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Topic: Chelating agents


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In the News (Wed 15 Feb 12)

  
  Chemical of the Week -- Chelates and Chelating Agents   (Site not responding. Last check: 2007-10-03)
A chelate is a chemical compound composed of a metal ion and a chelating agent.
Because the chelating agent is attached to the metal ion by several bonds, chelates tend to be more stable than complexes formed with monodentate ligands such as water.
Porphine is a chelating agent similar to ethylenediamine in that it forms bonds to a metal ion through nitrogen atoms.
scifun.chem.wisc.edu /chemweek/Chelates/Chelates.html   (889 words)

  
 Lead Poisoning -- Medications
Chelating agents are medications that bind with lead in blood and both soft and bony tissues and eliminate it quickly from the body, usually through the urine.
The decision to use chelating agents depends on how long the child has been exposed to lead, how high the blood lead level is, what the symptoms are, and whether the blood lead level remains high even after the source of lead is removed or reduced and nutrition is improved.
Chelating agents are chemicals that bind with lead for the treatment of lead poisoning.
www.webmd.com /hw/trauma_first_aid/aa37401.asp?printing=true   (442 words)

  
 Chelation Therapy | Chelation Therapy Practitioners
Chelation therapy options include IV chelation or oral chelation and involve the use of a chemical agent (EDTA) that is administered either intravenously or orally and binds to heavy metals in the blood.
Chelation therapy is a process involving the use of chelating agents such as EDTA to remove heavy metals from the body.
Chelation therapy is used as a treatment for acute mercury, arsenic, lead, plutonium and other forms of heavy metal poisoning, where the amounts are so high that there is enough risk to the health of the patient to justify the therapy.
www.getholistic.net /chelation_therapy.htm   (851 words)

  
 chelating agents - HighBeam Encyclopedia
A chelating agent that has two coordinating atoms is called bidentate; one that has three, tridentate; and so on.
Chlorophyll is a chelate that consists of a magnesium ion joined with a complex chelating agent; heme, part of the hemoglobin in blood, is an iron chelate.
Chelating agents are important in textile dyeing, water softening, and enzyme deactivation and as bacteriocides.
www.encyclopedia.com /doc/1E1-chelatin.html   (253 words)

  
 Chemical of the Week -- Chelating Agents   (Site not responding. Last check: 2007-10-03)
A chelating agent is a substance whose molecules can form several coordinate bonds to a single metal ion.
That is, a chelating agent is a polydentate ligand.
Chelating agents that coordinate through sulfur in the form of -SH (thiol or mercapto) groups are not as common in commercial applications, but they perform a significant role in complexing metal ions in biological systems.
scifun.chem.wisc.edu /chemweek/ChelatingAgents/ChelatingAgents.html   (633 words)

  
 Chelation - Wikipedia, the free encyclopedia
Chelation (from Greek χηλή, chelè, meaning claw) is the process of reversible binding (complexation) of a ligand - the chelant, chelator, chelating agent, sequestering agent, or complexing agent - to a metal ion, forming a metal complex, the chelate.
If a chelate were replaced by several monodentate ligands (such as water or ammonia), the total number of molecules would decrease, whereas if several monodentate ligands were replaced by a chelate, the number of free molecules increases.
Thus, metal chelates are relevant to the mobilization of metals in the soil, the uptake and the accumulation of metals into plants and micro-organisms.
en.wikipedia.org /wiki/Chelating_agent   (473 words)

  
 2001 Greener Synthetic Pathways Award | Presidential Green Chemistry Challenge | US EPA   (Site not responding. Last check: 2007-10-03)
Chelating agents are used in a variety of applications, including detergents, agricultural nutrients, and household and industrial cleaners.
Because of this poor biodegradability combined with high water solubility, traditionally used chelators are readily released into the environment and have been detected in the surface waters of rivers and lakes and in make-up water processed for drinking water.
This agent is characterized by excellent chelation capabilities, especially for iron(III), copper(II), and calcium, and is both readily biodegradable and benign from a toxicological and ecotoxicological standpoint.
www.epa.gov /greenchemistry/pubs/pgcc/winners/gspa01.html   (607 words)

