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Topic: Celecoxib


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  The Drug Monitor - Celecoxib (Celebrex) - Nasr Anaizi, PhD
Celecoxib is metabolized to inactive metabolites by the cytochrome P450 2C9.
Celecoxib is excreted in the milk of lactating animals and was found to be harmful to nursing infants.
Celecoxib is metabolized mainly by Cytochrome P450 2C9 and it is an inhibitor of the 2D6 isoform.
www.thedrugmonitor.com /celecoxib.html   (767 words)

  
 Celecoxib
Celecoxib (CELEBREX), approved by the Food and Drug Administration (FDA) for the symptomatic relief of osteoarthritis and rheumatoid arthritis, becomes the 20th member of the family known as nonsteroidal anti-inflammatory drugs, or NSAIDs for short.
Celecoxib is not approved by the FDA for the treatment of acute pain.
Celecoxib shares a chemical similarity to the sulfa drugs and should not be taken by people who are allergic to them.
www.citizen.org /hrg/NEWSLETTERS/celecoxibtext.htm   (1906 words)

  
 Mosby's Drug Consult Top 200   (Site not responding. Last check: 2007-09-04)
Celecoxib was evaluated for treatment of the signs and the symptoms of OA of the knee and hip in approximately 4200 patients in placebo- and active-controlled clinical trials of up to 12 weeks duration.
Celecoxib was evaluated for treatment of the signs and symptoms of RA in approximately 2100 patients in placebo- and active-controlled clinical trials of up to 24 weeks in duration.
Celecoxib at oral doses ≥150 mg/kg/day [approximately 2-fold human exposure at 200 mg bid as measured by AUC(0-24)], caused an increased incidence of ventricular septal defects, a rare event, and fetal alterations, such as ribs fused, sternebrae fused and sternebrae misshapen when rabbits were treated throughout organogenesis.
www.mosbysdrugconsult.com /DrugConsult/Top_200/Drugs/e3427.html   (6236 words)

  
 Celecoxib Information from Drugs.com
Celecoxib is used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Celecoxib is also used to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), to treat acute pain, and to treat pain associated with menstruation.
Celecoxib should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart.
drugs.com /Celecoxib.html   (1378 words)

  
 Howstuffworks "Celecoxib: A Profile of an Anti-Inflammatory Drug"
Celecoxib is used to treat the inflammation (pain, swelling, and stiffness) of certain types of arthritis.
Celecoxib is also used to reduce the risk of developing polyps in the colon in patients with hereditary colon disease.
Celecoxib is classified in Pregnancy Category C: The effects of this medication during pregnancy have not been thoroughly studied in humans.
health.howstuffworks.com /define-celecoxib.htm   (886 words)

  
 CELECOXIB
At the wide range of doses studied (50-400mg bd) celecoxib treatment was consistently associated with a significantly lower incidence of endoscopic gastro-duodenal ulcers than naproxen 500mg bd (6-9% vs 19-26%, p < 0.05) and ibuprofen 800mg tds (9% vs 28%, p < 0.05).
Celecoxib was however associated with a reduced incidence of endoscopic gastroduodenal ulcers compared to naproxen and high dose ibuprofen.
Celecoxib is associated with a significantly lower incidence of clinically significant upper gastrointestinal (UGI) events in osteoarthritis (OA) and rheumatoid arthritis (RA) patients as compared to NSAIDs.
www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/summaries/C/CELECOXIBs.html   (1289 words)

  
 Celecoxib for OA and RA
Celecoxib was as effective as NSAIDs, and had a modest effect in reducing serious GI adverse events.
Efficacy in RA Celecoxib was better than placebo for ACR 20 (NNT 8 with 95% CI 5.7 to 13; 33% of patients had an ACR 20 response at 12 weeks in all trials), and for painful and swollen joints.
Celecoxib was no different from placebo for endoscopic ulcers at 12 weeks, but was much better than NSAID (Figure 1).
www.jr2.ox.ac.uk /bandolier/booth/Arthritis/celerev.html   (470 words)

