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Topic: Cell adhesion

Related Topics

Cell fractionation

Cell membrane

Biological cell

Extracellular matrix

Transmembrane receptor

Passive transport

Action potential

Active transport

Ion channel

Biology

Connective tissue

Cardiac action potential

Electrochemical potential

Diffusion

Adenosine triphosphate

	Cell adhesion - Wikipedia, the free encyclopedia
		Cells are often not found in isolation, rather they tend to stick to other cells or non-cellular components of their environment.
		Cell adhesion generally involves protein molecules at the surface of cells, so the study of cell adhesion involves cell adhesion proteins and the molecules that they bind to.
		Cell adhesion proteins hold synapses together and the regulation of synaptic adhesion is involved in learning and memory.
	en.wikipedia.org /wiki/Cell_adhesion (505 words)

	Cell Biology, UVa School of Medicine
		Adhesion is one example of a cell surface process that regulates the associations of cells with one another and with molecules of the extracellular matrix (ECM).
		Cell adhesion makes it possible for embryos to develop, tissues to form, and cells to migrate and maintain shape.
		The Department of Cell Biology at the University of Virginia is home to several investigators who are at the forefront of research in the areas of cell adhesion and cell migration.
	www.virginia.edu /cellbiology/Research/Adhesionpage.htm (305 words)

	Category Description Cell Adhesion Molecules
		Cell adhesion molecules (CAM) are multi-functional proteins involved in a number of regulatory processes, including cell growth, differentiation and proliferation, migration, and regeneration.
		Two major types of cell adhesion processes are seen in multicellular organisms: cell-cell adhesion, where physical bonds are formed between adjacent cells; and cell-matrix adhesion, where cells bind to adhesive proteins in the extracellular matrix.
		Cells detect their extracellular milieu via interactions with cell adhesion molecule (CAM) components via integrins and syndecan molecules and with adjacent cells via cadherins, selectins, and the members of the Ig-CAM family.
	www.emdbiosciences.com /Products/PopupCategoryDescription.asp?catid=659 (260 words)

	RedOrbit - Science - Topographical Pattern Dynamics in Passive Adhesion of Cell Membranes
		Adhesion of red cells to the extracellular matrix and other cells is reported to play key roles in various pathological processes including malarial parasite invasion and sickle cell sequestration (Setty et al., 2002; Hillery et al., 1999; Mohandas and Evans, 1989) as well as physiological processes such as senescence (Oldenborg et al., 2000).
		This fused membrane shows the same pattern observed under intact cells, indicating that the pattern formation is independent of the tension in the upper membrane (Hategan et al., 2003), the integrity of the cell, and intracellular components ranging from ATP to hemoglobin.
		However, the red cell membrane is far more complex than a lipid bilayer, and the presence of integral membrane proteins, as well as the glycocalyx, may not allow the poly-L-lysine chains, even the longest, to reach and penetrate the lipid bilayer.
	www.redorbit.com /news/display/?id=104503 (8350 words)

	Cell Adhesion Molecules
		The extracellular domains of adhesion molecules extend from the cell and bind to other cells or matrix by binding to other adhesion molecules of the same type (homophilic binding), binding to other adhesion molecules of a different type (heterophilic binding) or binding to an intermediary 'linker' which itself binds to other adhesion molecules.
		Integrins participate in cell-cell adhesion and are of great importance in binding and interactions of cells with components of the extracellular matrix such as fibronectin.
		For example, a group of integrins responsible for binding of white blood cells to endothelium are normally inactive, allowing the blood cells to circulate freely, but become activated in response to inflammatory mediators, resulting in the white cells being "pulled" from blood into inflammed tissues.
	arbl.cvmbs.colostate.edu /hbooks/cmb/cells/pmemb/adhesion.html (626 words)

	Adhesion molecules
		Thus, the white blood cells lack the entire family of beta-2 receptors needed to bind to endothelial cells.
		ICAM (intercellular adhesion molecules) may be expressed on activated endothelial cells.
		Cells can be influenced heavily by the environment (matrix proteins) because of the presence of transmembrane glycoproteins called Integrins.
	cellbio.utmb.edu /cellbio/adhesion_molecules.htm (656 words)

