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Topic: Ceruloplasmin

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	Tissue-specific ceruloplasmin gene expression in the mammary gland.
		Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals.
		Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus.
		Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma.
	www.arclab.org /medlineupdates/abstract_1764031.html (275 words)

	INABIS '98 - Aceruloplasminemia
		Ceruloplasmin is a member of the highly conserved family of blue multicopper oxidases and is encoded in a 19 exon, single copy, 40 kB gene in the haploid human genome (1).
		Ceruloplasmin is thus responsible for moving iron out of the storage compartment of the reticuloendothelial system to the functional compartment of the bone marrow following recycling of senescent red blood cell iron mass.
		A defect in ceruloplasmin synthesis that results in aceruloplasminemia causes cellular damage due to (1) storage damage from excessive iron deposition, (2) oxyradical damage secondary to the presence of a free transition metal and H2O2 within the cell or (3) a lack of substrate and a failure of the functional compartment.
	www.mcmaster.ca /inabis98/templeton/harris0342/two.html (1575 words)

	University of Miami School of Medicine - Glossary - Ceruloplasmin deficiency
		Ceruloplasmin deficiency: Lack of the protein ceruloplasmin from the blood and accumulation of iron in the pancreas, liver and brain, causing diabetes and progressive nervous system degeneration with the tremors and gait abnormalities characteristic of Parkinson disease.
		Aceruloplasminemia is caused by mutations in the gene encoding ceruloplasmin on chromosome 3q.
		Ceruloplasmin is an essential ferroxidase, an enzyme which catalyzes the oxidation of ferrous iron to ferric iron.
	www.med.miami.edu /glossary/art.asp?articlekey=16208 (295 words)

	Ceruloplasmin
		Ceruloplasmin (CP) is a copper-binding protein in vertebrate plasma.
		As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen.
		A novel mutation of the ceruloplasmin gene was found in a patient with hereditary ceruloplasmin deficiency (HCD) daughter revealed a novel point mutation, G to A, at nucleotide 2630 in exon 15.
	www.mad-cow.org /~tom/ceruloplasmin.html (10804 words)

	Chen, Mol Vis 2003; 9:151-158.
		Ceruloplasmin is expressed in the human retina [18] and increased retinal ceruloplasmin expression occurs in the rat retina following optic nerve crush, where lipid peroxidation is associated with retinal ganglion cell death [19].
		Ceruloplasmin may facilitate iron loading onto transferrin in the retina, as transferrin is made by RPE and photoreceptors and bound by photoreceptors and other retinal cells [31,32].
		Tissue in situ hybridization indicated that ceruloplasmin is mainly expressed in the astrocytes in the ganglion cell layer and in the Muller cells in the inner nuclear layer [19,25].
	www.molvis.org /molvis/v9/a22 (5030 words)

	Primary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development.
		Primer extension reveals a single identical start site of ceruloplasmin gene transcription in lung and liver and biosynthetic studies indicate that each tissue synthesizes a ceruloplasmin protein which is qualitatively similar to that synthesized by adult liver.
		Ceruloplasmin mRNA is also detected in human fetal lung explant and a human lung adenocarcinoma cell line suggesting that a similar pattern of expression occurs in the developing human lung.
		These data indicate that lung is the predominant extrahepatic site of ceruloplasmin gene expression during fetal development and suggest that this protein may play a previously unappreciated role in lung development or pulmonary antioxidant defense.
	www.arclab.org /medlineupdates/abstract_2332446.html (295 words)

	A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes -- Patel and ...
		Ceruloplasmin is a copper-binding protein, which is the major ferroxidase in plasma of hepatic origin.
		The immunofluorescence staining indicates that ceruloplasmin is present on the surface of astrocytes and C6 glioma cells.
		of ceruloplasmin with the monoclonal antibody mAb 1A1 (lane 3).
	www.jbc.org /cgi/content/full/272/32/20185 (5699 words)

