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Topic: Cellular checkpoint

    Note: these results are not from the primary (high quality) database.

 Mitosis - Wikipedia, the free encyclopedia
During prophase, the two centrosomes - which replicate independently of mitosis- begin recruiting microtubules (which may be thought of as cellular ropes or poles) and forming mitotic spindles.
When the spindle grows to sufficient length, the microtubules begin searching for kinetochores to attach to.
Next, the spindle axis elongates, driving the centrioles (and the set of chromosomes to which they are attached) apart to opposite ends of the cell.
en.wikipedia.org /wiki/Mitosis

 A Spindle Checkpoint Arrest and a Cytokinesis Failure by the Dominant-negative Polo-box Domain of Plk1 in U-2 OS Cells -- Seong et al. 277 (35): 32282 -- Journal of Biological Chemistry
A Spindle Checkpoint Arrest and a Cytokinesis Failure by the Dominant-negative Polo-box Domain of Plk1 in U-2 OS Cells -- Seong et al.
Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4258 and
Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis
www.jbc.org /cgi/content/abstract/277/35/32282

 Israel - Details: Arafat's Fatah Tanzim trick Boy into being Suicide Bomber
The information leads to the conclusion that terrorists planned to activate the explosive device against the soldiers by use of a cellular telephone as the youth was passing through the checkpoint; namely to use the youth as a homocide bomber, without his knowledge.
Tanzim operators from the city Nablus took advantage of the innocent appearance of the boy and used him, without his knowlege, to transport an explosive device across the checkpoint.
It should be noted that this type of activity seriously harms innocent Palestinian population which passes through checkpoints on a daily basis and is evidence of the need for conducting checks at checkpoints.
www.kokhavivpublications.com /2004/israel/03/0403152216.html   (387 words)

Cellular senescence is controlled by tumor suppressor genes and seems to involve a checkpoint that prevents the growth of cells at risk for neoplastic transformation.
The senescence syndrome is characterized by distinct cellular and molecular changes, with the chloroplast the first part of the cell to undergo disassembly (producing the "yellowing").
One such mechanism is "cellular senescence", which arrests proliferation (essentially irreversibly) in response to potentially oncogenic events.
www.scienceweek.com /2005/sw050902-2.htm   (1564 words)

 New binding target for oncogenic viral protein
This protein corrupts the cellular checkpoint mechanisms that guard cell division and the transcription, replication and repair of DNA.
"These proteins are also some of the most broadly acting cellular oncogenes, and include cyclin E, c-Myc, Notch, and c-Jun," noted Dr. Clurman.
This protein is part of a ubiquitin ligase complex that adds ubiquitin to proteins to mark them for destruction by the cell.
www.eurekalert.org /pub_releases/2005-02/asfb-nbt022505.php   (1564 words)

 Xu Lab Publications
Xu, Y. and Baltimore, D. Dual roles of ATM in the cellular response to radiation and in cell growth control.
Xu, Y., Yang, E.M., Brugarolas, J., Jacks, T., and Baltimore, D. Involvement of p53 and p21 in the cellular defects and tumorigenesis in Atm-/- mice.
Post, S., Weng, Y-C., Cimprich K., Chen, L. B., Xu Y., and Lee, E.Y.-H.P. Phosphorylation serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage.
www-biology.ucsd.edu /labs/xu/publications.html   (1564 words)

 Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation -- Xu et al. 22 (4): 1049 -- Molecular and Cellular Biology
Mikhailov, A., Shinohara, M., Rieder, C. Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway.
Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery.
/M checkpoint measures the inhibition of cells that are in G
mcb.asm.org /cgi/content/full/22/4/1049   (1564 words)

 The B-Subunit of DNA Polymerase {alpha}-Primase Associates with the Origin Recognition Complex for Initiation of DNA Replication -- Uchiyama and Wang 24 (17): 7419 -- Molecular and Cellular Biology
Role of fission yeast primase catalytic subunit in the replication checkpoint.
Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.
Orp2 with primase Spp2/p58 in the four-subunit Pol
mcb.asm.org /cgi/content/full/24/17/7419   (7094 words)

 Replication Proteins Influence the Maintenance of Telomere Length and Telomerase Protein Stability -- Dahlén et al. 23 (9): 3031 -- Molecular and Cellular Biology
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.
spp1-9, and spp2-9 mutations on silencing at the telomere locus.
mcb.asm.org /cgi/content/full/23/9/3031   (5537 words)

 Fission yeast DNA replication
Cellular DNA replication requires precise regulation to ensure first, that the genome is replicated once completely in each cell cycle, and second, that the process of replication is coordinated with proper cell cycle entry and subsequent nuclear division.
In the case of these unusual checkpoint-deficient replication mutants, because they never even begin DNA replication, the cell never gets a signal that replication is in progress; thus the intact checkpoint is not activated.
A number of mutants affecting DNA replication after initiation have been found; these mutants are able to complete some synthesis, and arrest late in S phase with the elongated, cdc phenotype.
www-rcf.usc.edu /~forsburg/main2.html   (2346 words)

