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Topic: Chromosome 11 (human)

	Chromosome 11 - Genetics Home Reference
		Chromosome 11 is one of the 23 pairs of chromosomes in humans.
		Chromosome 11 spans about 134 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.
		Genes on chromosome 11 are among the estimated 20,000 to 25,000 total genes in the human genome.
	www.ghr.nlm.nih.gov /chromosome=11 (389 words)

	Human Genetics - UPD Maternal Chromosome 11 (Site not responding. Last check: 2007-11-05)
		The maternal chromosome is shown on the left.
		Ledbetter, D.H. and Engel, E. (1995): Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis.
		Morison, I.M. and Reeve, A.E.(1998): A catalogue of imprinted genes and parent-of-origin effects in humans and animals.
	www.genes.uchicago.edu /upd/upd11m.html (57 words)

	Identification of Possible Human Liver Tumor Suppressor Genes - DERT
		Background: Several distinct regions of human chromosome 11 demonstrate loss of heterozygosity or confer tumor suppression in chromosome transfer studies in specific types of human tumors, including liver cancer, suggesting the presence of multiple tumor suppressor genes on this chromosome.
		By developing a model in which human chromosome 11 was introduced into a rat liver tumor cell line this laboratory was able to create a new cell line that exhibits suppression of tumorigenicity.
		In preliminary analyses in four human carcinoma cell lines, the transcript of one gene, p53-induced protein (PIG11), was lost or significantly decreased in two of the lines identifying this gene for potential involvement in some human liver carcinomas.
	www.niehs.nih.gov /dert/profiles/hilites/2003/livergen.htm (264 words)

	Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human ... (Site not responding. Last check: 2007-11-05)
		Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
		Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2.
		Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/153077.html (177 words)

	Chromosome 11 (Site not responding. Last check: 2007-11-05)
		Chromosome 11, Partial Monosomy 11q is a rare chromosomal disorder in which a portion of the long arm (q) of chromosome 11 is missing (deleted or monosomic).
		Chromosome 11 / chromosome 11q.The European chromosome 11q network provides information on people with anomalies on chromosome 11 and especial the long arm of 11, 11q, as a reference guide for both parents and clinicians.
		Chromosome 11, Partial Trisomy 11q is a rare chromosomal disorder in which the end (distal) portion of the long arm (q...
	www.e-dna-tests.info /resources/chromosome-11.html (466 words)

	Human Chromosome 11 2D Map (Site not responding. Last check: 2007-11-05)
		A high resolution CEPH crossover mapping panel and integrated map of chromosome 11
		High resolution (0.1 cM) CEPH crossover mapping panels were constructed for chromosome 11.
		The 2D maps provide the resolution and flexibility needed to enhance current applications such as positional cloning and mapping complex disorders; while the mapping panels will greatly improve the resolution, reliability and efficiency of future genetic mapping.
	www.genlink.wustl.edu /mmp/chr11/11.2d.abs.html (241 words)

	A radiation hybrid map of 506 STS markers spanning human chromosome 11 - Nature Genetics
		Present address: The Wellcome Trust Centre for Human Genetics, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK Correspondence should be addressed to M.R.J. We present a high resolution radiation hybrid map of human chromosome 11 using 506 sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids.
		High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.
		Glaser, T., Rose, E., Morse, H., Housman, D. and Jones, C. A panel of irradiation-reduced hybrids selectively retaining human chromosome 11 p13: their structure and use to purify the WAGR gene complex.
	www.nature.com /doifinder/10.1038/ng0994-70 (882 words)

	Human Genome Research Group (Site not responding. Last check: 2007-11-05)
		Five years ago, in the framework of the international human genome project, and as an integrated part of the chromosome 21 community, we have formed a consortium of academic groups from Germany and Japan to map and sequence this chromosome.
		Analysis of the chromosome revealed 127 known genes, 98 predicted genes, and 59 pseudogenes.
		The completed genome sequences for chromosome 21, as published in Nature on May 18, 2000, are available from here.
	hgp.gsc.riken.go.jp /chr21 (296 words)

