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Topic: Chondroblast

In the News (Mon 21 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Aircast - Research Grants 2001
		It was known that chondroblast differentiation could be induced in vivo by placing implants of demineralized bone powder (DBP) under the skin.
		The long-term goals of the proposed project are to determine the molecular mechanisms by which DBP elicits a chondroblastic response in human dermal fibroblasts and to apply that knowledge for novel strategies for skeletal repair.
		Specific Aim II tests the hypothesis that Wnt-5a is necessary for induction of the chondroblast phenotype in fibroblasts.
	www.aircastfoundation.org /research/profiles/yates.html (602 words)

	hyaline cartilage
		Chondroblasts are found in the chrondrogenic (inner) layer of the perichondrium.
		Fibroblasts because it is in the fibrous layer.
		Chondroblasts because it is in the inner cellular layer.
	www3.umdnj.edu /histsweb/lab4/cartilage/lab4hyaline.html (707 words)

	Orthopaedic Journal at Harvard Medical School - annual publication Harvard Combined Orthopaedic Residency Program ...
		Chondrocytes are long-lived and the development of new cells that are capable of producing cartilage de novo (i.e., chondroblasts) is not a normal part of adult cartilage physiology.
		The fact that WNT genes were altered by DBP was striking because of the importance of that gene family in embryonic chondroblast differentiation and chondrogenesis.
		The potential role of WNT genes in post-natal chondroblast differentiation of hDFs was explored by characterizing WNT component gene expression during culture with DBP, and by activating the WNT/β-catenin signaling pathway in the absence of DBP.
	www.orthojournalhms.org /volume6/manuscripts/ms08.htm (1989 words)

	DREXEL BIOMED: News
		Next, the researchers poured the chondroblast solution into the bottom layer of plastic molds shaped like human mandibular condyles and exposed the solution to UV light, causing it to solidify.
		The resulting condyle-shaped objects, each about the size of a child"s marble, were placed under the skin of immunodeficient mice for up to three months, where the implants absorbed nutrients from the surrounding fluids.
		Later examination of the implants suggested that the osteoblasts and chondroblasts had begun producing normal bone and cartilage tissue, respectively.
	www.biomed.drexel.edu /content/news_events/display_news.cfm?NEWS_ID=202 (660 words)

	Session V Abstracts
		Although the pheonotypic changes associated with chondroblast differentiation have been well characterized, much less is known about the mechanisms underlying these changes.
		Retinoid excess has been associated with congenital malformations of the skeleton, premature closure of the growth plate and reduced bone mass, indicating that many of the stages within the skeletogenic program appear to be affected by retinoids.
		Overexpression of a weak constitutively form of the retinoic acid receptor, RSR, in the limbs of transgenic mice causes appendicular skeletal defects due to an interference of chondrogenesis (J. Cell Biol.
	www.mhecoalition.com /Session_V_Abstracts.html (1265 words)

	PTHrP Regulates Chondrocyte Maturation in Condylar Cartilage -- Rabie et al. 82 (8): 627 -- Journal of Dental Research
		differentiation of mesenchymal cells to chondroblasts (Rabie and Hagg, 2002).
		BrdU-labeled cells in the proliferative layer (P), and the subjacent chondroblast and hypertrophic layers (Sub-P) during natural growth (Cont) and mandibular advancement (Exp).
		chondroblasts in the mandibular condyle (Rabie et al.
	jdr.iadrjournals.org /cgi/content/full/82/8/627 (2697 words)

	Molecular Mechanisms Regulating Chondroblast Differentiation -- Hoffman et al. 85 (Supplement 2): 124 -- Journal of ...
		Molecular Mechanisms Regulating Chondroblast Differentiation -- Hoffman et al.
		a "master switch" for the differentiation of chondroblasts.
		activate p38 MAPK, which in turn induces chondroblast differentiation.
	www.ejbjs.org /cgi/content/abstract/85/suppl_2/124 (494 words)

	Regulation of Skeletal Progenitor Differentiation by the BMP and Retinoid Signaling Pathways -- Weston et al. 148 (4): ...
		to induce the expression of the chondroblastic phenotype in
		by regulating the emergence of chondroblasts from skeletal progenitors.
		Premature chondroblast differentiation is induced by the antagonist
	www.jcb.org /cgi/content/full/148/4/679 (7249 words)

