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Topic: Cerivastatin

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Atorvastatin

Rhabdomyolysis

Myoglobin

	Cerivastatin - Wikipedia, the free encyclopedia
		In pharmacology, cerivastatin (Baycol®, Lipobay®) is a synthetic member of the class of statins, used to lower cholesterol and prevent cardiovascular disease.
		Cerivastatin was marketed by the pharmaceutical company Bayer A.G. in the late 1990s as a new synthetic statin, to compete with Pfizer's highly successful Lipitor®.
		During post-marketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant renal failure.
	en.wikipedia.org /wiki/Cerivastatin (271 words)

	cerivastatin - [Medication]
		Cerivastatin is used to reduce the amounts of LDL (bad) cholesterol and total cholesterol in your blood.
		Cerivastatin also reduces the amounts of triglycerides (another type of fat) and apolipoprotein B (a protein needed to make cholesterol) in your blood and increases the amount of HDL (good) cholesterol in your blood.
		Cerivastatin is in the FDA pregnancy category X. This means that cerivastatin will cause birth defects if it is taken during pregnancy.
	www.peacehealth.org /kbase/multum/d04140a1.htm (1158 words)

	Cerivastatin Triggers Tumor-specific Apoptosis with Higher Efficacy than Lovastatin -- Wong et al. 7 (7): 2067 -- ...
		Lovastatin is one of the prototypic inhibitors of HMG-CoA reductase and is derived from fungal fermentation, whereas atorvastatin, cerivastatin, and fluvastatin are newer synthetic inhibitors of this rate-limiting enzyme of the mevalonate pathway.
		cerivastatin in PBS for 48 h, and induction of apoptosis was measured by the TUNEL assay.
		cerivastatin for 48 h, and induction of apoptosis was determined by the TUNEL assay.
	clincancerres.aacrjournals.org /cgi/content/full/7/7/2067 (4669 words)

	Baycol Online, Description, Chemistry, Ingredients, Blackbox - Cerivastatin - RxList Monographs
		Cerivastatin sodium is a white to off-white hygroscopic amorphous powder that is soluble in water, methanol, and ethanol, and very slightly soluble in acetone.
		Cerivastatin sodium is an entirety synthetic, enantiomeritally pure inhibitor of 3-hydroxy-3- methylglutatyl-coenzyme A (HMG-CoA) reductase.
		BAYCOL (cerivastatin sodium tablets) is supplied as tablets containing 0.2 or 0.4 mg of cerivastatin sodium, for oral administration.
	www.rxlist.com /cgi/generic2/cerivastat.htm (162 words)

	FDA Approves New Baycol (Cerivastatin) Dosage And Additional Indication For Hypercholesterolemia (Site not responding. Last check: 2007-11-01)
		The combined use of cerivastatin and gemfibrozil is contraindicated due to the risk for rhabdomyolysis.
		In the U.S. placebo-controlled clinical studies, discontinuations due to adverse events occurred in 3.1 percent of cerivastatin sodium tablet-treated patients and in 2.0 percent of patients treated with placebo.
		Efficacy and safety of cerivastatin, 0.2 mg and 0.4 mg, in patients with primary hypercholesterolemia: a multinational, randomised, double-blind study.
	www.pslgroup.com /dg/1da6ee.htm (1119 words)

	Yale-New Haven Hospital: HealthLINK: Cardiac October 2001
		Cerivastatin is one of a class of cholesterol-lowering drugs called statins, which are considered to be the first line of treatment for most patients with high cholesterol.
		In addition to cerivastatin, there are five commonly prescribed statin drugs that block the production of specific enzymes used by the body to make cholesterol.
		Smith and many other cardiologists are worried that the recall of cerivastatin might result in patients turning away from statin drugs in general.
	www.ynhh.org /healthlink/cardiac/cardiac_10_01.html (1551 words)

	cerivastatin - Cholesterol: health and medical information about high cholesterol and heart disease
		Cerivastatin may be used in pregnancy if the physician feels that its benefits outweigh its potential risks.
		Cerivastatin should be used with caution in patients with alcoholic or other liver diseases.
		Rare cases of muscle damage due to inflammation (myositis) have been reported with other drugs in the same class as cerivastatin, and is presumed also to occur with cerivastatin as well.
	www.medicinenet.com /cerivastatin/article.htm (733 words)

	Cerivastatin (Systemic)
		Cerivastatin should not be used during pregnancy or by women who plan to become pregnant in the near future.
		Cerivastatin passes into breast milk and should not be used during breast-feeding because it may cause serious unwanted effects in nursing babies.
		Studies on cerivastatin have been done only in adult patients and there is no specific information comparing use of cerivastatin in children with use in other age groups.
	allnutritionals.com /drugs/c/cerivastatin-systemic.shtml (1294 words)

