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Topic: Cholangiocarcinoma

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Klatskin tumor

Biliary duct

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	Lifespan's A - Z Health Information Library - Cholangiocarcinoma (Site not responding. Last check: 2007-10-08)
		Cholangiocarcinoma is a malignant (cancerous) growth in one of the ducts that carries bile from the liver to the small intestine.
		Malignant tumors of the bile ducts are usually slow-growing and late to spread (metastasize).
		Primary sclerosing cholangitis, choledochal (bile duct) cysts, and chronic biliary irritation are all associated with increased risk for this condition.
	www.lifespan.org /adam/healthillustratedencyclopedia/1/000291.html (470 words)

	Cholangiocarcinoma - Bile Duct Cancer (Site not responding. Last check: 2007-10-08)
		Cholangiocarcinomas are tumors that arise from the lining of the bile ducts.
		Cholangiocarcinomas that arise inside the liver are treated as liver tumors.
		The diagnosis of cholangiocarcinoma is obtained with a combination of imaging studies, as well as procedures for obtaining tissue samples for diagnosis.
	www.ercp.ucla.edu /pages/info/biliary/bile-duct-cancer.html (587 words)

	Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis -- Choi et al. 17 (3): 540 -- ...
		Cholangiocarcinoma is a biliary carcinoma that arises from the
		It is undisputed that the prevalence of cholangiocarcinoma
		Intraductal mucosal-spreading mucin-producing peripheral cholangiocarcinoma of the liver.
	cmr.asm.org /cgi/content/full/17/3/540 (6882 words)

	Better Outcomes with Liver Transplant for Hilar Cholangiocarcinoma Patients
		For patients with localized, node-negative hilar cholangiocarcinoma, liver transplantation preceded by radiation and chemotherapy may be an alternative to surgical resection, according to a study published in the Annals of Surgery.
		Cholangiocarcinoma is a type of liver cancer that develops in the bile ducts—the small tubes that carry bile (a substance that aids in the digestion of fats) from the liver to the intestine.
		Cholangiocarcinoma that develops where the left and right bile ducts meet is called hilar cholangiocarcinoma.
	patient.cancerconsultants.com /news.aspx?id=34970 (603 words)

	Cholangiocarcinoma of the Biliary Tract
		Interestingly, the pattern of allelic shifts was frequently not identical between the intraductal and invasive cholangiocarcinoma components; although the same microsatellite markers were shifted, alleles of differing lengths were generated in the intraductal and invasive components of the neoplasms with high-level microsatellite instability and of two neoplasms with low-level microsatellite instability.
		TTF-1 cytoplasmic staining was identified in 93% of HCCs (37/40), 100% of metastatic HCCs (4/4), 10% of cholangiocarcinomas (2/20), and 5% of MCs (1/20).
		Remarkably, the cytokeratin phenotype of intrahepatic cholangiocarcinoma was correlated with the morphologic appearance of intrahepatic cholangiocarcinoma.
	www.thedoctorsdoctor.com /diseases/biliary_cholangioca.htm (12990 words)

	Cholangiocarcinoma - Gastrointestinal and Colorectal Cancers - Stanford Comprehensive Cancer Center
		Cholangiocarcinoma (also called cholangioma or bile duct cancer) is a rare, malignant tumor of the bile duct, accounting for fewer than 1% of all cancers.
		Cholangiocarcinoma is a type of adenocarcinoma ("adeno" for gland) that originates in the mucous glands of the epithelium, or surface layer, of the bile ducts.
		Therefore, some some cholangiocarcinomas are true primary liver tumors in that they may originate in the liver, while others may spread there or to adjacent organs (including pancreas) through the bile ducts.
	cancer.stanford.edu /gastrocolo/cholangiocarcinoma.html (613 words)

	eMedicine - Cholangiocarcinoma : Article Excerpt by: Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR
		Background: Cholangiocarcinoma is a slow-growing malignancy of the bile duct.
		Biliary ductal calculi occur in 20-50% of patients with cholangiocarcinoma; however, the association of gallstones with cholangiocarcinoma is less marked than it is with carcinoma of the gallbladder.
		The incidence of cholangiocarcinomas in patients with ulcerative colitis is 0.4-1.4%, with a latent period of 15 y.)
	www.emedicine.com /radio/byname/cholangiocarcinoma.htm (558 words)

	Primary Liver Tumors (cont.) (Site not responding. Last check: 2007-10-08)
		Intrahepatic cholangiocarcinoma is a relatively rare malignant tumor or cancer of the liver.
		If the intrahepatic cholangiocarcinoma is limited to a portion of the liver that can safely be removed, then resection or removal of this part of the liver is the preferred treatment.
		Intrahepatic cholangiocarcinoma will account for 10 to 20% of the 15,300 cases of primary liver cancer that will be diagnosed in the United States in the year 2000.
	www.vicc.org /showcontent.php?id=334 (2616 words)