  
 Celebrex (Celecoxib) - What you should know about Celebrex.
Fluconazole (Diflucan) increases the concentration of celecoxib in the body by inhibiting the breakdown of celecoxib in the liver.
Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%.
Celecoxib does not interfere with the function of the blood platelets and, as a result, does not reduce clotting and lead to increased bleeding like other NSAIDs.
www.naturalessentials.com /celebrex.htm   (641 words)

  
 celecoxib (Celebrex) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood.
Celecoxib is used for the relief of pain, fever, swelling, and tenderness caused by
Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus.
www.medicinenet.com /celecoxib/article.htm   (978 words)

  
 MedlinePlus Drug Information: Celecoxib
Celecoxib is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine).
Celecoxib is also used to treat painful menstrual periods and pain from other causes.
It is also used with surgery and other treatments to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop).
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a699022.html   (1139 words)

  
 celecoxib - Order celecoxib Online. Low celecoxib Prices and Fast celecoxib Delivery.
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Tell your prescriber or celecoxib care professional; do not share this medicine celecoxib celecoxib Special care may be needed.
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 Order celecoxib at lowest price on the web.
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Keep celecoxib celecoxib the mouth, tingling in an ointment, gel, lotion and other measures to prevent celecoxib upset, pain, or fast heartbeat •swelling of the celecoxib cycle.
Keep out celecoxib the sun, or wear protective clothing during long periods celecoxib Tanning celecoxib should be enough to cover the affected areas and rub in gently.
celecoxib.i-doctors24.com   (362 words)

  
 Celecoxib (Celebrex): Is It a Breakthrough Drug?
Celecoxib is a new arrival, and you’ve never prescribed it before.
In deciding to licence celecoxib, scientists at the TPP presumably had access to full reports of trials establishing at the least that celecoxib is more effective than placebo and reasonably safe.
Since almost all clinical data about celecoxib remains unpublished and is therefore unavailable for critical appraisal and assessment, it is impossible for the TI to provide timely unbiased information to you and other health professionals.
www.ti.ubc.ca /pages/letter31.htm   (1246 words)

  
 Celecoxib - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-09-04)
Celecoxib (INN) (IPA: [sɛlɛˈkɒksɪb]) is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase, whereas traditional NSAIDs inhibit both COX-1 and COX-2.
Indeed an increased risk of heart attack and stroke was found in a National Cancer Institute study studying the use of 400-800 mg celecoxib daily for the prevention of colorectal adenoma (relative risk 2.3-3.4 vs placebo).
en.wikipedia.org /wiki/Celecoxib   (979 words)

  
 Celecoxib (Celebrex) - Vioxx Consumer Guide
Celecoxib is another COX-2 inhibitor drug developed to reduce pain associated with arthritis and other chronic inflammatory illnesses.
Celecoxib is the least potent of the COX-2 inhibiting drugs.
Recent government- and manufacturer-led studies, unveiled in late 2004, found that both celecoxib (marketed under the trade name of Celebrex) and valdecoxib (commercially sold as Bextra) may also induce myocardial infarction and cardiovascular side effects.
www.vioxxconsumerguide.com /celecoxib-celebrex.html   (260 words)

  
 MedlinePlus Drug Information: Celecoxib (Systemic)   (Site not responding. Last check: 2007-09-04)
Celecoxib (sell–a–COKS–ib) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain.
However, there is a chance that this medicine may cause unwanted effects on the heart or blood flow of the fetus or newborn baby if it is taken regularly during the last few months of pregnancy.
Studies in animals have shown that celecoxib has caused birth defects of the ribs and sternebrae.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/203736.html   (1690 words)

  
 celecoxib >> Get More Info About celecoxib Online! Order celecoxib.
Generic celecoxib Diethylpropion What is betamethasone skin preparations without advice celecoxib your prescriber or health care professional if they continue or are celecoxib •increased sensitivity to the fetus if celecoxib by a health-care professional in a hospital or celecoxib setting.
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celecoxib drug is also used for patients with increased pressure or heart disease or celecoxib difficulties •myasthenia gravis or celecoxib more serious illness.
celecoxib.drugs-4-health.com   (341 words)

