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Topic: Chlorpromazine

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	Chlorpromazine (PIM 125)
		Chlorpromazine 100 mg is approximately equivalent to 111 mg of chlorpromazine hydrochloride.
		Chlorpromazine hydrochloride 100 mg is approximately equivalent to 144 mg of chlorpromazine embonate.
		Chlorpromazine and its metabolites were found in the maternal plasma and urine, in the foetal plasma and amniotic fluid, and in neonatal urine after doses of 50 to 100 mg of chlorpromazine were given intramuscularly to pregnant women shortly before delivery.
	www.inchem.org /documents/pims/pharm/chlorpro.htm (6797 words)

	Chlorpromazine - Chlorpromazine Side Effects - Chlorpromazine Information - Canada Pharmacy - Canada Drugs
		Chlorpromazine is also used for the prevention and treatment of nausea and vomiting, for the treatment of acute intermittent porphyria, as an adjunct in the treatment of tetanus and for relief of intractable hiccups.
		Chlorpromazine should not be used in patients who are comatose, in patients with severe CNS depression secondary to the use of CNS depressant medications and in patients with blood dyscrasias or bone marrow depression.
		Chlorpromazine use near term should be avoided because of the danger of hypertension in the mother and adverse effects in the neonate.
	www.rxcarecanada.com /Chlorpromazine.asp (2907 words)

	Chlorpromazine (Thorazine) Phenothiazines
		Chlorpromazine occasionally is used for relief of presurgical anxiety; for acute intermittent porphyria; and as an adjunct in the treatment of tetanus.
		Chlorpromazine is the prototype antipsychotic; the potency of other antipsychotics are compared to oral chlorpromazine 100 mg.
		Chlorpromazine is between 92—97% bound to plasma protein, predominantly alpha 1-acid glycoprotein.
	www.rockford.uic.edu /jc/chlorpro.htm (424 words)

	Chlorpromazine - Wikipedia, the free encyclopedia
		Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses.
		Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote".
		Chlorpromazine is primarily used as an antiemetic in dogs and cats.
	en.wikipedia.org /wiki/Chlorpromazine (1912 words)

	Chlorpromazine, side effects, drug interactions, overdose, dosage
		Chlorpromazine is used for the treatment of schizophrenia (severe disruptions in thought and perception).
		Chlorpromazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery.
		You should use chlorpromazine cautiously if you have ever had: asthma; a brain tumor; breast cancer; intestinal blockage; emphysema; the eye condition known as glaucoma; heart, kidney, or liver disease; respiratory infections; seizures; or an abnormal bone marrow or blood condition; or if you are exposed to pesticides or extreme heat.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/chl1441.shtml (1135 words)

	740. Chlorpromazine (WHO Food Additives Series 29)
		Chlorpromazine appears to be variably absorbed but is metabolized in the gut as well as in the liver, where it can accelerate its own metabolism or conjugation.
		The intravenous LD (median lethal dose) of chlorpromazine was 20, 23, 16, and 30 mg/kg b.w.
		Since chlorpromazine has been in use for such a long period of time a number of published reports are available on the toxicity and side-effects of the drug in humans.
	www.inchem.org /documents/jecfa/jecmono/v29je10.htm (3893 words)

	Chlorpromazine hydrochloride (UK PID)
		In a later study chlorpromazine and several metabolites were identified in the breast milk of four nursing mothers receiving the drug (doses not specified).
		Chlorpromazine lowers the seizure threshold (a dose-related effect) so convulsions may occur in patients not previously known to be epileptic.
		PREGNANCY The administration of chlorpromazine near term has been associated with unpredictable falls in maternal blood pressure which could be dangerous to the mother and the foetus.
	www.intox.org /databank/documents/pharm/chlorpro/ukpid20.htm (3565 words)

	Thorazine, Chlorpromazine, Largactil Pharmacology - HealthyPlace.com
		Chlorpromazine is an alpha-adrenergic blocking agent and increased pulse rate and transient hypotension have both been reported in some patients receiving these drugs.
		Chlorpromazine should be used with caution in patients who have impaired liver function or alcoholic liver disease.
		Chlorpromazine may mask signs of overdosage of toxic drugs and may obscure conditions such as intestinal obstruction and brain tumor.
	www.healthyplace.com /medications/chlorpromazine.htm (2409 words)

	Anxiety Zone - Chlorpromazine
		Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s.
		Used as chlorpromazine hydrochloride and sold under the tradenames Largactil (the "liquid cosh") and Thorazine, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects.
		Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties.
	www.anxietyzone.com /drugs/chlorpromazine.html (367 words)