	Intrahepatic Cholangiocarcinoma
		Cholangiocarcinoma is the most common primary malignancy of the bile ducts and the second most prevalent liver cancer.
		Infiltrative cholangiocarcinoma is characterized by a focally thickened ductal wall and proximal biliary dilatation.
		Polypoid cholangiocarcinoma is characterized by a dilated bile duct filled with polypoid soft tissue and proximal biliary dilatation.
	brighamrad.harvard.edu /Cases/bwh/hcache/355/full.html (582 words)

	SSAT - 1998 Abstract: EFFECTIVE TOXIN GENE EXPRESSION VIA ADENOVIRAL INFECTION OF HUMAN CHOLANGIOCARCINOMA CELLS IN THE ... (Site not responding. Last check: 2007-10-08)
		Human cholangiocarcinoma cell lines (SK-ChA-1 and Oz) and HeLa, cervical carcinoma cells were infected at 100 plaque forming units (pfu)/cell in serum free media and in media with 10% human bile (filtered sterilized from a patient after Whipple resection).
		Susceptibility of cholangiocarcinoma cells to adenoviral delivered CD or HSV-tk, in the presence of bile was also analyzed.
		Cholangiocarcinoma cytotoxicity was induced with the addition of 5-FC and GCV following adenoviral infection, both in the control medium and bile.
	www.ssat.com /cgi-bin/abstracts/98ddw/abstscorrt-137.cgi?affiliation=other (486 words)

	Cholangiocarcinoma in primary sclerosing cholangitis
		Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study.
		Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis.
		Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis.
	www.ikp.unibe.ch /lab2/pscca.htm (564 words)

	Diagnosis and Treatment of Cholangiocarcinoma -- Anderson et al. 9 (1): 43 -- The Oncologist
		Cholangiocarcinoma is an uncommon malignancy arising from the
		Aggressive surgical resection for hilar-invasive and peripheral intrahepatic cholangiocarcinoma.
		Palliation of irresectable hilar cholangiocarcinoma with biliary drainage and radiotherapy.
	theoncologist.alphamedpress.org /cgi/content/full/9/1/43 (6653 words)

	p990316a - Cholangiocarcinoma (Site not responding. Last check: 2007-10-08)
		Abstract: Cholangiocarcinoma is associated with several etiological factors including cystic dilation of the bile duct, clonorchiasis, hepatolithiasis, and sclerosing cholangitis.
		Tumor markers are often normal, but a significant elevation of carcinoembryonic antigen or CA 19-9 should alert the clinician of a possible diagnosis of cholangiocarcinoma.
		Cholangiogram is essential to dileneate the bile duct anatomy in hilar or distal cholangiocarcinoma.
	www.emory.edu /WHSCL/grady/amreport/litsrch98/p990316a.html (252 words)

	Cholangiocarcinoma - New Treatments, January 2, 2007
		Patients who are sick from PSC can’t be distinguished from patients with primary cholangiocarcinoma with regard to most of the symptoms that most of these patients present with.
		So again, at Mayo, we have tried to develop a protocol which would allow us to transplant patients with cholangiocarcinoma and do something for patients with this abysmal disease, many of whom are young men with PSC who have young families, for whom we certainly want to try to pull out all the stops.
		Well, I think most importantly, with regard to cholangiocarcinoma, we have to continue to talk about surgical resection and I’m going to show you the results of one study which I think is fairly representative of all the studies in the literature over recent years, with regard to resection of this disease.
	www.ccspublishing.com /journals5a/cholangiocarcinoma.htm (497 words)

	ACS :: What Is Bile Duct Cancer?
		Cholangiocarcinoma is another name for a bile duct adenocarcinoma.
		Bile duct hamartomas and bile duct adenomas are benign (non-cancerous) tumors and, therefore, are not discussed further in this document.
		Their prognosis and treatment are not the same as cholangiocarcinomas, and depend on where the cancer started.
	www.cancer.org /docroot/cri/content/cri_2_4_1x_what_is_bile_duct_cancer_69.asp (459 words)

	Biliary - Bilateral Plastic Stent Placement for Cholangiocarcinoma
		Comments: This is a demonstration of ERCP with endoscopic placement of a bilateral biliary plastic stents in an active 94 year old physician with known Klatskin tumor.
		The cholangiogram demonstrates easy filling of the right hepatic ductal system and slower filling of the left ductal system with strictures of the left and right hepatic ducts consistent with the diagnosis of a cholangiocarcinoma.
		The goal of therapy is to first place two biliary guidewires into the left and right biliary systems with subsequent placement of stents in the right and left systems.
	dave1.mgh.harvard.edu /ViewFilms.cfm?Film_id=377 (511 words)

	Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document -- Khan et al. 51 (Supplement 6): ...
		This is elevated in 40–50% of cholangiocarcinoma patients.
		Cholangiocarcinoma: a spectrum of intrahepatic, perihilar and distal tumors.
		Serum tumor markers for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis.
	gut.bmjjournals.com /cgi/content/full/51/suppl_6/vi1 (3167 words)

