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Topic: Cefotetan

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	Virtual Hospital: P & T News
		Cefotetan, like cefoxitin, is used for the treatment of urinary tract, lower respiratory tract, skin and skin structure, bone and joint, gynecologic and intra-abdominal infections caused by susceptible organisms.
		Cefotetan has a half-life of 2.8 to 4.2 hours3 after IV or IM administration as opposed to cefoxitin with a half-life of approximately 1 hour;l therefore, cefotetan can be dosed every 12 hours instead of every 6 to 8 hours.
		Cefotetan is 88% plasma protein bound and is 51 to 81% excreted unchanged by the kidneys over a 24-hour period.2 The principal nonrenal route of elimination is biliary excretion; approximately 20% of a dose is reportedly excreted in the bile.1
	www.healthcare.uiowa.edu /pharmacy/PTNews/1995/01.95.html (1400 words)

	Data Sheet (Site not responding. Last check: 2007-10-18)
		APATEF (cefotetan disodium) is a sterile semisynthetic broad spectrum β-lactamase resistant cephalosporin (cephamycin) antibiotic for parenteral administration.
		The plasma elimination half-life of cefotetan is 3 to 4.6 hours after either intravenous or intramuscular administration in the absence of renal or hepatic impairment.
		Patients who receive cefotetan for the treatment or prophylaxis of infections should be monitored for signs and symptoms of haemolytic anaemia including, where appropriate, measurement of haematological parameters.
	www.medsafe.govt.nz /Profs/Datasheet/discontinued/Apatefinj.htm (3124 words)

	Cefotan Online, Description, Chemistry, Ingredients - Cefotetan - RxList Monographs
		CEFOTAN (cefotetan disodium for injection) and CEFOTAN (cefotetan injection) in Galaxy®* plastic container (PL 2040) as cefotetan disodium are sterile, semisynthetic, broad-spectrum, beta-lactamase resistant, cephalosporin (cephamycin) antibiotics for parenteral administration.
		CEFOTAN (cefotetan disodium for injection) is supplied in vials containing 80 mg (3.5 mEq) of sodium per gram of cefotetan activity.
		CEFOTAN (cefotetan injection) in the Galaxy® plastic container (PL 2040) is a frozen, iso-osmotic, sterile, nonpyrogenic premixed 50 mL solution containing 1 g or 2 g cefotetan as sterile cefotetan disodium.
	www.rxlist.com /cgi/generic2/cefotet.htm (416 words)

	Cefotan Pharmacology, Pharmacokinetics, Studies, Metabolism - Cefotetan - RxList Monographs
		High plasma levels of cefotetan are attained after intravenous and intramuscular administration of single doses to normal volunteers.
		No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug.
		The methoxy group in the 7-alpha position provides cefotetan with a high degree of stability in the presence of beta-lactamases including both penicillinases and cephalosporinases of gram-negative bacteria.
	www.rxlist.com /cgi/generic2/cefotet_cp.htm (942 words)

	Lyme Joseph Jemsek board North Carolina Clinic Moffatt Board Engel State Board of Medicine (Site not responding. Last check: 2007-10-18)
		To compare the effectiveness of cefotetan administered at 2 g once a day with cefoxitin at 1 or 2 g three times a day in the treatment of hospitalized patients with skin and superficial soft tissue infections, 194 patients from eight centers were enrolled in an open, randomized trial.
		The incidence of adverse reactions in the cefotetan group (17 percent) was significantly different from that for the cefoxitin group (6 percent) (p less than 0.05); however, the incidence of treatment-related reactions was not significant and the events were mild.
		Bacteriologically, 97% of the 58 evaluable patients in the cefotetan group and 89% of the 27 evaluable patients in the cefoxitin group had a satisfactory or presumed satisfactory response; two patients in the cefotetan group and three in the cefoxitin group were considered bacteriologic failures.
	www.personalconsult.com /articles/josephjemsekpublications.html (3112 words)