	Healthopedia.com Drugs Information - Cerivastatin : Before Using
		Cerivastatin may cause birth defects or other problems in the baby if taken during pregnancy.
		Children—Studies on cerivastatin have been done only in adult patients and there is no specific information comparing use of cerivastatin in children with use in other age groups.
		Gemfibrozil (e.g., Lopid)—Use of this medicine with cerivastatin is not recommended due to the risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure
	www.healthopedia.com /drugs/detailed/cerivastatin/before-using.html (768 words)

	Lipids Online Slides: cerivastatin, statins, simvastatin, pravastatin
		In the 2x2 factorial design, 5,000 patients were randomized to cerivastatin 0.4 mg versus placebo and micronized fenofibrate 200 mg or placebo.
		Evaluation of the 1,250 subjects on both cerivastatin and fenofibrate will provide good evidence on the safety as well as the additional efficacy of adding a fibrate to a statin, although the study is not fully powered for this.
		Cerivastatin was studied in 785 patients with primary hypercholesterolemia (mean baseline LDL-C 193 mg/dL); randomization was in a 1:4 ratio to cerivastatin 0.4 mg (n=162) or 0.8 mg (n=623) for 8 weeks.
	www.lipidsonline.org /slides/slide01.cfm?q=cerivastatin (495 words)

	Baycol (Cerivastatin) Not To Be Used In Combination With Gemfibrozil, Says Bayer
		Cerivastatin and gemfibrozil (another cholesterol-lowering drug) should never be used in combination due to the increased risk of a serious side effect.
		In Canada, combination therapy with cerivastatin and gemfibrozil is rare, however if you are one of those few patients taking this combination, you should contact your doctor immediately.
		In March 2000, Bayer Inc. amended the cerivastatin prescribing information available to all health care professionals to indicate that cerivastatin and gemfibrozil must not be used together.
	www.docguide.com /dg.nsf/PrintPrint/1A5E3335F04AD2D485256A94006FA564 (601 words)

	Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation ...
		Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models -- Vincent et al.
		Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models
		Effect of cerivastatin on FAK and Akt phosphorylation was monitored at 3, 12, and 24 hours of incubation.
	atvb.ahajournals.org /cgi/content/full/22/4/623 (3649 words)

	The Journal of International Research (Site not responding. Last check: 2007-11-01)
		Cerivastatin 0.8 mg reduced mean low density lipoprotein-cholesterol (LDL-C) by 41.8% compared with cerivastatin 0.4 mg (—35.6%, P < 0.0001) or placebo.
		Cerivastatin 0.8 mg also reduced mean total cholesterol by 29.9%, apolipoprotein B by 33.2% and median triglycerides by 22.9% (all P < 0.0001).
		Cerivastatin 0.8 mg is an effective and safe treatment for patients with primary hypercholesterolaemia who need aggressive LDL-C lowering in order to achieve NCEP-recommended levels.
	www.jimronline.net /nav/issue.asp?IssueID=18 (1159 words)

	cerivastatin - Fort Lauderdale, Florida (Site not responding. Last check: 2007-11-01)
		Cerivastatin blocks the production of cholesterol (a type of fat) in the body.
		Cerivastatin may also be used for purposes other than those listed in this medication guide.
		Cerivastatin passes into breast milk and can harm a nursing infant.
	www.browardhealth.org /19983.cfm (1171 words)

	Australian Adverse Drug Reactions Bulletin, Volume 20, Number 1, February 2001
		The 17 cases of rhabdomyolysis with cerivastatin occurred from just over a week to 18 months after the introduction of cerivastatin but most occurred in the first month of therapy.
		Seven of the 15 cases in which the dose was stated occurred with daily dosages of 400 µg or greater and two cases occurred shortly after the dose was increased to 800 µg daily.
		Cerivastatin should not be used in combination with gemfibrozil.
	www.tga.gov.au /docs/html/aadrbltn/aadr0102.htm (1398 words)

	Drug Information: Cerivastatin (Systemic) (Print Version)
		Cerivastatin (se-RIV-a-stat-in) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood.
		Cerivastatin belongs to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.
		It works by blocking an enzyme that is needed by the body to make cholesterol, thereby reducing the amount of cholesterol in the blood.
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/203060.html (1316 words)

	Cerivastatin Drug Information
		Children-Studies on cerivastatin have been done only in adult patients and there is no specific information comparing use of cerivastatin in children with use in other age groups.
		Niacin (nicotinic acid)-Use of these medicines with cerivastatin may increase the risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure
		Gemfibrozil (e.g., Lopid)-Use of this medicine with cerivastatin is not recommended due to the risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure
	www.drugs.com /cons/Cerivastatin.html (1600 words)

