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Topic: Chondrocyte

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In the News (Sun 18 Aug 19)

  Autologous Chondrocyte Implantation
Ideally, candidates for autologous chondrocyte implant should be between 15 and 45 years of age, have full thickness localized defects of the femoral condyles, have intact menisci, have no generalized chondromalacia, have no limb misalignment and are willing and able to undergo vigorous rehabilitation.
The TEC assessment noted that three of the four components of autologous chondrocyte implantation -- use of a periosteal flap, debridement and rehabilitation – are not unique to autologous chondrocyte implantation, and these components of the procedure may account for some or all of the clinical improvements noted in uncontrolled studies of this procedure.
The assessment noted that most of the available evidence for autologous chondrocyte implant is from uncontrolled case series, and that this literature is subject to bias because of the inherent weakness of case series.
www.aetna.com /cpb/medical/data/200_299/0247.html   (2607 words)

  Autologous Chondrocyte Implantation (ACI):
Meniscal cartilage is on the tibia and serves mostly as a shock absorber.
Autologous Chondrocyte Implantation is used to repair defects to the articular cartilage.
However, when the cartilage is damaged, the chondrocytes' distance from a blood supply means that they lack the ability to regenerate themselves, a process that requires an increased amount of nutrients and access through the blood stream to other cells and proteins that stimulate the regeneration.
biomed.brown.edu /Courses/BI108/BI108_1999_Groups/Cartilage_Team/christine/HowitWorks.html   (731 words)

 Autologous Chondrocyte Transplantation
Chondrocytes are separated by filtration, and the isolated chondrocytes are cultivated in culture medium for 11-21 days.
The authors state that further investigation is needed to determine if it is the transplanted autologous chondrocytes or the mesenchymal cells of the periosteal flap that develop in to the cellular component of the regenerated tissue.
Histologic appearance of reconstructed cartilage with chondrocytes and expression of collagen II, characteristic of hyaline cartilage was noted in those cases that underwent follow-up arthroscopy and biopsy.
www.regence.com /trgmedpol/surgery/sur87.html   (4190 words)

 NGC - NGC Summary
Three studies were reviewed that examined autologous chondrocyte implantation's (ACI's) cost-effectiveness.
Autologous chondrocyte implantation (ACI) may treat patients with cartilaginous defects of the femoral condyle.
Autologous chondrocyte implantation (ACI) may benefit some patients with full-thickness chondral defects involving the surface of the femoral condyle.
www.guideline.gov /summary/summary.aspx?ss=15&doc_id=4392&nbr=3310   (1265 words)

 The Physician and Sportsmedicine: Articular Cartilage Injury and Autologous Chondrocyte Implantation
Among such techniques is autologous chondrocyte implantation, in which a patient's own cartilage cells are harvested, grown ex vivo, and reimplanted in a full-thickness articular surface defect.
Once chondrocytes have grown to about 2.6 million to 5 million cells, they are ready for implantation, typically 11 to 21 days later.
Minas T: Chondrocyte implantation in the repair of chondral lesions of the knee: economics and quality of life.
www.physsportsmed.com /issues/2000/11_00/wroble.htm   (2939 words)

 Chondrocyte Implantation: Orthopaedic Specialists and Hand Surgical Associates
HOME > Bryn Mawr Cartilage Restoration Center > Chondrocyte Implantation
Autologous chondrocyte implantation is a technique to restore cartilage from your own knee in the area of the cartilage injury.
The technique first involves performing an arthroscopy and taking a small piece of cartilage from your knee (biopsy), which is then sent to a lab in Boston.
www.orthspec.com /chondrocyte_implantation.htm   (231 words)

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