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| | Elke Stein - Yale Cell Biology |
 | | One of the earliest steps in neuronal development is the growth of axons from their cell bodies of origin to their appropriate targets, to form a precise pattern of neuronal connections. |
 | | Recent progress in the field lead to the identification of several families of attractants and repellents, including the netrin, semaphorin and slit protein families, as well as receptors involved in mediating the responses of these factors, however only little is known how these guidance cues function in vivo. |
 | | To address this we are using a series of biochemical, cell biological and molecular techniques, in combination with functional approaches, including an axon turning assays utilizing Xenopus spinal and neuronal rodent cultures, in vitro explant and slice cultures, and in vivo assays using the developing chicken as a model. |
| www.cellbiology.yale.edu /cellbio/html/faculty/e_stein.shtml (499 words) |
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