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Topic: Chromosome 10 (human)

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	Human chromosomes 9 and 10 completed
		Chromosome 9 harbours four genes that can cause sex-reversal, all the human interferon type 1 genes (interferon is important in suppressing cancer development and in resisting virus infection), a gene implicated in neurodegenerative disease (CHAC), as well as a gene (abl) that is involved in 90 per cent of chronic myeloid leukaemia (CML) cases.
		Also of interest is the number of genes sharing the same space; 15 per cent of genes on chromosome 10 are found as overlapping pairs: conventionally it is thought that each gene occupies a unique region of DNA sequence.
		The two chromosome sequences point to the rich variety in our genome: chromosome 9 is peppered with regions copied from elsewhere in the genome; chromosome 10 is rich in overlapping genes.
	www.wellcome.ac.uk /en/genome/thegenome/hg01n012.html (500 words)

	Chromosome 10 - Genetics Home Reference
		Chromosome 10 is one of the 23 pairs of chromosomes in humans.
		Chromosome 10 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.
		Genes on chromosome 10 are among the estimated 20,000 to 25,000 total genes in the human genome.
	ghr.nlm.nih.gov /chromosome=10 (401 words)

	Human to Mouse Homology Region Map, Chromosome 10 (Site not responding. Last check: 2007-10-15)
		Human to Mouse Homology Region Map, Chromosome 10
		Gene order has been changed from that shown in the chromosome committee reports or online databases, as required by high-resolution human physical mapping data; these data also indicate a probable difference between human and mouse organization, e.g.
		The asterisk character ('') is used to indicate a different region of homology on the same mouse chromosome*.
	www.ncbi.nlm.nih.gov /Omim/Homology/human10.html (298 words)

	GNN - Human Chromosomes 9 and 10 Are Complete (Site not responding. Last check: 2007-10-15)
		The chromosome also carries genes implicated in cancer, and XY “sex reversal,” a rare condition that occurs when a person is physically female but has male sex chromosomes.
		Chromosome 10 carries genes linked to cancer and epilepsy, as well as genes associated with susceptibility to diseases like diabetes, schizophrenia, obesity, and Alzheimer’s.
		The other finished human chromosomes are 6, 7, 13, 14, 19, 20, 21, 22, and the Y. For more news visit GNN’s Chromosome Page.
	www.genomenewsnetwork.org /articles/2004/05/26/chromosomes.php (272 words)

	New evidence for Alzheimer's gene on chromosome (Site not responding. Last check: 2007-10-15)
		Researchers found evidence for a gene on human chromosome 10 that, in combination with the previously identified Alzheimer's gene APOE E4, significantly increases the risk for people with family histories of Alzheimer's to develop the disease.
		The precise location of the new susceptibility gene could not yet be determined, but it appears to be in a small segment of chromosome 10.
		"Though a draft sequence of the human genetic code was announced almost a year ago, the sequence for this portion of chromosome 10 still has holes in it, which impedes progress in pinpointing the gene," Zubenko was quoted as saying in the Pittsburgh Post-Gazette.
	www.genomenewsnetwork.org /articles/06_01/Alzheimers_chrom_10.shtml (250 words)

	Perfect Conserved Linkage Across the Entire Mouse Chromosome 10 Region Homologous to Human Chromosome 21 -- Wiltshire ...
		Genome cross-referencing and XREFdb: Implications for the identification and analysis of genes mutated in human disease.
		Physical mapping of the evolutionary boundary between human Chromosomes 21 and 22 on mouse Chromosome 10.
		Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3.
	www.genome.org /cgi/content/full/9/12/1214 (3988 words)

	Human Genetics - UPD Paternal Chromosome 10 (Site not responding. Last check: 2007-10-15)
		The paternal chromosome is shown on the right.
		Ledbetter, D.H. and Engel, E. (1995): Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis.
		Morison, I.M. and Reeve, A.E.(1998): A catalogue of imprinted genes and parent-of-origin effects in humans and animals.
	www.genes.uchicago.edu /upd/upd10p.html (57 words)

	Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene ... (Site not responding. Last check: 2007-10-15)
		Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21.
		Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21.Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family.
		In addition, using an interspecific backcross panel, we have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/8206730.html (161 words)

	The gene for mannose-binding protein maps to chromosome 10 and is a marker for multiple endocrine neoplasia type 2.
		The gene for mannose-binding protein maps to chromosome 10 and is a marker for multiple endocrine neoplasia type 2.
		The gene for mannose-binding protein maps to chromosome 10 and is a marker for multiple endocrine neoplasia type 2.Human mannose-binding lectin (MBL) is a serum protein which appears to function as an opsonin in first line host defense.
		The addition of MBL to the genetic map of the pericentromeric region of chromosome 10 should prove useful for improved localization of the MEN2A mutation.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/29622.html (190 words)