  
 Celebrex - Drugs & Vitamins - Drug Library - DrugDigest
CELECOXIB (Celebrex®) used to reduce inflammation and ease mild to moderate pain for such conditions as arthritis or painful menstrual cycles.
Celecoxib may also be used to treat certain other conditions such as familial adenomatous polyposis (FAP).
It is especially important not to use celecoxib during the last 3 months of pregnancy unless specifically directed to do so by your health care provider.
www.drugdigest.org /DD/DVH/Uses/0,3915,715|Celebrex,00.html   (923 words)

  
 Celecoxib   (Site not responding. Last check: 2007-09-04)
Celecoxib is used to treat rheumatoid arthritis and osteoarthritis; it is in a class of medications known as selective COX-2 inhibitor non-steroidal anti-inflammatory drugs (NSAIDs).
Until more information is available, people taking celecoxib should have their sodium and potassium blood levels monitored by their healthcare practitioner.
Lithium is a mineral that may be present in some supplements and is also used in large amounts to treat mood disorders such as manic-depression.
www.kroger.com /hn/Drug/Celecoxib.htm   (494 words)

  
 Celecoxib Lowers Risk of Colorectal Polyps - National Cancer Institute
celecoxib (Celebrex®) significantly reduces the risk of precancerous polyps recurring in the colon or rectum.
As reported previously, celecoxib use in both trials was also associated with a
The analysis also revealed dose-related increases in cardiovascular events and blood pressure, leading the authors to speculate that the increased cardiac events might be related to elevated blood pressure and that lower doses of the drug might have a wider safety margin with respect to cardiovascular disease while still reducing cancer risk.
www.cancer.gov /clinicaltrials/results/celecoxib0906   (359 words)

  
 Celebrex celecoxib.
Celecoxib (Celebrex) is one of the first designer drugs to be marketed, and its development is typical of the advances that modern molecular biology is bringing to the understanding and treatment of diseases.
Studies have shown that celecoxib causes many fewer side effects in the stomach, almost at the low level of the placebo used in the studies.
Celecoxib (a new aspirin?) has been shown to be as effective as the earlier NSAIDs in the treatment of mild to moderate pain, and chronic inflammatory conditions such as rheumatoid arthritis, arthrosis
www.anagen.net /celinf.htm   (926 words)

  
 celecoxib drug information, celecoxib side effects
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase, whereas...
Celecoxib is a nonsteroidal anti-inflammatory drug that exhibits anti-inflammatory, analgesic, and antipyretic...
Celecoxib is highly bound to plasma proteins (mainly albumin, but...
www.drugs.com /sch/celecoxib   (466 words)

  
 Celecoxib (Systemic) - MayoClinic.com
Celecoxib has not been studied in pregnant women.
Studies on this medicine have been done only in adult patients, and there is no specific information comparing the use of celecoxib in children with use in older age groups.
This medicine has been tested in a limited number of elderly patients 65 years of age and older and has not been shown to cause different side effects or problems in older people than it does in younger adults.
www.mayoclinic.com /health/drug-information/DR203736   (1704 words)

  
 Celecoxib - Buy Celecoxib Generic Celecoxib Online.Order Celecoxib Discount Celecoxib Cheap Celecoxib   (Site not responding. Last check: 2007-09-04)
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 Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis -- Caldwell et al. 99 (3): 132 -- ...
The doses of celecoxib studied were 200, 400 and 800 mg/day.
Celecoxib versus diclofenac in the management of osteoarthritis of the knee.
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
www.jrsm.org /cgi/content/full/99/3/132   (3114 words)

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