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Topic: Chronic myelogenous leukemia

Related Topics

CML

Acute myelogenous leukemia

Leukemia

Philadelphia chromosome

Chronic lymphocytic leukemia

Leukaemia

Acute lymphocytic leukemia

Bone marrow transplant

Polycythemia vera

Imatinib

Hairy cell leukemia

Splenomegaly

Myeloproliferative disorder

Thrombocytosis

Spherocytosis

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	Chronic myelogenous leukemia - Wikipedia, the free encyclopedia
		CML is a myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome.
		CML was the first malignancy to be linked to a clear genetic abnormality, the chromosomal translocation known as the Philadelphia chromosome.
		CML is often suspected on the basis on the complete blood count, which shows increased granulocytes of all types.
	en.wikipedia.org /wiki/Chronic_myelogenous_leukemia (1599 words)

	Leukemia & Lymphoma Society - Disease Information - Chronic Myelogenous Leukemia (Site not responding. Last check: 2007-10-09)
		Chronic myelogenous leukemia may be called by several names, including chronic granulocytic, chronic myelocytic or chronic myeloid leukemia.
		CML results from an acquired (not inherited) injury to the DNA of a stem cell in the marrow.
		Chronic myelogenous leukemia is distinguished from other leukemias by the presence of a genetic abnormality in blood cells, called the Philadelphia chromosome.
	www.leukemia-lymphoma.org /all_page?item_id=8501 (1432 words)

	Chronic Myelogenous Leukemia: (Site not responding. Last check: 2007-10-09)
		CML is a clonal disorder that is usually easily diagnosed because the leukemic cells of more than 95% of patients have a distinctive cytogenetic abnormality, the Philadelphia chromosome (Ph1).
		Accelerated phase chronic myelogenous leukemia is characterized by greater than 5% blasts in either the peripheral blood or bone marrow but 30% or less blasts in both the peripheral blood and bone marrow.
		Induction of graft-versus-host disease as immunotherapy for relapsed chronic myeloid leukemia.
	www.acor.org /cnet/62876.html (7306 words)

	Chronic Myelogenous Leukemia (CML), Gleevec and Transplant -- information for patients
		Chronic myelogenous leukemia (CML) is a slow-growing cancer of the white blood cells.
		CML is caused by a change in the genetic code of some of the cells in the bone marrow.
		The blast phase is similar to acute myelogenous leukemia.
	www.marrow.org /PATIENT/cml.html (1151 words)

	Chronic Myelogenous Leukemia Research Program, Congressionally Directed Medical Research Programs
		Chronic myelogenous leukemia (CML) is also known as chronic granulocytic leukemia or chronic myeloid leukemia.
		CML is an overgrowth of granulocytes, a type of white blood cell; its cause is unknown.
		In most cases, CML is characterized by a chromosomal abnormality that is known as the Philadelphia chromosome.
	cdmrp.army.mil /cmlrp (168 words)

	CML Support: Most Comprehensive Chronic Myelogenous Leukemia Information
		Chronic myelogenous leukemia (pronounced my-ah-lah-jeh-nes) is a cancer of the bone marrow.
		Bladder and colon cancer and leukemia were the most frequently encountered in men, while for women, colon, lung and breast malignancies were the most common.
		Both CML and this type of ALL are caused by a break in the so-called Philadelphia chromosome.
	www.cmlsupport.com (2242 words)

	Chronic myelogenous leukemia (CML)
		Chronic myelogenous leukemia (CML; also known as chronic myeloid leukemia or chronic granulocytic leukemia) is a cancer of the blood system in which too many white blood cells (WBCs) are made in the bone marrow.
		In CML, the translocation occurs between chromosomes 9 and 22 (human DNA is packaged in 23 pairs of chromosomes) and produces a new, abnormal gene called BCR-ABL.
		CML is divided into three phases depending on the maturity of the leukemia WBCs.
	www.antigenics.com /diseases/cml.html (1262 words)

	Chronic myelogenous leukemia
		CML can occur in children (2%-3% of all childhood leukemias are CML), but if Ph+, the prognosis for children may be better than that for adults.[8]
		The only consistently successful curative treatment of CML has been high-dose chemotherapy and total-body irradiation followed by rescue with transplantation of syngeneic or allogeneic bone marrow.[5] All patients younger than 60 years of age with an identical twin or with HLA-identical siblings should be considered for bone marrow transplantation (BMT) early in the chronic phase.
		Hydroxyurea is superior to busulfan in the chronic phase of CML, with significantly longer median survival and significantly fewer severe adverse effects.[27] A dose of 40 milligrams per kilogram per day is often used initially and frequently results in a rapid reduction of the white blood cell (WBC) count.
	www.meds.com /pdq/chronicmyelo_pro.html (4379 words)

	Chronic myelogenous leukemia
		Chronic myelogenous leukemia (CML) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made.
		Instead, the disease is generally divided into three worsening phases — chronic phase, accelerated phase and blast phase — depending on the amount of immature blood cells in the blood and bone marrow and the severity of symptoms.
		In general, treatment of chronic myelogenous leukemia depends on your age, your overall health, the phase of the disease and whether you have a suitable donor for bone marrow transplant.
	edition.cnn.com /HEALTH/library/DS/00564.html (2574 words)