	Conserved Synteny in Rat and Mouse for a Blood Pressure QTL on Human Chromosome 17 -- Zimdahl et al. 39 (6): 1050 -- ...
		on human chromosome 17 and rat chromosome 10 are syntenic.
		Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.
		Human hypertension caused by mutations in WNK kinases.
	hyper.ahajournals.org /cgi/content/full/39/6/1050 (1315 words)

	SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12.
		SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12.We report cloning a cDNA that encodes a novel short-chain dehydrogenase/reductase, SDR-O, conserved in mouse, human and rat.
		Human and mouse liver express SDR-O (short-chain dehydrogenase/reductase-orphan) mRNA intensely.
		Human SDR-O localizes on chromosome 12; mouse SDR-O localizes on chromosome 10 with CRAD1, CRAD2 and RDH4.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/9310652.html (174 words)

	Nature web focus: The Human Genome (Site not responding. Last check: 2007-10-15)
		Mutations of the RET proto-oncogene in Hirschsprung's disease.
		The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X
		A high-resolution recombination map of the human genome
	www.nature.com /nature/focus/humangenome/10.html (97 words)

	The Sanger Institute: Human Chromosome 10 Project Overview
		The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs.
		It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome.
		Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.
	www.sanger.ac.uk /HGP/Chr10 (191 words)

	Report of Chromosome 10 Workshop (Site not responding. Last check: 2007-10-15)
		As an example, the determination of the breakpoint of a paracentric inversion of urangutan chromosome 7 (syntenic of human chromosome 10) on a single YAC clone, was presented.
		Figure 4 illustrates genes from human chromosome 10 and their syntenic regions on mouse chromosomes 2, 18, 6 (human 10p arm) and 14, 10, 19 and 7 (human 10q arm).
		Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.
	ihg.gsf.de /chr10/report_text.html (5346 words)

	NFI søk: litteratur: A multiple interval physical map of the pericentromeric region of human chromosome 10. (Site not responding. Last check: 2007-10-15)
		NFI søk: litteratur: A multiple interval physical map of the pericentromeric region of human chromosome 10.
		A multiple interval physical map of the pericentromeric region of human chromosome 10.
		Tunnacliffe, et al.: A multiple interval physical map of the pericentromeric region of human chromosome 10.
	dbh.nsd.uib.no /nfi/litteratur/?key=310505 (90 words)

	[No title]
		The ultimate goal of the project is to determine the sequence of all human genes and develop tools for using this information in human biology and medicine.
		Human chromosome 10 is a medium size sub-metacentric chromosome representing 4.6% of the total length of the autosomes.
		Our current work for the improvement of the genetic map of chromosome 10 and its correlation with the physical and the cytogenetic map includes further screening of the CEPH families with novel microsatellite markers, either identified locally after systematic screening of chromosome 10-specific genomic libraries or provided through the EUROGEM network.
	www.imbb.forth.gr /groups/mammals/projects/HumChrom10.html (539 words)

	Chromosome 10 Human Genome Landmarks Poster
		These regions reflect the unique patterns of light and dark bands seen on human chromosomes that have been stained to allow viewing through a light microscope.
		Chromosomal regions that vary in staining intensity and are sometimes called heterochromatin (meaning "different color").
		(e.g., on chromosome 21) denote variable regions, called stalks, that connect a very small chromosome arm (a "satellite") to the chromosome.
	www.ornl.gov /hgmis/posters/chromosome/chromo10.html (348 words)

	Human Aldolase Chromosomal locations (Site not responding. Last check: 2007-10-15)
		The chromosomal locations of the HUMAN aldolase genes provides insight into their tissue-specific and developmentally regulated expression and evolution.
		Spot-blot analysis of sorted chromosomes mapped human aldolase A to chromosome 16, aldolase C to chromosome 17, a pseudogene to chromosome 10, and the aldolase B gene to chromosome 9 (1,2).
		These locations on similar chromosome pairs predict that the aldolase pseudogene arose when sequences from the aldolase A gene were inserted into the homologous aldolase location on chromosome 10 (2).
	www.bu.edu /aldolase/lab/aldolase/molecular/location.html (262 words)

	The Sanger Institute: Human Chromosome 1 Project Overview
		Chromosome 1 is the largest human chromosome and comprises approximately 300Mb of DNA (approximately 10% of the human genome).
		Our aim, in close collaboration with the chromosome 1 community, is to construct a comprehensive map of human chromosome 1, including all genes and other biologically important sequences, up to the level of the DNA sequence itself.
		In order to determine the complete genomic sequence of the chromosome 1, we are sequencing minimal tiling paths from our bacterial clone contigs.
	www.sanger.ac.uk /HGP/Chr1 (153 words)

	Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 -- ...
		are syntenic to an interstitial fragment of mouse chromosome
		10 Lamb, J., Wilkie, A.O.M., Harris, P.C., Buckle, V.J., Lindenbaum, R.H., Barton, N.J., Reeders, S.T., Weatherall, D.J. and Higgs, D.R. (1989) Detection of breakpoints in submicroscopic chromosomal translocation, illustrating an important mechanism for genetic disease.
		63 Kamei, M., Webb, G.C., Young, I.G. and Campbell, H.D. (1998) SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zin-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia).
	hmg.oupjournals.org /cgi/content/full/10/4/339 (7118 words)

