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	Chromosome 13 - Genetics Home Reference
		Chromosome 13 spans about 114 million base pairs (the building blocks of DNA) and represents between 3.5 percent and 4 percent of the total DNA in cells.
		Genes on chromosome 13 are among the estimated 20,000 to 25,000 total genes in the human genome.
		In a small percentage of cases, trisomy 13 is caused by a rearrangement of chromosomal material between chromosome 13 and another chromosome.
	ghr.nlm.nih.gov /chromosome=13 (727 words)

	Chromosome 13, Partial Monosomy 13q
		Chromosome 13, Partial Monosomy 13q is a rare chromosomal disorder in which a portion of the long arm (q) of chromosome 13 is missing (deleted or monosomic).
		Chromosome 13, Partial Monosomy 13q is usually apparent at birth and may be characterized by low birth weight, malformations of the head and facial (craniofacial) area, abnormalities of the eyes, defects of the hands and/or feet, genital malformations in affected males, and/or additional physical abnormalities.
		Chromosome 13 Ring is a rare chromosomal disorder in which chromosome 13 breaks at both ends (i.e., the ends of the long arm [13q] and the short arm [13p]).
	hw.healthdialog.com /kbase/nord/nord643.htm (4288 words)

	Chromosome 13 (human) - Wikipedia, the free encyclopedia
		Chromosome 13 spans about 113 million base pairs (the building material of DNA) and represents between 3.5 and 4 % of the total DNA in cells.
		Retinoblastoma: A small percentage of retinoblastoma cases are caused by deletions in the region of chromosome 13 (13q14) containing the RB1 gene.
		Other chromosomal conditions: Partial monosomy 13q is a rare chromosomal disorder that results when a piece of the long arm (q) of chromosome 13 is missing (monosomic).
	en.wikipedia.org /wiki/Chromosome_13_(human) (573 words)

	ring13.html
		By using chromosome painting, one of the rings of one case was shown to be composed entirely of chromosome 12 material.
		It was done in 13 cases with structurally rearranged chromosomes, seven of them with non-satellited marker chromosomes; in two of the latter an isochromosome 18p was identified which was consistent with a clinical picture of a tetrasomy 18p.
		The small ring chromosome 21 [r(21)], present in only 52% of the patient's blood lymphocytes, did not appear to be associated with the abnormal phenotype since all 13 chromosome 21 markers that were examined in genomic DNA were present in 2 copies, and the phenotype of the patient was consistent with the 18q- syndrome.
	www.indiana.edu /~pietsch/ring13.html (4978 words)

	ABNORMALITIES IN CHROMOSOME STRUCTURE
		Individuals and families have been described with a translocation chromosome abnormality and a concurrent genetic condition; the genetic condition occurring because the chromosome breakpoint is in the midst of a gene.
		The chromosomes are distributed to the daughter cells by the centromeres which are attached to spindle fibers.
		In contradistinction, a numerical chromosome abnormality in a child is presumed to be due to a sporadic cell division error and parental chromosome studies are not indicated.
	med.usd.edu /som/genetics/curriculum/1ECHROM3.htm (1824 words)

	High-Risk Newborn - Trisomy 18 and 13
		Again, trisomy 18 or trisomy 13 simply means there are three copies of the #18 chromosome (or of the #13 chromosome) present in each cell of the body, rather than the usual pair.
		Since trisomy 18 and trisomy 13 each have a unique group of characteristics, a physician may be able to determine simply by physical examination whether a baby has trisomy 18 or 13.
		Chromosomal abnormalities such as trisomy 18 and 13 can be diagnosed before birth by analyzing cells in the amniotic fluid or from the placenta.
	www.musckids.com /health_library/hrnewborn/trisomy.htm (1631 words)

	Trisomy 13 - KP Genetics Northern California
		Trisomy 13 is a rare chromosome abnormality, affecting about one in every 5,000 to 10,000 babies, which involves both severe mental retardation and physical birth defects.
		Chromosomes, which normally come in pairs (one in each pair from the mother, and one from the father), are the packages of genetic material which give the baby instructions for growth and development.
		The extra chromosome was present in either the sperm or the egg which went to form the baby, and this mistake occurred either prior to or just at conception.
	www.dor.kaiser.org /genetics/home/trisomy13.htm (717 words)