	Comparative Analysis of the {alpha}-Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a Mechanism ... (Site not responding. Last check: 2007-11-05)
		-globin cluster on mouse Chromosome 11 (Elliott and Pazik
		ancestral mouse Chromosome 17 and it is proposed that a recombination
		Elliott, R.W. and Pazik, J. An interstitial telomere array near Hba on mouse Chr 11 is a candidate for the homolog of the telomere at human 16p13.3.
	www.genome.org /cgi/content/full/14/4/623 (3616 words)

	The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17. (Site not responding. Last check: 2007-11-05)
		The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17.We report the mapping of the human and mouse genes encoding SEK1 (SAPK/ERK kinase-1), a newly identified protein kinase that is a potent physiological activator of the stress-activated protein kinases.
		The human SERK1 gene was assigned to human chromosome 17 using genomic DNAs from human-rodent somatic cell hybrid lines.
		The mouse Serk1 gene was mapped to chromosome 11, closely linked to D11Mit4, using genomic DNAs from a (C57BL/6J x Mus spretus)F1 x M. spretus backcross.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/635746.html (121 words)

	EUKARYOTIC CHROMOSOME STRUCTURE 11
		Chromosomal derivatives of the nuclear envelope: I. Nuclear pore complexes and their relation to chromosomes.
		GOLOMB, H. Correlation of the fluorescent banding pattern and ultrastructure of a human chromosome.
		Metaphase and chromosome banding are distinct entities of chromosome substructure.
	www.lce.hut.fi /~engelhar/Doc/Diss-Ref.html (2789 words)

	Gene Control
		One function of theses proteins seems to be the folding and packaging of DNA into chromosome form: the 2 m of DNA in a human cell are packaged into 46 chromosomes with a combined length of 200nm (a nm remember is 10-6m).
		Loops (or puffs) in insect chromosomes are areas of active RNA synthesis, suggesting again the functional genes are located in open areas of the chromatin (or, the euchromatin).
		Human beta-globin genes are scattered at five loci on human chromosome 11.
	www.estrellamountain.edu /faculty/farabee/BIOBK/BioBookGENCTRL.html (2832 words)

	A 7.5 Mb Sequence-Ready PAC Contig and Gene Expression Map of Human Chromosome 11p13-p14.1 -- Gawin et al. 9 (11): 1074 ... (Site not responding. Last check: 2007-11-05)
		Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis.
		Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.
		Deletion of chromosome 11p13-11p15.5 sequences in invasive human ovarian cancer is a subclonal progression factor.
	www.genome.org /cgi/content/full/9/11/1074 (5011 words)

	HUGO HGM2005 - Presentation 46 - Detailed gene annotation of human chromosome 11
		The current tiling path of chromosome 11 consists of 8 contigs (ranging from 503kb to 49.6Mb) containing 1121 accessions.
		Chromosome 11 is relatively gene-dense and harbors genes for several well-known disorders such as: Beckwith Wiedemann syndrome, type 1 diabetes, ataxia telangiectasia, and Long QT syndrome.
		Over one-third of all human olfactory receptor genes are on chromosome 11.
	hgm2005.hgu.mrc.ac.uk /Abstracts/Publish/WorkshopOrals/Workshop07/hgm046.html (387 words)

	A complete NotI restriction map covering the entire long arm of human chromosome 11 -- Hosoda et al. 2 (5): 345 -- ... (Site not responding. Last check: 2007-11-05)
		BACKGROUND: Human chromosome 11 is one of the autosomes on which many disease genes have been mapped.
		CONCLUSIONS: The restriction map of the entire long arm of human chromosome 11 is the longest restriction map of the human genome.
		This mapping has disclosed unique features regarding the organization of the chromosome, indicating that restriction sites of NotI, a CpG-recognition enzyme, are primarily distributed in R (or T) bands and that genetic distance is considerably longer in R (or T) bands than in G bands.
	www.genestocellsonline.org /cgi/content/abstract/2/5/345 (339 words)

