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Topic: Cesar Milstein


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  César Milstein 1927-2002   (Site not responding. Last check: 2007-10-20)
The major part of Milstein's research career was devoted to studying the structure of antibodies and the mechanism by which antibody diversity is generated.
Milstein was born in Argentina where he started his research career at the University of Buenos Aires in enzymology, working with Prof A Stoppani on aldehyde dehydrogenase.
Milstein's early work on antibodies focussed on the nature of their diversity at the amino acid level as well as on the disulphide bonds by which they were held together.
www2.mrc-lmb.cam.ac.uk /Cesar_Milstein.html   (519 words)

  
 César Milstein - Wikipedia, the free encyclopedia
César Milstein (October 8, 1927 – March 24, 2002), an Argentine scientist, was born in Bahia Blanca, Argentina.
He was elected a Fellow of the Royal Society in 1975, won the Copley Medal in 1989, and became a Companion of Honour in 1995.
César Milstein died in March 2002 at age 74 in Cambridge, United Kingdom.
en.wikipedia.org /wiki/C%C3%A9sar_Milstein   (258 words)

  
 César Milstein (1927 - )   (Site not responding. Last check: 2007-10-20)
Born in Bahía Blanca, Argentina, César Milstein graduated from Buenos Aires University with an undergraduate degree in chemistry in 1945.
Milstein conducted groundbreaking work into the synthesis of antibodies, proteins that are produced by the cells of the immune system in response to attacks by foreign bodies called antigens.
For his efforts, Milstein was awarded the Nobel Prize for Physiology or Medicine with Georges Kohler and Niels Jerne in 1984.
www.accessexcellence.org /AB/BC/Cesar_Milstein.html   (258 words)

  
 Milstein, César   (Site not responding. Last check: 2007-10-20)
Milstein and his colleagues had thus devised a means of accessing the immune system for purposes of research, diagnosis, and treatment.
Milstein was born in Bahia Blanca and studied at Buenos Aires.
Milstein and his colleagues were among the first to determine the complete sequence of the short, low-molecular-weight part of the immunoglobulin molecule (known as the light chain).
cartage.org.lb /en/themes/biographies/mainbiographies/M/Milstein/1.html   (169 words)

  
 César Milstein, 1927-2002   (Site not responding. Last check: 2007-10-20)
Milstein was born in 1927 in Bahia Blanca, Argentina, the middle of three sons.
It gave Milstein great pleasure to see this political recognition of his work, but the event also showed that the authoritative history of this important lesson in technology transfer still needs to be written.
Milstein was lucky to live so close to Papworth Hospital, a leading centre of cardiac surgery, and his surgeon fondly boasted that his contribution to science was in keeping Milstein alive.
www.admin.cam.ac.uk /news/dp/2002032701   (1637 words)

  
 The Lasker Foundation | Former Award Winners, Basic Medical Research 1984, Obituary   (Site not responding. Last check: 2007-10-20)
In 1975, Dr. Milstein and Dr. Georges Köhler, a postdoctoral fellow of his at Cambridge, invented a method of forcing immune system cells to produce one particular type of antibody.
Milstein and Dr. Köhler's research on pure antibodies, known as monoclonal antibodies, provided an important cornerstone in molecular biology research.
Born in Bahía Blanca, Argentina, César Milstein was educated at the University of Buenos Aires and received his Ph.D. from Cambridge in 1960.
www.laskerfoundation.org /awards/obits/milsteinobit.shtml   (530 words)

  
 AllRefer.com - CEsar Milstein (Medicine, Biography) - Encyclopedia   (Site not responding. Last check: 2007-10-20)
CEsar Milstein 1927–2002, Anglo-Argentine immunologist, Ph.D. Cambridge Univ., 1960.
Their method for monoclonal antibody production has since been adopted universally, and such antibodies are used in laboratory research, in medical diagnostics, and in medical treatments to neutralize bacterial toxins.
In 1984, Milstein (with KOhler and Niels K. Jerne) shared the Nobel Prize in Physiology or Medicine.
reference.allrefer.com /encyclopedia/M/MilsteinC.html   (238 words)