	CIGNA - Chromosome 13, Partial Monosomy 13q (Site not responding. Last check: 2007-10-27)
		Chromosome 13, Partial Monosomy 13q is a rare chromosomal disorder in which a portion of the long arm (q) of chromosome 13 is missing (deleted or monosomic).
		Chromosome 13, Partial Monosomy 13q is usually apparent at birth and may be characterized by low birth weight, malformations of the head and facial (craniofacial) area, abnormalities of the eyes, defects of the hands and/or feet, genital malformations in affected males, and/or additional physical abnormalities.
		Chromosome 13 Ring is a rare chromosomal disorder in which chromosome 13 breaks at both ends (i.e., the ends of the long arm [13q] and the short arm [13p]).
	www.cigna.com /healthinfo/nord643.html (4325 words)

	Ring Chromosome 13 Syndrome
		A case of ring 13 syndrome in an 18-year-old male is presented with particular focus on mental retardation.
		Furthermore, in contrast to the characteristic description of ring chromosome 13 syndrome which describes marked mental retardation a small number of cases with mild mental retardation exist.
		Chromosomal analysis performed on 30 peripheral blood lymphocyte by the G-Banding technique revealed ring chromosome 13 in all 30 cells.By high- resolution G-Banding the breakpoints were identified (Fig 2)*.
	www.matsuishi-lab.org /chromosome13.htm (1444 words)

	Trisomy 13 Syndrome
		Trisomy 13 Syndrome is a rare chromosomal disorder in which all or a portion of chromosome 13 appears three times (trisomy) rather than twice in cells of the body.
		Pairs of human chromosomes are numbered from 1 through 22, with an unequal 23rd pair of X and Y chromosomes for males and two X chromosomes for females.
		In most individuals with Trisomy 13 Syndrome, duplication of chromosome 13 is caused by spontaneous (de novo) errors during the division of reproductive cells in one of the parents (e.g., nondisjunction during meiosis).
	hw.healthdialog.com /kbase/nord/nord218.htm (2684 words)

	Trisomy 13 Information on Healthline (Site not responding. Last check: 2007-10-27)
		Trisomy 13, also called Patau syndrome, is a congenital (present at birth) disorder associated with the presence of an extra copy of chromosome 13.
		When an extra copy (trisomy) of a chromosome is made, it may either be a total trisomy (in which an extra copy of the entire chromosome is made), or partial trisomy (in which only one part of the chromosome is made an extra time).
		Seventy-five to 80% of the cases of trisomy 13 are caused by a trisomy of chromosome 13.
	www.healthline.com /galecontent/trisomy-13 (772 words)

	eMedicine - Patau Syndrome : Article by Robert G Best, PhD, FACMG
		Patau syndrome may occur as a freestanding trisomy of chromosome 13 or, more rarely, as a Robertsonian translocation with an extra copy of chromosome 13 attached to another acrocentric chromosome (eg, 13-15, 21, 22) or as a structural chromosome abnormality wherein only a part of chromosome 13 is duplicated.
		Mosaicism for trisomy 13 is associated with a milder degree of severity, with the mildest expression typically in the lowest levels of mosaicism.
		In general, for freestanding trisomy 13, the recurrence risk for trisomy 13 or another clinically viable trisomy (ie, trisomy 21, trisomy 18) is approximately 0.5% above the mother's age-related risk for autosomal trisomies.
	www.emedicine.com /ped/topic1745.htm (2146 words)

	Human Chromosome 13
		Chromosome 13 is the largest human acrocentric chromosome.
		The short arm of the chromosome is heterochromatic and is homologous to the short arms of chromosomes 14, 15, 21 and 22.
		The systematic sequencing of chromosome 13 began at the Sanger Institute in 1998.
	www.sanger.ac.uk /HGP/Chr13 (207 words)