  
 Properties of chelating agents
Chelating of the pulp can also be carried out using a mixture of a nitrogen-containing agent and one or more non-nitrogen containing chelator like lactic, citric, tartaric, gluconic or glucoheptonic acid [43, 44].
The percentages of residuals of the chelating agents were based on division of the analysed concentration by the theoretical concentration calculated by equation (3.1).
According to the mechanisms of equations (3.2) and (3.3), chelating agents are not directly degraded through the reaction with undissociated hydrogen peroxide, which partly explains the high percentages of EDTA residual observed in this work and suggests that the undissociated form is not responsible for the decomposition.
herkules.oulu.fi /isbn9514269756/html/c275.html   (1646 words)

  
 MoonDragon's Health & Wellness: Chelation Therapy
Chelating agents used in this therapy are available in over-the-counter formulas that can be taken orally at home, and in intravenous solutions that must be administered under the supervision of a health care provider.
Chelating agents are used to bind with heavy toxic metals such as cadmium, lead, and mercury - substances that enter the body through food, water, and other means - and excrete these metals from the body.
Chelation therapy is also used in the treatment of atherosclerosis and other circulatory disorders, as well as in the treatment of gangrene, which often is the result of poor circulation.
www.moondragon.org /health/therapy/chelationtherapy.html   (1330 words)

  
 CHEMTECH-Novel Polymers in microparticulate diagnotic agents
The objective is to accumulate a sufficient quantity of a contrast agent in the area of interest and to minimize its presence in normal tissues and organs.
Membranotropic chelates are suitable for micelle incorporation (they anchor to the lipophilic micelle core), and they also may be suitable for loading micelles with heavy radio metals (Figure 1).
The PAP synthesis - a single-terminus-activated chelating polymer preparation and the attachment of a lipophilic anchor to it - is described in Figure 4.
pubs.acs.org /hotartcl/chemtech/99/nov/novel.html   (3135 words)

  
 The Great Plains/Rocky Mountain HSRC - Chelating Extraction of Heavy Metals from Contaminated Soils
Chelating extraction of heavy metals from contaminate d soils is a relatively new treatment method.
Chelators that are identified, studied, and recommended as a result of this project could be used in on-site soil washing processes following excavation.
Results indicated that the complexation ability of the chelating agents are determined by factors including various molecular descriptors, numbers of hydroxyl, amino, carboxylic groups, as well as protons and heteroatoms.
www.engg.ksu.edu /HSRC/chelating.html   (532 words)

  
 Chelation therapy - Wikipedia, the free encyclopedia
Chelation therapy is a process involving the use of chelating agents to remove heavy metals from the body.
Chelating agents were introduced into medicine as a result of the use of poison gas in World War I.
Chelation therapy is used as a treatment for acute mercury, iron, arsenic, lead, plutonium and other forms of heavy metal poisoning, where the amounts are so high that there is enough risk to the health of the patient to justify the therapy.
en.wikipedia.org /wiki/Chelation_therapy   (2304 words)

  
 Methods of regenerating metalworking fluids with chelating agents - Patent 5445945
Chelating agents are typically non-toxic and user-friendly and even when used in amounts greater than required, generally have minimal detrimental effects on the operation of the MWF and the safety of the operator.
Based on this analysis, an operator would consult the manufacturer's data sheet for a particular chelating agent to determine the amount of chelating agent needed to be added for the effective sequestration of the free metal ions in solution.
The determination of the amount of chelating agent needed to be effective is thus a function of the particular chelating agent and the types and concentration of dissolved metals freely present in the MWF.
www.freepatentsonline.com /5445945.html   (5688 words)

  
 Polyvalent metal ion chelating agents for xanthan solutions - Patent 4466889
The solution wherein the chelating agent is employed in an amount of from about 1.0-1000 ppm of the total solution is preferred as is the solution wherein the xanthan biopolymer is in the form of a fermentation broth containing cells of an organism belonging to the genus Xanthomonas.
This is accomplished, when desired, by the addition of a chelating agent such as ethylenediaminetetraacetic acid or other suitable compound known to those skilled in the art at a concentration of about 1 to 20 millimolar, preferably 2 to 8 millimolar.
Chelating agents were introduced as organic acids or sodium salts thereof, to give a concentration equivalent to 1000 ppm of the organic acid.
www.freepatentsonline.com /4466889.html   (4387 words)