 Fission Yeast Rad17 Associates with Chromatin in Response to Aberrant Genomic Structures -- Kai et al. 21 (10): 3289 -- Molecular and Cellular Biology
A novel allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.
Purified Rad17 protein, but not the checkpoint-defective Rad17(K118E) mutant protein, binds ATP in vitro.
A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S phase progression to prevent premature mitosis.
mcb.asm.org /cgi/content/full/21/10/3289   (2346 words)

 Iron homeostasis: new tales from the crypt -- Roy and Enns 96 (13): 4020 -- Blood
The most important checkpoint of iron homeostasis in higher organisms is contained in the epithelial cell layer of the duodenum,
Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.
Iron and gene expression: molecular mechanisms regulating cellular iron homeostasis.
www.bloodjournal.org /cgi/content/full/96/13/4020   (6339 words)

 Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding -- Chen et al. 23 (21): 7488 -- Molecular and Cellular Biology
Morgan, M. A., Parsels, L. A., Parsels, J. D., Mesiwala, A. K., Maybaum, J., Lawrence, T. Role of Checkpoint Kinase 1 in Preventing Premature Mitosis in Response to Gemcitabine.
Ferguson, A. M., White, L. S., Donovan, P. J., Piwnica-Worms, H. Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases.
Palmer, G. E., Johnson, K. J., Ghosh, S., Sturtevant, J. Mutant alleles of the essential 14-3-3 gene in Candida albicans distinguish between growth and filamentation.
mcb.asm.org /cgi/content/abstract/23/21/7488   (402 words)

 mRNA Capping Enzyme Activity Is Coupled to an Early Transcription Elongation -- Kim et al. 24 (14): 6184 -- Molecular and Cellular Biology
checkpoint window by reinforcing the checkpoint security circuit
A mutation in the guanylyltransferase subunit gene (CEG1) of the mRNA capping enzyme confers an allele-specific sensitivity to 6AU.
mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain.
mcb.asm.org /cgi/content/full/24/14/6184   (402 words)

 NDT80 and the Meiotic Recombination Checkpoint Regulate Expression of Middle Sporulation-Specific Genes in Saccharomyces cerevisiae -- Hepworth et al. 18 (10): 5750 -- Molecular and Cellular Biology
Ufano, S., San-Segundo, P., del Rey, F., Vazquez de Aldana, C. SWM1, a Developmentally Regulated Gene, Is Required for Spore Wall Assembly in Saccharomyces cerevisiae.
Trilla, J. A., Durán, A., Roncero, C. Chs7p, a New Protein Involved in the Control of Protein Export from the Endoplasmic Reticulum that Is Specifically Engaged in the Regulation of Chitin Synthesis in Saccharomyces cerevisiae.
Pijnappel, W.W.M. P., Schaft, D., Roguev, A., Shevchenko, A., Tekotte, H., Wilm, M., Rigaut, G., Seraphin, B., Aasland, R., Stewart, A. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.
mcb.asm.org /cgi/content/abstract/18/10/5750   (402 words)

 Developmental Biology and Genetics Track
The Developmental Biology and Genetics track emphasizes research training in molecular and genetic aspects of cellular and developmental biology.
Cell cycle checkpoint pathways and molecular genetic studies of breast cancer using mouse models
Students in the Genetics and Development Biology track are required to take four core courses (MB203, MB204, DB231B and MB206) plus a course in genetics (DB210 or MBB207), followed by two additional courses chosen as electives (e.g., DB231C, MBB212, PandB210).
www.bio.uci.edu /academic/grad/mbgb_dev.html   (714 words)

 Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1 -- Noguchi et al. 23 (21): 7861 -- Molecular and Cellular Biology
The DNA replication checkpoint response stabilizes stalled replication forks.
Stalled replication forks are prone to collapse, regression,
Foss (16) proposed that Tof1 and Rad9 have overlapping
mcb.asm.org /cgi/content/full/23/21/7861   (7218 words)

 Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G2/M Checkpoint -- Zhu et al. 24 (16): 7140 -- Molecular and Cellular Biology
Fixed cells were stained with fluorescein isothiocyanate-conjugated mouse antibromodeoxyuridine antibody or fluorescein isothiocyanate-conjugated mouse immunoglobulin G1 as a negative control and propidium iodide (PI).
The percentage of cells in each gate is indicated in the panel; 10,000 cells were counted for FACS analysis.
) cells treated as in panel A were treated with 15 µM bromodeoxyuridine for the last 30 min and stained with DAPI and antibromodeoxyuridine antibody.
mcb.asm.org /cgi/content/full/24/16/7140   (7218 words)

 Analysis of Fission Yeast Primase Defines the Checkpoint Responses to Aberrant S Phase Initiation -- Tan and Wang 20 (21): 7853 -- Molecular and Cellular Biology
indicate that Spp2 is the bridge protein between Spp1 and Pol
The spp1 results and the concomitant decrease of Spp1 and Spp2
suggesting that Spp2 is the bridge protein between Spp1 and Pol
mcb.asm.org /cgi/content/full/20/21/7853   (7218 words)

 p53-Dependent S-Phase Damage Checkpoint and Pronuclear Cross Talk in Mouse Zygotes with X-Irradiated Sperm -- Shimura et al. 22 (7): 2220 -- Molecular and Cellular Biology
Medical Research Institute, Kanazawa Medical University, Uchinada-machi, Kahoku-gun, Ishikawa 920-02, Japan,
mcb.asm.org /cgi/content/abstract/22/7/2220   (388 words)

