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Human Chromosome 15 A chromosome is a treadlike linear strand of DNA found in the nucleus of a cell that carries the genes in the transmission of hereditary information. Humans have 46 chromosomes: 22 homologous pairs and either XX (females) or XY (males). This webpage is devoted to Chromosome 15 and the diseases and proteins associated with it. jzhu4.tripod.com   (93 words)

Chromosome 15 Ring Chromosome 15 Ring results from loss (deletion) of genetic material from both ends of the 15th chromosome and a joining of the ends to form a ring. Pairs of human chromosomes are numbered from 1 through 22, with an unequal 23rd pair of X and Y chromosomes for males and two X chromosomes for females. Chromosomal analysis and genetic counseling are typically recommended for parents of an affected child to help confirm or exclude the presence of Chromosome 15 Ring, potential mosaicism, or a balanced translocation in one of the parents. www.peacehealth.org /kbase/nord/nord971.htm   (767 words)

Chromosome 15 - Genetics Home Reference Chromosome 15 is one of the 23 pairs of chromosomes in humans. Chromosome 15 spans about 100 million base pairs (the building material of DNA) and represents between 3 and 3.5 percent of the total DNA in cells. Genes on chromosome 15 are among the estimated 20,000 to 25,000 total genes in the human genome. www.ghr.nlm.nih.gov /chromosome=15   (1193 words)

Human Genetics - UPD Paternal Chromosome 15   (Site not responding. Last check: 2007-10-21) The paternal chromosome is shown on the left. Knoll, J. H.;Glatt, K. A.;Nicholls, R. D.;Malcolm, S.;Lalande, M. (1991): Chromosome 15 uniparental disomy is not frequent in Angelman syndrome. Ledbetter, D.H. and Engel, E. (1995): Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis. www.genes.uchicago.edu /upd/upd15p.html   (363 words)

Mapping of the focal adhesion kinase ( Fadk) gene to mouse chromosome 15 and human chromosome 8. Mapping of the focal adhesion kinase (Fadk) gene to mouse chromosome 15 and human chromosome 8.Focal adhesion kinase (pp125FAK or FAK) is a cytoplasmic protein-tyrosine kinase stimulated in response to cell interactions with extracellular matrix components and by exposure to a variety of agonists, including neuropeptides. We have identified sequence variants in the 3' untranslated regions of the focal adhesion kinase gene in mice and used a PCR-based oligonucleotide hybridization assay to map the mouse gene (Fadk) to Chromosome (Chr) 15 distal to the myelocytomatosis protooncogene (Myc). On the basis of synteny of mouse and human chromosomal maps, the position of the human PTK2 gene probably corresponds to human Chr 8q24-qter. www.pdg.cnb.uam.es /UniPub/iHOP/gp/246137.html   (174 words)

Danger on chromosome 15 In the case of chromosome 15, disease can be caused by rearrangements such as occurs in Prader-Willi and Angelman. Scientists have known that Prader-Willi and Angelman can be attributed to the disruption of genes that sit near breakpoints — regions in the chromosome that are prone to being re-arranged by the cell's genetic machinery before the chromosomes are passed to their offspring. Prader-Willi occurs when the chromosome is inherited from the father, and features mild cognitive impairment and morbid obesity; while Angelman is inherited from the mother, and is characterized by seizures, movement disorders, and severe mental retardation. www.eurekalert.org /pub_releases/2003-09/uopm-doc092503.php   (610 words)

Chromosome 15: Human Genome Landmarks Poster These regions reflect the unique patterns of light and dark bands seen on human chromosomes that have been stained to allow viewing through a light microscope. Chromosomal regions that vary in staining intensity and are sometimes called heterochromatin (meaning "different color"). (e.g., on chromosome 21) denote variable regions, called stalks, that connect a very small chromosome arm (a "satellite") to the chromosome. www.ornl.gov /hgmis/posters/chromosome/chromo15.html   (348 words)

Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for ... Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22. Considering our previous assignment of a gene for diaphorase-1 (DIA1) to the same mouse chromosome, we have evidence for another syntenic relationship that has been conserved, since the homologous loci for human ARSA and DIA1 are both located on human chromosome 22. Because MMU 15 and HSA 22 are quite dissimilar in size and banding patterns, we have attempted to identify the conserved portion by regional mapping of human DIA1 and ARSA using somatic cell hybrids segregating a human chromosome translocation t(15;22)(q14;q13.31). www.pdg.cnb.uam.es /UniPub/iHOP/gp/3916305.html   (156 words)

Human Genetics - UPD Maternal Chromosome 15   (Site not responding. Last check: 2007-10-21) The maternal chromosome is shown on the left. Devriendt, K.;Matthijs, G.;Claes, S.;Legius, E.;Proesmans, W.;Cassiman, J. J.;Fryns, J. Prader-Willi syndrome in a child with mosaic trisomy 15 and mosaic triplo-X: a molecular analysis. (1994): Bloom syndrome and maternal uniparental disomy for chromosome 15. www.genes.uchicago.edu /upd/upd15m.html   (484 words)

The Sanger Institute: Human Chromosome 6 Project Overview   (Site not responding. Last check: 2007-10-21) Chromosome 6 is a submetacentric chromosome that constitutes about 6% of the human genome. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we have shown that this cluster co-localizes with a region of high transcriptional activity. The Chromosome 6 ACEDB database (6ace) is used as a tool for managing the in-house data and acts as the primary means by which chromosome 6 data generated at The Sanger Institute will be released into the public domain in an annotated and usable form. www.sanger.ac.uk /HGP/Chr6   (545 words)

Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through ... 4',6-Diamidino-2-phenylindole-stained normal reference chromosomes, fluorescence ratio images (blue, normal balanced state of chromosome material; red, underrepresentation; and green, overrepresentation in the tumor genome), and idiogram with ratio profiles (left, center, and right vertical lanes represent lower, average, and upper thresholds of the normal range) are shown for each chromosome. Whereas SCC-13 cells show a normal ratio profile of chromosome 15, it is underrepresented in SCL-I cells, as is chromosome 4p. Gray represents chromosomal regions of highly repetitive DNA sequences that are suppressed by Cot I DNA and excluded from evaluation. www.pnas.org /cgi/content/full/96/5/2065   (5647 words)

Alpha Satellite DNA Variant-Specific Oligoprobes Differing by a Single Base Can Distinguish Chromosome 15 Homologs -- ... The chromosome with the large pTRA-20 signal is positive for 15VAR2.4, while the chromosome with the small pTRA-20 signal is negative for 15VAR2.4. Durfy, S.J. and Willard, H.F. Patterns of intra- and inter-array sequence variation in alpha satellite from the human X chromosome: evidence for short-range homogenization of tandemly repeated DNA sequences. Waye, J.S., Greig, G.M., and Willard, H.F. Detection of novel centromeric polymorphisms associated with alpha satellite DNA from human chromosome 11. www.genome.org /cgi/content/full/10/9/1342   (4766 words)

Maternal Methylation Imprints on Human Chromosome 15 Are Established During or After Fertilization. Maternal Methylation Imprints on Human Chromosome 15 Are Established During or After Fertilization. Assuming that imprints are reset in the germ line, we and others have suggested that this region constitutes part of the 15q imprinting center (IC) and is important for the maternal to paternal imprint switch in the male germ line [3, 4]. But the SNURF-SNRPN region analyzed is part of the IC, is especially CpG-rich, is conserved between human and mouse, carries the minimal elements for imprinting as determined by transgenic studies [13], and is epigenetically active in Drosophila melanogaster [14]. www.euchromatin.org /El-Maari01.htm   (928 words)