  
 Cesar Milstein   (Site not responding. Last check: 2007-10-20)
Born in Bahia Bianca, Argentina, Milstein is an immunologist.
They are called "monoclonal antibodies," and Milstein's pioneering discovery of how to form them made him co-winner of a 1984 Nobel Prize for Physiology or Medicine.
Dividing his time between South America and Great Britain, Milstein today holds that country'' prestigious Companion of Honour award.
www.jewishvirtuallibrary.org /jsource/biography/Milstein.html   (131 words)

  
 Personality of the Week - Milstein
From 1961-63 he was at the National Institute of Microbiology in Buenos Aires and then moved to Cambridge University to head its protein and nucleic chemistry division.
In 1984 Milstein was awarded a Nobel Prize in Medicine for his work into the body's immunological system and his role in developing a revolutionary method for producing antibodies.
Cesar Milstein Winner of the 1984 Nobel Prize in Medicine
www.bh.org.il /NAMES/POW/Milstein.asp   (89 words)

  
 BBC News | SCI/TECH | Scientists salute 25-year-old discovery   (Site not responding. Last check: 2007-10-20)
It is 25 years ago this summer that Cambridge researchers Drs Cesar Milstein and George Kohler found a way to make any required antibody in pure form, in the test tube.
But they found a way to stimulate cells to produce any required antibody, and then to make those cells into "immortal" cell cultures, that could be grown to any required size that would go on producing just the one wanted antibody for as long as it was required.
Dr Milstein thinks the next big breakthrough may come in the development of antibodies able to penetrate the surfaces of cancer cells and target the abnormal proteins inside.
news.bbc.co.uk /hi/english/sci/tech/newsid_833000/833042.stm   (711 words)

  
 BBC News | SCI/TECH | British science mourns research great   (Site not responding. Last check: 2007-10-20)
Dr Cesar Milstein, one of the great post-war figures in British science, has died.
Dr Milstein died at Addenbrooke's Hospital in Cambridge on Sunday.
Drs Milstein and Kohler announced their breakthrough in 1975 in the journal Nature.
news.bbc.co.uk /hi/english/sci/tech/newsid_1893000/1893932.stm   (489 words)

  
 [No title]   (Site not responding. Last check: 2007-10-20)
Nobel scientist Dr César Milstein, who died on 24 March 2002, will be remembered as one of the greatest molecular biologists of the last century.
Dr César Milstein was born in Bahia Blanca, Argentina, in 1927.
César Milstein is pictured here on the right after receiving the MRC Millennium Medal in 2000.
www.mrc.ac.uk /public-cesar_milstein.htm   (381 words)

  
 Köhler, Georges Jean Franz on Encyclopedia.com   (Site not responding. Last check: 2007-10-20)
He worked (1974-76) with César Milstein at the Laboratory of Molecular Biology in Cambridge, England.
Their technique for antibody production has since been universally adopted, and the antibodies are used in diagnostics and in fighting leukemia.
In 1984 he became a director of the Max Planck Institute of Immune Biology in Freiburg and, with Milstein and Niels K. Jerne, shared the Nobel Prize in Physiology or Medicine.
www.encyclopedia.com /html/K/Kohler-G1.asp   (130 words)

  
 Cesar Milstein --  Britannica Student Encyclopedia
More results on "Cesar Milstein" when you join.
March 1, 1995, Freiburg im Breisgau, Germany), shared the 1984 Nobel Prize for Physiology or Medicine for his contribution to the discovery (1975) of a method of producing unlimited amounts of extremely pure proteins known as monoclonal antibodies, each of which could be directed against a specific antigen.
Jerne, Niels K. Danish immunologist who shared the 1984 Nobel Prize for Physiology or Medicine with César Milstein and Georges Köhler for his theoretical contributions to the understanding of the immune system.
www.britannica.com /ebi/article-9330142?tocId=9330142   (568 words)