	HUMAN CHROMOSOME #11 (Site not responding. Last check: 2007-11-05)
		Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
		Chromosomal localization of gene encoding the transcrition factors, c-rel, NF-kappaBp50, NF-kappaBp65, and lyt-10 by fluorescence in situ hybridization.
		Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenoxin to 11q22; adrenoxin reductase to 17q24-25; and P450c17 to 10q24-q25.
	www.il-st-acad-sci.org /genecats/hsa11.html (707 words)

	Chromosome 11, Partial Trisomy 11q
		It is possible that the main title of the report Chromosome 11, Partial Trisomy 11q is not the name you expected.
		Chromosome 11, Partial Trisomy 11q is a rare chromosomal disorder in which the end (distal) portion of the long arm (q) of the 11th chromosome appears three times (trisomy) rather than twice in cells of the body.
		Chromosomal analysis is necessary for a definite diagnosis.
	www.bchealthguide.org /kbase/nord/nord1021.htm (393 words)

	Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regions -- Hitchins et al. 38 ... (Site not responding. Last check: 2007-11-05)
		hetero- and isodisomy for chromosome 7, with a homozygous mutation
		An ideogram of human chromosome 7 is shown with vertical fl bars indicating the two SRS candidate regions on both the p and q arm.
		Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.
	jmg.bmjjournals.com /cgi/content/full/38/12/810 (7291 words)

	Spatial organization of active and inactive genes and noncoding DNA within chromosome territories -- Mahy et al. 157 ... (Site not responding. Last check: 2007-11-05)
		chromosome territory subdomains and the expression of tissue-restricted
		The spatial organisation of human chromosomes in the nuclei of normal and emerin-mutant cells.
		Williamson, K.A. Involvement of the WT1 and PAX6 genes in Wilms' tumour and human malignant mesothelioma.
	www.jcb.org /cgi/content/full/157/4/579 (7285 words)

	Johns Hopkins - Brady Urological Institute- Prostate Cancer Update
		Through painstaking lab work, he and colleagues are adding human chromosomes from normal cells to these nasty, metastatic cancer cells.
		It's a form of "roll call," in which they're testing, one by one, all 23 pairs of chromosomes in the human body.
		Among the most exciting is on chromosome 11, where "we've not only identified the region" (the cancer-suppressing "neighborhood" is on the chromosome's short, or petite arm, called the "P" arm) "but we've cloned and tested the genes.
	urology.jhu.edu /newsletter/newsletter.php?var=416.php&id=4 (2470 words)

	In this paper I will be studying chromosome 11 of the human genome.
		In this paper I will be studying chromosome 11 of the human genome.
		Below is a short sample of the essay "In this paper I will be studying chromosome 11 of the human genome.".
		Alan Gandy summarizes Wilms tumor as an "embryonal renal neoplasm which is characterized usually by an abdominal mass."(Gandy, 1 March 1995) Wilms tumour is caused by the deletion of the gene WT2-1 on chromosome 11p13.
	www.coursework.info /i/70065.html (393 words)

	Role of human chromosome 11 in determining surface antigenic phenotype of normal and malignant cells. Somatic cell ...
		Role of human chromosome 11 in determining surface antigenic phenotype of normal and malignant cells.
		chromosome 11, and surface expression of all eight antigens was studied.
		chromosome 11 permitted the regional assignment of genes controlling
	www.jem.org /cgi/content/abstract/162/5/1603 (292 words)

	Variable Numbers of Pepsinogen Genes are Located in the Centromeric Region of Human Chromosome 11 and Determine the ... (Site not responding. Last check: 2007-11-05)
		A panel of 26 mouse--human somatic cell hybrids containing different human chromosome complements was analyzed with a cloned human pepsinogen cDNA probe to determine the chromosomal location and the number of genes encoding these proteins.
		Examination of somatic cell hybrids containing single copies of chromosome 11 and the corresponding human parental cell lines revealed a restriction fragment length polymorphism determined by pepsinogen haplotypes that contained two or three genes, respectively.
		Concurrent studies of DNA from individuals exhibiting the most common pepsinogen electrophoretic phenotypes with exon-specific probes demonstrated that the absence of one gene among the different restriction fragment patterns correlated with the absence of one specific isozymogen (Pg 5).
	www.pnas.org /cgi/content/abstract/82/18/6240 (319 words)