Additional Complexity on Human Chromosome 15q: Identification of a Set of Newly Recognized Duplicons (LCR15) on ... The long arm of human chromosome 15 is characterized by the relatively frequent appearance of cytogenetic alterations. 24 mya, chromosomes 6 and 15 sequences 38 mya, and chromosomes Goy, A., Gilles, F., Remache, Y., and Zelenetz, A.D. Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22. www.genome.org /cgi/content/full/11/1/98   (7465 words)

Tim Donlon's Research on Chromosome 15   (Site not responding. Last check: 2007-10-21) Two different clinical syndromes, the Prader-Willi (PWS) and the Angelman syndromes (AS) are caused by deletion of the same chromosomal region at 15q11.2 however, deletion of the paternal homolog results in PWS while maternal deletion in AS. The exact phenotype is somewhat variable because it is a function of the size, breakpoints, and parental origin of the deletion on chromosome 15q11.2; all classic PWS patients have a ÒcoreÓ deletion of minimum size. We are dissecting this region of chromosome 15 with the goal of identifying specific genes that are deleted and characterizing their roles in the production of these specific phenotypic abnormalities. www2.hawaii.edu /~donlon/research.15.html   (452 words)

HUMAN CHROMOSOME #15   (Site not responding. Last check: 2007-10-21) Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15. Localization of the genes for human inositol 1,4,5-triphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-21 and 1q41-43, respectively, by in situ hybridization. Human chromosomal localization of genes encoding the gamma1 and gamma2 subunits of the gamma-aminobutyric acid receptor indicates that members of this family are often clustered in the genome. www.il-st-acad-sci.org /genecats/hsa15.html   (341 words)

Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in ... Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in patients with a proximal duplication of 15q -- Fantes et al. Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in patients with a proximal duplication of 15q on chromosome 15, or as the parent of a fetus with a proximal jmg.bmjjournals.com /cgi/content/full/39/3/170   (4917 words)

Genetic Definitions Chromosomes: are composed of DNA, which itself is composed of 4 nucleotides: A (adenine), T (thymine), C (cytosine) and G (guanine). Haplogroup: "Distinct Y chromosomes, defined solely on the basis of unique mutation events (UME) character states, are designated as haplogroups." Each haplogroup consists of a variable number of Y chromosomes that share the same UME character state but vary in Y-STR haplotype.(from Peter de Knijff). Alternatively, the position on a chromosome at which the gene for a particular trait resides. www.duerinck.com /define.html   (1651 words)

Additional Complexity on Human Chromosome 15q: Identification of a Set of Newly Recognized Duplicons (LCR15) on ... Additional Complexity on Human Chromosome 15q: Identification of a Set of Newly Recognized Duplicons (LCR15) on 15q11-q13, 15q24, and 15q26 -- Pujana et al. chromosome regions that are rearranged in human genomic disorders, The Evolutionary Chromosome Translocation 4;19 in Gorilla gorilla is Associated with Microduplication of the Chromosome Fragment Syntenic to Sequences Surrounding the Human Proximal CMT1A-REP www.genome.org /cgi/content/abstract/11/1/98   (529 words)

Danger On Chromosome 15 -- Unstable Region Yields Genes For Prader-Willi/Angelman Syndromes And Spastic Paraplegia Philadelphia, PA -— While it might have given our ancestors an evolutionary advantage, an "unstable" region on human chromosome 15 is also the source of a set of inherited neurological diseases. Details of Chromosome 22 Structure Offer Clues to How Genes Are Lost in a Genetic Disease (March 2, 2000) -- Chromosome 22, a hot spot for human disease, yielded a few more secrets to genetics researchers from The Children's Hospital of Philadelphia. Sequence Of Human Chromosome 7 Is Fine-tuned And Finished (July 10, 2003) -- Researchers at Washington University School of Medicine in St. Louis, in collaboration with investigators at five other centers, have finished sequencing human chromosome 7. www.sciencedaily.com /releases/2003/09/030926065654.htm   (830 words)