  
 Abstract of CEH report Chelating Agents   (Site not responding. Last check: 2007-10-03)
Chelating agents or chelants include a number of compounds, all having the ability to coordinate with metal ions at a minimum of two sites.
The total regional consumption of aminopolycarboxylic chelating agents (excluding NTA) in the United States, Western Europe and Japan during 2002 was approximately 150 thousand metric tons—about 5% lower than in 1998.
These chelating agents are used as components or process chemicals in a wide variety of applications, but five uses—cleaning compounds, pulp and paper manufacture, water treatment, photography and agriculture—account for about 80% of worldwide consumption.
www.sriconsulting.com /CEH/Public/Reports/515.5000/Abstract.html   (564 words)

  
 Chelation-Common Chelating Agents
Below are some common chelating agents and their known and proposed mechanisms of action, side-effects, and principle uses.
This chelator is used to treat iron toxicity found is certain hematological disorders such as sickle cell anemia and types of thalassemia.
Dexrazoxane is a chelator that has been approved by the FDA to be used to reduce the severity of doxirubicin induced cardiomyopathy in women with metastatic breast cancer who have received more than 300 mg/kg of doxirubicin.
altmed.creighton.edu /chelation/chelatingagents.htm   (360 words)

  
 General Cleaners Chemistry
The word surfactant is short for "Surface Active Agent." In general, they are chemicals that, when dissolved in water or another solvent, orient themselves at the interface (boundary) between the liquid and a solid (the dirt we are removing), and modify the properties of the interface.
The metal ions are surrounded by the claw-like chelating agent which alters the electronic charge of the metal ions from positive to negative (see diagram below.) This makes it impossible for the metal ions to be precipitated with the surfactants.
Chelating agents and builders are added to the formula to keep water hardness from interfering with the cleaning process.
www.essind.com /Cleaners/GC-chemistry.htm   (1478 words)

  
 Argonne Chemistry Research Areas
The focus of the activities of this research group is the design, synthesis, characterization, and application of chelating agents for metals separations and recovery.
The chelating agents include lipophilic ligands that function as extractants, water-soluble species having use in separations and water treatment, and chelating agents immobilized in a polymeric matrix or adsorbed on an inert support for chromatographic applications.
The critical parameters for the design of a new chelating agent are complex strength, solubility of the ligand and its complexes, selectivity for particular metals or classes of metals, and the thermal stability of the chelated complexes.
chemistry.anl.gov /heavy-element/sepsci.html   (1404 words)

  
 Deaths Associated with Hypocalcemia from Chelation Therapy --- Texas, Pennsylvania, and Oregon, 2003--2005
Chelating agents bind lead in soft tissues and are used in the treatment of lead poisoning to enhance urinary and biliary excretion of lead, thus decreasing total lead levels in the body (1).
Chelating agents, especially those intended for use in children, should be effective in reducing lead and other heavy metals from the body without producing substantial adverse effects on levels of critical serum electrolytes, such as calcium.
The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood.
www.cdc.gov /mmwr/preview/mmwrhtml/mm5508a3.htm   (2021 words)

  
 IronToxicity.com - Iron Chelating Agents
Currently, the only approved iron chelation agent in the U.S. is deferoxamine.
First introduced in the early 1960s, deferoxamine mesylate (Desferal) is still the gold standard therapy for chelation of iron toxicity in countries in which it is available.
Deferoxamine chelates NTBI both in reticuloendothelial macrophages, where it becomes available for urinary excretion by the kidneys, and in hepatocytes, where it is excreted into the gut via bile.
www.irontoxicity.com /hcp/treating/iron_chelating_agents.jsp   (314 words)

