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Topic: Chronic lymphocytic leukemia


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  Chronic lymphocytic leukemia - Wikipedia, the free encyclopedia
Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, is a type of leukemia in which too many lymphocytes are produced.
CLL is an abnormal neoplastic proliferation of B cells.
CLL is closely related to (and most consider it the same as) a disease called small lymphocytic lymphoma (SLL), a type of non-Hodgkin's lymphoma which presents primarily in the lymph nodes.
en.wikipedia.org /wiki/Chronic_lymphocytic_leukemia   (1623 words)

  
 Leukemia: Chronic Lymphocytic | AHealthyMe.com
Chronic leukemia is a disease in which too many white blood cells are made in the bone marrow.
Chronic leukemia is a cancer that starts in the blood cells made in the bone marrow.
Unlike acute leukemias, in which the process of maturation of the blast cells is interrupted, in chronic leukemias, the cells do mature and only a few remain as immature cells.
www.ahealthyme.com /topic/leukemialympho   (2217 words)

  
 Leukemia & Lymphoma Society - Disease Information - Chronic Lymphocytic Leukemia
CLL results from an acquired injury to the DNA of a single cell, a lymphocyte, in the bone marrow.
The result is the uncontrolled growth of CLL cells in the marrow, leading to an increased concentration in the blood.
Chronic lymphocytic leukemia is not associated with high-dose radiation or benzene exposures, as is the case with the other three major types of leukemia.
www.leukemia-lymphoma.org /all_page?item_id=7059   (889 words)

  
 Chronic Lymphocytic Leukemia Treatment - National Cancer Institute
Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
Chronic lymphocytic leukemia (also called CLL) is a blood and bone marrow disease that usually gets worse slowly.
CLL is the second most common type of leukemia in adults.
www.cancer.gov /cancerinfo/pdq/treatment/CLL/patient   (756 words)

  
 About Chronic Lymphocytic Leukemia
After chronic lymphocytic leukemia has been diagnosed, tests are done to find out how far the cancer has spread in the blood and bone marrow.
In stage I chronic lymphocytic leukemia, there are too many lymphocytes in the blood and the lymph nodes are larger than normal.
In stage II chronic lymphocytic leukemia, there are too many lymphocytes in the blood, the liver or spleen is larger than normal, and the lymph nodes may be larger than normal.
www.jamesline.com /cancertypes/leukemia/about/chronic   (2831 words)

  
 Chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a disorder of morphologically mature but immunologically less mature lymphocytes and is manifested by progressive accumulation of these cells in the blood, bone marrow, and lymphatic tissues.
CLL occurs primarily in middle-aged and elderly individuals, with increasing frequency in successive decades of life.[3] The clinical course of this disease progresses from an indolent lymphocytosis without other evident disease to one of generalized lymphatic enlargement with concomitant pancytopenia.
CLL B cells express relatively low levels of surface-membrane immunoglobulin (compared with normal peripheral blood B cells) and a single light chain (kappa or lambda).[2] CLL is diagnosed by an absolute increase in lymphocytosis and/or bone marrow infiltration coupled with the characteristic features of morphology and immunophenotype.
www.uoc.muni.cz /guidelines/19krev/CLL.htm   (2910 words)

  
 MedlinePlus Medical Encyclopedia: Chronic lymphocytic leukemia (CLL)
Chronic lymphocytic leukemia is cancer of the white blood cells (lymphocytes).
Chronic lymphocytic leukemia (CLL) causes a slow increase in the number of B lymphocytes in the bone marrow.
The average age of a patient with this type of leukemia is 70.
www.nlm.nih.gov /medlineplus/ency/article/000532.htm   (608 words)

  
 Chronic Lymphocytic Leukemia
Leukemia is cancer of the blood cells, usually the white blood cells.
Based on these findings, the leukemia is then classified into one of the four main types of leukemias: acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); acute lymphocytic leukemia (ALL); or chronic lymphocytic leukemia (CLL).
Chronic lymphocytic leukemia (CLL) is a cancer of the blood in which too many lymphocytes, a type of white blood cell, are produced by the bone marrow and by organs of the lymph system.
www.healthsystem.virginia.edu /uvahealth/adult_blood/chronlym.cfm   (508 words)

  
 Chronic Lymphocytic Leukemia (CLL)
Chronic lymphocytic leukemia (CLL) is a condition characterized by an accumulation of abnormal white blood cells or lymphocytes in the blood and the bone marrow.
These lymphocytes cannot perform their normal infection-fighting functions and interfere with the production of other blood cells, leading to multiple complications including immune deficiency, bleeding, swollen lymph nodes and other conditions.
About 10,000 new cases of chronic lymphocytic leukemia (CLL) are expected to be diagnosed in the United States this year.
www.fhcrc.org /research/diseases/cll   (934 words)