Keyword   (Site not responding. Last check: 2007-10-21) It is the fourth mammal to have its full genome sequenced, after the mouse, rat and human being.Some of the scientific analysis of the 3bn chemical "letters" of the chimp's genetic code focused... Dozens of new genes identified: By intensely and systematically comparing the human X chromosome to genetic information from chimpanzees, rats and mice, a team of scientists from the United States and India has uncovered dozens of new genes, many of which are located in regions of the chromosome already tied to disease. Regions of the X chromosome, one of the two sex chromosomes (Y is the other), have been linked to mental retardation and numerous other disorders, but finding the particular genetic abnormalities involved has been difficult. www.freerepublic.com /focus/keyword?k=genetics   (5527 words)

Genetic evidence for different male and female roles during cultural transitions in the British Isles -- Wilson et al., ... Human history is punctuated by periods of rapid cultural change. The frequency distribution in the indigenous Orkney chromosomes is consistent with a substantial Scandinavian contribution The Y chromosome complements of Basque- and Celtic-speaking populations are strikingly similar (Fig. www.pnas.org /cgi/content/full/071036898v1   (4975 words)

Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in ... Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells -- Nogami et al. Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells territory, its centromere, the SNRPN gene on this chromosome, and the jcs.biologists.org /cgi/content/abstract/113/12/2157   (416 words)

Gene Expression: Dusty Baker pt II - Entine Weighs In Acknowledging the fact that human body type varies with climate does not in and of itself establish that "race" is any more clearcut or meaningful a term than its' detractors say it is. No practicing researcher in the field of genetics will deny that human variation exists, or that a very small portion of that variation is geographically tied, but there simply aren't any clean divisions into "races", whatever you'd like to believe. It turns out at the sequence level (due to the Y chromosome being so much different than the X chromosome) that male humans are also closer to male chimps than to female humans. www.gnxp.com /MT2/archives/000744.html   (10021 words)

Human to Mouse Homology Region Map, Chromosome 15 Human to Mouse Homology Region Map, Chromosome 15 Gene order has been changed from that shown in the chromosome committee reports or online databases, as required by high-resolution human physical mapping data; these data also indicate a probable difference between human and mouse organization, e.g. The asterisk character ('*') is used to indicate a different region of homology on the same mouse chromosome. www.ncbi.nlm.nih.gov /Omim/Homology/human15.html   (298 words)

Human Chromosome 15 Chromosome 15 - BACs -- University of California, Santa Cruz release Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y For answers to questions about genetics or the Human Genome Project visit our Human Genome Project Information web site at http://www.ornl.gov/hgmis/ or contact us via this form. www.ornl.gov /sci/techresources/Human_Genome/launchpad/chrom15.shtml   (441 words)

Human Genome Sequencing Status, June, 1998: Chromosome 15   (Site not responding. Last check: 2007-10-21) Each chromosome of the Human genome is shown with its low resolution banding pattern. Regions that are being worked on are indicated by bars to the right of each chromosome, with a different colour for each sequencing centre. Solid bars indicate sequencing is in progress whereas empty bars indicated that it is planned. bioinformatics.weizmann.ac.il /HGP/chr15.html   (158 words)

Interleukin 15: biology and relevance to human disease -- Fehniger and Caligiuri 97 (1): 14 -- Blood   (Site not responding. Last check: 2007-10-21) The IL-15 gene spans 34 kb or more, mapping to human chromosome 4q31 and the central region of mouse chromosome 8. The human IL-15 locus consists of 9 exons and 8 introns and is located on chromosome 4q31. Human macrophages express high-affinity binding sites for IL-15 that are up-regulated upon activation with LPS. www.bloodjournal.org /cgi/content/full/97/1/14   (6653 words)

Molecular Biology databases/Bioinformatics databases-Species Specific databases Chr16 TIGR - Human chromosome 16 db at TIGR Chr21 at ERI - Human chromosome 21 genomic sequence db from the Eleanor Roosevelt Institute ADB - Albinism db (Mutations in human genes causing albinism) www.geocities.com /bioinformaticsweb/speciesspecificdatabases.htm   (2235 words)

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