  
 Role of Chelating Agents for Prrevention, Intervention, and Treatment of Exposures to Toxic Metals
The role of chelating agents for the prevention, intervention, and treatment of exposures to toxic metals was the topic of a conference held at the National Institute of Environmental Health Sciences, 22-23 September 1994.
The objective of the conference was to review experimental and clinical studies concerned with the effectiveness and potential toxicity of chelating agents used to reduce the body burden of various metals and to identify research needs in the area of chelation.
In: Abstracts from the conference on the role of chelating agents for the prevention, intervention, and treatment of exposures to toxic metals, 22-23 September 1994, Research Triangle Park, NC; A19.
www.ehponline.org /docs/1995/103-11/meetingreport.html   (4374 words)

  
 U.N.X. INCORPORATED Laundry Chemicals Cleaning Chemicals
A performance formulation of alkaline agents, surfactants, chelating agents and dispersing agents provides 5 STAR with superior soil removing and suspending capabilities.
A special combination of buffered alkalis and chelating agents will safely soften and remove the toughest dried on food soils.
The unique blend of heavy duty surfactants, chelating and dispersing agents allows ORACLE to maintain superior performance with soil, grease, and oil removal and suspension throughout the washing and rinsing process.
www.unxinc.com /wwpg1.html   (372 words)

  
 Cereal Chem 2000 | Effects of Natural Chelating Agents on the Solubility of Some Physiologically Important Mineral ...
The solubility of mineral elements from oat bran and flake samples was studied by a method using equilibrium dialysis after enzymatic digestion of starch and proteins.
The effects of six potential chelating agents common in food were tested on the solubility of mineral elements.
The minerals studied were calcium, magnesium, iron, manganese, zinc and potassium, and the chelating agents were citric, lactic, malic, and ascorbic acids, glucose and xylitol.
www.aaccnet.org /cerealchemistry/abstracts/2000/0809-02R.asp   (273 words)

  
 Chelating agents for lead poisoning
Iron deficiency must be corrected either before or after chelation therapy, not at the same time.
Chelation will bind to iron as well as lead and cause it to be eliminated, which can cause other health problems such as anemia.
If a pregnant woman has a high blood lead level, the risk of exposing the fetus to chelating agents and to lead must be weighed.
www.webmd.com /hw/health_guide_atoz/hw119558.asp?printing=true   (377 words)

  
 Lead Poisoning
Chelating agents are medicines that bind with lead in blood and both soft and bony tissues and eliminate it quickly from the body, usually through the urine.
In general, drug treatment is recommended when blood lead levels are above 45 micrograms per deciliter (mcg/dL) or when there are symptoms of lead poisoning, especially lead encephalopathy.
There is disagreement over whether chelation therapy is needed for children with blood lead levels between 25 mcg/dL and 44 mcg/dL—one study showed no benefit to the child.
www.peacehealth.org /kbase/topic/major/hw119898/drugtrt.htm   (533 words)

  
 V-Labs, Inc. - Chelating Agents
Chitosan is a natural linear biopolymer derived from the chitin found in the exoskeleton of shellfish.
It is used in waste water treatment and metal chelation.
Carboxymethylchitosan is a derivative of chitosan with a carboxymethyl group attached to the functional groups.
www.v-labs.com /Products/chelatet.html   (127 words)

  
 Iron chelating agents for treating malaria
Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined.
To assess the effects of iron-chelating agents combined with antimalarial drugs, or iron chelators alone, for treating Plasmodium falciparum malaria in adults and children, in relation to mortality, coma recovery time, parasite clearance, and adverse effects.
All randomised controlled trials comparing iron chelating agents with placebo, or comparing iron chelating agents in conjunction with other antimalarials with antimalarial treatment alone in adults or children with falciparum malaria.
www.cochrane.org /reviews/en/ab001474.html   (406 words)

  
 BIODEGRADATION OF CHELATING AGENTS USED FOR METAL REMOVAL FROM CONTAMINATED SOILS   (Site not responding. Last check: 2007-10-03)
Chelating agents such as EDTA NTA, DTPA, etc. have been used widely in a variety of industrial applications.
In these applications the contaminated soils are treated with selected chelating agents to extract the metals from the soil phase to the aqueous phase.
The chelating compounds in the aqueous phase can later be recovered for reuse by pH modifications.
www.engg.ksu.edu /HSRC/97abstracts/p24.html   (320 words)

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