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Topic: Cetus Corporation

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	Cetus Corporation (Site not responding. Last check: 2007-10-19)
		Cetu.s has a Board o~Scientific Advisors, each one of which, we understandi, has a significant equity stake in Cetus and for most of them Cetus represents their exclu.sive industrial involvement.
		Professor Stanley N. Cohen os Stanford, who is described by Cetus as a renowned leader in the field he pioneered, recombinant DNA.
		Professor Stanley Falkow of the U.niv.ersity o~ Washington, who is described by Cetus as a recognized authority on the molecular biology of plasmids, infectious diseases, and the plasmid- mediated resistance to antibiotics.
	tobaccodocuments.org /pm/1000229854-9857.html (466 words)

	Cetus
		Because Cetus is so large, there are only a few months that the complete figure is visible in the sky.
		The brightest star in Cetus is called Deneb Kaitos, which is a combonation of Greek and Arabic that means "tail of the sea monster".
		Cetus does not lie near the Milky Way, which means that dimmer galaxies that can't normally be seen are clearly visible.
	www.windows.ucar.edu /tour/link=/the_universe/Constellations/cetus.html&edu=high (289 words)

	HYLE 4-2 (1998): Ethography of a Nobel Prize
		Cetus, in particular, was attractive because its "organizational structure was less hierarchical and more interdisciplinary" than other corporations and academia (p.
		Much of the second chapter, "Cetus Corporation: A Credible Force", is concerned with the company's financial situation and how their prospectus and annual reports represented their work and its prospects.
		Cetus was in a race with DuPont to produce ample quantities for lab use.
	www.hyle.org /journal/issues/4/bilsker.htm (1433 words)

	HOFFMANN-LA ROCHE v. Promega
		Cetus licensed the ’818 patent to Promega Corporation in June 1990.
		Kunkel stated that he was aware of Dr. Gelfand’s knowledge of template dependency and fidelity and that Dr. Gelfand could not possibly believe that the experiments indicated that the prior art enzyme was promiscuous and not suitable for template-directed synthesis.
		The district court found that the examiner "did not indicate in any way that she considered the greater purity of the Cetus enzyme to be a basis for patentability." Nonetheless, the statement of "single band purity" of the product of Example VI is raised by the panel majority as grounds of inequitable conduct.
	www.ll.georgetown.edu /federal/judicial/fed/opinions/00opinions/00-1372.html (12217 words)

	Board of Directors: Onyx Pharmaceuticals
		She is currently Corporate Vice President and Chief Financial Officer of Edwards Lifesciences Corporation, a leading cardiovascular technology company.
		Renton served as President of Cetus Corporation from August 1990 to December 1991 and as Chief Operating Officer of Cetus Corporation from 1987 to August 1990.
		Wiggans also serves on the boards of Connetics Corporation and Abgenix, Inc. In addition, he is a director of the Biotechnology Industry Organization (BIO), and serves as a member of its Executive Committee and its Emerging Company Section.
	www.onyx-pharm.com /wt/page/bod (936 words)

	What is PCR?
		In the 1980s, Kary Mullis at Cetus Corporation conceived of a way to start and stop a polymerase's action at specific points along a single strand of DNA.
		When other Cetus scientists eventually succeeded in making the polymerase chain reaction perform as desired in a reliable fashion, they had an immensely powerful technique for providing essentially unlimited quantities of the precise genetic material molecular biologists and others required for their work.
		Another scientist at Cetus, Stephen Scharf, is more perceptive when he says that the truly astonishing thing about PCR is precisely that it wasn't designed to solve a problem; once it existed, problems began to emerge to which it could be applied.
	sunsite.berkeley.edu /PCR/whatisPCR.html (1013 words)

	Geron - Press Releases
		Prior to joining Geron, Kaster held the position of director, intellectual property, at Affymax, where he established a patent system for the company and was responsible for the filing and prosecution of over 60 patents.
		From 1988 to 1991, he served Cetus Corporation as patent attorney and played a pivotal role in the company's ability to keep and enforce its rights to its polymerase chain reaction (PCR) technology.
		Geron Corporation, a privately-held company, has established a leadership position in the biology of cell senescence, which plays a causal role in aging.
	www.geron.com /pressview.asp?id=525&print=yes (413 words)

