| | Cerebral Cavernous Malformation, Familial -- GeneReviews -- NCBI Bookshelf |
 | | Familial cerebral cavernous malformation is defined as the occurrence of CCMs in at least two family members, and/or the presence of a disease-causing mutation in one of the genes associated with CCM and/or the presence of multiple CCMs. |
 | | Familial cerebral cavernous malformation is defined as the occurrence of CCMs in at least two family members [Verlaan, Davenport et al 2002] and/or the presence of a disease-causing mutation in one of the genes associated with CCM and/or the presence of multiple CCMs [Denier, Labauge et al 2004; Verlaan et al 2004]. |
 | | Cavernous malformations occur in two forms: a "sporadic" form, in which individuals usually present with one or two lesions and no family history of neurologic disease, and the familial form, characterized by multiple lesions and a strong family history of related neurologic deficits. |
| www.ncbi.nlm.nih.gov /bookshelf/br.fcgi?book=gene&part=ccm (4083 words) |