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Topic: Chromosome 18 (human)

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	Chromosome 18 - Genetics Home Reference (Site not responding. Last check: 2007-10-14)
		Chromosome 18 is one of the 23 pairs of chromosomes in humans.
		Genes on chromosome 18 are among the estimated 20,000 to 25,000 total genes in the human genome.
		Rarely, Edwards syndrome is caused by a rearrangement of chromosomal material between chromosome 18 and another chromosome; as a result, a person has the two usual copies of chromosome 18, plus extra material from chromosome 18 attached to another chromosome.
	ghr.nlm.nih.gov /chromosome=18 (735 words)

	Non-disjunction of chromosome 18 -- Bugge et al. 7 (4): 661 -- Human Molecular Genetics
		For chromosome 18 we have examined the frequency of normal disjunction from nullichiasmate tetrads by reconstruction of the chiasma distribution from crossovers in normal meiosis and compare this with the distribution from transitions in non-disjunction.
		Chromosomes 16 and 18 are rather similar in size, shape and female genetic map length, but they have extremely different patterns of meiotic error, with mat MI non-disjunction being very common for chromosome 16 while mat MII non-disjunction is unknown (33).
		For chromosome 18 we have tested the null hypothesis that all tetrads are chiasmate using the crossover distribution derived from CEPH v.8.1 (Table 5).
	hmg.oxfordjournals.org /cgi/content/full/7/4/661 (6120 words)

	Diabetes: Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse ... (Site not responding. Last check: 2007-10-14)
		In the diabetes-linked region of chromosome 18q12-q21, a candidate gene, deleted in colorectal carcinoma (DCC), was tested for association with human autoimmunity in 3,380 families with type 1 diabetes, MS, and RA.
		Human, mouse, and rat chromosome 18 orthology relationships were established using www3.ncbi.nlm.nih.gov/Homology, www.informatics.jax.org/searches/oxfordgrid_form.shtml, www.nih.gov/niams/ scientific/ratgbase, www.otsuka.genome.ad.jp/ratmap, and www.well.ox.ac.uk/ ~bihoreau.
		Distances along human chromosome 18 were taken from a combination of www.cedar.genetics.soton.ac.uk/pub and www.genethon.fr, along mouse chromosome 18 from www.informatics.jax.org, and along rat chromosome 18 from www.well.ox.ac.uk/~bihoreau and waldo.wi.mit.edu/ rat/public/.
	www.findarticles.com /p/articles/mi_m0922/is_1_50/ai_70385297 (1160 words)

	trisomy 18 -- Encyclopædia Britannica
		human chromosomal disorder that results from an extra (third) copy of chromosome 18.
		However, the newborn incidence represents a small fraction of chromosome mutations, the vast majority being lethal and resulting in prenatal death or stillbirth.
		Infants born with this disorder have profound mental retardation and severe developmental malformations that include a small head, a cleft palate and lip, tiny eyes and eye openings, extra digits on hands and feet (polydactyly), clenched fingers, central nervous system abnormalities, and...
	www.britannica.com /eb/article?tocId=9002474 (681 words)

	[No title] (Site not responding. Last check: 2007-10-14)
		00002 Hsym Msym Human Mouse Rat Pig Cow Sheep ------------------------------------------------------------------------------------------------------------------------ p28 Rojas K, Silverman GA, Hudson JR & Overhauser J (1995) Integration of the 1993-94 Genethon genetic linkage map for chromosome 18 with the physical map using a somatic cell hybrid mapping panel.
		Chromosomal reassignment:YACS containing both YES1 and Thymidylate Synthase map to the short arm of chromosome 18.
		High-density radiation hybrid map of human chromosome 18 and contig of 18p.
	www.cedar.genetics.soton.ac.uk /ldb/chrom18/ref (767 words)