	THE HISTORY OF PCR [RU 9577] - Smithsonian Videohistory Collection
		He joined the Cetus Corporation in 1979 and was appointed senior scientist and director of Human Genetics in 1981.
		In 1988, he returned to Cetus as a research assistant where he worked on the application of PCR to the discovery of new retroviruses and he further refined PCR detection techniques.
		In 1978, he joined the Cetus Corporation as a scientist, and was promoted to director of Molecular and Biological Research and associate director of Research and Development in 1981.
	www.si.edu /archives/ihd/videocatalog/9577.htm (2916 words)

	What is PCR? (Site not responding. Last check: 2007-10-19)
		The work was originally commissioned in 1980 by Doctors Thomas J. White and Kary Mullis for their scientific laboratory at Cetus corporation in Emeryville, Ca.
		And ast he painting was conceived during a period of public concern about genetic engineering and cloning, it also seemed thematically natural to interweave a familiar allegory of social responsibility and live bait fishing into the visual narrative.
		The painting was later purchased by Cetus and moved to the entrance lobby.
	sloan.stanford.edu /pcr/Wehrlepict.html (232 words)

	Letter to the Shareholders (Site not responding. Last check: 2007-10-19)
		Thus, Cetus is now engaged in developing a wide range of biologically-based industrial, processes, each with potentially profound, economic im- pact.
		Cape w~s a founder of Cetus in 1971.
		Gelfand joined Cetus after brilliant accomplishments as a post-doctoral fellow at the University of California at San Diego and at San Francisco in the laboratory of Dr. Gordon M. Tomkins, where he and.
	tobaccodocuments.org /pm/1000229906-9913.html (2982 words)

	NTII - Neurobiological Technologies, Inc.
		He co-founded Cetus Corporation in 1971 and served as its chairman for 20 years and chief executive officer for 13 years until Cetus merged with Chiron Corporation in 1991.
		Cetus was a world leader and pioneer in genetic engineering, developing a technology that was ultimately awarded a Nobel Prize.
		Cape serves on the board of EntreMed, Inc. and also serves as a director for several privately held biotechnology companies, including Caprion, Inc. and Neugenesis Corp. He was a founding member of the Industrial Biotechnology Association (now the Biotechnology Industry Organization, or BIO), where he served as President from 1983 until 1985.
	www.shareholder.com /ntii/releasedetail.cfm?ReleaseID=148790 (637 words)

	DuPont v. Cetus (Site not responding. Last check: 2007-10-19)
		Plaintiff Du Pont brings this action seeking a declaration of invalidity of defendant Cetus Corporation's U.S. patents 4,683,202 ("'202 patent") and 4,683,195 ("'195 patent"), which encompass the process of polymerase chain reaction ("PCR") using an exponential process of replication.
		In its motion for summary judgment, plaintiff argued that a National Science Foundation grant proposal submitted by Dr. Gobind Khorana ("NSF Grant Proposal") anticipates the subject matter of the '202 patent and thus invalidates the patent under 35 U.S.C. 102(b).
		It therefore rules as a matter of law that the two documents are prior art within the meaning of 35 U.S.C. 102(b).
	www.ipo.uc.edu /file_html/Cetus.html (1262 words)

	Planet Biotechnology - Executive Officers and Directors (Site not responding. Last check: 2007-10-19)
		Prior to Cetus, he was a Senior Patent Attorney at Stauffer Chemical Company, with primary responsibility for agricultural biotechnology, and a patent Attorney in private practice.
		While at Cetus he pioneered the use of PCR for the construction of recombinant antibodies.
		Price was formerly Senior Vice President of Research and Development at Cetus Corporation, (later acquired by Chiron Corporation, Emeryville, CA), where he directed a staff of approximately 500 scientists, engineers, physicians and support personnel.
	www.planetbiotechnology.com /management.html (689 words)