	Cell Adhesion
		The overarching aim of the cell adhesion theme is to decipher the molecular mechanisms whereby adhesive cues on the outside of cells are transduced into functional responses on the inside (and vice versa) and to develop approaches for intervening experimentally and therapeutically in these processes.
		Dysregulation of adhesion contributes to disease progression either by disrupting the normal anchorage and movement of cells, thereby altering regulatory signalling, or by promoting inappropriate temporal and spatial adhesion.
		Among the readouts of adhesion signalling are cell migration, survival/apoptosis, axonal growth and cell fate decisions during development.
	www.ls.manchester.ac.uk /research/themes/celladhesion (364 words)

	BioCarta - Charting Pathways of Life
		Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape.
		The cadherins are cell surface adhesion molecules that help form tight junctions between cells such as formation of epithelial cell layers.
		Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation.
	www.biocarta.com /pathfiles/h_cell2cellPathway.asp (194 words)

	New DNA-based cell adhesion strategy
		A new technique in which single strands of synthetic DNA are used to firmly fasten biological cells to non-biological surfaces has been developed by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley.
		Many of the vast assortment of biological cells are naturally sticky, a property that enables individual cells to adhere to other cells and non-cellular components, which in turn enables them to assemble into different types of tissue, or carry out functions critical to an organism's health and well-being.
		Cell adhesion is now being used to incorporate biological cells into simple devices, but is expected to be important for the future production of complex nanotechnology devices.
	www.news-medical.net /?id=15832 (1143 words)

	Expression of Podocalyxin Inhibits Cell-Cell Adhesion and Modifies Junctional Properties in Madin-Darby Canine Kidney ... (Site not responding. Last check: 2007-10-16)
		Cells stably transfected with the inducible expression vector pIND-PC were treated with 0.1-10 µM ponasterone A for 24 h and lysed in TDU buffer, after which 100 µg of cell lysate or kidney lysate (right lane) was separated by 7.5% SDS-PAGE and immunoblotted with anti-PC serum (0601).
		Cells were induced with 10 µM ponasterone A for 24 h, detached and resuspended as in Figure 6, and treated for 30 min with or without sialidase (Arthrobacter ureafaciens) at room temperature, and aggregation was quantitated as in Figure 6 (b and c).
		relocalization of cadherin, occludin, and ZO-1 in MDCK cells overexpressing
	www.molbiolcell.org /cgi/content/full/11/9/3219 (7604 words)

	Consortium Updates
		Vinculin is an actin-binding protein that suppresses cell migration by stabilizing focal adhesions.
		Whereas in 2D environments cells compensate for a decrease in the number of receptors by shifting the maximum speed to higher ligand densities, cells in 3D matrices shift their maximum speed to lower traction forces.
		Cell 2006 April 10 (4), 497-508 in press) is posted at the bottom of the Montell data page at http://www.cellmigration.org/resource/discovery/montell_up_mig.shtml.
	www.cellmigration.org /resource/cmcnews.shtml (7853 words)

	University of Chicago Hospitals: Cell-cell adhesion process
		The researchers used keratinocytes, a type of skin cell, to study the earliest stages of cell-cell binding.
		Because cell-cell adhesion is dependent on calcium concentration, Vasioukhin was able to capture cells in the act of forming puncta.
		When Vasioukhin disrupted the actin filaments with chemicals, the adhesion zippers and adhesion junctions were unable to form.
	www.uchospitals.edu /news/2000/20000121-celladhesion.html (637 words)

	Amazon.ca: Cell Adhesion: Books: Mary Beckerle (Site not responding. Last check: 2007-10-16)
		Hansjurgen Volkmer: The immunoglobulin superfamily of cell adhesion molecules 2.
		Bette Dzamba, Margaret Bolton and Douglas Desimone: The integrin family of cell adhesion molecules 5.
		Cell adhesion, where a cell sticks to another cell or to the network of fibres surrounding cells, is critical for normal development and physiology.
	www.amazon.ca /Cell-Adhesion-Mary-Beckerle/dp/0199638713 (427 words)