	Bartell Drugs \| Drug Information & Details
		Cefotetan was approved by the FDA in December 1985.
		Mechanism of Action: Cefotetan, a beta-lactam cephamycin similar to penicillins and cephalosporins, inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall.
		Cefotetan is largely excreted unchanged into the urine via glomerular filtration and tubular secretion.
	www.bartelldrugs.com /cpdruginfo/showMono.jsp?cpnum=103&gname=Cefotetan (575 words)

	Bartell Drugs \| Drug Information&Details
		Cefotetan kills bacteria that cause infection, or stops the growth of bacteria.
		Cefotetan treats many kinds of infections of the skin, bone, stomach, respiratory tract, sinuses, ear, and urinary tract.
		Cefotetan is for injection into a muscle or infusion into a vein.
	www.bartelldrugs.com /cpdruginfo/selectedDrug.jsp?drug=103&gname=Cefotetan (617 words)

	Complete Cefotetan information from Drugs.com
		Cefotetan is usually administered as an injection at your doctor's office, hospital, or clinic.
		Failure to do so may decrease the effectiveness of Cefotetan and increase the risk that the bacteria will no longer be sensitive to Cefotetan and will not be able to be treated by this or certain other antibiotics in the future.
		Cefotetan is to be used only by the patient for whom it is prescribed.
	www.drugs.com /cdi/cefotetan.html (1178 words)

	We report the case of a severe immune hemolytic anemia associated with cefotetan, a second generation cephalosporin
		The patient, a 36 years old woman, third geste had an allo-anti-Jka antibody positive and she received cefotetan prophylactically for cesarean section.
		Ten days after cesarean, she was readmitted to the hospital with clinical and biological signs of severe haemolytic anemia.
		Recent reports in the literature show increasing number of drug induced immune hemolytic anemia associated with cephalosporin (38/43 including 35 cases with prophylactic use of cefotetan) and 29 % resulted in fatal issue when the diagnosis was delayed.
	www.macopharma.nl /research/isbt/P458.html (250 words)

	Merck News Item (Site not responding. Last check: 2007-10-18)
		Post-operative anastomotic leak occurred in 2.9 percent (10/346) of ertapenem patients and 4.1 percent (14/339) of cefotetan patients.
		Unexplained antibiotic use occurred in 8.4 percent (29/346) and 7.7 percent (26/339) of ertapenem and cefotetan patients, respectively.
		The modified intent-to-treat (MITT) population consisted of 451 ertapenem patients and 450 cefotetan patients and included all patients who were randomized, treated, and underwent elective colorectal surgery with adequate bowel preparation.
	www.merck.com /newsroom/press_releases/product/2006_1220.html (1443 words)

	Cefotetan - Wikipedia, the free encyclopedia
		Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections.
		It is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe converage.
		It is marketed outside Japan by AstraZeneca with the brand names Apatef and Cefotan.
	en.wikipedia.org /wiki/Cefotetan (99 words)

	MedlinePlus Drug Information: Cefotetan Disodium Injection
		Cefotetan eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, gynecological, and urinary tract infections.
		If you are told to store additional cefotetan in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
		If you are receiving cefotetan in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a686015.html (868 words)

	2000 FDA Forum Poster Abstract F06 - Viraraghavan (Site not responding. Last check: 2007-10-18)
		Cefotetan use and reports of hemolytic anemia have prompted an FDA review of the overall number, severity, and causality of such cases.
		Moderate degree of hemolysis was reflected in a drop in hemoglobin level by 5.3 mg/dL (n=13) and final hemoglobin level of 5.2 mg/dL (n=53).
		Direct antiglobulin test was positive in 50 patients (59%), and serologic studies revealed antibodies to cefotetan in 30 patients (35%).
	vm.cfsan.fda.gov /~frf/forum00/f06.htm (160 words)

	Virtual Hospital: Rx Update (Site not responding. Last check: 2007-10-18)
		This conversion is being made because of the similarity in antimicrobial spectrums of activity, the less frequent dosing requirements of cefotetan, and the lower cost-per-day of therapy with cefotetan.
		The dose of cefotetan must be adjusted downward in renally compromised patients.
		The adverse effects experienced with cefotetan are similar to other second-generation cephalosporins and include gastrointestinal distress (1.5%), hematologic laboratory abnormalities (1.4%), hepatic enzyme elevations (1.2%), and hypersensitivity reactions, including rash and itching (1.2%).
	www.healthcare.uiowa.edu /pharmacy/RxUpdate/1995/03.March.95.html (210 words)

