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Topic: Chemotherapy regimens

	Chemotherapy - Wikipedia, the free encyclopedia
		As chemotherapy affects cell division, tumours with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time.
		Depending on the patient, the cancer, the stage of cancer, the type of chemotherapy, and the dosage, IV chemotherapy may be given on either an inpatient or outpatient basis.
		Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms.
	en.wikipedia.org /wiki/Chemotherapy (2266 words)

	Encyclopedia article: Chemotherapy (Site not responding. Last check: 2007-10-09)
		Depending on the patient, the cancer, the stage of cancer, the type of chemotherapy, and the dosage, IV chemotherapy may be given on either an inpatient (A patient who is residing in the hospital where he is being treated) or outpatient basis.
		Combined modality chemotherapy is the use of drugs with other cancer treatments, such as radiation therapy ((medicine) the treatment of disease (especially cancer) by exposure to radiation from a radioactive substance) or surgery (The branch of medical science that treats disease or injury by operative procedures).
		Chemotherapy may increase the risk of cardiovascular disease (A disease of the heart or blood vessels) and occasionally leads to secondary cancer (Type genus of the family Cancridae).
	www.absoluteastronomy.com /encyclopedia/c/ch/chemotherapy.htm (2426 words)

	Chemotherapy
		New chemotherapy regimens and agents are being investigated for use in myeloma.
		Because this regimen is more intensive than conventional chemotherapy, it is used less frequently in patients over the age of 70, and may not be suitable for patients who have significantly impaired kidney function or performance status, or other coexisting conditions.
		Chemotherapy may be used as salvage therapy, that is, treatment for patients who have not responded to primary or subsequent therapy or who experience relapsed disease after an initial response to therapy.
	www.multiplemyeloma.org /treatments/3.02.html (1554 words)

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		Chemotherapy is considered "systemic therapy." This means that the drug enters the bloodstream and circulates throughout the body to reach and destroy the cancer cells.
		Chemotherapy is an effective way to destroy any cancer cells that break off from the main tumor and travel in the bloodstream to lymph nodes or distant organs.
		The most commonly used chemotherapy regimens are cisplatin, etoposide, and bleomycin for 3 cycles, or cisplatin and etoposide for 4 cycles.
	www.cancer.org /docroot/CRI/content/CRI_2_4_4X_Chemotherapy_41.asp?sitearea= (482 words)

	Chemotherapy regimens - Wikipedia, the free encyclopedia
		Chemotherapy regimens are often identified with acronyms, identifying the agents used in combination.
		Unfortunately, the letters used are not consistent across regimens, and in some cases (for example, "BEACOPP") the same letter is used to represent two different treatments.
		The term "Induction regimens" refers to a chemotherapy regimen which is used for the initial treatment of a disease.
	en.wikipedia.org /wiki/Chemotherapy_regimens (191 words)

	Figures (Site not responding. Last check: 2007-10-09)
		Metronomic chemotherapy regimens differ from the standard maximum tolerated dose (MTD) chemotherapy regimens that have been common practice in medical oncology for decades.
		In b and c, examples of metronomic chemotherapy regimens are shown where, for example, the chemotherapy drug is administered more frequently, such as weekly (b) or daily (c), with no prolonged drug-free interruptions.
		Omission of prolonged drug-free periods is a key aspect of the basis for the anti-angiogenic effects of low-dose metronomic chemotherapy regimens, as these breaks allow repair and recovery from the anti-angiogenic effects of chemotherapy drugs on developing tumour blood vessels.
	www.medscape.com /content/2004/00/48/07/480745/480745_fig.html (320 words)

	Chemotherapy
		Chemotherapy is a systemic therapy; this means it affects the whole body by going through the bloodstream.
		Chemotherapy is effective against cancer cells because the drugs love to interfere with rapidly dividing cells.
		You'll also read about the different chemotherapy regimens and about deciding together with your medical oncologist which regimen would be best suited to you.
	www.breastcancer.org /tre_sys_chemo_idx.html (384 words)

