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Topic: Cervical intraepithelial neoplasia

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	Management of Histologic Abnormalities of the Cervix - January 1, 2006 -- American Family Physician
		The options for management of cervical intraepithelial neoplasia 1, 2, and 3 are ranked according to the strength of the recommendation and the quality of the evidence.
		Biopsy-confirmed cervical intraepithelial neoplasia 2 and 3 requires treatment except during pregnancy and in compliant adolescents with cervical intraepithelial neoplasia 2 and negative endocervical curettage.
		The preferred management for CIN identified at the margin of a diagnostic excisional procedure or in postprocedure endocervical sampling is colposcopy and endocervical sampling at the four- to six-month follow-up evaluation.
	www.aafp.org /afp/20060101/105.html (3988 words)

	Cervical Dysplasia - Abstracts : Online Reference For Health Concerns (Site not responding. Last check: 2007-10-11)
		Cases of cervical intraepithelial neoplasia are excellent for studying the effectiveness of retinoids as chemopreventive agents because the process can be closely followed by serial colposcopic and pathologic (cytology or biopsy) means and changes in the condition safely monitored.
		Cervical HPV infection (especially with the high-risk types) was the out-standing risk factor for all grades of neoplasia, the association being strongest for HSIL.
		In addition, it suggests consistency between the epidemiology of intraepithelial and invasive cervical neoplasia for risk factors that are likely to act on one of the first stages of the process of carcinogenesis (i.e., indications of sexual habits) but differences for hormone-mediated factors (i.e., reproductive variables or oral contraceptives).
	www.lef.org /protocols/abstracts/abstr-120.html (12950 words)

	Cervical Cancer - OncologyChannel
		Cervical cancer develops in the lining of the cervix, the lower part of the uterus (womb) that enters the vagina (birth canal).
		CIN may progress to squamous intraepithelial lesion (SIL; condition that precedes cervical cancer) or to carcinoma in situ (cancer that does not extend beyond the epithelial membrane).
		Cervical cancer that has spread (metastasized) to other organs may cause constipation, blood in the urine (hematuria), abnormal opening in the cervix (fistula), and ureteral obstruction (blockage in the tube that carries urine from the kidney to the bladder).
	www.oncologychannel.com /cervicalcancer (605 words)

	ASM 15(4): Intraepithelial Neoplasia
		Occurrence of cervical intraepithelial neoplasia (CIN) was studied in 10,659 females attending obstetric and gynecology clinics in Jordan.
		The frequency rate of intraepithelial neoplasia was 1.1% in 7743 Jordanian females and 2916 non-Jordanian residents of younger age during the period from 1982 to 1991 inclusive.
		Further study is desired to demonstrate the etiology of cervical intraepithelial neoplasia and the role of HPV in this population.
	www.kfshrc.edu.sa /annals/154/94261/94261.html (2649 words)

	Cervical Dysplasia - References: Online References For Health Concerns
		Evaluation of the risk of cervical intraepithelial neoplasia and human papillomavirus infection in renal transplant patients receiving immunosuppressive therapy.
		Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer.
		Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer.
	www.lef.org /protocols/female_reproductive/cervical_dysplasia_refs.htm (1506 words)

	CERVICAL INTRAEPITHELIAL NEOPLASIA - [Alternative Medicine] (Site not responding. Last check: 2007-10-11)
		Cervical intraepithelial (in-truh-ep-e-theel-e-ul) neoplasia (nee-o-play-zhuh) is also called "CIN." Sometimes it may be called cervical dysplasia (diss-play-zhuh).
		CIN means that there is a change in the cells on the surface of the cervix.
		With CIN, normal cells are replaced with cells that are not normal (abnormal).
	www.luhs.org /health/kbase/htm/mdx-/amm0/103/mdx-amm0103.htm (1194 words)

	eMedicine - Conization of Cervix : Article by Istvan Nyirjesy, MD
		It is used for the definitive diagnosis of squamous or glandular intraepithelial lesions, for excluding microinvasive carcinomas, and for conservative treatment of cervical intraepithelial neoplasia (CIN).
		If the results of these tests are negative for CIN or glandular atypia and if the patient wishes to preserve her childbearing potential, the author preserves the cranial extremity of the endocervical canal.
		In cases of histologically diagnosed cervical intraepithelial neoplasia grades 2 and 3, prebiopsy cytology results were reported as high-grade squamous intraepithelial lesions, low-grade squamous intraepithelial lesions, and atypical squamous cells of undetermined significance in nearly equal proportions (data from 6 independent studies).
	www.emedicine.com /med/topic3338.htm (6003 words)

	OBGYN.net The Female Patient: Electrosurgery for Cervical Intraepithelial Neoplasia
		Women with cervical intraepithelial neoplasia now have a number of treatment options including cold-knife conization, laser ablation, and loop electrosurgery but, all too often, the physician s preference is the determining factor in selection of therapy.
		The management of cervical microinvasive carcinoma during pregnancy is frequently associated with significant morbidity, and the tissue changes of pregnancy interfere with diagnostic sampling.
		Cervical intraepithelial neoplasia extending to the margins of resection in conization of the cervix.
	www.obgyn.net /femalepatient/default.asp?page=epperson_tfp (4998 words)

