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Topic: Chromosome 6 (human)

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	Nature web focus: The Human Genome (Site not responding. Last check: 2007-10-14)
		The DNA sequence and analysis of human chromosome 6
		SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer
		Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15
	www.nature.com /nature/focus/humangenome/6.html (135 words)

	Chromosome - Wikipedia, the free encyclopedia
		Chromosomes were first observed by Karl Wilhelm von Nägeli in 1842 and their behavior later described in detail by Walther Flemming in 1882.
		Sexually reproducing species have somatic cells (body cells), which are diploid [2n] (they have two sets of chromosomes, one from the mother, one from the father) or polyploid [Xn] (more than two sets of chromosomes), and gametes (reproductive cells) which are haploid [n] (they have only one set of chromosomes).
		Some chromosome abnormalities do not cause disease in carriers, such as translocations, or chromosomal inversions, although it may lead to a higher chance of having a child with an chromosome disorder.
	en.wikipedia.org /wiki/Chromosome (1175 words)

	Chromosome 6 - Genetics Home Reference (Site not responding. Last check: 2007-10-14)
		Chromosome 6 is one of the 23 pairs of chromosomes in humans.
		Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6 percent of the total DNA in cells.
		Genes on chromosome 6 are among the estimated 20,000 to 25,000 total genes in the human genome.
	www.ghr.nlm.nih.gov /chromosome=6 (398 words)

	Chromosome 6 Sequenced (Site not responding. Last check: 2007-10-14)
		Chromosome 6 carries one of the most important regions in our genome for fighting disease.
		Mutations in genes on chromosome 6 are also responsible for a form of childhood Parkinson's, epilepsy, and some cancers.
		Chromosome 6 joins 7, 14, 20, 21, 22, and Y among the ranks of essentially complete and published chromosomes.
	www.genomenewsnetwork.org /articles/10_03/chromosome6.shtml (294 words)

	Prostate Cancer, Hereditary - October 2001: 710722 (Site not responding. Last check: 2007-10-14)
		FISH using chromosome-specific centromeric probes was used to assess transitional changes in the frequency of aneuploidy for chromosomes 7, 8, 10, 12, 16, X, and Y in prostate cancer during the pre- and post-treatment periods.
		Introduction of the chromosome resulted in significant suppression of the metastatic ability of the hybrid cells, by as much as 98%, without any interference with the in vivo growth rate or tumorigenicity of primary tumor in SCID mice.
		In this report, an invasive; and metastatic human prostate tumor cell line, androgen-repressed human prostate cancer cell line (ARCaP), either transduced with wild-type human AR (hAR) or a control neomycin-resistant plasmid DNA, was used to evaluate the direct role of AR in regulating prostate tumor cell growth and gene transcription.
	www.acor.org /cnet/710722.html (12628 words)

	The Sanger Institute: Human Chromosome 6 Project Overview (Site not responding. Last check: 2007-10-14)
		Chromosome 6 is a submetacentric chromosome that constitutes about 6% of the human genome.
		Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we have shown that this cluster co-localizes with a region of high transcriptional activity.
		The Chromosome 6 ACEDB database (6ace) is used as a tool for managing the in-house data and acts as the primary means by which chromosome 6 data generated at The Sanger Institute will be released into the public domain in an annotated and usable form.
	www.sanger.ac.uk /HGP/Chr6 (545 words)

	Multiple Sclerosis References 2003; Authors: B
		Concepts of the molecular mechanisms that underlie linkage and association of the human leukocyte antigen (HLA) region to MS need to be revised to accommodate these data.
		Rat and human T cells that had been repeatedly stimulated 7-10 times with antigen were readily distinguished on the basis of their high levels of Kv1.3 channels (>600 channels/cell) and ShK-F6CA staining from resting T cells or cells that had undergone 1-3 rounds of activation.
		Both patients were human immunodeficiency virus negative; one patient with rheumatoid arthritis was taking etanercept.
	lansbury.bwh.harvard.edu /ms_references_2003_authors_b.htm (12061 words)

	Chromosome 6 Ring
		Chromosome 6 Ring is a rare disorder in which there is loss (deletion) of chromosomal material from both ends of the 6th chromosome and joining of the ends to form a ring.
		However, many with the chromosomal abnormality are affected by growth retardation; varying degrees of mental retardation; mild to severe delays in the acquisition of skills requiring the coordination of mental and physical activities (psychomotor retardation); and/or various abnormalities of the skull and facial (craniofacial) region.
		Chromosome 6 Ring usually appears to result from spontaneous (de novo) errors very early in the development of the embryo that occur for unknown reasons (sporadically).
	www.bchealthguide.org /kbase/nord/nord928.htm (501 words)