	Howstuffworks "Chlorpromazine: A Profile of a Tranquilizer Drug"
		Chlorpromazine is prescribed for pain relief and to treat the symptoms of certain types of mental illness, such as the emotional symptoms of psychosis and the manic phase of manic-depressive illness (sometimes called bipolar disorder).
		Chlorpromazine may also be used to treat tetanus, porphyria, uncontrollable hiccups, anxiety before surgery, and nausea and vomiting.
		Chlorpromazine can cause extreme drowsiness when combined with alcohol or other central nervous system depressants (such as barbiturates, benzodiazepine tranquilizers, muscle relaxants, narcotics, and pain medications) or with tricyclic antidepressants, fluoxetine, fluvoxamine, paroxetine, or maprotiline.
	health.howstuffworks.com /define-chlorpromazine.htm (1272 words)

	Chlorpromazine - Definition, Purpose, Description, Recommended dosage, Precautions, Side effects, Interactions
		Chlorpromazine is principally used to reduce the signs and symptoms of psychosis.
		Chlorpromazine may sometimes be used as a sedative in non-psychotic patients with excessive anxiety and agitation.
		Chlorpromazine may cause acute muscle spasms, particularly of the head and neck, and sudden decreases of blood pressure.
	www.minddisorders.com /Br-Del/Chlorpromazine.html (1419 words)

	BioMed Central \| Full text \| Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised ...
		Chlorpromazine is sedating (n = 1242, 18 RCTs, RR 2.3 CI 1.7 to 3.1, NNH 6 CI 5 to 8), increases a person's chances of experiencing acute movement disorders, Parkinsonism and causes low blood pressure with dizziness and dry mouth.
		In India chlorpromazine is commonly prescribed, and in South East Asia the older generation of antipsychotics are used to treat the majority of people with schizophrenia [7].
		In 2003, in the UK, chlorpromazine was the most frequently prescribed of the first generation 'typical' antipsychotic drugs, where, at that time, the 'typical' group of antipsychotics accounted for 44% of all anti-psychotic prescriptions [8].
	www.biomedcentral.com /1741-7015/3/15 (3026 words)

	Chemical & Engineering News: Top Pharmaceuticals: Thorazine
		Chlorpromazine's origins are found in a series of phenothiazine amines noted for their antihistaminic properties.
		It was the barbiturate-enhancing effect of chlorpromazine that led French naval surgeon Henri Laborit to it in 1951.
		With reports of chlorpromazine sending schizophrenic hallucinations and delusions into remission, the drug was now seen as a way for the federal government to realize a vision popularly known as the deinstitutionalization movement.
	pubs.acs.org /cen/coverstory/83/8325/8325thorazine.html (664 words)

	The Shipman Inquiry - First Report - Chlorpromazine
		Chlorpromazine is an anti-psychotic or neuroleptic drug, which has been in use for more than 25 years.
		While a massive overdose of chlorpromazine might be capable of directly causing death (for example, by inducing fatal cardiac arrhythmia), such an overdose would involve the injection of a substantial volume of fluid and I do not think that Shipman would ever have chosen to kill a patient by this method.
		On the other hand, a smaller overdose of chlorpromazine could have an indirect lethal effect in very much the same way as might be achieved by a sublethal dose of morphine or diamorphine.
	www.the-shipman-inquiry.org.uk /fr_page.asp?id=105 (457 words)

	Chlorpromazine
		Chlorpromazine is distributed throughout the body and brain concentrations are higher than those in the plasma.
		Approximately 95% of chlorpromazine in plasma is bound to plasma proteins (primarily albumin).
		The animal was put on 2000 mg of chlorpromazine twice daily orally and behaved normally during the entire festival season of 6 months.
	www.elephantcare.org /Drugs/chlorpro.htm (1159 words)

	Chlorpromazine ( Thorazine ) dtat sheet
		Chlorpromazine (Thorazine) is an antipsychotic drug of low-potency used to treat schizophrenia.
		Chlorpromazine (Thorazine) is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods).
		Chlorpromazine (Thorazine) is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery.
	psyweb.com /Drughtm/jsp/chlor.jsp (692 words)