	Biotech @ 25: Berkeley's Bioentrepreneurs
		They include Kary Mullis and Donald A. Glaser, two Nobel Laureates associated with Cetus Corporation, where a major biotechnology tool (PCR or the polymerase chain reaction) was invented.
		Cetus was later acquired by Chiron Corporation, co-founded by another Berkeleyan, Ed Penhoet.
		Kiley suggests that McKnight's participation is critical to recruiting Goeddel, whose record as an industrial scientist at Genentech, in turn, would help assure venture capitalists that Tularik was a worthwhile risk.
	bancroft.berkeley.edu /Exhibits/Biotech/entre.html (1125 words)

	Biotechnology Timeline 1977 - Present
		Cetus patented the process, and in the summer of 1991 sold the patent to Hoffman-La Roche, Inc. for $300 million.
		Cetus Corporation's develops GeneAmp polymerase chain reaction (PCR) technology, which could generate billions of copies of a targeted gene sequence in only hours.
		Researchers at the University of Texas reported that the enzyme telomerase appears to be responsible for the unchecked growth of cells seen in human cancers.
	www.accessexcellence.org /AB/BC/1977-Present.html (3276 words)

	Industry of Life: The Birth of the Gene Machine ANTHONY J. PARISI / New York Times 29jun80 (Site not responding. Last check: 2007-10-19)
		One of the promising DNA companies is the Genex Corporation, formed in 1977 by Dr. Glick, a molecular and cell biologist by training, with seed money from a venture capital company called InoVen.
		Although an assortment of major corporations had been entwined with the small cloning companies for some time through a web of equity interests, joint ventures and research contracts, most refrained from establishing their own programs, until recently.
		Cetus, which is 61 percent owned by the Standard Oil Company of California, the Standard Oil Company (Indiana) and the National Distillers and Chemical Corporation, operates out of 12 different buildings, has 250 employees and is worth about $300 million, according to Mr.
	www.mindfully.org /GE/Birth-Of-Gene-Machine.htm (1849 words)

	JAMES E. RURKA - MICROCIDE PHARMACEUTICALS - (MCDE): 01-01-08
		He was most recently President of the Cetus Oncology division of Chiron Corporation (a 95-person, $40 million sales revenue group), with US responsibility for clinical research, business development, project management and marketing/sales functions for the company’s cancer and infectious disease therapeutic products.
		The third corporate partnership is with the RW Johnson Pharmaceutical Research Institute, a division of J&J. That collaboration has been underway since October of 1995 and is in the field of cephalosporin antibiotics.
		Our corporate partnerships are worldwide corporate partnerships and for the foreseeable future, we’ll be relying on corporate partners to develop and commercialize our products in Europe and in Asia.
	www.twst.com /ceos/mcde.html (3564 words)

	Orchid - Press Releases
		Cetus developed interleukin-2 and beta-interferon and discovered, in its labs, the ubiquitous DNA technology now known as polymerase chain reaction (PCR).
		Dr. Cape was head of Cetus from its founding until it merged with Chiron in 1991.
		Ellipsis Biotherapeutics Corporation is a post-genomics company that is using its integrated technology platform in genomics, bioinformatics, proteomics and target validation for drug discovery.
	www.orchid.com /news/view_pr.asp?ID=218 (1371 words)

	About
		C.P. Liu is the founder of Pepgen Corporation.
		Prior to Pepgen, he was the President and CEO of General Biologicals Corporation in Taiwan, a biological reagent company based in Hsin Chu, Taiwan, specializing in manufacturing and marketing immunodiagnostic kits for the detection of human viral infections, cancer markers and various diseases.
		He was a co-founder of Cetus Immune, Immulogic and CellGate and has served on the SAB of multiple companies.
	www.pepgen.com /about.html (2113 words)

	Management Team: Onyx Pharmaceuticals
		He joined Cetus in 1981 and was Chief Financial Officer from 1983 to 1987.
		From 1997 to 2001, she served in roles of increasing responsibility at Coulter Pharmaceutical, which was acquired by Corixa Corporation in 2001.
		Wood was Senior Director of Investor Relations and Corporate Communications at Caliper Technologies Corp. She has served in a similar capacity at Sangamo BioSciences and Chiron Corporation.
	www.onyx-pharm.com /wt/page/management (1258 words)