	News: FDA Approves New Indication for INVANZ(R) (ertapenem) for the Prevention of Surgical Site Infections (SSI) ...
		The rates of successful prophylaxis at 4 weeks posttreatment in the clinically evaluable patients were 70.5 percent (244/346) for ertapenem and 57.2 percent (194/339) for cefotetan.
		In the MITT analysis, the prophylactic success rates at 4 weeks posttreatment were 58.3 percent (263/451) for ertapenem and 48.9 percent (220/450) for cefotetan (difference 9.4 percent, (95 percent CI, 2.9, 15.9), p=0.002).
		Post-operative anastomotic leak occurred in 2.9% (10/346) ertapenem patients and 4.1% (14/339) cefotetan patients.
	www.genengnews.com /news/bnitem.aspx?name=10571620 (8902 words)

	NEJM -- Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		NEJM -- Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		901 (451 in the ertapenem group and 450 in the cefotetan group)
	content.nejm.org /cgi/content/short/355/25/2640 (393 words)

	Topical treatment of acne with cephalosporins - Patent 5409917
		Suitable cephalosporins include cefaclor, cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonicid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, ceftriaxone moxalactam (a 1-oxa-beta-lactam), cefuroxime, cephalexin, cephalosporin C cephalosporin C, sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, the 1-acetyloxy ethyl ester of cefuroxime (cefuroxime-axetil), dihydratecephalothin, and moxalactam.
		A topical dermatological gel composition containing cefotetan antibiotic and benzoyl peroxide in a gel carrier or vehicle is obtained as follows.
		Then the alcoholic solution of cefotetan is added to the first container, and all the ingredients are mixed to form the topical gel composition of the invention which contains both cefotetan and benzoyl peroxide.
	www.freepatentsonline.com /5409917.html (15198 words)

	INTRAABDOMINAL INFECTIONS/ANTIMICROBIAL PROPHYLAXIS IN SURGERY
		Comment: Although agents such as cefoxitin, cefotetan, beta lactam/inhibitor combinations and carbapenems have activity against aerobes and anaerobes isolated in IA infections, there is still the possibility of aerobic gram-negative isolates which may be resistant to these agents.
		If clindamycin, cefoxitin, or cefotetan were selected for their antianaerobic activity, you should also take into consideration the prevalence of Bacteroides species resistant to these antianaerobic agents within the hospital.
		In cases where emergency surgery is required, and there is no time for prophylaxis with the oral regimen of neomycin, erythromycin, and mechanical bowel preparation, these parenteral cephalosporins are alternatives.
	www.uic.edu /classes/pmpr/pmpr652/Final/Itokazu/INTRAAABDOMINAL.html (1727 words)

	Medcompare - Medical News : FDA Approves New Indication For INVANZ® (ertapenem) For The Prevention Of Surgical Site ...
		The primary endpoint in the PREVENT study was the test of prophylaxis, which was defined as no evidence of SSI, post-operative anastomotic leak, or unexplained antibiotic use through four weeks post-surgery in the clinically evaluable and MITT populations.
		Prophylaxis failure due to SSI, including superficial incisional, deep incisional or organ space infections, occurred in 18.2 percent (63/346) of ertapenem patients and 31 percent (105/339) of cefotetan patients.
		Patients were evaluated during hospitalization, at discharge, and four weeks after surgery for signs or symptoms of infection at the surgical site and to determine that no further anti-microbial therapy or surgery was necessary.
	www.medcompare.com /news.asp?newsid=164436 (1441 words)

	Cefotan (cefotetan) - Cephalosporins - antibiotics used to treat infections caused by bacteria
		This medicine contains the antibiotic cefotetan which is a member of a group of antibiotics called cephalosporins.
		Apatef is used for the treatment of infections caused by certain bacteria in many different parts of the body, including the abdomen (body trunk), chest and women's reproductive organs.
		Any medical information on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.
	www.patienthealthinternational.com /product/2342.aspx (173 words)