	SF AIDS Fdn: BETA 6/96 -- Cervical Intraepithelial Neoplasia
		Squamous intraepithelial lesions (SIL) is another term that is used with regard to CIN, and describes the type of cervical cells that undergo changes in 80% of cervical neoplasia.
		CIN III, severe dysplasia and carcinoma in situ are all different names for the same thing--early cervical cancer.
		Cervical intraepithelial neoplasia (CIN) is a condition characterized by new growth (neoplasia) in the normal tissue (epithelium) of the cervix, the lowest portion of the uterus leading into the vagina (see diagram on page 33).
	www.sfaf.org /treatment/beta/b29/b29cin.html (3011 words)

	MoonDragon's Obgyn Information - Cervical Dysplasia (Cervical Intraepithelial Neoplasia [CIN]; Squamous Intraepithelial ...
		Cervical cancer, a major complication of cervical dysplasia, is the leading cause of death in many developing and poorer countries and accounts for 4,800 deaths in the United States every year.
		Cervical cancer constitutes more than 10% of cancers worldwide and it is the second leading cause of death in women between the ages of 15 and 34.
		Cervical dysplasia can be caused, or at least promoted, by the same virus responsible for genital warts (human papillomavirus) and possibly by those viruses that cause herpes (herpes simplex types 1 and 2), although not all women with warts or herpes necessarily develop dysplasia.
	www.moondragon.org /obgyn/disorders/cervicaldysplasia.html (4722 words)

	Cervical Cancer Risk May Linger
		Cervical cancer is one of the leading causes of cancer deaths among women.
		But the risk of being diagnosed with cervical cancer or dying from it is dramatically lower in countries that have cervical cancer screening programs in place.
		When potentially precancerous cells are found in the cervix through cervical cancer screening, a condition known as cervical intraepithelial neoplasia (CIN), removal of the cells is recommended to reduce the risk of the cells turning into cancer.
	www.webmd.com /content/article/115/111775 (373 words)

	Cervical Cancer
		CIN I lesions often regress and simply require careful follow-up to make certain that the Pap smear and colposcopic exam return to normal.
		Therefore, finding CIN II or III is an indication for the removal of the entire extent of the suspicious area, often by an outpatient technique called loop electrosurgical excision procedure (LEEP).
		If extensive areas of CIN II or III can not be entirely discerned by a colposcopy or if they extend into the mucous membrane in the cervical canal, a more aggressive procedure called conization (cone biopsy) may be performed instead.
	www.icaa.cc /WCI/articles/000046_8.htm (1022 words)

	UpToDate Cervical intraepithelial neoplasia: Etiology, diagnosis, and natural history
		Cervical intraepithelial neoplasia (CIN) refers to a preinvasive pathological intermediate of cervical cancer that is slow to progress and can be easily detected and treated.
		CIN I refers to cellular dysplasia confined to the basal third of the epithelium (formerly mild dysplasia).
		CIN II refers to lesions confined to the basal two-thirds of the epithelium (formerly moderate dysplasia).
	patients.uptodate.com /topic.asp?file=gen_gyne/11845 (629 words)

	MedlinePlus Medical Encyclopedia: Cervical dysplasia
		Cervical dysplasia is the abnormal growth of cells on the surface of the cervix. Although this is not cancer, this is considered a pre-cancerous condition.
		CIN III -- severe dysplasia to carcinoma-in-situ (cancer confined to the surface layer of the cervix)
		Colposcopy-directed biopsy to confirm dysplasia and the extent of cervical involvement.
	www.nlm.nih.gov /medlineplus/ency/article/001491.htm (623 words)

	UpToDate Cervical intraepithelial neoplasia: Management
		• Congenital cervical anomalies and benign cervical lesions
		The initial evaluation of women with abnormal cervical cytology and the etiology, natural history, and nomenclature relating to cervical intraepithelial neoplasia are discussed separately.
		Cervical smears are performed to predict, on the basis of cytologic analysis of cells, what histology will be present on examination of tissue.
	patients.uptodate.com /topic.asp?file=gen_gyne/13946 (545 words)

	Association of Reproductive Health Professionals
		Cervical carcinoma and its high-grade precursor lesion, CIN 3, are most commonly found at the junction between the squamous and glandular cells, which is called the squamocolumnar junction (SCJ).
		CIN 1 and 2 correspond to mild and moderate dysplasia, respectively; CIN 3 is analogous to severe dysplasia or carcinoma-in-situ.
		A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection.
	www.arhp.org /healthcareproviders/cme/onlinecme/hpvcp/infection.cfm (2905 words)

	Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN ...
		After all vulvar and cervical biopsy diagnoses were confirmed by a pathologist (C.Z.A.), the 10 Papanicolaou tests from the VIN III cases and 10 Papanicolaou tests from biopsy-proven cases of CIN I were reviewed blindly by the same pathologist (C.Z.A.).
		Using standard criteria; the diagnosis of a low-grade squamous intraepithelial lesion (LGSIL) consistent with CIN I was confirmed on the Papanicolaou tests in all 20 cases (Figure 2, a and b).
		Five cases of biopsy-proven CIN I and 3 cases of biopsy-proven VIN III demonstrated prominent orangeophilia of the cytoplasm of the dysplastic cells.
	www.findarticles.com /p/articles/mi_qa3725/is_200301/ai_n9204687 (782 words)

	Healthopedia.com - Cervical Dysplasia (Cervical Intraepithelial Neoplasia (CIN), Precancerous Changes of the Cervix)
		Cervical dysplasia is a condition in which a woman has abnormal changes in the top layer of cells of her cervix.
		The earliest microscopic change is mild dysplasia or cervical intraepithelial neoplasia, also referred to as CIN 1.
		Cervical dysplasia is a precursor to cancer of the cervix, which is the second most common cancer of the female reproductive system.
	www.healthopedia.com /cervical-dysplasia (596 words)

	Cervical intraepithelial neoplasia - Wikipedia, the free encyclopedia
		Cervical intraepithelial neoplasia, or CIN, is the abnormal growth of precancerous cells in the cervix.
		Most cases of CIN stay the same or are eliminated by the host's immune system without intervention, but a small percentage of cases progress to become cervical cancer, usually cervical squamous cell carcinoma, or SCC (Agorastos et al., 2005).
		The major cause of CIN is infection with the sexually transmitted human papillomavirus (HPV), usually the high-risk HPV type 16.
	en.wikipedia.org /wiki/Cervical_intraepithelial_neoplasia (407 words)

	Histopathologic Extent of Cervical Intraepithelial Neoplasia 3 Lesions in the Atypical Squamous Cells of Undetermined ...
		Histopathologic Extent of Cervical Intraepithelial Neoplasia 3 Lesions in the Atypical Squamous Cells of Undetermined Significance Low-grade Squamous Intraepithelial Lesion Triage Study: Implications for Subject Safety and Lead-time Bias -- Sherman et al.
		Histopathologic Extent of Cervical Intraepithelial Neoplasia 3 Lesions in the Atypical Squamous Cells of Undetermined Significance Low-grade Squamous Intraepithelial Lesion Triage Study
		Cervical intraepithelial neoplasia 3 (CIN3) is the precursor
	cebp.aacrjournals.org /cgi/content/full/12/4/372 (5794 words)

	AllRefer Health - Cervical Dysplasia (Cervical Intraepithelial Neoplasia (CIN), Precancerous Changes of the Cervix)
		Cervical dysplasia is the abnormal growth of the epithelial tissue on the surface of the cervix.
		It refers to a spectrum or continuum of changes specified as: CIN I -- mild dysplasia; CIN II -- moderate to marked dysplasia; and CIN III -- severe dysplasia to carcinoma-in-situ (cancer localized to the intraepithelial tissue/superficial layer of the cervix).
		It may occur in women aged 15 and older, with the peak incidence in women aged 25 to 35.
	health.allrefer.com /health/cervical-dysplasia-info.html (399 words)

	Dictionary of Cancer Terms - National Cancer Institute
		Cervical lymph nodes are located in the neck.
		Cervical cancer refers to cancer of the uterine cervix, which is the lower, narrow end (the âneckâ) of the uterus.
		A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception.
	www.cancer.gov /dictionary/db_alpha.aspx?expand=c (6206 words)

	AllRefer Health - Cervical Neoplasia - Cervical Dysplasia Pictures & Images (Cervical Intraepithelial Neoplasia ...
		AllRefer Health - Cervical Neoplasia - Cervical Dysplasia Pictures and Images (Cervical Intraepithelial Neoplasia (CIN), Precancerous Changes of the Cervix)
		Cervical intraepithelial neoplasia (CIN) is the presence of abnormal cells on the surface of the cervix.
		A Pap smear and colposcopy are two of the procedures performed to monitor the cells and appearance of the cervix.
	health.allrefer.com /health/cervical-dysplasia-cervical-neoplasia.html (294 words)

	CIN, VIN, and VAIN - cervical intraepithelial neoplasia
		It is categorized into CIN 1, 2, or 3, depending on the severity of the abnormality and the thickness of the abnormal cell layer.
		VIN stands for vulvar intraepithelial neoplasia, and VAIN stands for vaginal intraepithelial neoplasia.
		dysplasia, SIL (squamous intraepithelial lesio), Bowens disease is the older term for VIN
	www.baymoon.com /~gyncancer/library/glossary/bldefcin.htm (103 words)

	Surgery for cervical intraepithelial neoplasia
		Cervical pre-cancer (cervical intraepithelial neoplasia) can be treated in different ways depending on the severity of the disease.
		Cervical intra-epithelial neoplasia is treated by local ablation or lower morbidity excision techniques.
		The objective of this review was to assess the effects of alternative surgical treatments for cervical intra-epithelial neoplasia.
	www.cochrane.org /reviews/en/ab001318.html (370 words)

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