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Topic: Cell migration

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	Home : Cell Migration Gateway
		Migration is a cyclical process in which a cell extends protrusions at its front and retracts its trailing end.
		Understanding the mechanisms underlying cell migration is also important to emerging areas of biotechnology which focus on cellular transplantation and the manufacture of artificial tissues, as well as for the development of new therapeutic strategies for controlling invasive tumour cells.
		Cytokines are among the molecules known to upregulate endothelial cell adhesion molecules, recruit leukocytes and induce smooth muscle cell migration and proliferation.
	www.cellmigration.org /science (2120 words)

	YouTube - Dictyostelium cell migration
		Join YouTube for a free account, or log in if you are already a member.
		Wild type cells on the left migrate under agarose more slowly then myosin-2 mutant cells on the right.
		Folic acid is a chemoattractant for these slime mold cells.
	www.youtube.com /watch?v=eTAulGhrevA (387 words)

	Basic Concepts: Cell Migration « Migrations
		Defects in the migration proteins involved later on in development can result in malformed embryos, where tissues are disorganized because their component cells have failed to travel to their appropriate location or despite having traveled appropriately they fail to form the appropriate connections with neighboring cells and their surroundings.
		Migration is a dynamic, cyclical process in which a cell extends a protrusion at its front, which in turn attaches to the substratum on which the cell is migrating.
		This is followed by a contraction that moves the cell body forward toward the protrusion, and finally the attachments at the cell rear release as the cell continues to move forward.
	migration.wordpress.com /2007/01/29/basic-concepts-cell-migration (1211 words)

	BioMed Central \| Full text \| A high-throughput cell migration assay using scratch wound healing, a comparison of ...
		Cell migration is a complex phenomenon that requires the coordination of numerous cellular processes.
		Wells showing decreased migration or aberrant morphology are readily apparent by visual inspection as are wells showing an increase in the number of mitotic cells, which manifest as bright spheres (in the actin channel) in an otherwise intact and adherent monolayer [Figure 1D].
		Fischer EG, Stingl A, Kirkpatrick CJ: Migration assay for endothelial cells in multiwells.
	www.biomedcentral.com /1472-6750/4/21 (4555 words)

	Role of alpha vbeta 3-integrin in TNF-alpha -induced endothelial cell migration -- Gao et al. 283 (4): C1196 -- AJP - ...
		The migration of endothelial cells was evaluated by using a well-established in vitro wound-healing assay (10, 15, 34).
		Cells were incubated at 37°C for 30 min either in a serum-free medium on fibronectin-coated surfaces (Fn-coated, A and C) or in the presence of 20% serum on noncoated surfaces (noncoated, B and D).
		cell-matrix dissociation of endothelial cells (7, 14, 23,
	ajpcell.physiology.org /cgi/content/full/283/4/C1196 (4185 words)

	B.E.N. @ PENN - Research / Cell Motility
		Research is conducted using biophysics, biochemistry, genetics, physiology and ultrastructure to understand cell migration, intracellular transport, smooth, cardiac and skeletal muscle contraction, the structure/function relationship of molecular motors, chromosome segregation, cell division, muscle cell development, myofibril assembly and gene therapy targeted to muscle.
		Cell migration and intracellular transport are complex cellular processes that require a dynamic cytoskeleton (actin and microtubules) and molecular motors (myosin, kinesin, and dynein).
		Cell migration is crucial for several normal and pathological processes, including: cell and tissue development, wound healing, immune response, and metastases of tumors.
	www.upenn.edu /ben-penn/cell_motil.html (1666 words)

	Cell Migration
		Ongoing work involves locally perturbing cell locomotion using single cell photomanipulative techniques that are operative on the micron distance scale and 100s of ms time scale as a complement to genetic manipulation.
		Chem., Cell Motility and the Cytoskeleton and Biophys.
		Superimposed over the cell is the traction map (fl arrows) generated for this experiment, which is based on the analysis of bead displacements in the substratum.
	www.unc.edu /jacoblab/migration.htm (975 words)

	Appendix A: Early Development [Stem Cell Information]
		Rather, as early cell division proceeds, the amount of cytoplasm of each daughter cell is reduced by half, and the total volume of the early embryo remains unchanged from that of the fertilized egg [30, 35].
		ES cells that are grown in the laboratory most closely resemble cells of the epiblast [5], but ES cells are not identical to epiblast cells [42].
		Thus, the regulation of PG cell fate in the mammalian embryo is a result of the local environment of the cells, a recurring theme in mammalian embryogenesis, and the expression of genes in the PG cells [37].
	stemcells.nih.gov /info/scireport/appendixA.asp (8759 words)

	Neural Crest Migration
		Neurons, glial cells, the epinephrine-producing cells of the adrenal gland, pigmented cells of the epidermis, and various skeletal and connective tissue of the head are some of the fates that await neural crest cells.
		Cells that migrate from the 6th rhombomere have Hoxb-2 as well as Hoxb-3 expressed causing their migration to the 3rd pharyngeal arch.
		The cells in the 1st pharyngeal arch are responsible for the formation of the jawbones as well as the incus and malleus bones of the ear.
	www.trinity.edu /rblyston/craftyMol/ncm.htm (1166 words)