	Bioline International Official Site (site up-dated regularly)
		The present study was undertaken to elucidate the role of estrogen on ceruloplasmin level in acute stress induced by forced swimming in the Wistar rat model.
		Ortho-Dianisidine dihydrochloride is oxidized by ceruloplasmin at pH 5.0 in the presence of oxygen.
		Serum ceruloplasmin (Table 1) level found in stressed rats with intact ovaries was about 98 mg/100ml, as against the Normal control, which was lower than control value.
	www.bioline.org.br /request?ms04025 (1581 words)

	Role of Endogenous Ceruloplasmin in Low Density Lipoprotein Oxidation by Human U937 Monocytic Cells -- Ehrenwald and ...
		Ceruloplasmin was purified from human plasma by a modification (28) of the method of Noyer et al.
		Samokyszyn, V.M., D.M. Miller, D.W. Reif, and S.D. Aust (1989) Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin.
		Lunec, A.F. Drake, and D.R. Blake (1988) Role of oxidative modification in the lability of ceruloplasmin.
	www.jci.org /cgi/content/full/97/3/884 (5015 words)

	Biochemical Analysis of a Missense Mutation in Aceruloplasminemia -- Hellman et al. 277 (2): 1375 -- Journal of ...
		Ceruloplasmin is a member of the multicopper oxidase family of enzymes, which use the facile electron chemistry of the bound
		Site-directed Mutagenesis of Ceruloplasmin-- The P177R mutation was identified by sequencing of genomic DNA from an affected patient with aceruloplasminemia.
		Ceruloplasmin was immunoprecipitated from cell lysates (IC) and media (EC) and analyzed by 7.5% SDS-PAGE as described under "Experimental Procedures." B, exon structure and divergent translated amino acid sequences of GPI-linked and secreted ceruloplasmin (Cp).
	www.jbc.org /cgi/content/full/277/2/1375 (4235 words)

	Cirrhosis in a Young Woman From Central America -- Answer
		Wilson's disease is associated with low serum ceruloplasmin because of an abnormal ATPase that is required for copper to enter the secretory pathway, bind to apoceruloplasmin, and exit into the plasma bound to ceruloplasmin.
		Low-normal levels (20-22 mg/dL) are found in 5% to 15% of patients with Wilson's disease for 2 reasons: (1) ceruloplasmin is an acute-phase reactant and therefore may increase because of infection or inflammation; and (2) rather than measuring oxidase activity, some laboratories use immunologic assays that measure both ceruloplasmin and apoceruloplasmin in the serum.
		A key biochemical difference is that in all other disorders of chronic cholestasis, the ceruloplasmin level is normal or increased, suggesting a defect in biliary copper excretion past the point of entry into the secretory pathway.
	www.medscape.com /content/2003/00/44/82/448293/ans4.html (642 words)

	Lab News, Sept 1996d, Department of Laboratory Medicine at Yale
		The primary indication for measuring ceruloplasmin is as a screening test for the diagnosis of Wilson's Disease (hepatolenticular degeneration).
		In addition, very low levels of ceruloplasmin are observed in 10-20% of hetero-zygotes as well as some patients with nephrotic syndrome, sprue, and severe hepatic failure, none of whom show the clinical abnormalities of Wilson's disease.
		Previously, ceruloplasmin was measured in the Chemistry laboratory by a functional assay that relied on the ability of ceruloplasmin to catalyze the oxidation of phenylenediamine.
	info.med.yale.edu /labmed/labnews/sept1996d.html (369 words)

	Nat' Academies Press, Copper in Drinking Water (2000)
		Ceruloplasmin has recently been shown to function as an antioxidant in neutralizing nitric oxide via nitrosothiol formation (Inoue et al.
		In one patient with the disease, a 5-bp insertion in exon 7 caused an out-of-frame shift that generated a stop codon that aborted the protein from the ribosome before synthesis was completed (Harris et al.
		Copper-deficiency studies in which ceruloplasmin is lowered never achieve a total absence of the protein, as is observed in aceruloplasminemia.
	www.nap.edu /books/0309069394/html/63.html (596 words)