	Controlled conversion of an immortalized mesodermal progenitor cell towards osteogenic, chondrogenic, or adipogenic ... (Site not responding. Last check: 2007-11-02)
		In the absence of cell contact before the addition of inducers, the C1 cells maintain a stable undifferentiated phenotype while expressing potential regulators of embryonic mesodermal stem cell fate such a M-twist and Id1.
		The teratocarcinoma-derived C1 clone behaves as a mesodermal tripotential progenitor cell whose choice of fate, either osteoblast, chondroblast, or adipoblast, is strictly dependent on the spatial organization of the cells and the nature of the induction.
		In the presence of beta glycerophosphate and ascorbate, provided the cells have formed aggregates, 95% of the C1 cells mineralize with a kinetics of gene expression close to that of osteoblasts (Poliard, A., D. Lamblin, P. Marie, M. Buc, and O. Kellerman.
	www.ihop-net.org /UniPub/iHOP/gp/369221.html (265 words)

	Champion Alstoe Animal Health Inc.
		The original fibers and matrix of cartilage are formed by cells called chondroblasts.
		Each chondroblast becomes surrounded by the fibers and matrix that it produces.
		When the cartilage formation is complete, the chondroblast produces only enough matrix to maintain the cartilage.
	www.championalstoe.com /prosamine.html (1710 words)

	Requirement for RAR-mediated gene repression in skeletal progenitor differentiation -- Weston et al. 158 (1): 39 -- The ...
		To confirm the influence of RAR activity on chondroblast differentiation,
		to describe the molecular regulation of chondroblast differentiation.
		the expression of a gene(s) whose function is to inhibit chondroblast
	www.jcb.org /cgi/content/full/158/1/39 (8381 words)

	Chondroblastoma - Children's Hospital Boston
		Chondroblastoma is a rare, benign bone tumor comprised of cells that produce cartilage, known as chondroblasts.
		Chondroblastoma is one of the few benign bone tumors that have the potential to metastasize (spread) to the lungs.
		Chondroblastoma occurs when a single chondroblast (cell that produces cartilage) abnormally divides out of control.
	www.childrenshospital.org /az/Site1039/mainpageS1039P0.html (954 words)

	Developmental Disorders of Bones (Site not responding. Last check: 2007-11-02)
		The three main constituents of the bone tissue are derived form one type of mesoblast, which has differentiated into fibroblast with collagen as intercellular substance, chondroblast with chondroid as intercellular substance and osteoblast with osteoid as intercellular substance.
		Heterotropoic proliferation of chondroblasts of the growth plats e.g.
		Abnormal maturation of chondroblasts of the growth plate.
	www.bonetumour.org /book/APTEXT/chapter3/ch3_sub1.html (535 words)

	Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells -- Qi et al. ...
		of MPCs induced to differentiate to chondroblasts and osteoblasts,
		and MPCs induced to the osteoblast lineage or to the chondroblast
		to osteoblasts and chondroblasts to identify TFs and signaling
	www.pnas.org /cgi/content/full/100/6/3305 (4515 words)

	Osteoblast and chondroblast differentiation. (Site not responding. Last check: 2007-11-02)
		Osteoblast and chondroblast differentiation.A variety of other molecules are also upregulated in the mature OB, including epsilon BP and CD44s.
		Recently, we have focused on the osteoprogenitors that divide and differentiate into mature OBs forming bone nodules in fetal rat calvaria cell cultures.
		By replica plating and PCR, we have begun to study the expression of the messenger RNAs (mRNAs) for potential regulatory molecules (e.g., PTHrP) and their receptors (e.g., PTHR, FGFR-1, and PDGFR alpha) and have found all to be modulated during the progression from committed osteoprogenitor to mature OB.
	www.ihop-net.org /UniPub/iHOP/gp/497576.html (259 words)

	Laboratory Six: Cartilage, Bone and Bone Development
		On the surface of the tracheal ring identify the perichondrium.
		The perichondrium contains fibroblast-like cells and cells that give rise to chondroblasts.
		In the HandE preparation, the elastic fibers are best seen at higher magnification.
	medinfo.ufl.edu /year1/histo/review/lab06.html (853 words)

	TUMOURS OF BONE (Site not responding. Last check: 2007-11-02)
		This is useful to understand the pathogenesis of the tumour.
		Tumours of the bone arise from any of the following type cells constituting bone tissue such as osteoblast, chondroblast and fibroblast.
		The following the classification based on the basic tissue cell type giving rise to the tumour under general groupings as Benign and Malignan.
	www.bonetumour.org /book/APTEXT/chapter9/ch9_sub1.html (1375 words)