	Human Genome Research Group (Site not responding. Last check: 2007-10-14)
		Five years ago, in the framework of the international human genome project, and as an integrated part of the chromosome 21 community, we have formed a consortium of academic groups from Germany and Japan to map and sequence this chromosome.
		Analysis of the chromosome revealed 127 known genes, 98 predicted genes, and 59 pseudogenes.
		The completed genome sequences for chromosome 21, as published in Nature on May 18, 2000, are available from here.
	hgp.gsc.riken.go.jp /chr21 (296 words)

	chromosome 18 trisomy
		A syndrome characterized by the presence of an extra (third) chromosome on an otherwise diploid chromosome 18 associated with a broad spectrum of variable abnormalities consisting of more than 130 individual defects of the craniofacial structures, brain, heart, kidneys, and gut.
		Trisomy 18 mosaicism is often associated with normal intelligence and mild phenotype.
		Heredity: Trisomy 18 may be associated with trisomy 13, trisomy 21, chromosome XXX syndrome, chromosome XXXY syndrome, XXY syndrome, syndrome XO syndrome, and chromosome 18 mosaicism.
	www.nlm.nih.gov /mesh/jablonski/syndromes/syndrome191.html (452 words)

	Differences in the Localization and Morphology of Chromosomes in the Human Nucleus -- Croft et al. 145 (6): 1119 -- The ...
		with nuclear substructure for human chromosomes 18 and 19.
		Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells.
		The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression.
	www.jcb.org /cgi/content/full/145/6/1119 (7695 words)

	Workshop On Chromosome 18: The Current State Of The Science - Office of Rare Diseases (Site not responding. Last check: 2007-10-14)
		Cody indicated that to understand and develop treatments for chromosomal abnormalities, investigators must determine at the molecular level which genes are deleted or duplicated and describe precisely the phenotypes associated with the duplications and deletions identified.
		The participants thought that chromosomal analysis might be the more logical approach to testing MBP status, since insurers may not pay for the more detailed fluorescence in situ hybridization (FISH), and investigators may not be able to inform the family of the outcome of the assay otherwise.
		Human genes are often more available than mouse genes, but may produce different effects than the endogenous gene when introduced into the mouse germline by various means.
	rarediseases.info.nih.gov /html/workshops/fy2001/chromosome1820010709.html (16672 words)

	Chromosome Data - Human, Chimpanzee and Mouse - (Site not responding. Last check: 2007-10-14)
		In a two-pronged approach we are analyzing animal genomes to serve as comparison for the human genome.
		In the mouse, analysis is focusing on chromosome number 21.
		An international consortium including the GSC has succeeded in the determination of a 33Mb segment of the chimp chromosome number 22 which corresponds to chromosome number 21 in humans.
	hgp.gsc.riken.go.jp /sequence/mammaliachr.asp (126 words)

	Division of Human Genetics (Site not responding. Last check: 2007-10-14)
		Chromosome 18 is involved in tetrasomy 18p and in trisomy 18 syndromes.
		Thus, we isolated 600 cosmid clones of which 60 new cosmids are mapped on the short and long arms of chromosome 18 either by R or by DAPI banding and simultaneous fluorescence in situ hybridization.
		Human adenosine deaminase (ADA) catalyzes the conversion of adenosine to inosine with the release of ammonia.
	www.nig.ac.jp /labs/nenpo-95e/E/E-a-1.html (2666 words)

	Human Genome Chromosome Databases
		This is a graphical representation of the status of sequencing each of the human chromosomes.
		Human Chromosome Ideograms can be selected and displayed, courtesy of David Adler.
		Cytogenetics is the study of chromosomes and chromosome abnormalities.
	www.biologie.uni-hamburg.de /b-online/library/genomeweb/GenomeWeb/human-gen-db-chromosomes.html (402 words)

	HUMAN CHROMOSOME #18 (Site not responding. Last check: 2007-10-14)
		Report of the committee on the genetic constitution of chromosome 18.
		Magenis RE, Smith L, Nadeau JH, Johnson KR, Mountjoy KG, Cone RD. Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse ans human.
		Mapping the human melanocortin 2 receptor (Adrenocorticotropic hormone receptor; ACTHR) gene (MC2R) to the small arm of chromosome 18 (18p11.21-pter).
	www.il-st-acad-sci.org /genecats/hsa18.html (233 words)

	Chromosome 18: Human Genome Landmarks Poster
		These regions reflect the unique patterns of light and dark bands seen on human chromosomes that have been stained to allow viewing through a light microscope.
		Chromosomal regions that vary in staining intensity and are sometimes called heterochromatin (meaning "different color").
		(e.g., on chromosome 21) denote variable regions, called stalks, that connect a very small chromosome arm (a "satellite") to the chromosome.
	www.ornl.gov /sci/techresources/Human_Genome/posters/chromosome/chromo18.shtml (348 words)

