| |
| | THE 90 kDa MOLECULAR CHAPERONE FAMILY (Site not responding. Last check: 2007-09-19) |
 | | Chaperones play an essential role in the aetiology of numerous diseases, with a rapidly increasing role in clinical practice (Latchman, 1991; Welch, 1992; Burdon, 1993; Snyder and Sabatini, 1995; Jindal, 1996; van Eden and Young, 1996; Welch and Brown, 1996; Brooks, 1997). |
 | | The characteristic chaperone functions of the different families show that the 90 kDa molecular chaperones are somewhat different from the others, being the most "passive", since in most cases they only prevent the aggregation of unstable protein conformers, which is a rather general feature of almost all proteinaceous and chemical chaperones (Welch and Brown, 1996). |
 | | The ER chaperone complex is not as well characterized as the cytoplasmic foldosome, but if one takes into account the extremely high protein concentration of the ER lumen (estimated to be around 100 mg/ml), it is reasonable to assume that grp94 might be part of an even more complex supramolecular organization than hsp90. |
| www.chaperone.sote.hu /cikk2inf.htm (16422 words) |
|