting proteins and lipids in caveolae microdomains ( Caveolin is a small molecular weight protein shown to be associated with the caveolar plasma membranes. The N-terminal region is responsible for the homo-oligomerization and the interaction with caveolin-associated signalling molecules. www.dmd.nl /cav3_home.html   (1244 words)

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling -- Wei et al. 144 (6): 1285 ... In this case integrin (green) and caveolin (red) fluorescent signals emerge and colocalize (E-G) with clustering in comparison with that of nonclustered cells (H) or clustered cells stained without primary caveolin antibodies (I). The corresponding decrease in caveolin levels for each of the clones, as judged by densitometry of immunoblots, was as follows: m1, 0% decrease; m2, 83%; m3, 89%; m4, 96%; and m5, 73%. 1 integrins sequentially immunoblotted for caveolin, Src, and cortactin as in Fig. www.jcb.org /cgi/content/full/144/6/1285   (5774 words)

Localization of Caveolin 1 in Aortic Valve Endothelial Cells Using Antigen Retrieval -- Rajamannan et al. 50 (5): 617 ... Caveolin 1 is an homooligomer of heavily crosslinked The antibody to caveolin 1 was a rabbit polyclonal to the N-terminus The labeling of caveolin (arrows) is patchy and appears to be concentrated in zones near the plasma membranes. www.jhc.org /cgi/content/full/50/5/617   (5015 words)

Caveolin Caveolin is not found in normal prostate epithelial cells, or in carcinoma in situ, but it's "very prominently" expressed in metastatic cells, he said. The tool that found caveolin's role in metastases was a mouse system for comparing cancer cells, Dr. Thompson explained at the Fourth Annual Scientific Retreat of The Association for the Cure of Cancer of the Prostate (CaP CURE) here this September. That reversal lowered the cells' caveolin protein production "substantially," and also lowered their metastatic activity, when they were returned to mouse prostates. www.nasw.org /users/nasw/nbauman/caveolin.htm   (803 words)

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells -- Kawabe et al. 286 ... inhibited the increases in detergent-soluble caveolin in response For downregulation of caveolins, adenovirus vectors harboring antisense genes of caveolin-1 and -3 at a multiplicity of infection (MOI) of 0–100 were transfected and incubated for 48 h. Downregulation of caveolins was achieved by antisense caveolin-1 and -3 adenovirus vectors at a MOI of 100, and the cells were then stimulated with cyclic stretch for indicated times. ajpheart.physiology.org /cgi/content/full/286/5/H1845   (4456 words)

Caveolin 3 ( M-caveolin) antibodies from Research Diagnostics Inc It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. www.researchd.com /miscabs/caveol3.htm   (505 words)

Qaddoumi, Mol Vis 2003; 9:559-568. Both clathrin and caveolin are thought to be ubiquitous proteins, although their existence and role in conjunctival epithelial cells have not been studied systematically. The localization of caveolin at the cell membrane of corneal epithelium was previously reported in the context of wound healing [16]. Since caveolin-1 is the most widely investigated of the caveolin proteins (3 isoforms in all) and because over 90% of caveolin-1 is found associated with caveolae, it can be reliably used as a marker for caveolae structures [40]. www.molvis.org /molvis/v9/a68   (5815 words)

Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and ... Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide In endothelial cells (EC), caveolin is also known to directly interact with the endothelial nitric oxide synthase (eNOS) and thereby to modulate nitric oxide (NO)-mediated processes including vasodilation and angiogenesis. A dramatic tumor growth delay was observed in mice transfected with caveolin- vs. sham-transfected animals. www.fasebj.org /cgi/content/abstract/04-2682fjev1   (323 words)

Role of caveolin and caveolae in insulin signaling and diabetes -- Cohen et al. 285 (6): 1151 -- AJP - Endocrinology ... Caveolins 1 and 2 co-localize and form a stable heterooligomeric complex in vivo. Caveolins in cholesterol trafficking and signal transduction: implications for human disease. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro. ajpendo.physiology.org /cgi/content/full/285/6/E1151   (6680 words)