	Diagnosis-Histopathology-Pathogenesis of Cervical Cancer - May 2001: 705180 (Site not responding. Last check: 2007-10-14)
		However, because human papilloma viruses (HPV) are causative agents and alter the cell cycle in cervical neoplasms, host genes interacting directly or indirectly with HPV oncoproteins have been identified in vitro.
		Multiple brain lesions developed in 4 of 6 patients and consisted of multiple tumors distributed in the cerebral hemispheres (2 patients) or both the cerebral and the cerebellar hemispheres (2 patients).
		The PTEN gene was mutated in 8 of the 50 (16%) patients (2 of Stage III, and 6 of Stage IV).
	www.acor.org /cnet/705180.html (7041 words)

	Chromosome 6 unravelled
		By WT The DNA sequence of chromosome 6, which constitutes about 6 per cent of the human genome, has been completed by researchers from the Wellcome Trust Sanger Institute.
		The seventh of the 24 human chromosomes to be completed - joining chromosomes 7, 14, 20, 21, 22 and Y – chromosome 6 is the largest to be fully analyzed to date.
		Chromosome 6 was already known to include genes with implications for cancer, heart disease and mental health.
	www.wellcome.ac.uk /en/genome/thegenome/hg01n007.html (337 words)

	Diabetes: Human glucagon-like peptide-1 receptor gene: localization to chromosome band 6p21 by fluorescence in situ ... (Site not responding. Last check: 2007-10-14)
		Human metaphase cells were prepared from phytohemagglutinin-stimulated peripheral blood lymphocytes.
		GLP1R was localized by analyzing the segregation of the human gene in DNA samples from a panel of human-rodent somatic cell hybrids containing different human chromosomes.
		Specific labeling of 6p12-p21 was observed on four (9 cells), three (13 cells), or two (3 cells) chromatids of the chromosome 6 homologues in 25 cells examined.
	www.findarticles.com /p/articles/mi_m0922/is_n8_v42/ai_14105939 (1411 words)

	Human Artificial Chromosome.
		Artificial human chromosomes should be well suited both for germline manipulations and for ex-vivo somatic manipulations (those done on tissue such as blood, which can be removed from the body, manipulated in the lab, and then returned to the body).
		The human artificial chromosome survived for as long as 6 months in cells, retaining its integrity while replicating during many cell divisions, Willard and his team report in the April Nature Genetics.
		At the center of each chromosome is the mysterious centromere, which plays a vital role in the chromosome's segregation in a dividing cell.
	www.ess.ucla.edu /huge/HAC.html (815 words)

	BioMed Central \| Full text \| Optimization of biotinyl-tyramide-based in situ hybridization for sensitive ...
		Human chromosome DNA specific to alpha-satellite centromeric regions was also obtained from the ATCC [catalog numbers: 61078 (D9Z3, chromosome 9); 61396 (D10S71, chromosome 10); 65438 (D11Z1 chromosome 11); 61398 (D12Z1, chromosome 12) and 65442 (D17Z1, chromosome 17).
		H-labeled probe and chromosome identification by Geimsa staining [10] and by detection of biotin-labeled HPV probe detected with avidin-FITC, which enabled detection of integrated HPV in metaphase spreads as a 'pin-prick' signal [11].
		By comparison with previous studies [10,11] and because of the consistency of this result, it is concluded that this signal represents the integrated HPV 16 on chromosome 13.
	www.biomedcentral.com /1472-6890/3/2 (4940 words)

	HUM-MOLGEN: Chromosome 6 In The Spotlight
		Weighing in at just over 166 million bases, it is the largest human chromosome to be analysed and published so far.
		Chromosome 6 is most famed for the major histocompatibility complex (MHC), a previously sequenced region that is involved in the immune response.
		This is the seventh human chromosome to be sequenced, joining the ranks of 20, 21, 22, 7, 14 and Y. "A finished chromosome 6 reveals an abundance of biological information previously buried within the draft of the human genome assembly," say Jane Grimwood and Jeremy Schmutz in an accompanying News and Views article.
	hum-molgen.org /NewsGen/11-2003/msg02.html (234 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair ...
		The NA IC(50) value was measured in 27 human liver samples using six concentrations of NA ranging from 1.05 microM to 34 microM.
		We excluded a mutation in the sex-determining region on chromosome Y (SRY) by direct sequencing of the SRY gene.
		An involvement of the subtelomeric region of chromosome 9p (9p 24.3) recently reported to be involved in XY-sex reversal phenotypes was excluded by molecular testing for loss of heterozygosity as well as fluorescence in situ hybridization studies.
	www.hair-loss-stop.com /ref-testosterone/testosterone-research-abs4.96.html (1441 words)