	Leukemia: Chronic Myelogenous (CML) (Site not responding. Last check: 2007-10-09)
		Chronic myelogenous leukemia (CML) is a rare, life-threatening cancer that starts in the bone marrow.
		CML develops mainly in people who are middle-aged and sometimes in people who are older.
		The chronic phase of CML is often controlled by medicine to keep the white blood cell count normal.
	www.cancer.med.umich.edu /learn/leukcml.htm (717 words)

	MedlinePlus Medical Encyclopedia: Chronic myelogenous leukemia (CML)
		Chronic myelogenous leukemia is a malignant cancer of the bone marrow.
		Chronic myelogenous leukemia is characterized by a chronic phase that can last for months or years.
		A bone marrow transplant preceded by high-dose chemotherapy and radiation therapy remains the standard treatment, however, although not all people with CML are suitable candidates for transplantation or have a suitable donor.
	www.nlm.nih.gov /medlineplus/ency/article/000570.htm (816 words)

	Chronic myelogenous leukemia definition - Cancer information on MedicineNet.com
		Chronic myelogenous leukemia: A chronic malignant disease in which too many white blood cells belonging to the myeloid line of cells are made in the bone marrow.
		The disease is due to the growth and evolution of an abnormal clone of cells containing a chromosome rearrangement known as the Philadelphia (or Ph) chromosome.
		Radiation for CML usually comes from a machine outside the body (external radiation therapy) and is sometimes used to relieve symptoms or as part of therapy given before a bone marrow transplant.
	www.medterms.com /script/main/art.asp?articlekey=15477 (984 words)

	Chronic myelogenous leukemia - MayoClinic.com
		Chronic myelogenous leukemia (CML) is a rare type of cancer of the blood cells.
		But the good news is that the prognosis for people with chronic myelogenous leukemia may be improving because of new medications to treat the condition.
		Although a bone marrow transplant may still be an option, many people with chronic myelogenous leukemia are able to manage their condition long term with the use of chemotherapy-like pills.
	www.mayoclinic.com /health/chronic-myelogenous-leukemia/DS00564 (251 words)

	eMedicine - Chronic Myelogenous Leukemia : Article by Emmanuel C Besa, MD
		In patients in the chronic phase who were previously treated with interferon and whose treatment failed or who were unable to tolerate therapy, a complete hematologic remission was achieved in 88% (532 patients), with a major cytogenetic response (ie, complete remission in 0%, partial remission in 1-35%, Ph-positive metaphases) in 49% of patients.
		In 90% of patients with CML in the Western countries are diagnosed in the early or chronic phase of the disease.
		A German study of 139 low-risk patients with CML, according to the Sokal index, shows that the median survival with busulfan is 6 years (50 patients), with hydroxyurea is 6.5 years (55 patients), and with interferon alfa is approximately 9.5 years (34 patients), indicating improvement in survival with new therapy.
	www.emedicine.com /med/topic371.htm (6933 words)

	CML Help - Chronic myelogenous leukemia treatments and new research information about leukemia and CML.
		CML Help is a comprehensive resource for patients and families living with Chronic Myeloid Leukemia (CML).
		Chronic myeloid leukemia (CML or chronic myelogenous leukemia) is a disease in which too many white blood cells are made in the bone marrow.
		Chronic myeloid leukemia progresses slowly and usually occurs in people who are middle-aged or older, although it can also occur in children.
	www.cmlhelp.org (331 words)

	Chronic Myelogenous Leukemia
		Accelerated-phase CML is characterized by 10% to 19% blasts in either the peripheral blood or bone marrow.
		Patients older than 60 years with chronic phase CML have a hematologic and cytogenetic response rate and duration of cytogenetic response similar to that in younger patients; however, the incidence of complications is greater in elderly patients.
		Sawyers CL, Hochhaus A, Feldman E, et al.: Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.
	www.meb.uni-bonn.de /cancer.gov/CDR0000062876.html (7693 words)

	Chronic myelogenous leukemia
		Chronic myelogenous leukemia (also called CML or chronic granulocytic leukemia) is a disease in which too many white blood cells are made in the bone marrow.
		Chronic myelogenous leukemia progresses slowly and usually occurs in people who are middle-aged or older, although it also can occur in children.
		Once chronic myelogenous leukemia (CML) has been found (diagnosed), more tests may be done to find out if leukemia cells have spread into other parts of the body such as the brain.
	cancerweb.ncl.ac.uk /cancernet/201031.html (1912 words)

	Chronic Myelogenous Leukemia -- Druker et al. 2001 (1): 87 -- Hematology
		CML in chronic phase refractory to IFN, AP and BC have established
		CML was identified as a fatal disease with a median
		shortening is correlated with the duration of chronic phase.
	www.asheducationbook.org /cgi/content/full/2001/1/87 (9774 words)

	Chronic Myelogenous Leukemia -- Druker et al. 2002 (1): 111 -- Hematology
		to prolong the chronic phase of the disease indefinitely.
		A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
		Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.
	www.asheducationbook.org /cgi/content/full/2002/1/111 (9307 words)

	Sloan-Kettering - Chronic Myelogenous Leukemia (Site not responding. Last check: 2007-10-09)
		Researchers have noticed an increasing proportion of younger patients with chronic myelogenous leukemia (CML) in recent years.
		Radiation therapy is sometimes used for leukemia in the central nervous system.
		Investigators are pursuing a variety of strategies to control the disease -- approaches that can kill tumor cells directly, inhibit the body's production of substances that promote their growth, or that enhance the immune response against leukemic cells.
	www.mskcc.org /mskcc/html/5429.cfm (193 words)

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