	Fenteany Research Group: Cell Sheet Migration
		Wounds induced in MDCK epithelial cell monolayers close by Rac- and phosphoinositide-dependent cell crawling, with formation of lamellipodia at the wound margin, and not by contraction of a perimarginal actomyosin purse-string.
		The rate of migration is inversely proportional to distance from the margin, and cells move coordinately yet still partly autonomously toward the wound area.
		In addition, some cell proliferation occurs at a delay after wounding but does not contribute to closure, instead apparently serving to replace damaged cells so that intact spread cells can revert to their normal cuboidal morphology and the original cell density of the unbroken sheet can be restored.
	www.biochemweb.org /fenteany/research/cell_migration (557 words)

	Home : Cell Migration Gateway
		This gateway represents a unique collaboration between The Cell Migration Consortium (CMC) and Nature Publishing Group (NPG) and is designed to facilitate navigation through the complex world of cell migration research.
		Cell Migration Update brings you the latest cell migration research, news and events.
		At the Cell Migration Knowledgebase, you can access data generated by scientists from the Consortium, as well as key factfiles for molecules relevant to cell migration.
	www.cellmigration.org (167 words)

	Video Microscopy of Neuronal Migration - Movies from the Hatten Lab
		The neuron forms an interstitial junction along the length of the cell soma, which is released as the cell begins to move.
		Immature granule neurons, purified from the early postnatal cerebellar cortex, migrate along the processes of glial cells isolated from hippocampus.
		To provide an assay for cell surface receptor systems that function in neuronal migration, low power views are used to track the movement of a large population of cerebelar granule cells.
	www.rockefeller.edu /labheads/hatten/cellmigration.html (297 words)

	CELL DEATH PROTEIN HAS SURPRISING ROLE IN CELL MIGRATION
		At a certain point in development of the egg, a single small cluster of these epithelial cells normally detaches from the others and moves from the edge of the egg chamber to the center, sliding between nurse cells and coming to rest at the edge of the oocyte.
		Returning a working Rac protein to these cells allowed about half of the epithelial clusters to complete their journey, as did overexpression of IAP and overexpression of proteins called actin and profilin, two components of cells' internal skeletons, the researchers found.
		The use of these so-called mosaic flies is crucial for studying cell migration, since migration gets all the cells of a developing embryo where they need to be to form a normal, viable insect.
	www.hopkinsmedicine.org /Press_releases/2004/07_13a_04.html (724 words)

	Cell Communication and Signaling \| Full text \| Serine phosphorylation regulates paxillin turnover during cell migration
		These structures are spatially regulated during cell migration as they assemble at the leading edge to stabilize new membrane protrusions and disassemble at the rear of the cell to allow cell detachment [3].
		Cells were plated on increasing concentrations of collagen for 1 h, fixed, and the number of adherent cells quantified by a colorimetric assay.
		Reduction in cell spreading induced by the expression of mutant paxillin is consistent with an increase in cell motility, as cells derived from mice deficient in the focal adhesion molecule vinculin likewise show reduced cell spreading and increased cell migration [42].
	www.biosignaling.com /content/4/1/8 (6423 words)

	Cell and Developmental Biology at Carolina - Keith Burridge, Ph.D.
		The interaction of cells with the surrounding extracellular matrix (ECM) affects many aspects of cell behavior, including the migration of cells, their growth and differentiation.
		This migration is a critical aspect of the inflammatory response.
		As a consequence, the cells remained tethered in their rears, although the leading edge of the cell often continues to migrate for some distance, giving rise to cells with long drawn out tails.
	www-cellbio.med.unc.edu /grad/depttest/burridge.htm (1084 words)

	Cell Motility and Migration
		The failure of cells to migrate or migration of cell to inappropriate locations can result in life threatening consequences such as the congenital defects prominent in the brain.
		Cell movement begins with the extension of one or more lamellipodia from the leading edge of the cell (Step 1).
		The trailing edge of the cell remains attached to the substratum untill the tail eventually detaches and retracts into the cell body (Step 4).
	www.uni-leipzig.de /~pwm/kas/motility/migration.html (692 words)

	ScienceDaily: Protein Modifications Affect Cell Migration
		The guidance of cell migration is achieved by signals intrinsic to the cell or from its surrounding environment.
		Interactions between the basement membrane of the migrating gonad and that of the body wall are one of the keystone processes of gonadal development.
		The C. elegans gonad is U-shaped, the result of the directed migration of cells known as distal tip cells present at the leading ends of the developing gonad in larvae.
	www.sciencedaily.com /releases/2003/12/031228165124.htm (840 words)

	Cell Migration
		Cell migration is a critical process for every type of living organism.
		Cells in the body will often move from place to place to complete their functions.
		The process of cell migration is important in such things as wound repair and cell differentiation.
	student.biology.arizona.edu /honors2001/group08/intro/intro1.htm (142 words)