Caveolin-1 modulates the activity of the volume-regulated chloride channel -- Trouet et al. 520 (1): 113 -- The Journal ...   (Site not responding. Last check: 2007-10-21) The principal protein component of caveolae is caveolin, a 21-24 kDa membrane protein that inserts into the caveolar membrane via an intramembrane hairpin loop. Okamoto, T., Schlegel, A., Scherer, P. and Lisanti, M. Caveolins, a family of scaffolding proteins for organizing ''preassembled signaling complexes'' at the plasma membrane. Rizzo, V., Sung, A., Oh, P. and Schnitzer, J. Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae. jp.physoc.org /cgi/content/full/520/1/113   (4482 words)

Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a ... Glenney, J.R. The sequence of human caveolin reveals identity with VIP 21, a component of transport vesicles. Glenney, J.R., and Soppet, D. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in RSV-transformed fibroblasts. Koleske, A.J., Baltimore, D., and Lisanti, M.P. Reduction of caveolin and caveolae in oncogenically transformed cells. www.molbiolcell.org /cgi/content/full/12/8/2229   (8830 words)

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation -- Liu et al. 280 (4): C823 ... Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways. Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer's disease, and muscular dystrophy. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution: identification and epitope mapping of an isoform-specific monoclonal antibody probe. ajpcell.physiology.org /cgi/content/full/280/4/C823   (6805 words)

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae -- Razani et al. ... The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin heterooligomers: implications for the assembly of caveolae membranes in vivo. Loss of caveolin expression in type I pneumocytes as an indicator of subcellular alterations during lung fibrogenesis. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. mcb.asm.org /cgi/content/full/22/7/2329   (8815 words)

The {alpha}-Isoform of Caveolin-1 Is a Marker of Vasculogenesis in Early Lung Development -- Ramirez et al. 50 (1): 33 ... Caveolins are a family of integral membrane proteins (caveolin-1, Newman GR, Campbell L, von Ruhland C, Jasani B, Gumbleton M (1999) Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function. Okamoto T, Schlegel A, Scherer PE, Lisanti MP (1998) Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. www.jhc.org /cgi/content/full/50/1/33   (4237 words)

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities -- Razani et al. 276 ... Caveolin was first identified in 1989 by Glenney and colleagues (1, 2) as a major v-Src substrate in Rous sarcoma virus-transformed The Absence of Caveolin-1 Leads to Degradation and Redistribution of Caveolin-2-- Currently, the caveolin gene family is composed of caveolin-1, -2, and -3. Cav-1 knockout mice are in effect deficient in two caveolins. www.jbc.org /cgi/content/full/276/41/38121   (9698 words)

Caveolins, Liquid-Ordered Domains, and Signal Transduction -- Smart et al. 19 (11): 7289 -- Molecular and Cellular ... Caveolins are a family of 21- to 25-kDa integral membrane proteins that have been implicated in a variety of cellular functions Caveolins are thought to associate with membranes via a central 33-amino-acid hydrophobic domain (81). Caveolins have been functionally implicated in a wide variety of signal transduction processes (Table 2). mcb.asm.org /cgi/content/full/19/11/7289   (7320 words)

A Molecular Dissection of Caveolin-1 Membrane Attachment and Oligomerization. TWO SEPARATE REGIONS OF THE CAVEOLIN-1 ... To assess whether other caveolin proteins contain C-terminal membrane attachment domains, the C termini of caveolin-2 and -3 were fused to GFP. Residues conserved between caveolin-1 and caveolins 2 and 3 are boxed. Note that the final 8 residues of all three human caveolins are highly divergent, perhaps accounting for the known homotypic isoform specificity of caveolin oligomer/oligomer interactions. www.jbc.org /cgi/content/full/275/28/21605   (7125 words)

Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3 -- Rybin et al. ... Caveolin (CAV) and flotillin expression in the developing ventricle. Cell-type and tissue-specific expression of caveolin-2: caveolins 1 and 2 co-localize and form a stable heterooligomeric complex in vivo. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. ajpheart.physiology.org /cgi/content/full/285/1/H325   (4573 words)

Intracellular Retention of Glycosylphosphatidyl Inositol-Linked Proteins in Caveolin-Deficient Cells -- Sotgia et al. ... The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin hetero-oligomers. Caveolin is palmitoylated on multiple cysteine residues: palmitoylation is not necessary for localization of caveolin to caveolae. Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae. mcb.asm.org /cgi/content/full/22/11/3905   (9834 words)