	The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate ...
		The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome -- Bentley et al.
		The absence of exon 10 in isoform 2 is deduced to cause a frameshift at amino acid 347 and creates 57 amino acids of new sequence showing no similarity with zinc carboxypeptidase.domain (shown in a hatched box).
		Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue - and isoform-specific fashion.
	jmg.bmjjournals.com /cgi/content/full/40/4/249 (5320 words)

	Dr. N.K. Moschonas' Recent Publications (Site not responding. Last check: 2007-10-15)
		Human hepatocyte nuclear factor-4 gene (hHNF-4) maps to chromosome 20q12-q13.2 between D20S44 (PLC1) and D20S17.
		Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP.
		Map integration at human chromosome 10: molecular and cytogenetic analysis of a chromosome-specific somatic cell hybrid panel and genomic clones, based on a well-supported genetic map.
	www.imbb.forth.gr /people/moschon/NewNMPublications.html (305 words)

	The Chromosome 10 Monosomy Common in Human Melanomas Results from the Loss of Two Separate Tumor Suppressor Loci -- ...
		Alteration of chromosome 10 is common in human melanomas and
		PCR primers specific for human PTEN exons 1 and 8 (42) were used to determine whether PTEN was present (+) or absent (-) in the donor cell lines.
		Early passage cells contained an intact transferred copy of chromosome 10, whereas later passage cells have lost all transferred material distal to 10q22.3 (D10S201) due to IVLOH (28).
	cancerres.aacrjournals.org /cgi/content/full/59/15/3596 (4422 words)

	Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10 -- ...
		Inherited thrombocytopenia is a rare human condition that is frequently mistaken for an acquired platelet disorder.
		Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2.
		Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.
	www.bloodjournal.org /cgi/content/full/96/1/118 (4854 words)

	HUMAN CHROMOSOME #10 (Site not responding. Last check: 2007-10-15)
		Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MX11 to human chromosome 10 and mouse chromosome 19.
		Chromosomal localization of gene encoding the transcrition factors, c-rel, NF-kappaBp50, NF-kappaBp65, and lyt-10 by fluorescence in situ hybridization.
		Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenoxin to 11q22; adrenoxin reductase to 17q24-25; and P450c17 to 10q24-q25.
	www.il-st-acad-sci.org /genecats/hsa10.html (459 words)

	The Role of Wnk4 in Polygenic Hypertension: A Candidate Gene Analysis on Rat Chromosome 10 -- Monti et al. 41 (4): 938 ...
		Schematic representation of chromosome 10 congenic W.S10-BP/SP-1b strain.
		The rat and human Wnk4 protein are highly conserved (93%) in the predicted amino acid sequence.
		Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
	hyper.ahajournals.org /cgi/content/full/41/4/938 (2518 words)

	[Genome] synteny bug
		I compared our site with Ensembl, and we both agree that chr19:53,000,000-57,000,000 on mouse is syntenic with a region on human chromosome 10.
		Coincidentally, we also both agree that mouse chr19:5,300,000-5,700,000 is syntenic with a region on human chromosome 11.
		The result shows from Golden Path is chromosome 11 in > > human, which is not consistant from ensymble and ncbi (their results show > > the synteny for the same region as human chromosome 10).
	www.cse.ucsc.edu /pipermail/genome/2003-September/003044.html (227 words)

	Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia -- Haviernik et al. 83 ...
		Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia -- Haviernik et al.
		Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia
		Schmidt, M., Nazarov, V., Stevens, L., Watson, R. and Wolff, L. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis.
	vir.sgmjournals.org /cgi/content/full/83/4/819 (4545 words)

	Neocentromeres and human artificial chromosomes: An unnatural act -- Willard 98 (10): 5374 -- Proceedings of the ...
		in the human genome, from many different chromosomal regions (8-10).
		Minichromosomes, generated by telomere-associated truncation (27, 28), can be formed from either centromeric or neocentromeric chromatin that already possesses the epigenetic modifications necessary for functional centromere competence (18).
		In contrast, human artificial chromosomes can be generated de novo from isolated centromeric DNA (alpha satellite; refs.
	www.pnas.org /cgi/content/full/98/10/5374 (1910 words)

	Comparative Maps of Human 19p13.3 and Mouse Chromosome 10 Allow Identification of Sequences at Evolutionary Breakpoints ...
		Comparative Maps of Human 19p13.3 and Mouse Chromosome 10 Allow Identification of Sequences at Evolutionary Breakpoints -- Puttagunta et al.
		Comparative Maps of Human 19p13.3 and Mouse Chromosome 10 Allow Identification of Sequences at Evolutionary Breakpoints
		Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution
	www.genome.org /cgi/content/abstract/10/9/1369 (572 words)

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