	[No title]
		The high- and low-affinity human carnitine transporters, OCTN2 and OCTN1, are multifunctional polyspecific organic cation transporters; therefore, defects in these transporters may have widespread implications for the absorption and/or elimination of a number of key pharmacological agents such as cephalosporins, verapamil, quinidine and valproic acid.
		The data from animal and human in vivo studies suggest that cardiac function is dependent in part on the normal function of the GH/IGF-1 axis (growth hormone/insulin-like growth factor-1).
		We studied in humans the cardiac effects of hexarelin administration in 7 normal adults, in 7 severe GH-deficient patients, and in 12 patients with severe dilated cardiomyopathy.
	home.planet.nl /~allri004/PWK/030816a.doc (15567 words)

	Current Lymphoma Research Genetic Changes in Human Lymphoma: Their Relevance to Lymphocyte Differentiation - New York ...
		The bcl-6 gene located on chromosome 3q27 codes for a DNA-binding transcriptional repressor that plays an important role in the development of both the normal germinal center and T cell-dependent antigen responses.
		The bcl-6 gene was discovered by virtue of its involvement in a balanced translocation involving the immunoglobulin (1g) heavy chain gene on chromosome 14q32.
		Involvement of the bcl-2 gene in human follicular lymphoma.
	nydailynews.healthology.com /nydailynews/16487.htm (2721 words)

	Faculty > Michael Christman (Site not responding. Last check: 2007-10-14)
		The genome project reveals that humans are 99.9% identical to each other at the DNA sequence level.
		We have recently begun a novel genome-wide association study to map human complex disease loci in a subset of the Framingham Heart Study (FHS) population.
		Humans contain a related HAT complex that is likely to function similarly.
	gg.bu.edu /people/faculty/christman.htm (761 words)

	CBC News: Researchers analyse key chromosome (Site not responding. Last check: 2007-10-14)
		Chromosome 6 is home to the major histocompatibility complex (MHC).
		Other important genes are found on chromosome 6, including PARK2, which is involved in a juvenile-onset form of Parkinson's.
		"Gene abnormalities on chromosome 6 are also implicated — although not yet confirmed — as a contributory cause of several genetically complex diseases, including schizophrenia, epilepsy, cancer and heart disease," wrote Stanford genetics researchers Jane Grimwood and Jeremy Schmutz in an accompanying article.
	www.cbc.ca /story/science/national/2003/10/22/xsome6_031022.html (425 words)

	BBC NEWS \| Science/Nature \| Key human chromosome unravelled
		Called chromosome six, it is the largest such structure so far fully decoded in the human genome project.
		Chromosome six is the site of the major histocompatability complex, a large region in the DNA that is important for our immune response.
		Researchers have identified roughly 130 genes on chromosome six that may predispose humans to certain diseases.
	news.bbc.co.uk /2/hi/science/nature/3204661.stm (549 words)

	Kidney Disease - Abstracts : Online Reference For Health Concerns
		GSPE was also shown to demonstrate cytotoxicity towards human breast, lung and gastric denocarcinoma cells, while enhancing the growth and viability of normal human gastric mucosal cells.
		PKD1 gene, localized on chromosome 16, responds for the clinical course in the majority of ADPKD patients, whereas PKD2 gene, localized on chromosome 4, is responsible for less than 10-15% of cases, with presumed milder phenotypic manifestations.
		We contend that it may be an emerging infectious disease and/or microbial toxicosis in a vulnerable human subpopulation.
	www.lef.org /protocols/abstracts/abstr-065.html (9997 words)

	Prevention Protocols - Abstracts : Online Reference For Health Concerns
		In the present study the activity of a 20% methanolic extract of stinging nettle roots (Urtica dioica L., Urticaceae) on the proliferative activity of human prostatic epithelial (LNCaP) and stromal (hPCPs) cells was evaluated using a colorimetric assay.
		In two human studies, boron deprivation caused changes in variables associated with calcium metabolism in a manner that could be construed as being detrimental to bone formation and maintenance; these changes apparently were enhanced by low dietary magnesium.
		Although human diets are unlikely to be as severely methyl deficient as those used in these experiments, in some parts of the world intake of diets that are low in methionine and choline and contaminated with mycotoxins, such as aflatoxin, are common.
	www.lef.org /protocols/abstracts/abstr-131.html (16052 words)