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and ... Caveolins are membrane proteins that are the major coat proteins This protein has a caveolin signature sequence (conserved in all caveolin proteins), a scaffolding domain known to bind various signaling proteins and a hydrophobic intramembrane domain. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. jcs.biologists.org /cgi/content/full/116/23/4739   (7302 words)

Directory of open access journals   (Site not responding. Last check: 2007-10-21) We recently found that host cell caveolin-1 is associated with the intracellular vacuoles and inclusions of some chlamydial strains and species, and that entry of those strains depends on intact lipid raft domains. Caveolin-2 is another member of the caveolin family of proteins that is present in caveolae, but of unknown function. Nevertheless, this second caveolin protein can now be added to the small number of host proteins that are associated with the inclusions of this obligate intracellular pathogen. www.doaj.org /abstract?id=95262&toc=y   (344 words)

Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric ... Caveolin and eNOS expression in endothelial cells exposed to normocholesterolemic and hypercholesterolemic human serum. (c) The caveolin immunoblots from endothelial cells exposed to NC or HC serum in the presence or absence of the cysteine protease inhibitor ALLN (25 µM). Note that to obtain the S fractions, the supernatants from the caveolin IP were again immunoprecipitated with anti–caveolin-1 antibody in order to detect quantitatively the amount of caveolin left behind the initial IP. www.jci.org /cgi/content/full/103/6/897   (6592 words)

Caveolin-3 Upregulation Activates beta -Secretase-Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer's ... Caveolin antibodies [caveolin-1 (rabbit polyclonal IgG; mouse monoclonal antibodies, clones 2234 and 2297), caveolin-2 Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG (1990) Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Scherer PE, Tang Z-L, Chun MC, Sargiacomo M, Lodish HF, Lisanti MP (1995) Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution: identification and epitope mapping of an isoform-specific monoclonal antibody probe. www.jneurosci.org /cgi/content/full/19/15/6538   (6773 words)

A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance -- Pol ... A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance -- Pol et al. The caveolin mutant causes the intracellular accumulation of Caveolin Interacts with the Angiotensin II Type 1 Receptor during Exocytic Transport but Not at the Plasma Membrane www.jcb.org /cgi/content/abstract/152/5/1057   (1988 words)

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular ... Okamoto, T., Schlegel, A., Scherer, P.E., and Lisanti, M.P. Caveolins, a family of scaffolding proteins for organizing "pre-assembled signaling complexes"at the plasma membrane (Mini-review). Smart, E., Ying, Y.-S., Conrad, P., and Anderson, R.G.W. Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation. Yamamoto, M., Toya, Y., Schwencke, C., Lisanti, M.P., Myers, M., and Ishikawa, Y. Caveolin is an activator of insulin receptor signaling. www.molbiolcell.org /cgi/content/full/14/10/4075   (7520 words)

Caveolin-1 Inhibits Epidermal Growth Factor-stimulated Lamellipod Extension and Cell Migration in Metastatic Mammary ... Although the functions attributed to caveolae and the caveolin gene family are still a matter of intense research, their role Construction of Recombinant Caveolin Adenoviral Vectors-- The adenoviral vector (pAd-tet) used consisted of a tetracycline-regulatable expression cassette (a heptamer of tetO sequences Note that both caveolin-1 and caveolin-2 expression is absent in motile MTLn3 cells, but is present in its non-motile counterpart, MTC cells. www.jbc.org /cgi/content/full/275/27/20717   (6315 words)

Identification of Caveolin and Caveolin-Related Proteins in the Brain -- Cameron et al. 17 (24): 9520 -- Journal of ... Caveolin, a 21-24 kDa integral membrane protein, appears to be the principal structural protein of caveolae (Peters et al., In astrocytes, caveolin immunoreactivity is detected at the cell surface and in association with multiple intracellular vesicles. Smart EJ, Ying Y-S, Donzell WC, Anderson RGW (1996) A role for caveolin in transport of cholesterol from endoplasmic reticulum to the plasma membrane. www.jneurosci.org /cgi/content/full/17/24/9520   (8331 words)

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