	Causes of Dyslexia on Chromosome 18
		A study of more than 200 families of children who are dyslexic has revealed that a region of chromosome 18 — one of the 23 pairs of human chromosomes — is strongly associated with the condition.
		Scientists from the Wellcome Trust Centre for Human Genetics in Oxford say that the biggest dyslexia study of its kind has identified what could turn out to be the most important gene involved in causing dyslexia.
		They correlated their findings with the pattern of inheritance and looked for links with specific regions of each of the 23 pairs of chromosomes, leading them to a region of chromosome 18.
	www.dyslexia-teacher.com /t125.html (216 words)

	Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 ...
		Linkage of chromosome 18 to an autoimmune phenotype in (A) rodent and (B) human by Fisher's method of combining P values.
		Linkage of chromosome 18 to an autoimmune phenotype in (A) rodent and (B) human by GSMA.
		Linkage of human chromosome 18q to type 1 diabetes in 882 affected sib-pair families.
	diabetes.diabetesjournals.org /cgi/content/full/50/1/184 (7256 words)

	PHYSICAL LOCALISATION OF BLOOD PRESSURE QUANTITATIVE TRAIT LOCUS (QTL) ON DAHL RAT CHROMOSOME 18 POTENTIALLY RELEVANT ... (Site not responding. Last check: 2007-10-14)
		Since human populations are heterogenous, it is difficult to identify genes causing hypertension.
		Previously, rat Chromosome 18 was shown by linkage analysis to contain a quantitative trait locus (QTL) for blood pressure.
		In each congenic strain, the whole genome and the rest of Chromosome 18 is the same as S, except for the congenic region, which is from LEW.
	www.pulsus.com /ccc2004/abs/a166.htm (368 words)

	chromosome (Site not responding. Last check: 2007-10-14)
		Cell & Chromosome is ready to receive papers on all aspects of cell division, including interphase...
		Chromosome Deletion Outreach, Inc. (CDO) is a non-profit organization for families affected by any type of rare chromosome disorder: deletions, translocations, trisomies, rings and inversions...
		We are the world’s largest private DNA paternity testing laboratory chromosome Routinely, we test 24 genetic markers, more than any other laboratory performing DNA paternity tests
	www.geneticdiscovery.co.uk /chromosome.html (305 words)

	Human to Mouse Homology Region Map, Chromosome 18
		Human to Mouse Homology Region Map, Chromosome 18
		Gene order has been changed from that shown in the chromosome committee reports or online databases, as required by high-resolution human physical mapping data; these data also indicate a probable difference between human and mouse organization, e.g.
		The asterisk character ('') is used to indicate a different region of homology on the same mouse chromosome*.
	www.ncbi.nlm.nih.gov /Omim/Homology/human18.html (298 words)

	Human Genome Chromosome Databases
		humace - analysed human genomic sequences from the Sanger
		As the Human Genome Project scales up, it becomes more important to have a means to coordinate and track the sequencing effort.
		humace is the acedb database of analysed human genomic sequence generated by the human sequence analysis group at the Sanger Centre.
	www.cbi.pku.edu.cn /mirror/GenomeWeb/human-gen-db-chromosomes.html (402 words)

	ARS \| Publication request: Short Communication: An Updated Linkage and Comparative Map of Porcine Chromosome 18
		Genetic markers were developed which resided near genes expected to map to pig chromosome 18 based on the current human-pig comparative map.
		The gene assignments have increased the resolution of the human-pig comparative map and detected a previously unknown rearrangement between the human and porcine genomes.
		In order to increase the marker density, seven genes from human chromosome 7 (HSA7) expected to map to SSC18 were selected for marker development.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=122213 (369 words)

	Human Chromosome 18
		Chromosome 18 - BACs -- University of California, Santa Cruz release
		Human Chromosome 18 -- Riken Genomic Sciences Center
		Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y
	www.ornl.gov /sci/techresources/Human_Genome/launchpad/chrom18.shtml (458 words)