	Radiologic Spectrum of Cholangiocarcinoma: Emphasis on Unusual Manifestations and Differential Diagnoses -- Lee et al. ...
		Thickening of the bile duct wall (arrowheads) is shown adjacent to the exophytic mass (ie, infiltrative cholangiocarcinoma).
		with cholangiocarcinoma are diffuse and uniform dilatation of
		These imaging findings are difficult to differentiate from those of polypoid cholangiocarcinoma or cholangiocarcinoma with malignant foci, as well as hepatocellular carcinoma with intraductal growth.
	radiographics.rsnajnls.org /cgi/content/full/21/suppl_1/S97 (7086 words)

	Cholangiocarcinoma - WrongDiagnosis.com
		Cholangiocarcinoma is a relatively rare tumor in most populations.
		Early detection of cholangiocarcinomas is difficult, and the overall prognosis after resection is poor (adapted from WHO, 2000).
		Cholangiocarcinoma: Cholangiocarcinoma is listed as a type of (or associated with) the following medical conditions in our database: Cancer, Biliary disorder, Gall bladder conditions, Bile Duct Conditions
	www.wrongdiagnosis.com /medical/cholangiocarcinoma.htm (403 words)

	SSAT - 1997 Abstract: 133 Results of resection for hilar cholangiocarcinoma: American versus Asian experience. (Site not responding. Last check: 2007-10-08)
		Cholangiocarcinoma involving the hepatic hilum is notorious for locoregional extension and surgical inaccesibility.
		This study compares the experiences with management of hilar cholangiocarcinoma at two institutions, one American and one Japanese.
		Conclusion: More liberal use of combined liver and bile duct resection significantly increases the rate of margin-negative resections and is currently the only way to surgically improve the overall survival rate of patients with hilar cholangiocarcinoma.
	www.ssat.com /cgi-bin/abstracts/97ddw/ddw133.cgi?affiliation= (268 words)

	uhrad.com - Body Imaging Teaching Files (Site not responding. Last check: 2007-10-08)
		Diagnosis may be facilitated by PTC, ERCP and CT. In severe cases stricture may prevent complete opacification of the ducts and CT is better able to demonstrate segments which are isolated by severe strictures.
		There is an increased incidence of cholangiocarcinoma and sclerosing cholangitis is considered to be a premalignant condition.
		Rapid, focal progression of disease in a patient with sclerosing cholangitis should increase ones suspicion regarding cholangiocarcinoma.
	www.uhrad.com /ctarc/ct110.htm (343 words)

	Cholangiocarcinoma: Morphologic Classification According to Growth Pattern and Imaging Findings -- Lim 181 (3): 819 -- ...
		Cholangiocarcinoma is a malignant tumor arising from the epithelium
		Intrahepatic cholangiocarcinoma arises from the mucosa of a
		Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnosis.
	www.ajronline.org /cgi/content/full/181/3/819 (3316 words)

	Disease - Cholangiocarcinoma - Hartford, Connecticut
		Nonetheless, by the time a diagnosis is made, many of these tumors are too advanced to be removed surgically.
		A cholangiocarcinoma can arise anywhere along the liver secretion (biliary) ducts.
		Call your health care provider if persistent jaundice or other symptoms of cholangiocarcinoma are present.
	www.saintfranciscare.com /11458.cfm (484 words)

	MR Imaging of Intrahepatic Cholangiocarcinoma: Use of Ferumoxides for Lesion Localization and Extension -- Braga et al. ...
		MR Imaging of Intrahepatic Cholangiocarcinoma: Use of Ferumoxides for Lesion Localization and Extension -- Braga et al.
		The conspicuity of cholangiocarcinoma was improved in all patients
		In hilar cholangiocarcinoma, the intrahepatic tumor spread is
	www.ajronline.org /cgi/content/full/177/1/111 (2050 words)

	Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998 -- Taylor-Robinson et ...
		cholangiocarcinoma are solely caused by an improvement in diagnosis
		Another explanation for the steady rise in ASMR for intrahepatic cholangiocarcinoma between 1968 and 1998 is a true increase
		We have shown a dramatic increase in ASMR and ASpMR for intrahepatic cholangiocarcinoma from 1968 to 1998 in England and Wales.
	gut.bmjjournals.com /cgi/content/full/48/6/816 (2819 words)

	Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage ...
		Fleming,K.A., Boberg,K.M., Glaumann,H., Berquist,A., Smith,D. and Clausen,O.P. (2001) Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis.
		Shimonishi,T., Sasaki,M. and Nakanuma,Y. (2000) Precancerous lesions of intrahepatic cholangiocarcinoma.
		Praet,M.M. and Roels,H.J. (1984) Histogenesis of cholangiomas and cholangiocarcinomas in thioacetamide fed rats.
	carcin.oxfordjournals.org /cgi/content/full/25/4/631 (2606 words)

	Cholangiocarcinoma - Common Bile Duct
		Intrahepatic cholangiocarcinoma with a long-term survival of 12 years after surgical resection: report of a case and review of the literature.
		Chong VF; Heng A. Cholangiocarcinoma complicating ulcerative colitis.
		Bilateral internal biliary drainage of hilar cholangiocarcinoma with modified Gianturco Z stents inserted via a single percutaneous tract.
	home.flash.net /~drrad/tf/081197.htm (373 words)

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