	Leukocyte & Tumor Cell Migration (V.Niggli)
		Leukocyte and Tumor Cell Migration - Peptide Receptors - Vascular Diseases -
		Cell locomotion requires, in addition to a dynamic actin network, reversible actin-membrane linkage, development of a polarized shape and reversible contacts with the substratum.
		We are interested in identifying signalling systems affecting neutrophil and tumor cell locomotion and concomitant actin reorganization, as well as in cytoskeletal targets of these signals.
	www.pathology.unibe.ch /Forschung/cytoskeleton/vniggli_intro.htm (410 words)

	Journal Home - Nature Cell Biology
		Surprisingly, the role of the PAR proteins in cell polarity is still unclear.
		Nature Reports Stem Cells is a new, free hub of information about stem cells: their biology, clinical applications, and ethical issues they raise.
		Updated monthly, the Cell Migration Gateway features free access to highlights of key articles, a continuously updated library of essential papers, primary data on migration-related research and much more.
	www.nature.com /ncb (538 words)

	Molecular Analysis of Cell Surface {beta}-1,4-Galactosyltransferase Function During Cell Migration -- Appeddu and Shur ...
		Despite the identification and characterization of cell surface receptors for the extracellular matrix, it is unknown how their relative expression and cytoskeletal association regulate cell migration.
		Previous studies have identified ß-1,4-galactosyltransferase (GalTase; EC 2.4.1.38) on the surface of migrating cells, where it mediates cell migration on basal lamina matrices by associating with the cytoskeleton and binding to N-linked oligosaccharides in the E8 domain of laminin.
		In this study, the function of GalTase during cell migration was examined directly by analyzing the migration rate of stably transfected cell lines in which the relative level of surface GalTase and its ability to associate with the cytoskeleton were altered.
	www.pnas.org /cgi/content/short/91/6/2095 (597 words)

	Human neutrophils facilitate tumor cell transendothelial migration -- Wu et al. 280 (4): C814 -- AJP - Cell Physiology
		PMN to tumor cells is a prerequisite for PMN-assisted tumor cell
		PMN adhesion and extravasation as a paradigm for tumor cell dissemination.
		Influence of migratory blood cells on the attachment of tumor cells to vascular endothelium.
	ajpcell.physiology.org /cgi/content/full/280/4/C814 (4583 words)

	» Cell Migration In Development And Disease - Blue tooth cell phones - The Tooth Fairy
		Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine.
		This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.
		Perfect for the frequent traveler, this rapid cell phone charger is compatible with a variety of Samsung phones.
	www.blueenabledcellphones.com /Cell_Migration_In_Development_And_Disease/articles/3553519 (291 words)

	Compound reveals new link between signaling protein and cell migration
		University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells.
		The researchers used an approach sometimes called "forward chemical genetics" whereby they first identified locostatin as an inhibitor of cell migration, then used locostatin itself as a kind of bait to fish out the protein to which it binds.
		In each case, the result was consistent with RKIP having an important, positive role in the control of cell migration.
	www.eurekalert.org /pub_releases/2005-09/uoia-crn092305.php (516 words)

	fig001cso: Cell adhesion and cell migration
		Membrane extension at the front of the cell is mediated by the combined effects of actin polymerisation and actin movement mediated by myosin.
		The physical process of cell movement results from the retrograde flux of polymerised actin (and associated membrane receptors) and the cyclical flux of membrane from the rear to the front of the cell.
		The final stage of cell movement involves the disruption or severing of matrix attachments at the rear of the cell and retraction of the trailing edge of the cell (fig001cso).
	www-ermm.cbcu.cam.ac.uk /99000630h.htm (285 words)

	DM-GRASP Is Necessary for Nonradial Cell Migration during Chick Diencephalic Development -- Heffron and Golden 20 (6): ... (Site not responding. Last check: )
		DM-GRASP Is Necessary for Nonradial Cell Migration during Chick Diencephalic Development -- Heffron and Golden 20 (6): 2287 -- Journal of Neuroscience
		Cell migration is fundamental to normal CNS development.
		cell migration begins in the developing chick diencephalon.
	www.jneurosci.org /cgi/content/short/20/6/2287 (465 words)

	UNSW Embryology- Movie - Primordial Germ Cell Migration
		These movies shows the migration of primordial germ cells (PGCs) in the embryonic mouse between E9 and E10.5 (corresponding to Carnegie stage 9 to 12).
		Abstract: "In mouse embryos, the primordial germ cells arise during gastrulation prior to, and distant from, the prospective gonads.
		Movies on this page show in sequence the migration of labelled primordial germ cells within the early mouse embryo (E9 to E10.5) from the hindgut region into the genital ridges and their accumulation in this region.
	embryology.med.unsw.edu.au /Movies/genital/germcell.htm (742 words)

	Differential Effects of Culture Conditions on the Migration Pattern of Stromal Cell-Derived Factor-Stimulated ...
		The aptitude of hematopoietic stem cells (HSCs) to migrate is
		Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.
		Smooth muscle cell migration stimulated by interleukin 6 is associated with cytoskeletal reorganization.
	stemcells.alphamedpress.org /cgi/content/full/22/6/890 (2631 words)

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