	BayBio - Ronald E. Cape, Ph.D.
		He was the co-founder of Cetus Corporation, where he was chairman for 20 years and CEO for 13 years until the company merged with Chiron Corporation.
		Cetus was a world leader and pioneer in genetic engineering and was particularly well known for its development of genetically engineered interleukin-2 and beta-interferon and for the discovery and development of GeneAmp PCR, the polymerase chain reaction.
		He was the founding chairman of Darwin Molecular Corporation, which was later sold to Chiroscience plc, and is chairman and director of Caprion, Inc., Cellicon Biotechnologies, and several other biotechnology companies.
	www.baybio.org /wt/page/brd_cape (283 words)

	Untitled Document
		Cetus enters a joint venture agreement with Perkin-Elmer to develop PCR instrumentation.
		December 26 - The '818 patent for Taq polymerase is awarded to Cetus.
		Techical inaccuracies and mis-representations in the original Cetus patent applications (activity and putiry of the native Taq vs. the rTaq),
	www.iupui.edu /~marrs/Biol540/pcr.html (902 words)

	Nat' Academies Press, Intellectual Property Rights and Research Tools in Molecular Biology: Summary of a Workshop Held ...
		Cetus Corporation sold the PCR patent to Hoffman-LaRoche for $300 million in 1991.
		The fact that Roche had paid Cetus $300 million for the portfolio of PCR patents led some observers to think that Roche intended to recoup its investment through licensing revenues, a point that Daniell disputed.
		She pointed out that Roche's business is the sale of products and that licensing revenues are far less than what would be needed to recoup the $300 million over a time period that would be relevant from a business viewpoint.
	www.nap.edu /books/0309057485/html/44.html (744 words)

	Cetus Links: 16604 Links on Objects and Components / Object-Oriented Language & Development Environment: Visual ...
		Microsoft Corporation released Visual Foxpro in September 1995, shortly after the introduction of Windows 95.
		Finally, PL/SQL from Oracle Corporation for Oracle 7 and Oracle 8 is also an OO 4GL.
		It is not based on xBase, and is a server language rather than a Windows client, but does provide both native SQL as well as classes and objects.
	www.cetus-links.org /oo_visual_foxpro.html (773 words)

	ALZA Corporation Promotes Peter Staple and Bruce Cozadd to Senior Vice President
		PALO ALTO, Calif., Nov. 25 /PRNewswire/ -- ALZA Corporation (NYSE: AZA) today announced the promotion of Peter D. Staple to Senior Vice President and General Counsel, and the promotion of Bruce C. Cozadd to Senior Vice President and Chief Financial Officer, both effective January 1, 1997.
		Staple was Vice President and Associate General Counsel of Cetus Corporation prior to the merger of Cetus and Chiron.
		ALZA Corporation, headquartered in Palo Alto, Calif., is a leader in the development and commercialization of innovative pharmaceutical products using advanced drug delivery technologies to add medical and economic value to drug therapies.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/43516&EDATE= (349 words)

	Roche Diagnostics - Roche Molecular Diagnostics - Taq DNS Polymerase (Site not responding. Last check: 2007-10-19)
		PCR technology was invented by Dr. Kary Mullis at Cetus Corporation in 1983.
		However, Dr. Mullis and other scientists at Cetus foresaw the need of a thermostable DNA polymerase, one that could withstand the temperature extremes involved in the cycles of PCR, in order to automate the PCR process and to maximize its applications.
		Susanne Stoffel of Cetus Corporation purified such a thermostable DNA polymerase, referred to as native Taq, from the organism Thermus aquaticus.
	www.roche-diagnostics.com /ba_rmd/pcr_taq_dns_polymerase.html (219 words)

	The Net Net: ReadMe
		When Kary Mullis won the Nobel Prize for his idea of PCR, Cetus proved itself a worthy testing ground for the hypothesis that private industry was somehow unable to produce useful or interesting research.
		Rabinow interviews Cetus scientists about their decisions to go to Cetus rather than remain or seek jobs in the academy, and their responses make up some of the best reading in this book.
		There is a central irony in Making PCR: While the actual implementation of a useful form of PCR was accomplished by exactly the kind of collaborative science that is most highly valued by nearly all the voices represented in this book, the "story" of PCR has often been told in terms of lone genius.
	www.thenetnet.com /readme/pcr.html (581 words)

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