	Copper transport to mammary gland and milk during lactation in rats -- Donley et al. 283 (4): 667 -- AJP - ...
		of milk ceruloplasmin is the mammary gland and not the maternal
		Ceruloplasmin and copper transport during the latter part of gestation in the rat.
		Ceruloplasmin is found in milk and amniotic fluid and may have a nutritional role.
	ajpendo.physiology.org /cgi/content/full/283/4/E667 (5657 words)

	Ceruloplasmin impairs endothelium-dependent relaxation of rabbit aorta -- Cappelli-Bigazzi et al. 273 (6): 2843 -- AJP ...
		ceruloplasmin gene have an impaired iron metabolism (11).
		It is known that ceruloplasmin can bind NO when exposed to high tensions of the authentic gas (10, 27).
		Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium.
	ajpheart.physiology.org /cgi/content/full/273/6/H2843 (4067 words)

	Wilson's Disease
		The serum ceruloplasmin concentration is routinely available in all clinical laboratories and has a normal range of 20 to 50 mg/dL.
		The ceruloplasmin and therefore the ceruloplasmin copper are typically low in WD and may explain an overall reduction in total serum copper.
		To calculate the free copper, the ceruloplasmin in mg/dL is multiplied by 3 and this number is then subtracted from the total serum copper in µg/dL.
	www.clevelandclinicmeded.com /diseasemanagement/gastro/wilsons/wilsons.htm (2962 words)

	A case of aceruloplasminaemia: abnormal serum ceruloplasmin protein without ferroxidase activity -- Takeuchi et al. 72 ...
		Ceruloplasmin is a multicopper oxidase that catalyzes the oxidation
		A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis.
		Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family.
	jnnp.bmjjournals.com /cgi/content/full/72/4/543 (1485 words)

	Delayed Translational Silencing of Ceruloplasmin Transcript in Gamma Interferon-Activated U937 Monocytic Cells: Role of ...
		Ceruloplasmin (Cp) is an acute-phase protein with ferroxidase, amine oxidase, and pro- and antioxidant activities.
		Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
		Induction of ceruloplasmin gene expression in rat lung during inflammation and hyperoxia.
	mcb.asm.org /cgi/content/full/19/10/6898 (6013 words)

	Dietary Iron Status Has Little Effect on Expression of Ceruloplasmin but Alters That of Ferritin in Rats -- Tran et al. ... (Site not responding. Last check: 2007-10-21)
		Expression of ceruloplasmin mRNA in livers of iron-deficient (D) and iron-supplemented (normal) rats (N).
		The ceruloplasmin mRNA detected migrated in the position of 28 S rRNA, and G3PDH considerably faster than the 18 S rRNA in agarose gel electrophoresis.
		The ceruloplasmin band migrated in the position of 28 S rRNA in agarose gel electrophoresis.
	www.nutrition.org /cgi/content/full/132/3/351 (4048 words)

	Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury -- Patel et al. 22 (15): 6578 -- ...
		Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form.
		Ceruloplasmin is expressed by astrocytes in the brain, cerebellum, and retina and by the epithelial cells of the choroid plexus
		Richardson DR (1999) Role of ceruloplasmin and ascorbate in cellular iron release.
	www.jneurosci.org /cgi/content/full/22/15/6578 (6177 words)

	Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations -- Bosio et al. 100 (6): 2246 ...
		Aceruloplasminemia is a recessive disorder characterized by anemia, iron overload, and neurodegeneration, caused by the absence
		The disease is caused by the absence of ceruloplasmin (Cp), a
		Yonekawa M, Okabe T, Asamoto Y, Ohta M. A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation: administration of fresh-frozen human plasma.
	www.bloodjournal.org /cgi/content/full/100/6/2246 (1874 words)