	Chromosome 18 - References - Genetics Home Reference (Site not responding. Last check: 2007-10-14)
		These sources were used to develop the Genetics Home Reference chromosome summary on chromosome 18.
		Trapping and sequence analysis of 1138 putative exons from human chromosome 18.
		Gilbert F. Disease genes and chromosomes: disease maps of the human genome.
	ghr.nlm.nih.gov /chromosome=18/show/References (118 words)

	Chromosome 18 Links (Site not responding. Last check: 2007-10-14)
		Whitehead list of markers assigned to chromosome 18
		links to some genetic disorders and other human conditions linked to chromosome 18
		Table of chromosome 18 genes associated with disease found in NCBI's OMIM pages
	nucleus.cshl.org /humchr18web/chr18links.htm (53 words)

	Scientists Link Fatal, Cholesterol-Storage Disorder to Chromosome 18: National Institute of Neurological Disorders and ...
		In the current study, a collaborative team of scientists analyzed DNA samples from 12 affected families and identified a small region on chromosome** 18 most likely to house the recessive disease gene.
		The region we've identified covers less than 3 percent of chromosome 18, and, with a little luck, we should identify the precise gene soon," Dr. Pentchev said.
		The NINDS, one of the 16 National Institutes of Health located in Bethesda, MD, is the nation's leading supporter of research on disorders of the brain and nervous system and a lead agency, along with the National Institute of Mental Health, for the congressionally mandated Decade of the Brain.
	www.ninds.nih.gov /news_and_events/press_releases/pressrelease_npc_030193.htm (626 words)

	Myopia (Site not responding. Last check: 2007-10-14)
		Since 1992, genetic markers that may be associated with genes for myopia have been located on human chromosomes 1, 2, 12, and 18.
		Genetic information for low myopia appears to be located on the short arm of chromosome 1, but it is not known whether this information governs the structure of the eye itself or vulnerability to environmental factors.
		In 1998 a team of American researchers presented evidence that a gene for familial high myopia with an autosomal dominant transmission pattern could be mapped to human chromosome 18 in eight North American families.
	www.healthatoz.com /healthatoz/Atoz/ency/myopia.jsp (3413 words)

	Inserting Chromosome 18 into Pancreatic Cancer Cells Switches Them to a Dormant Metastatic Phenotype -- Lefter et al. 9 ...
		was observed in all 10 of the human pancreatic primary tumor
		Normal human serum medium was used as a negative control.
		18 was transferred into human pancreatic cancer cells.
	clincancerres.aacrjournals.org /cgi/pmidlookup?view=full&pmid=14581380 (4761 words)

	MEDIS-Research-Division of Human Genetics-Members-A Collins (Site not responding. Last check: 2007-10-14)
		Integrated maps permit investigation of the relationship between recombination and the sequence, the level of recombination varying between chromosomes, the sexes, and with position along the chromosome.
		The distance (Kb) to which association extends in different populations, for different chromosome regions and different classes of polymorphic marker influences the density of markers required to cover a candidate region.
		In the Fragile X chromosome region markers pairs with trinucleotide repeat polymorphisms (in orange), being more mutable, show less association than pairs with dinucleotides (in purple), and single nucleotide polymorphisms (in blue).
	www.som.soton.ac.uk /research/geneticsdiv/members/acollins.htm (2175 words)

	[No title] (Site not responding. Last check: 2007-10-14)
		Chromosome 3 -- University of Texas, San Antonio: The human chromosome 3 database server
		Chromosome 7 -- The Hospital for Sick Children, in Toronto, CA
		Y Chromosome -- from Cambridge University Human Molecular Genetics Group (UK), has 1994 & 1995 Y chromosome workshop abstracts.
	www.genlink.wustl.edu /otherlinks/page/HChrSites.html (167 words)

	Molecular Biology databases/Bioinformatics databases-Species Specific databases
		Chr16 TIGR - Human chromosome 16 db at TIGR
		Chr21 at ERI - Human chromosome 21 genomic sequence db from the Eleanor Roosevelt Institute
		ADB - Albinism db (Mutations in human genes causing albinism)
	www.geocities.com /bioinformaticsweb/speciesspecificdatabases.htm (2235 words)

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