  
 Chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a disease in which too many infection-fighting white blood cells called lymphocytes are found in the body.
Lymphocytes are made in the bone marrow and by other organs of the lymph system.
Treatment of chronic lymphocytic leukemia depends on the stage of the disease, and the patient's age and overall health.
www.meds.com /pdq/chroniclympho_pat.html   (2087 words)

  
 Chronic Lymphocytic Leukemia (CLL): Leukemias: Merck Manual Home Edition
Chronic lymphocytic leukemia is a disease in which mature lymphocytes become cancerous and gradually replace normal cells in lymph nodes.
Hairy cell leukemia, a slow-growing uncommon type of B-cell leukemia, produces a large number of abnormal white blood cells with distinctive hairlike projections that are visible under a microscope.
Staging is based on factors such as the number of lymphocytes in the blood and bone marrow, size of the spleen and liver, presence or absence of anemia, and platelet count.
www.merck.com /mmhe/sec14/ch176/ch176d.html   (885 words)

  
 Chronic lymphocytic leukemia - MayoClinic.com   (Site not responding. Last check: 2007-10-11)
Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made.
It's called lymphocytic leukemia because it affects a group of white blood cells called lymphocytes, which typically fight infection.
A decade ago, doctors thought chronic lymphocytic leukemia always affected older adults and rarely posed enough risk to warrant cancer treatments, so "watchful waiting" was the treatment of choice.
www.mayoclinic.com /health/chronic-lymphocytic-leukemia/DS00565   (361 words)

  
 Chronic Lymphocytic Leukemia -- Byrd et al. 2004 (1): 163 -- Hematology
and infectious morbidity of fludarabine-refractory CLL and SLL
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia.
www.asheducationbook.org /cgi/content/full/2004/1/163   (9848 words)

  
 Leukemia Insights Newsletter-M.D. Anderson Cancer Center   (Site not responding. Last check: 2007-10-11)
Many patients with CLL are now being diagnosed coincidently while they are asymptomatic and the only evidence of disease is increase in lymphocyte count often with no lymphadenopathy or only minor enlargement of lymph nodes.
The oral idarubicin is given in a chronic low-dose schedule (daily for 28 days) and is extremely well tolerated by patients gaining substantial periods of stability of their disease.
The status of the p16 and p15 is being further investigated in CLL cases and correlated with the expression of other genes involved in cell cycle regulation such as retinoblastoma, p53, and MDM-2 protein.
www3.mdanderson.org /leukemia/insight/letter14.html   (5032 words)

  
 eMedicine - Chronic Lymphocytic Leukemia : Article by Michael Perry, MD
CLL also should be distinguished from prolymphocytic leukemia, in which more than 65% of the cells are morphologically less mature prolymphocytes.
CLL is a disease that primarily affects elderly individuals, with the majority of cases reported in individuals older than 55 years.
CLL is an acquired disorder, and reports of truly familial cases are exceedingly rare.
www.emedicine.com /med/topic370.htm   (3132 words)

  
 Chronic Lymphocytic Leukemia
Infections in chronic lymphocytic leukemia: risk factors, and impact on survival, and treatment.
Forty-two CLL patients with hypogammaglobulinemia (IgG < 600 mg/dL) and/or a history of at least one episode of severe infection in the 6 months preceding inclusion in the study were randomly allocated to receive either an infusion of 300 mg/kg IVIG every 4 weeks for 6 months or no treatment.
Abstract: Patients with chronic lymphocytic leukemia (CLL) are at an increasing risk of infectious morbidity and mortality.
www.emory.edu /WHSCL/euhosp/euhreport/2000/s010207a.html   (1321 words)

  
 Chronic Lymphocytic Leukemia -- Kay et al. 2002 (1): 193 -- Hematology
Immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) and lymphomas that resemble it.
Apparent physical association of the leukemic CLL B cell with these various cell types suggests that there is significant cellular crosstalk that assists in the induction of a microenvironment favorable to the leukemic CLL B cell.
3-21 genes characterize a new subset of chronic lymphocytic leukemia.
www.asheducationbook.org /cgi/content/full/2002/1/193   (9154 words)

  
 Chronic lymphocytic leukemia
CLL lymphocytes coexpress the B-cell antigens CD19 and CD20 along with the T-cell antigen CD5.[6] This coexpression only occurs in one other disease entity, mantle cell lymphoma.
Catovsky D, Fooks J, Richards S: Prognostic factors in chronic lymphocytic leukaemia: the importance of age, sex and response to treatment in survival: a report from the MRC CLL 1 trial.
CLL Trialists' Collaborative Group: Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials.
cancerweb.ncl.ac.uk /cancernet/101003.html   (4941 words)