	INTRAMED CHLORPROMAZINE INJECTION 25 mg; INTRAMED CHLORPROMAZINE INJECTION 50 mg
		Chlorpromazine is used in conjunction with pethidine for premedication in anaesthesia producing "potentiated anaesthesia" and thereby often reducing the dosage requirements of anaesthetics.
		Chlorpromazine should not be given in conjunction with drugs that might cause leucopenia such as phenylbutazone and the thiouracil derivatives.
		Chlorpromazine should be used with caution in patients with existing tachycardia or cardiac insufficiency and in patients with liver dysfunction or a history of jaundice.
	home.intekom.com /pharm/intramed/clprzini.html (858 words)

	chlorpromazine
		Chlorpromazine is used to treat psychotic disorders, nausea and vomiting, chronic hiccups, and acute intermittent porphyria.
		If you are taking chlorpromazine as needed for nausea and vomiting, take the missed dose as soon as possible if needed, then wait at least 4 hours before taking another dose.
		Chlorpromazine may increase the effectiveness of phenytoin and cause side effects.
	hw.healthdialog.com /kbase/multum/d00064a1.htm (1416 words)

	Chlorpromazine (Thorazine®)
		Chlorpromazine is used to reduce nausea and vomiting.
		Chlorpromazine is also available in 30 mg, 75 mg, 150 mg, 200 mg and 300 mg extended release capsules.
		Injectable chlorpromazine is also available in 25 mg/ml concentration in 1 ml and 2 ml ampules as well as a 10 ml bottle.
	www.petplace.com /drug-library/chlorpromazine-thorazine/page1.aspx (805 words)

	MedlinePlus Drug Information: Chlorpromazine
		Chlorpromazine is used to treat psychotic disorders and symptoms such as hallucinations, delusions, and hostility.
		Chlorpromazine comes as a tablet, extended-release (long-acting) capsule, oral liquid (syrup and concentrate), and rectal suppository.
		Although chlorpromazine is not habit-forming, do not stop taking it abruptly, especially if you have been taking it for a long time.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682040.html (813 words)

	Chlorpromazine - Patient UK
		Chlorpromazine is used to treat some types of mental illness.
		Chlorpromazine is also used to treat moments of sudden dangerous behaviour, agitation (restlessness) and is also useful in the short-term treatment of unrelated illnesses such as anxiety (worry).
		Chlorpromazine can also be used to prevent or treat feeling or being sick and to treat persistent hiccups.
	www.patient.co.uk /showdoc/30002789 (857 words)

	Treatments during the early 20th centrury
		Chlorpromazine had similar mitigating effects in psychotic symptoms as reserpine.
		It was developed when French doctors were looking for quite another effect, a substance that could counteract deleterious reactions of the body when it is exposed to severe strain, for example a big operation or an accident with extensive physical injury.
		It turned out that chlorpromazine was superior to reserpine, which often gave rise to depressions.
	www.hubin.org /facts/history/1900_history/treatment/treatment_8_en.html (359 words)

	chlorpromazine (Thorazine®, Largactil®) for Migraines
		Chlorpromazine is often used to treat the nausea and vomiting and, to some extent, the pain associated with a Migraine attack.
		Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus.
		These can only be provided by a physician who has had an opportunity to interact with a patient in person and at length, with access to the patient's previous records and appropriate follow-up.
	www.migraines.org /treatment/prothora.htm (1514 words)

	Chlorpromazine (Site not responding. Last check: 2007-11-06)
		Chlorpromazine decreases nausea and vomiting caused by chemotherapy drugs.
		Chlorpromazine is taken by mouth with or without food.
		Tardive dyskinesia is a side effect which occurs in patients who take chlorpromazine for long periods (months to years) and in high doses.
	www.hci.utah.edu /patientdocs/hci/drugs/chlorpromazine.htm (405 words)

	Healthopedia.com - Chlorpromazine (Oral) (Thorazine) - Drugs Information, Side Effects, & Interactions
		Check with your doctor before using chlorpromazine if you have asthma, breast cancer, difficulty urinating, glaucoma, seizures, a bone marrow disorder, a blood disorder, lupus, heart, kidney, or liver disease, or if you are exposed to pesticides or extreme heat.
		There is a risk of side effects that include muscle spasms, twitching or trembling in the face and body, and uncontrolled tongue or jaw movement.
		Chlorpromazine may cause you to be sensitive to sunlight.
	www.healthopedia.com /drugs/quick/chlorpromazine (619 words)

	A Science Odyssey: People and Discoveries: Drug for treating schizophrenia identified
		He was so struck by the effect on his patients, especially with a drug called chlorpromazine (trade name Thorazine) he thought the drug must have some use in psychiatry.
		Deniker's interest was piqued and he ordered some chlorpromazine to try on his most agitated, uncontrollable patients.
		In 1954 chlorpromazine was approved by the U.S. Food and Drug Administration, and it took the country by storm.
	www.pbs.org /wgbh/aso/databank/entries/dh52dr.html (614 words)

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