	[No title] (Site not responding. Last check: 2007-10-14)
		PG - 870-4 AB - BACKGROUND AND AIMS OF THE STUDY: The study aim was to identify the value of broad-range bacterial PCR in infective endocarditis (IE) of bacterial etiology, and to determine its specificity and sensitivity.
		PG - 918-24 AB - A triplet repeat (CAG) expansion mutation in the huntingtin gene on chromosome 4 is responsible for Huntington's disease (HD).
		PG - 601-7 AB - BACKGROUND: This study was conceived to explore the correspondence between scintigraphic imaging of the sympathetic innervation of human postischemic left ventricular aneurysms and direct immunohistochemical localization of the nerve fibers in the same area.
	www.ee.columbia.edu /~abhi/MLProj/DIAGNOSIS/d6.txt (9302 words)

	: The AMEDEO Literature Guide
		Polymorphism in the E6 gene of human papillomavirus type 16 in the cervical tissues of Korean women.
		Age-specific incidence and clearance of high-risk human papillomavirus infections in women in the former Soviet Union.
		Human papillomavirus prevalence at the USA-Mexico border among women 40 years of age and older.
	www.amedeo.com /medicine/cvc/cvc2.htm (826 words)

	PETRO GREEN
		Overall summary evaluation of carcinogenic risk to humans is group 1: /As a group, hexavalent chromium compound/ are carcinogenic to humans.
		Hexavalent chromium is known to be carcinogenic in humans by the inhalation route of exposure.
		Sixty-nine S-12 (post mitochondrial) preparations of human lung (43 of peripherial lung parenchyma and 26 bronchial preparations) were assayed for their ability to activate procarcinogens to mutagenic metabolites in the Ames test or to lower the mutagenic response of direct-acting compounds.
	www.frankmckinnon.com /petro_green.htm (3095 words)

	Chromosome 6
		Chromosome 6 has more than 170 million base pairs and consists of about 5.5 to 6 percent of the total DNA in human cells.
		Chromosome 6 has numerous genes that are coded to produce proteins.
		If these genes are mutated the proteins they produce will not function correctly and may cause a disorder in the body.
	gumidemilo0.tripod.com (116 words)

	Immunohistochemistry - In Situ Hybridization - Biotinyl-tyramide-based In Situ Hybridization (Site not responding. Last check: 2007-10-14)
		Samples (Figures 3, 4, 5, 6, 7, 8, href="http://www.biomedcentral.com/1472-6890/3/2/figure/F9">9, 10) were similarly processed apart from incubation with AEC or DAB.
		HPV 16 has been shown to be integrated at 13q21-q31 by in situ hybridization analysis with 3 H-labeled probe and chromosome identification by Geimsa staining [10] and by detection of biotin-labeled HPV probe detected with avidin-FITC, which enabled detection of integrated HPV in metaphase spreads as a 'pin-prick' signal [11].
		The most important factors for high sensitivity were the use a sodium citrate step followed by the use of pepsin/HCl for tissue unmasking, the use of probes at a concentration of > 0.5 ng/μl hybridization mix, and, the concentration of primary streptavidin-peroxidase.
	www.immunoportal.com /modules.php?name=News&file=article&sid=70 (5007 words)

	Amazon.com: Books: Chromosome 6 (Site not responding. Last check: 2007-10-14)
		Chromosome 6 has a great premise: what happens if medical technology accelerates to the point that scientists can create genetic doubles for people; doubles who serve as living organ reservoirs for possible future organ transplant needs-a sort of biological insurance policy?
		Chromosome 6 is a very believable scenario of a technology designed with the best of intentions being corrupted for the sake of profit.
		The characters in Chromosome 6 are as flat as road kill, the action as watered down as a glass of coke left in the sun until all of the ice has melted.
	www.amazon.com /exec/obidos/tg/detail/-/0425161242?v=glance (1934 words)

	Human Chromosome 6
		Human Genome Landmarks Poster -- requires ShockWave plugin
		Chromosome 6 - BACs -- University of California, Santa Cruz release
		Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y
	www.ornl.gov /sci/techresources/Human_Genome/launchpad/chrom06.shtml (461 words)

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