  
 25 Years Of Monoclonal Antibodies
The fusion experiment was carried out and the cell line cloned in late 1974, Kohler and Milstein submitted their paper to Nature in May 1975 and it was accepted for publication in June 1975, finally appearing in print in August 1975.
Sp1 is still going strong, we obtained a clone of this line from César, last year, for a student project we were running in the Department of Pathology.
When Köhler and Milstein, working at the MRC Laboratory of Molecular Biology, first discovered a method for making monoclonal antibodies, they did not for various reasons patent their discovery.
www.path.cam.ac.uk /~mrc7/mab25yrs   (527 words)

  
 wikien.info: Main_Page   (Site not responding. Last check: 2007-10-20)
Encyclopedia : C : CE : CES : Cesar Milstein
During this work he collaborated with Fred Sanger whose group he joined with a short-term Medical Research Council appointment.
He was elected a Fellow of the Royal Society in 1975 and became a Companion of Honour in 1995.
www.alanaditescili.net /index.php?title=Cesar_Milstein   (195 words)

  
 Both DNA strands of antibody genes are hypermutation targets -- Milstein et al. 95 (15): 8791 -- Proceedings of the ...
Both DNA strands of antibody genes are hypermutation targets -- Milstein et al.
Articles by Milstein, C. Articles by Staden, R. Vol.
Milstein, C. & Rada, C. The Maturation of the Antibody Response (Academic, London)
www.pnas.org /cgi/content/full/95/15/8791   (2714 words)

  
 Agence France Presse English: Nobel medicine prize winner Cesar Milstein dead at 74@ HighBeam Research   (Site not responding. Last check: 2007-10-20)
Nobel medicine prize winner Cesar Milstein dead at 74
Renowned molecular biologist Cesar Milstein, who won the 1984 Nobel Prize for Medicine, has died aged 74, Britain's Cambridge University, where he did much of his research, announced.
Milstein, who was born in Argentina but later acquired British citizenship, died Sunday as the result of a heart condition.
www.highbeam.com /library/doc0.asp?docid=1P1:51638352&refid=ink_tptd_np   (205 words)

  
 Milstein, Cesar --  Encyclopædia Britannica
March 24, 2002, Cambridge, Eng.), was awarded the Nobel Prize for Physiology or Medicine in 1984 for his work in the development of a technique for producing monoclonal antibodies; Milstein shared the prize with Georges Köhler and Niels K. Jerne.
"Milstein, César." Britannica Book of the Year, 2003 from Encyclopædia Britannica Premium Service.
Köhler, Georges J.F. German immunologist who in 1984, with César Milstein and Niels K. Jerne, received the Nobel Prize for Physiology or Medicine for his work in developing a technique for producing monoclonal antibodies—pure, uniform, and highly sensitive protein molecules used in diagnosing and combating a number of diseases (see).
www.britannica.com /eb/article-9389368?tocId=9389368   (637 words)

  
 AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization -- Rada et al. 99 ...
Articles by Rada, C. Articles by Milstein, C. Articles citing this Article
Betz, A., Rada, C., Pannell, R., Milstein, C. & Neuberger, M. Proc.
Milstein, C., Neuberger, M. & Staden, R. Proc.
www.pnas.org /cgi/content/full/99/10/7003   (3540 words)

  
 César Milstein (1927-), Molecular biologist   (Site not responding. Last check: 2007-10-20)
Born in Argentina, Milstein has worked in Cambridge on the Scientific Staff of the Medical Research Council since 1963.
His research has concentrated on the genetics, biosynthesis and chemistry of antibodies.
National Portrait Gallery, St Martin's Place, London WC2H OHE.
www.npg.org.uk /live/search/person.asp?LinkID=mp06521   (124 words)

  
 University of Cambridge News and Events Service
Obituary for Nobel Laureate Cesar Milstein, Fellow of Darwin College, Cambridge and Deputy Director of the Medical Research Council's Laboratory of Molecular Biology in Cambridge from 1988 until 1995.
Report on charity run by Cambridge student Jennifer Fitzpatrick.
Report on new survey revealing questions asked at Oxbridge admissions interviews.
www.admin.cam.ac.uk /news/daily/archive.cgi?1017014400   (838 words)

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