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Topic: Celebrex


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Celebrex was evaluated for treatment of the signs and symptoms of Rheumatoid Arthritis in approximately 2,100 patients by comparing placebo and Celebrex treated patients in clinical trials of up to 24 weeks in duration.
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Celebrex is a non-steroidal anti-inflammatory drug (NSAID) that represents a huge breakthrough in the treatment of pain, inflammation, and stiffness of arthritis.
CELEBREX is not a substitute for aspirin for heart attack or stroke prevention.
Celebrex should not be used in late pregnancy because it may harm the fetus.
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Celebrex works by reducing substances that cause inflammation, pain, and fever in the body and is used to treat osteoarthritis, rheumatoid arthritis, and other painful conditions.
Celebrex and Vioxx are both members of the new class of NSAIDs called Cox-2 inhibitors.
In this new study, patients taking 400 mg or 800 mg of Celebrex daily had an approximately 2.5-fold increase in their risk of experiencing a major fatal or nonfatal heart attack compared with those patients taking a placebo.
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FDA ALERT-[4/7/2005]: Celebrex has been linked to an increased risk of serious cardiovascular (CV) events (such as heart attack or stroke) which appears to be a risk shared by all medicines called non-steroidal anti-inflammatory drugs (NSAIDs) (excluding aspirin).
FDA has requested that the package insert (labeling) for all NSAIDs, including Celebrex, be revised to include a “boxed” or serious warning to highlight the potential increased risk of CV events, and the well known risk of serious, and potentially life-threatening, stomach bleeding.
Celebrex is used along with the usual care for FAP patients such as surgery and exams of the rectum and colon.
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Celebrex is used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Celebrex is also used to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), to treat acute pain, and to treat pain associated with menstruation.
Celebrex should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart.
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Celebrex (Generic: Celecoxib) is a COX-2 inhibitor, a class of drugs linked to an increased risk of blood clots, heart attacks and strokes.
Celebrex and the recently withdrawn Bextra are both marketed by the Pharmacia Corporation and Pfizer Inc. in the United States.
Celebrex and the other COX-2 inhibitors are prescribed for the treatment of osteoarthritis, adult rheumatoid arthritis, and the pain associated with menstrual cramping.
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Celebrex is an anti-inflammatory medicine, commonly used to treat arthritis.
Celebrex is a cyclooxygenase-2 (COX-2) inhibitor that is FDA approved for the treatment of arthritis.
In addition, Celebrex will be provided free of charge, for up to one year, to enrolled subjects regardless of group assignment at the end of the 12 month study period.
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 Celebrex, Celecoxib, side effects, drug interactions, overdose, dosage
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis.
Celebrex has also been found to reduce the number of colorectal polyps (growths in the wall of the lower intestine and rectum) in people who suffer from the condition called familial adenomatous polyposis (FAP), an inherited tendency to develop large numbers of colorectal polyps that eventually become cancerous.
Although Celebrex is easy on the stomach, it still poses some degree of risk—especially if you've had a stomach ulcer or gastrointestinal bleeding in the past.
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Celebrex may be used to manage acute pain in adults associated with strains and sprains or pain after surgery.
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But new research shows that Celebrex's cancer-fighting potential is overshadowed by the danger it poses to the heart, leading researchers to warn patients not to take Celebrex to prevent colorectal disease.
Celebrex dramatically reduced the risk of recurrent polyps: 33% to 43% of patients who took the pain reliever developed colorectal growths within three years, vs. 50% to 60% of those who took placebos, the two studies show.
That makes Celebrex too risky to be used for polyp prevention, according to an editorial in the New England Journal by Bruce Psaty of the University of Washington and John Potter of the Fred Hutchinson Cancer Research Center in Seattle.
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CELEBREX was the first COX-2–specific inhibitor approved for treating the pain, inflammation, and stiffness that accompanies osteoarthritis and adult rheumatoid arthritis.
Celebrex is in the same class of drugs as Vioxx and Bextra.
Since Celebrex is in the same drug class as Vioxx experts believe that the Celebrex side effects are identical to Vioxx side effects.
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 CELEBREX FAQs   (Site not responding. Last check: 2007-11-04)
CELEBREX is approved to relieve the pain, swelling, and stiffness of osteoarthritis and adult rheumatoid arthritis.
CELEBREX should be used during pregnancy only if you and your doctor decide that the potential benefit justifies the potential risk to the fetus.
CELEBREX may be used to relieve the joint pain, inflammation, and stiffness associated with the 2 most common types of arthritis: osteoarthritis and adult rheumatoid arthritis.
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Celebrex is used to relieve pain and inflammation associated with arthritis.
Celebrex has not been studied in children or adolescents under 18 years of age.
Celebrex use is not recommended in pregnancy unless your doctor considers it essential.
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Celebrex has also been known to cause serious allergic reactions and Stevens Johnson Syndrome (SJS).
Andy Birchfield, Beasley Allen’s lead Celebrex Litigation attorney, is spearheading the review of 406 cases, having filed 58 of those cases against Pfizer dating back to 2000.
In light of the recent findings which undeniably link Celebrex to greater heart-attack risks, it is time for Pfizer to act responsibly and pull the drug from the market,” said Mr.
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CELEBREX (celecoxib) is chemically designated as 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide and is a diaryl-substituted pyrazole.
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The inactive ingredients in CELEBREX capsules include: croscarmellose sodium, edible inks, gelatin, lactose monohydrate, magnesium stearate, povidone, sodium lauryl sulfate and titanium dioxide.
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