	Patau's syndrome Encyclopedia of Medicine - Find Articles (Site not responding. Last check: 2007-10-27)
		Patau's syndrome, also called trisomy 13, occurs when a child is born with three copies of chromosome 13.
		Trisomy 13 is detectable during pregnancy through the use of ultrasonography, amniocentesis, and chorionic villus sampling.
		The stained chromosomes are examined under a microscope and identified as chromosomes 1-22 and X or Y. There should be two copies each of chromosomes 1-22.
	www.findarticles.com /p/articles/mi_g2601/is_0010/ai_2601001030 (911 words)

	Trisomy 18 and 13 - Children's Hospital of Philadelphia
		Since trisomy 18 and trisomy 13 each have a unique group of characteristics, a physician may be able to determine simply by physical examination whether a baby has either.
		A chromosome analysis -- whether performed on a blood sample, cells from the amniotic fluid, or placenta -- is over 99.9 percent accurate.
		Families who have or have had a baby with trisomy 18 or trisomy 13 are particularly helpful and supportive since they have faced many of the same questions and emotions.
	www.chop.edu /consumer/your_child/condition_section_index.jsp?root_id=0&id=-8770 (1616 words)

	High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH -- Shaughnessy et ... (Site not responding. Last check: 2007-10-27)
		The chromosome length is not to scale and gaps have been placed in the chromosome to indicate large regions of nonlinkage.
		Chromosome 13 myeloma is a distinct entity with poor prognosis despite tandem autotransplants [abstract].
		Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma: Intergroupe Francophone du Myelome.
	www.bloodjournal.org /cgi/content/full/96/4/1505 (4936 words)

	Leukemia - Abstract of article: Deletion of chromosome 13 detected by conventional cytogenetics is a critical ...
		Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
		13 detected by metaphase analysis is a critical prognostic factor in myeloma.
		13, even in those patients yielding only normal or no metaphases, is associated with a relatively good prognosis.
	www.nature.com /doifinder/10.1038/sj.leu.2404304 (360 words)

	Trisomy 13
		Typically, trisomy 13 is recognizable at birth and sometimes even prior to birth due to abnormalities seen on a detailed look at the fetus with ultrasound.
		Trisomy 13 is caused by the presence of an
		A small percentage of people with trisomy 13 may have an extra chromosome 13 in some of their cells but not all of them (this is called mosaicism), or they may have an extra chromosome 13 attached to another chromosome (this is called translocation).
	www.labcorp.com /genetics/genetic_disorders/trisomy_13.html (868 words)

	Dicentric (13;14) Karyotype (Site not responding. Last check: 2007-10-27)
		In this case the entire q, or long arm, plus centromere of a chromosome 13 has been fused with the entire q arm, plus centromere of a chromosome 14.
		There are two normal chromosome 13's plus the chromosome 13 involved with the translocation, thus there are three copies of chromosome 13.
		The chromosome number remains 46 because the long arms of chromosomes 13 and 14 have basically fused into one chromosome.
	members.aol.com /chrominfo/dic1314.htm (179 words)

	MedlinePlus Medical Encyclopedia: Trisomy 13
		Trisomy 13 is a syndrome associated with the presence of a third (extra) number 13 chromosome.
		Trisomy 13 is associated with multiple abnormalities, including defects of the brain that lead to seizures, apnea, deafness, and eye abnormalities.
		Chromosome studies show trisomy 13, partial trisomy, trisomy 13 mosaic, or translocation.
	www.nlm.nih.gov /medlineplus/ency/article/001660.htm (509 words)

	Patau syndrome Summary
		Patau syndrome, also known as trisomy 13, is a chromosomal aberration, a disease in which a patient has an additional chromosome 13 due to a non disjunction of chromosomes during meiosis.
		Most cases of Patau syndrome result from trisomy 13, which means each cell in the body has three copies of chromosome 13 instead of the usual two copies.
		Trisomy 13 was first observed by Erasmus Bartholin in 1657 but the chromosomal nature of the disease was assertained by Dr. Klaus Patau in 1960.
	www.bookrags.com /Patau_syndrome (1544 words)