	Immunetics - Cell Adhesion Flow Chamber for performing dynamic cell adhesion assays
		The Immunetics Cell Adhesion Flow Chamber is designed for performing dynamic cell adhesion assays in a laminar flow environment.
		The transparent acrylic device permits the study of interactions between cells immobilized on a microscope slide and cells in the fluid phase.
		Immobilized cells are grown on a detachable slide culture vessel.
	www.immunetics.com /products/celladh.html (295 words)

	Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under ... (Site not responding. Last check: 2007-10-16)
		cells arrested in capillaries (24) and in lung microvasculature
		B: cell accumulation in the absence or presence (platelet-to-LS174T cell ratio of 25:1) of platelets.
		Lysis of tumor cells by natural killer cells in mice is impeded by platelets.
	ajpcell.physiology.org /cgi/content/full/287/2/C539 (5537 words)

	InterPro: IPR009138 Neural cell adhesion
		Expressed in neurons, glial cells and skeletal muscle, NCAM binds both homophilically and heterophilically, mediating processes such as neural cell growth and migration [ 1, 2, 3 ].
		Walsh F.S. Doherty P. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance.
		Cellular component is the part of a cell of which a gene product is a component; GO includes the extracellular environment of cells; a gene product may be a component of one or more parts of a cell.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR009138 (3221 words)

	Research Summary :: Cell Adhesion :: Laboratory of Molecular Carcinogenesis :: NIEHS
		Jen received her Ph.D in Genetics and Cell Biology from Washington State University where she completed her thesis on microsatellite instability and XPA protein expression in HMGA1-expressing human breast cancer cells under the direction of Dr. Ray Reeves.
		Cell adhesion and migration contribute to normal processes such as differentiation, embryonic development, and wound healing as well as to the progression of diseases and pathological conditions that can result from either acute or chronic exposure to environmental toxicants, such as cancer and inflammatory responses.
		The overall goal of our research is to characterize the molecular mechanisms of integrin-mediated adhesion processes, integrin activation, and the resulting downstream processes induced by adhesive proteins such as fibronectin important for the control of proliferation, adhesion, migration, and invasion of cells with a particular emphasis on human tumor cells.
	dir.niehs.nih.gov /dirlmc/cell-rs.htm (501 words)

	Douglas C. Dean, Ph.D (Site not responding. Last check: 2007-10-16)
		To this end, we are examining the pattern of expression of these adhesion proteins in the developing mouse, and we are using model culture systems to analyze their role in different developmental processes.
		Therefore, we have cloned the promoter regions for various adhesion protein genes and we are examining the molecular basis for what controls their developmentally-specific pattern of expression.
		At least some of its activity is mediated through a cell cycle-dependent interaction with the trans-activating protein, E2F, which binds to the promoters of a number of cell cycle control genes.
	www.cellbio.wustl.edu /FACULTY/dean_d.htm (460 words)

	Cell Adhesion & Extracellular Matrix - BioChemWeb.org
		Epithelium and Cell Junctions (Kimberly Brown, Vanderbilt University)
		Inflammation: The Leukocyte Adhesion Cascade - Information on luekocyte adhesion and the involvement of integrins, selectins and immunoglobulin-like cell adhesion molecules (CAMs).
		The Bacterial Cell Wall - "The bacterial cell wall is a unique structure which surrounds the cell membrane.
	www.biochemweb.org /adhesion_ecm.shtml (494 words)

	[No title] (Site not responding. Last check: 2007-10-16)
		Cell-cell and cell-substrate adhesion and the structure and assembly of the extracellular matrix are absolutely seminal to most cellular activities.
		In 2005, awards were made to Dr. Qiang Ding, Department of Medicine, for the study of FRNK in lung fibrosis and to Dr. Fang-Tsyr Lin, Department of Cell Biology, for the study of TRIP6 in ovarian tumor motility.
		It co-hosted a symposium “Research Frontiers: the interface between biomaterials, bone cells and matrices” with the School of Engineering and the CMBD on April 9, 2003.
	www.uab.edu /uasom/research/docs/center_celladhesion.doc (1658 words)