	Glycosyl Phosphatidylinositol-Anchored Ceruloplasmin Is Expressed by Rat Sertoli Cells and Is Concentrated in ...
		Glycosyl Phosphatidylinositol-Anchored Ceruloplasmin Is Expressed by Rat Sertoli Cells and Is Concentrated in Detergent-Insoluble Membrane Fractions -- Fortna et al.
		Glycosyl Phosphatidylinositol-Anchored Ceruloplasmin Is Expressed by Rat Sertoli Cells and Is Concentrated in Detergent-Insoluble Membrane Fractions
		The copper-binding protein, ceruloplasmin, is both a serum component
	www.biolreprod.org /cgi/content/abstract/61/4/1042 (391 words)

	Dr. Koop - Ceruloplasmin
		This test measures the amount of ceruloplasmin (a copper-containing protein) in blood serum.
		Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand.
		Ceruloplasmin is the major copper-containing protein in plasma.
	www.drkoop.com /ency/93/003662.html (466 words)

	The multifunctional oxidase activity of ceruloplasmin as revealed by anion binding studies -- Musci et al. 265 (2): 589 ... (Site not responding. Last check: 2007-10-21)
		The multifunctional oxidase activity of ceruloplasmin as revealed by anion binding studies -- Musci et al.
		Frieden, E. (1979) Ceruloplasmin: the serum copper transport protein with oxidase activity.
		Percival, S.S. and Harris, E.D. (1990) Copper transport from ceruloplasmin: characterization of the cellular uptake mechanism.
	content.febsjournal.org /cgi/content/full/265/2/589 (5664 words)

	Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease -- Hochstrasser et al. 63 ...
		Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease -- Hochstrasser et al.
		Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
		ceruloplasmin (Cp), which is vitally involved in iron transport
	www.neurology.org /cgi/content/abstract/63/10/1912 (376 words)

	Cerebellar ataxia associated with heteroallelic ceruloplasmin gene mutation -- Miyajima et al. 57 (12): 2205 -- ...
		Cerebellar ataxia associated with heteroallelic ceruloplasmin gene mutation -- Miyajima et al.
		Cerebellar ataxia associated with heteroallelic ceruloplasmin gene mutation
		Being heterozygous for mutation of the ceruloplasmin gene may
	www.neurology.org /cgi/content/abstract/57/12/2205 (397 words)

	High levels of ceruloplasmin in the serum of transgenic mice developing hepatocellular carcinoma -- Pousset et al. 268 ... (Site not responding. Last check: 2007-10-21)
		High levels of ceruloplasmin in the serum of transgenic mice developing hepatocellular carcinoma -- Pousset et al.
		Mukhopadhyay, C.K., Mazumder, B. and Fox, P.L. (2000) Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency.
		Senra Varela, A., Lopez Saez, J.J. and Quintela Senra, D. (1997) Serum ceruloplasmin as a diagnostic marker of cancer.
	content.febsjournal.org /cgi/content/full/268/5/1491 (5603 words)

	Selective Activation of Ceruloplasmin Promoter in Ovarian Tumors: Potential Use for Gene Therapy -- Lee et al. 64 (5): ...
		Selective Activation of Ceruloplasmin Promoter in Ovarian Tumors: Potential Use for Gene Therapy -- Lee et al.
		promoter to be critical for optimal ceruloplasmin promoter activity.
		P = 0.007) between expression levels of c-jun and ceruloplasmin.
	cancerres.aacrjournals.org /cgi/content/abstract/64/5/1788 (279 words)

	Ceruloplasmin antibody (ab8749) datasheet (Site not responding. Last check: 2007-10-21)
		This antibody reacts with human ceruloplasmin, a 140 kD a globulin of blood plasma.
		If Ceruloplasmin antibody (ab8749) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Caeruloplasmin is a copper-binding plasma glycoprotein consisting of a single polypeptide chain.
	www.abcam.com /?datasheet=8749 (383 words)

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