	A comparative evaluation of the safety and efficacy of cefotetan and cefoxitin in surgical prophylaxis -- Shwed et al. ...
		A comparative evaluation of the safety and efficacy of cefotetan and cefoxitin in surgical prophylaxis -- Shwed et al.
		A comparative evaluation of the safety and efficacy of cefotetan and cefoxitin in surgical prophylaxis
		Safety and efficacy were evaluated and compared retrospectively in 77 patients who received cefotetan (CTN) and 51 patients who received cefoxitin (CFX) for surgical prophylaxis.
	www.theannals.com /cgi/content/abstract/25/1/10 (289 words)

	Cephalexin Drug Information, Professional
		Cefoxitin and cefotetan have the greatest activity of all the cephalosporins against anaerobes, particularly the Bacteroides fragilis group
		Cefotetan has activity similar to that of cefoxitin against B.
		Cefoxitin and cefotetan are used primarily in the treatment of mixed aerobic-anaerobic bacterial infections, including aspiration pneumonia, diabetic foot infections, intraabdominal infections, and female pelvic infections
	www.drugs.com /MMX/Cephalexin.html (2570 words)

	October 1996 - New Concepts in Drug Induced Hemolytic Anemias
		Donald Kelley, M.D. Darrell J. Triulzi, M.D. : A 43 year old white male with carcinoma of the colon resected in 1992 was admitted for cryosurgical resection of liver metastasis, during which he received cefotetan, a second generation cephalosporin antibiotic.
		Thus, the degree of complement activation and hemolysis for a given amount of drug can be many times greater than that seen with antibodies reacting by the drug adsorption mechanism.
		In some cases, the presence of a specific blood group antigen on red cells is also required for reactivity.
	www.itxm.org /TMU1996/tmu10-96.htm (1101 words)

	cefotan drug information, cefotan side effects
		CEFOTAN (cefotetan disodium for injection) is supplied in vials...
		Cefotetan disodium injection (Cefotan) in 1-g and 2-g vials, AstraZeneca...
		Cefotetan is the generic drug name for Cefotan, Cefotan, and Cefotan.
	www.drugs.com /drug/cefotan (390 words)

	Drugs and Treatments - Cefotetan Inj - Patient Handout from WebMD
		Cefotetan is an antibiotic used to treat a wide variety of bacterial infections.
		Before using cefotetan, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies.
		Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
	webmd.com /drugs/drug-5920-Cefotetan+Disodium+Injection.aspx?... (1225 words)

	Red Cells (Site not responding. Last check: 2007-10-18)
		We tested 7 serum samples previously identified to contain cefotetan antibodies and one serum sample previously identified to contain ceftriaxone antibodies against 9 other cephalosporins, penicillin, and 7-amino-cephalosporanic acid in the presence of RBCs and also used hapten inhibition to indicate cross-reactivity.
		Serum samples containing cefotetan antibodies showed some cross-reactivity with cephalothin and cefoxitin (and to a much lesser extent with penicillin and ceftazidime).
		There was very little cross-reactivity between cefotetan antibodies and the drugs tested in the present study.
	www.thedoctorsdoctor.com /bodysites/red_cells.htm (1333 words)

	Drug Shortage Bulletin: Cefotetan Disodium and Cefoxitin Sodium Injection
		Cefotetan in 1-g frozen premixed bags from Baxter will be available until current supplies are depleted.
		Current guidelines recommend cefotetan as the preferred agent with cefazolin or cefoxitin as an alternative.
		Current guidelines recommend cefotetan, cefoxitin, or the combination of cefazolin and metronidazole.
	www.ashp.com /shortage/drug.cfm?cfid=11166879&CFToken=36806815&id=1081 (696 words)

	To Save Money on Cefotetan Disodium Click Here for Cefotetan Disodium Discount Sources.
		Rev 10/02 SIC 64173-02 CEFOTAN® cefotetan disodium for injection...
		Cefotetan disodium is also used to treat gonorrhea...
		Cephalosporins such as cefotetan disodium are prescribed when other antibiotics are not...
	www.institute-dc.org /res/18/Cefotetan-Disodium.html (246 words)

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