	Bone Morphogenetic Protein-6 Production in Human Osteoblastic Cell Lines . Selective Regulation by Estrogen -- Rickard ...
		Bone morphogenetic proteins (BMPs) induce differentiation of osteoblast and chondroblast lineage cells from uncommitted mesenchymal
		Because estrogen affects key aspects of bone growth and remodeling and because the BMPs represent a novel class of cytokines
		chondroblastic lineage cells, we tested the hypothesis that estrogen
	www.jci.org /cgi/content/full/101/2/413 (5627 words)

	Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation ...
		Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation -- Fujii et al.
		Asahina, I., Sampath, T.K., and Hauschka, P.V. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells.
		Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V. Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria.
	www.molbiolcell.org /cgi/content/full/10/11/3801 (6146 words)

	eMedicine - Chondromyxoid Fibroma : Article Excerpt by: Hannah D Morgan, MD (Site not responding. Last check: 2007-11-02)
		Please click here to view the full topic text: Chondromyxoid Fibroma
		Background: Chondromyxoid fibroma (CMF) is a rare slow-growing bone tumor of chondroblastic derivation.
		Jaffe and Lichtenstein first described the condition in 1948.
	www.emedicine.com /orthoped/byname/chondromyxoid-fibroma.htm (291 words)

	[No title]
		In short, a bone-chewing cell Growth and Healing of Bone Endochondral ossification (invasion of blood (apoptosis and replacement of chondroblast with osteoblast.
		During the healing process, first there is rapid deposit of soft tissue, inflammation and blood clot formation.
		Dr.Rubin showed a histological slide of a growth plate: chondroblast are laid down, they look like a stack of pennies.
	www.uhmc.sunysb.edu /som/students/2003/Lectures/CT/CT12.doc (2242 words)

	Understanding Adipocyte Differentiation -- GREGOIRE et al. 78 (3): 783 -- Physiological Reviews
		behave as progenitor cells with osteoblast, chondroblast, or adipoblast
		Our current understanding of adipocyte differentiation indicates that a pluripotent stem cell precursor gives rise to a mesenchymal precursor cell with the potential to differentiate along mesodermal lineages of myoblast, chondroblast, osteoblast, and adipocyte.
		As discussed in text, given appropriate environmental and gene expression cues, preadipocytes undergo clonal expansion and subsequent terminal differentiation.
	physrev.physiology.org /cgi/content/full/78/3/783 (8338 words)

	eMedicine - Chondromyxoid Fibroma : Article by Hannah D Morgan, MD (Site not responding. Last check: 2007-11-02)
		Synonyms and related keywords: CMF, bone tumor, chondroblast, chondrosarcoma, benign tumor
		Chondrosarcomas tend to behave in a more malignant fashion, with more severe symptoms and faster growth, extraosseous invasion, and metastases than CMF.
		Chondroblastoma and CMF typically occur in the individuals of the same age group and may have very similar histologic features, including chondroblastic differentiation, numerous giant cells, and a markedly positive S-100 stain result; thus, they may be very difficult to distinguish.
	www.emedicine.com /orthoped/topic471.htm (2910 words)

	Steve Harris Oral Biology Faculty Publications Page
		Xu C, Brown D, Olson EN, Harris MA, Mundy GR, Harris SE.
		The basic-Helix loop-Helix transcription factor, Scleraxis, regulates chondroblast differentiation by inhibition of BMP2 expression.
		Xu C, Harris MA, Rubenstein JLR, Mundy GR, Harris SE. (2001) Bone Morphogenetic Protein-2 Signaling to the Col2µ1 Gene in Chondroblasts Require Homeobox Gene Dlx2. DNA and Cell Biology 20(6): 359-365.
	dentistry.umkc.edu /oralbiology/harris_pub.htm (498 words)

	Mediaphys
		Scramble the list of structures in the diagrams; they are presently in the same order as the numbers.
		Flashcards - Error: a chondroblast is a cartilage producing cell, whereas a chondrocyte is a mature cartilage cell.
		Module 2 Body Fluids Visual effect: good Accuracy: Add Mg++.
	faculty.southwest.tn.edu /rburkett/mediaphys.htm (1945 words)

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