  
 Chronic Lymphocytic Leukemia Research Consortium (CRC)
The CLL Research Consortium is a multi-institutional program project, funded by the National Institute of Health that has brought together institutions that, under normal circumstances, would not engage one another as they currently can under the auspices of CRC.
BAFF And APRIL Support Chronic Lymphocytic Leukemia B Cell Survival Through Activation Of The Canonical NF-{kappa}B Pathway.
CLL Research Consortium program project grant is renewed by the National Cancer Institute!!!!
cll.ucsd.edu   (261 words)

  
 Chronic Lymphocytic Leukemia
But, in CLL, the cells are immature and over abundant.
CLL usually occurs in people 60 years of age or older.
The following are the most common symptoms for chronic lymphocytic leukemia, however, each individual may experience symptoms differently:
www.umm.edu /blood/chronlym.htm   (267 words)

  
 Learn about chronic lymphocytic leukemia treatment options at Mayo Clinic
Each year several hundred patients are diagnosed with chronic lymphocytic leukemia (CLL) at Mayo Clinic, and many more receive ongoing care.
Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia, with more than 7,000 people diagnosed each year in the United States.
CLL results from a genetic mutation of bone marrow cells that causes abnormal blood cells to form.
www.mayoclinic.org /chronic-lymphocytic-leukemia/index.html   (343 words)

  
 Leukemia Causes, Diagnosis, Information, Treatments, and Symptoms on MedicineNet.com
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal.
Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
Acute Lymphocytic Leukemia; Acute Myeloid Leukemia; ALL; AML; Blood Cell Cancer; Cancer Of The Blood; Chronic Lymphocytic Leukemia; Chronic Myeloid Leukemia; CLL; CML; Hairy Cell Leukemia
www.medicinenet.com /leukemia/index.htm   (195 words)

  
 Loyola Univ. Health Sys. - Blood Disorders - Chronic Lymphocytic Leukemia   (Site not responding. Last check: 2007-10-11)
You are here: Home > Health Information > Health Topics > Blood Disorders > Chronic Lymphocytic Leukemia
> When the cancer develops in the lymphocytes (lymphoid cells), it is called lymphocytic leukemia.
In addition to a complete medical history and physical examination, diagnostic procedures for chronic lymphocytic leukemia may include:
www.luhs.org /health/topics/blood/chronlym.htm   (412 words)

  
 Chronic lymphocytic leukemia
(Refer to the PDQ summaries on Adult Acute Lymphocytic Leukemia Treatment; Childhood Acute Lymphocytic Leukemia Treatment; Adult Acute Myeloid Leukemia Treatment; Childhood Acute Myeloid Leukemia Treatment; Chronic Myelogenous Leukemia Treatment; and Hairy Cell Leukemia Treatment for more information.)
A clinical trial evaluating bone marrow or peripheral stem cell transplantation.
Surgery to remove the spleen or external radiation therapy to the spleen to reduce symptoms caused by the enlargement of the spleen.
cancerweb.ncl.ac.uk /cancernet/201003.html   (2289 words)

  
 Leukemia: Treatment - National Cancer Institute
Expert-reviewed information summary about the treatment of childhood acute myeloid leukemia, myelodysplastic syndromes, and other myeloproliferative disorders.
Expert-reviewed information summary about the treatment of chronic lymphocytic leukemia.
Expert-reviewed information summary about the treatment of chronic myelogenous leukemia.
www.cancer.gov /cancerinfo/treatment/leukemia   (254 words)

  
 Chronic Lymphocytic Leukemia (CLL) – Expert information about symptoms, treatments and new medications - HealthTalk ...
Chronic Lymphocytic Leukemia (CLL) – Expert information about symptoms, treatments and new medications - HealthTalk CLL Community
CLL survivor Andrew Schorr writes about the latest health news and shares his views.
Research CLL and many other conditions in our illustrated, interactive encyclopedia.
www.healthtalk.com /chroniclymphocyticleukemia/index.cfm   (179 words)

  
 Chronic Lymphocytic Leukemia
Stage I, Stage II, Stage III, and Stage IV Chronic Lymphocytic Leukemia
Treatment of stage I, stage II, stage III, and stage IV chronic lymphocytic leukemia may include the following:
This page was last modified on Donnerstag, 04-Jan-2007 11:39:11 MEZ
www.meb.uni-bonn.de /cancer.gov/CDR0000258005.html   (2651 words)

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