	Julie R. Korenberg \| Molecular Genetics \| Neurogenetics
		The Visible Genetic Map of Human Chromosome 11.
		Thirty BACs for 27 STS markers on chromosome 11 were labelled with one of six color combinations in groups of 1-3.
		All DNAs were hybridized simultaneously and images were collected as described in the methods.
	www.csmc.edu /csri/korenberg/chroma11.html (144 words)

	Human and Mouse Genomic Sequencing (Site not responding. Last check: 2007-11-05)
		Search all the Human Genomic Sequences determined at the University of Oklahoma Using Blastn, TBlastn or TBlastx on the OU Server.
		Search all the Human Genomic Sequences determined at the University of Oklahoma Using Blastall on the OU Server.
		Ian Dunham and collegues at the Sanger Center have developed and are maintaining an WebAce version of the human chromosome 22 database.
	www.genome.ou.edu /human.html (301 words)

	Human Chromosome 11
		Human Chromosome 11 -- Riken Genomic Sciences Center
		Human Genome Landmarks Poster -- requires ShockWave plugin
		Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y
	www.ornl.gov /sci/techresources/Human_Genome/launchpad/chrom11.shtml (465 words)

	[No title] (Site not responding. Last check: 2007-11-05)
		To search for the existence of tumor- suppressor gene(s) associated with oral squamous cell carcinoma (SCC) on chromosome 11, we have performed high-resolution deletion mapping in 31 patients with oral SCC using 22 microsatellite markers for this chromosomal region.
		LOH was observed in 14 of 25 cases (56.0%) that were informative with at least one locus.
		Our results suggest that at least 2 tumor-suppressor genes involved in the development of oral SCC are present on the long arm of chromosome 11.
	www2n.biglobe.ne.jp /~a-komiya/15.html (202 words)

	Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule ... (Site not responding. Last check: 2007-11-05)
		Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule Assembly and Sperm Tail Function -- Clark et al.
		Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule Assembly and Sperm Tail Function
		11 that is required for spermiogenesis and male fertility.
	www.biolreprod.org /cgi/content/abstract/70/5/1317 (343 words)

	Human Genetics - UPD Paternal Chromosome 11 (Site not responding. Last check: 2007-11-05)
		The paternal chromosome is shown on the right.
		Grundy, P.;Telzerow, P.;Paterson, M. C.;Haber, D.;Berman, B.;Li, F.;Garber, J. Chromosome 11 uniparental isodisomy predisposing to embryonal neoplasms [letter].
		Webb, A.;Beard, J.;Wright, C.;Robson, S.;Wolstenholme, J.;Goodship, J. A case of paternal uniparental disomy for chromosome 11.
	www.genes.uchicago.edu /upd/upd11p.html (203 words)

	Chromosome 11 - Genetics Home Reference
		Is there a standard way to diagram chromosome 11?
		Chromosome 11 likely contains between 1,300 and 1,700 genes.
		Ideograms show a chromosome's relative size and its banding pattern.
	ghr.nlm.nih.gov /chromosome=11 (389 words)

	Human to Mouse Homology Region Map, Chromosome 11
		Gene order has been changed from that shown in the chromosome committee reports or online databases, as required by high-resolution human physical mapping data; these data also indicate a probable difference between human and mouse organization, e.g.
		Subsequent hyperlinks on the marker will provide marker details and hyperlink to the actual Human Gene Map region (by selecting the interval defined by the Genethon Map loci intervals).
		The asterisk character ('') is used to indicate a different region of homology on the same mouse chromosome*.
	www.ncbi.nlm.nih.gov /Omim/Homology/human11.html (298 words)

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