	Cancer Chemotherapy - Print Version : Online Reference For Health Concerns
		Chemotherapy drugs have a high rate of failure because they usually kill only specific types of cancer cells within a tumor or the cancer cells mutate and become resistant to the chemotherapy.
		The blockade of the overexpression of the EGF receptor and the inhibition of the signaling pathways, bFGF and VEGF, is dose-dependent response.
		Chemotherapy patients should consider taking 30-60 grams a day of whey protein concentrate (in divided doses) 10 days before initiation of chemotherapy, during chemotherapy, and at least 10 days after the chemotherapy session is completed.
	www.lef.org /protocols/prtcls-txt/t-prtcl-024.html (12681 words)

	ipedia.com: Chemotherapy Article (Site not responding. Last check: 2007-10-09)
		Chemotherapy is the use of certain drugs to treat disease, as distinct from other forms of treatment, such as surgery.
		Cancer is the uncontrolled growth of cellss due to damage to DNA (mutations) and, occasionally, due to an inherited propensity to develop certain tumours.
		Chemotherapy may increase the risk of cardio-vascular disease and occasionally leads to secondary cancer.
	www.ipedia.com /chemotherapy.html (1436 words)

	Treatment of non-small-cell lung cancer: a perspective on the recent advances and the experience with gefitinib (Site not responding. Last check: 2007-10-09)
		Regimens such as cisplatin or carboplatin combined with paclitaxel, vinorelbine, gemcitabine, docetaxel or irinotecan are among the platinum-based combinations currently used in clinical practice.
		All had received their last dose of chemotherapy within the previous 90 days and had recurrent disease or were unable to tolerate further chemotherapy, usually as a result of chemotherapy-associated neuropathy.
		However, chemotherapy for NSCLC in Japan is controversial because the differences in the efficacies of combination chemotherapies, including new agents such as irinotecan, paclitaxel and vinorelbine, have not been recognised in randomised controlled trials.
	www.nature.com /bjc/journal/v91/n2s/full/6602062a.html (4159 words)

	Study of chemotherapy regimens of 5 and 7 months' duration and the role of corticosteroids in the treatment of ... (Site not responding. Last check: 2007-10-09)
		Study of chemotherapy regimens of 5 and 7 months' duration and the role of corticosteroids in the treatment of sputum-positive patients with pulmonary tuberculosis in South India
		A controlled clinical trial of 3 short-course chemotherapy regimens was undertaken in patients with bacteriologically positive, newly diagnosed pulmonary tuberculosis.
		The patients were allocated at random to receive one of 3 regimens: rifampicin, streptomycin, isoniazid and pyrazinamide daily for 2 months, followed by streptomycin, isoniazid and pyrazinamide twice weekly for 3 months (R/5) or for 5 months (R/7), and the same regimen as (R/7) but without rifampicin (Z/7).
	www.trc-chennai.org /Publications/pub59.htm (517 words)

	ASCO: Risk of Infection Doubles With Reduced (Filgrastim) Administration
		Delivering planned chemotherapy doses on time is considered to be an extremely important factor in helping patients receive maximum benefit from chemotherapy.
		Neupogen (Filgrastim) is indicated to decrease the incidence of infection as manifested by febrile neutropenia in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a significant incidence of severe neutropenia with fever.
		Neulasta is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia.
	www.docguide.com /dg.nsf/PrintPrint/6B795BC08118641585256D390056A83B (887 words)

	Important Principles in Chemotherapy: Regimens Treating And Androgen-Independent Prostate Cancer (AIPC) - Prostate ...
		Regimen B with its more frequent lower doses has less toxicity due to lower peak blood levels than Regimen A with its higher but less frequent dosing.
		With the advent of agents that can stimulate the bone marrow, we now are able to give chemotherapy at higher doses by supporting and/or preventing such toxicities as low white blood cell counts, anemia, and low platelet counts.
		If chemotherapy extravasation does occur, 70% DMSO applied topically prevents tissue injury and should be administered at least 4-6 times a day until the site of extravasation is fully healed.
	www.prostate-cancer.org /education/sidefx/Strum_PrinciplesInChemotherapy.html (2411 words)