	CAMRC - Welcome to the Cell Adhesion and Matrix Research Center at UAB!
		The Cell Adhesion and Matrix Research (CAMRC) of the University of Alabama at Birmingham was inaugurated in the summer of 1995.
		The interests of the CAMRC encompass the diverse areas of cell-cell and cell-matrix adhesion, the structure-function of extracellular matrix molecules and their receptors, and models of cell motility and invasion.
		A partial list of the interests of its membership include studies of cell-cell and cell-matrix adhesion, the structure and function of connective tissue molecules and their receptors, cell adhesion signaling, extracellular matrix assembly and remodeling/degradation, cell motility and invasion, extracellular matrix-growth factor regulation, and the genetics of matrix and cell adhesion molecules.
	main.uab.edu /camrc/show.asp?durki=47063 (417 words)

	Cell -- Paratcha et al. (Site not responding. Last check: 2007-10-16)
		The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands
		Here, we show that the neural cell adhesion molecule NCAM can function as a signaling receptor for members of the GDNF ligand family.
		GDNF stimulates Schwann cell migration and axonal growth in hippocampal and cortical neurons via binding to NCAM and activation of Fyn, but independently of RET.
	www.cell.com /content/article/abstract?uid=PIIS0092867403004355 (246 words)

	ANAT3231-L13:Cell Adhesion - Dr Mark Hill
		Cell adhesion occurs by a number of different, often interacting, mechanisms.
		Adhesion Molecules - Overview of types of adhesion and the molecules involved.
		Escape to Adhesion - General cell adhesion resources, including information about antibodies to adhesion proteins.
	anatomy.med.unsw.edu.au /cbl/teach/anat3231/2003/ANAT3231L13.htm (945 words)

	Neural Cell Adhesion Molecule Contributes to Hemopoiesis-Supporting Capacity of Stromal Cell Lines -- Wang et al. 23 ...
		Neural Cell Adhesion Molecule Contributes to Hemopoiesis-Supporting Capacity of Stromal Cell Lines -- Wang et al.
		cells were significantly suppressed by repression of NCAM in
		Stem Cells, March 1, 2006; 24(3): 482 - 493.
	stemcells.alphamedpress.org /cgi/content/abstract/23/9/1389 (338 words)

	Amazon.com: Signaling Through Cell Adhesion Molecules: Books: Jun-Lin Guan (Site not responding. Last check: 2007-10-16)
		The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years.
		Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing, and malignant transformation.
		While I did find this a very detailed and HIGHLY useful book for signal transduction as a whole, I feel that there is a bias towards cell-to-matrix adhesion (integrins, what not) versus cell-to cell (cadherins, CAMs, etc).
	www.amazon.com /Signaling-Through-Cell-Adhesion-Molecules/dp/0849333857 (757 words)

	UASOM Research: Cell Adhesion and Matrix Research Center (Site not responding. Last check: 2007-10-16)
		The mission of the Cell Adhesion and Matrix Research Center is to promote outstanding research and education in the field of cell adhesion and extracellular matrix biology with the goal of developing translational opportunities for the application of this knowledge to the treatment of human disease.
		The CAMRC is a unique center in that it is funded on the strength and internationally-known expertise of its basic science.
		The Center maintains a website (www.uab.edu/camatrix) highlighting the activities of its members, with links to external sites pertinent to cell adhesion, extracellular matrix, and cell migration.
	www.uab.edu /uasom/research/html/center_celladhesion.htm (1679 words)

	Cell adhesion molecules - Glossary Entry - Genetics Home Reference
		Cell adhesion molecules - Glossary Entry - Genetics Home Reference
		Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion.
		Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
	ghr.nlm.nih.gov /ghr/glossary/celladhesionmolecules (95 words)

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