	Cerivastatin (withdrawal from sale)
		Cerivastatin is one of the statin class of drugs taken to lower cholesterol.
		Reporting of adverse reactions to cerivastatin in a number of countries has highlighted two problems with cerivastatin.
		All other patients taking cerivastatin should stop taking cerivastatin immediately and arrange to have a discussion with their doctor within the next week about changing to alternative therapy.
	www.tga.gov.au /docs/html/cerivast.htm (530 words)

	Baycol (Cerivastatin) Not To Be Used In Combination With Gemfibrozil, Says Bayer (Site not responding. Last check: 2007-11-01)
		Cerivastatin belongs to a class of drugs referred to as statins and is used by patients who have not been able to achieve a sufficient reduction of blood cholesterol levels with diet and exercise alone.
		In a very small percentage of patients, there is a risk of muscle breakdown resulting in kidney damage, which in rare instances can lead to life-threatening kidney failure.
		Cerivastatin was approved in Canada in March, 1998.
	www.pslgroup.com /dg/201D9E.htm (584 words)

	Cerivastatin
		The FDA noted that the company initiated this action due to reports of rhabdomyolysis, including reports of fatal cases, which have been associated with the use of this lipid-lowering agent.
		Fatal rhabdomyolysis was reported most frequently in specific clinical situations, including the use of higher doses of cerivastatin, use in elderly patients, and use in combination with gemfibrozil.
		Hypersensitivity to cerivastatin or any component of the formulation; active liver disease; unexplained persistent elevations of serum transaminases; concurrent use of gemfibrozil; pregnancy; breast-feeding
	www.musc.edu /pharmacyservices/Drugs/C/Cerivastatin.htm (505 words)

	cerivastatin - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-11-01)
		Do not take cerivastatin without first talking to your doctor if you have liver disease.
		Do not take cerivastatin if you are breast-feeding a baby.
		Your pharmacist has additional information about cerivastatin written for health professionals that you may read.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100107028 (1215 words)

	An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and ... (Site not responding. Last check: 2007-11-01)
		Cerivastatin treatment did not affect macrophage death in atheroma of WHHL rabbits.
		Shiomi M, Ito T. Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits.
		Effect of the new HMG-CoA reductase inhibitor cerivastatin (BAY W 6228) on migration, proliferation and cholesterol synthesis in arterial myocytes.
	circ.ahajournals.org /cgi/content/full/103/2/276 (4276 words)

	Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated ...
		Cerivastatin [10,11] is rapidly absorbed, with 60% bioavailability
		Pharmacokinetics of single-dose cerivastatin in subjects with normal and impaired renal function.
		Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients.
	ndt.oxfordjournals.org /cgi/content/full/16/1/141 (2672 words)

	Medical Dictionary: Cerivastatin - WrongDiagnosis.com
		Cerivastatin: The sodium salt of a synthetic lipid-lowering agent.
		Cerivastatin sodium competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.
		A hierarchical classification of Cerivastatin: The following list attempts to classify Cerivastatin into categories where each line is subset of the next.
	www.wrongdiagnosis.com /medical/cerivastatin.htm (245 words)

	Cerivastatin (Site not responding. Last check: 2007-11-01)
		Warning: On August 8, 2001, Bayer Pharmaceutical Division voluntarily withdrew Baycol (cerivastatin) from the U.S. market because of reports of sometimes fatal rhabdomyolysis, a severe muscle adverse reaction from this cholesterol-lowering (lipid-lowering) product.
		Cerivastatin is used to lower elevated blood cholesterol and triglyceride levels when low-fat diets and lifestyle changes are ineffective.
		However, niacin has also been used in combination with statin drugs without ill effects, and has been found to enhance the cholesterol-lowering effect of these drugs.
	www.kroger.com /hn/Drug/Cerivastatin.htm (387 words)

	Baycol - FDA Talk Paper: Bayer Voluntarily Withdraws Baycol (Cerivastatin)
		FDA Talk Papers are prepared by the Press Office to guide FDA personnel in responding with consistency and accuracy to questions from the public on subjects of current interest.
		Baycol (cerivastatin), which was initially approved in the U.S. in 1997, is a member of a class of cholesterol lowering drugs that are commonly referred to as "statins." Statins lower cholesterol levels by blocking a specific enzyme in the body that is involved in the synthesis of cholesterol.
		While all statins have been associated with very rare reports of rhabdomyolysis, cases of fatal rhabdomyolysis in association with the use of Baycol have been reported significantly more frequently than for other approved statins.
	www.legallawhelp.com /safety_and_health/baycol/bayer.html (539 words)

	Cerivastatin Information
		Cerivastatin was sold under the brand name of Baycol.
		Baycol is a member of a class of cholesterol lowering drugs that are commonly referred to as "statins." It was approved for use in the U.S. in 1997.
		If you are taking Baycol and experience muscle pain, discontinue Baycol immediately and contact your physician for further advice.
	www.prodworks.com /Cerivastatin.htm (325 words)

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