	Breast Cancer Chemotherapy (Site not responding. Last check: 2007-10-09)
		In support of the efficacy of combination regimens, in vitro experiments using human non-small-cell lung cancer lines have suggested that gemcitabine and paclitaxel have synergistic cytotoxic effects, since administration of the taxane led to accumulation of difluorodeoxycytidine triphosphate, the active metabolite of gemcitabine.
		Trastuzumab-gemcitabine regimens were evaluated in 64 patients who had received up to 3 prior chemotherapy regimens for MBC but no previous trastuzumab or gemcitabine.
		Chemotherapy plus trastuzumab significantly increased the median TTP, from 4.6 to 7.4 months (P <.001); median response duration was increased from 6.1 to 9.1 months (P <.001), and the objective response rate was increased from 32% to 50% (P <.001) when compared with standard chemotherapy.
	www.medceu.com /tests/breastchemo.htm (8139 words)

	Chemotherapy
		There is no single answer as to how often it is given because there are so many different regimens and the frequency depends in a large part upon how well the patient is able to tolerate the treatment and how quickly their blood counts recover.
		Patients are sometimes under the misconception that the chemotherapy schedule is based upon the fact that many of the drugs are cell cycle specific, and that the chemo cycle is timed to match the cell cycle.
		There are a variety of different ways to kill a cancer cell so many chemotherapy regimens combine various drugs that each have a different mechanism of action, in order to obtain the best results.
	www.nhlcyberfamily.org /treatments/chemotherapy.htm (2387 words)

	PREVENTION OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING (Site not responding. Last check: 2007-10-09)
		It is clear that the emetogenic potential of chemotherapy agents is not simply a factor of dose, but it may also be affected by the route of administration or schedule.
		The rationale for using combination regimens of antiemetics to prevent or treat chemotherapy-induced nausea and vomiting stems from the multiple neurotransmitters which influence the vomiting center of the medulla.
		Tailoring the antiemetic regimen to the intrinsic emetogenicity of the chemotherapy regimen is considered a basic principle of preventing chemotherapy-induced nausea and vomiting.
	daccx.bsd.uchicago.edu /drug/Bulletins/n0696.html (3912 words)

	'Dose dense' chemotherapy improves survival in breast cancer patients
		While previous research has evaluated the use of various forms of "dose dense" chemotherapy, this is the first major controlled study to show a clear survival benefit for women with node-positive breast cancer.
		Since frequent administration of chemotherapy can result in a condition called neutropenia, a decline in the number of a certain type of white blood cells, the researchers administered filgrastim to patients on the dose dense regimens.
		Side effects were found to be no more severe among patients on the dose dense regimens than among those on the conventional treatments, and patients on the dose dense regimens suffered fewer cases of neutropenia.
	www.eurekalert.org /pub_releases/2002-12/nci-dc121202.php (806 words)

	Lymphoma Information Network - Childhood Hodgkin's Disease Chemotherapy
		Chemotherapy is the use of drugs to kill cancer cells and shrink tumors.
		Chemotherapy is called a systemic treatment because the drugs enter the bloodstream, travel through the body, and can kill cancer cells throughout the body.
		Chemotherapy is delivered many different ways depending on the drugs and treatment.
	www.lymphomainfo.net /childhood/hd-chemo.html (613 words)

	Lymphoma Information Network - CHOP Chemotherapy
		CHOP is one of the most common chemotherapy regimens for treating Non-Hodgkin's lymphoma.
		Also some regimen drugs may cause constipation which should be closely monitored.
		Abstract of a 2002 study - CHOP chemotherapy plus Rituxan (rituximab) compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.
	www.lymphomainfo.net /therapy/chemotherapy/chop.html (812 words)