	IMF: Chromosome 13 and New Ways To Stage Myeloma
		Chromosome 13 incorporates a gene called the retroblastoma gene (Rb), which produces Rb protein capable of inhibiting myeloma cell growth.
		Chromosome 13 testing by FISH is therefore a useful new test.
		Although abnormal Chromosome 13 is highly predictive, similar prediction can be achieved using a combination of other factors including lg type, age and sex, along with traditional Stage and Sß2M.
	www.myeloma.org /main.jsp?source=link&source_link_id=286&type=article&tab_id=1&menu_id=0&id=186 (411 words)

	Trisomy 18 & 13 - Children's Hospital Boston
		Trisomy 13 is seen in about one in 7500 to one in 10,000 births.
		BABIES WITH TRISOMY 13 - Babies with trisomy 13 often have a low birthweight, even when born full-term.
		However, the average age of the mother at delivery of a baby with trisomy 18 is 32 years, and for trisomy 13, 31 years.
	www.childrenshospital.org /az/Site1789/printerfriendlypageS1789P0.html (1680 words)

	Trisomy 18 & 13 - Lucile Packard Children's Hospital
		Trisomy 13 is seen in about one in every 5,000 live births.
		There are organizations across the country that provide information and support for families with children affected by trisomy 18 and trisomy 13.
		Lucile Packard Children's Hospital is located in Palo Alto, adjacent to Stanford University Hospital, approximately 20 miles north of San Jose, CA and 40 miles south of San Francisco.
	www.lpch.org /DiseaseHealthInfo/HealthLibrary/genetics/trisomy.html (1728 words)

	Chromosome 13: Human Genome Landmarks Poster
		These regions reflect the unique patterns of light and dark bands seen on human chromosomes that have been stained to allow viewing through a light microscope.
		Chromosomal regions that vary in staining intensity and are sometimes called heterochromatin (meaning "different color").
		(e.g., on chromosome 21) denote variable regions, called stalks, that connect a very small chromosome arm (a "satellite") to the chromosome.
	www.ornl.gov /sci/techresources/Human_Genome/posters/chromosome/chromo13.shtml (348 words)

	Patau syndrome
		Seventy-five to 80 percent of the cases of Patau syndrome are caused by a trisomy of chromosome 13.
		Partial trisomy of the distal segment of chromosome 13 results in generally less severe, but still serious, symptoms and a distinctive facial appearance including a short upturned nose, a longer than usual area between the nose and upper lip (philtrum), bushy eyebrows, and tumors made up of blood capillaries on the forehead (frontal capillary hemangiomata).
		Partial trisomy of the proximal segment of chromosome 13 is much less likely to be fatal and has been associated with a variety of facial features including a large nose, a short upper lip, and a receding jaw.
	www.healthatoz.com /healthatoz/Atoz/ency/patau_syndrome.jsp (2161 words)

	Trisomy 13 Syndrome
		Trisomy 13 Syndrome is a rare chromosomal disorder in which all or a portion of chromosome 13 appears three times (trisomy) rather than twice in cells of the body.
		In individuals with Trisomy 13 Syndrome, the range and severity of associated symptoms and findings may depend on the specific location of the duplicated (trisomic) portion of chromosome 1, as well as the percentage of cells containing the abnormality.
		Many infants with Trisomy 13 Syndrome fail to grow and gain weight at the expected rate (failure to thrive) and have severe feeding difficulties, diminished muscle tone (hypotonia), and episodes in which there is temporary cessation of spontaneous berathing (apnea).
	www.webmd.com /hw/health_guide_atoz/nord218.asp (666 words)

	Specialty Laboratories ::: we help doctors help patients
		A new class of chromosome 13 marker chromosomes have also been identified which are characterized by the presence of a neocentromere in the 13q32 region which can stabilize the chromosome for appropriate segregation during meiosis and mitosis.
		In ring 13, certain features of partial or complete 13 trisomy can be seen, due to partial duplication of the rings.
		Ocular abnormalities in Patau syndrome (chromosome 13 trisomy syndrome).
	www.specialtylabs.com /books/display.asp?id=1180 (769 words)

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