 The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents -- Hirose et al. 23 (22): 8306 -- Molecular and Cellular Biology
agents such as methyl methane sulfonate and ethyl methane sulfonate
mcb.asm.org /cgi/content/full/23/22/8306   (388 words)

 Fox Chase Cancer Center: Erica A. Golemis, Ph.D.
Cotsiki, M., Lock, R.L., Cheng, Y., Williams, G.L., Zhao, J., Perera, D., Freire, R., Entwistle, A., Golemis, E.A., Roberts, T.M., Jat, P.S., Gjoerup, O.V. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1.
Dadke, D., Fryer, B.H., Golemis, E.A., Field, J. Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation.
Methods in Molecular Biology: The Proteomics Handbook, Humana Press, in press.
www.fccc.edu /research/pid/golemis   (388 words)

 Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3 -- Lee and Spencer 101 (29): 10655 -- Proceedings of the National Academy of Sciences
budding yeast Mad1 and Mad2 are essential members of the cellular
of yeast Mad3 during nocodazole-induced spindle checkpoint arrest.
yeast to arrest the cell cycle in response to sister kinetochore
www.pnas.org /cgi/content/full/101/29/10655   (388 words)

 HHMI News: Zebrafish May Point the Way to Mending a Broken Heart
Two months after the surgery, all evidence of scarring is gone, and the size, shape and cellular activity of the zebrafish hearts appear to be no different from typical zebrafish.
The investigators looked at zebrafish with a mutation in Mps1, a gene that encodes a mitotic checkpoint kinase protein critical in cells that regenerate zebrafish fins.
In the zebrafish studied, Keating and his colleagues made surgical incisions in the ventral side of adult zebrafish, pushed out the two-chambered heart and then clipped off a chunk at its apex equaling about 20 percent of the total organ.
www.hhmi.org /news/keating5.html   (1001 words)

 Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3' Phosphatases -- Vance and Wilson 21 (21): 7191 -- Molecular and Cellular Biology
Karumbati, A. S., Wilson, T. Abrogation of the Chk1-Pds1 Checkpoint Leads to Tolerance of Persistent Single-Strand Breaks in Saccharomyces cerevisiae.
Vance, J. R., Wilson, T. Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.
Karumbati, A. S., Deshpande, R. A., Jilani, A., Vance, J. R., Ramotar, D., Wilson, T. The Role of Yeast DNA 3'-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions.
mcb.asm.org /cgi/content/full/21/21/7191   (1001 words)

 Tyrosine Phosphorylation of Cdc2 Is Required for the Replication Checkpoint in Schizosaccharomyces pombe -- Rhind and Russell 18 (7): 3782 -- Molecular and Cellular Biology
Shimada, M., Nabeshima, K., Tougan, T., Nojima, H. The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast.
Price, D. M., Jin, Z., Rabinovitch, S., Campbell, S. Ectopic Expression of the Drosophila Cdk1 Inhibitory Kinases, Wee1 and Myt1, Interferes With the Second Mitotic Wave and Disrupts Pattern Formation During Eye Development.
mcb.asm.org /cgi/content/abstract/18/7/3782   (1001 words)

 The Fission Yeast Rad32 (Mre11)-Rad50-Nbs1 Complex Is Required for the S-Phase DNA Damage Checkpoint -- Chahwan et al. 23 (18): 6564 -- Molecular and Cellular Biology
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
The fission yeast MRN proteins are required for the S-phase DNA damage checkpoint but not the G
Fission yeast Nbs1, Rad32 (the homolog of Mre11),
mcb.asm.org /cgi/content/full/23/18/6564   (1001 words)

 The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
Damage-induced hyperphosphorylation of Rad9 correlated with checkpoint functions (cell-cycle arrest and transcriptional induction) and was cell-cycle stage- and progression-independent.
Treatment with various types of DNA damaging agents results in a rapid hyperphosphorylation of Rad9 that persists until the cellular responses to DNA damage are completed.
Moreover, DNA damage-dependent hyperphosphorylation of Rad9 correlates with induction of the DDR in a dose-dependent manner.
www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v17/n19/full/7591262a.html   (1001 words)

 Regulation of Cellular and SV40 Virus Origins of Replication by Chk1-dependent Intrinsic and UVC Radiation-induced Checkpoints -- Miao et al. 278 (6): 4295 -- Journal of Biological Chemistry
DNA mediated by a caffeine-sensitive checkpoint suggests that
SV40 DNA Replication Analysis-- The effects of UVC radiation on SV40 DNA replication were analyzed as we described previously (27, 28).
SV40 replication intermediates recovered from Hirt extracts were separated on two-dimensional agarose gels and visualized by Southern blotting and hybridization to
www.jbc.org /cgi/content/full/278/6/4295   (7039 words)

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