	The Clinical Efficacy of Neoadjuvant Chemotherapy in Squamous Esophageal Cancer: A Prospective Nonrandomized Study of ...
		A pilot study of neoadjuvant chemotherapy with 5-fluorouracil and cisplatin with surgical resection and postoperative radiation therapy and/or chemotherapy in adenocarcinoma of the esophagus.
		Endoscopic ultrasonography in the quantitative assessment of response to chemotherapy in patients with adenocarcinoma of the esophagus and esophagogastric junction.
		Assessment of response of esophageal carcinoma to induction chemotherapy.
	www.annalssurgicaloncology.org /cgi/content/full/9/7/617 (3369 words)

	Chemo for Breast Cancer
		He should explain the details of chemotherapy regimens, potential side effects and any long-term ill effects.
		There are a few established regimens of chemotherapy for breast cancer including CMF and CAF.
		These regimens are outpatient regimens which are administered in the oncologist's office or in a hospital outpatient setting.
	www.tirgan.com /chembrst.htm (319 words)

	Dr. Murray Online \| Articles
		In fact chemotherapy can induce those symptoms and many more, however newer medications have made most chemotherapy regimens much better tolerated than in the past.
		One of the problems with chemotherapy is that it is active against any actively dividing cell whether it is cancerous or not.
		One of the most controversial recommendations to support chemotherapy (as well as radiation therapy) is the recommendation to use antioxidant nutrients during the active phase of the treatment.
	www.doctormurray.com /articles/chemotherapy.htm (3102 words)

	colon cancer chemotherapy (Site not responding. Last check: 2007-10-09)
		Chemotherapy is the treatment of cancer with drugs that can destroy colon cancer cells by impeding their growth and reproduction.
		For colon and rectal cancer, chemotherapy is usually used after you've had surgery to remove the cancer.
		Resisting cancer chemotherapy; researchers are struggling to learn how cancer cells survive in the presences of lethal drugs.
	www.prostatecancernet.org /colon-cancer-chemotherapy.html (416 words)

	Chemotherapy of Metastatic Breast Cancer: What to Expect in 2001 and Beyond -- Esteva et al. 6 (2): 133 -- The ... (Site not responding. Last check: 2007-10-09)
		chemotherapy, and the durations of response and survival have
		chemotherapy, the RR were 32% to 62% [29-33].
		Chemotherapy and survival in advanced breast cancer: the inclusion of doxorubicin in Cooper type regimens.
	theoncologist.alphamedpress.org /cgi/content/full/6/2/133 (5228 words)

	Colon Cancer Today - Steady Gains Made Against Digestive Cancers
		One study found that adding the drug oxaliplatin to standard chemotherapy regimens in individuals with stage II or III colorectal cancer reduced the relative risk of a recurrence by 21 percent.
		The chemotherapy drug gemcitabine, currently used to treat patients with inoperable pancreatic cancer, can also benefit patients with the operable form of the disease, another study showed.
		Five years after their diagnosis, 36 percent of the chemotherapy group was still alive, compared with 23 percent of the surgery group.
	www.coloncancertoday.com /ms/news/525732/main.html (657 words)

	manageCINV \| Emetogenic Potential of Chemotherapy Regimens
		Independent of patient risk factors, the risk of emetogenicity for chemotherapy varies depending on the type of anticancer agents used.
		The majority of patients receiving chemotherapy are administered moderately emetogenic regimens.
		Defining the emetogenicity of cancer chemotherapy regimens: relevance to clinical practice.
	www.managecinv.com /channels/2.asp?id=29 (170 words)

	Lung Cancer Online: Topics & Issues in NSCLC Chemotherapy
		The large, randomized study compared the chemotherapy (cisplatin and etoposide) and radiation combination to radiation alone.
		Concludes that response is significantly higher with platinum-containing regimens.
		Data from all randomized controlled trials conducted from 1980 through 2001 comparing a doublet regimen with a single-agent regimen or comparing a triplet regimen with a doublet regimen in patients with advanced NSCLC were examined.
	www.lungcanceronline.org /treatment-nsclc/topicschemo.html (570 words)

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