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Topic: Chronotherapy

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	Chronotherapy Aids Chemotherapy (Site not responding. Last check: 2007-10-08)
		According to the report, chronotherapy reduced the rate of the severe effects of the treatment on the lining of the gastrointestinal tract by five-fold, and cut the incidence of peripheral neuropathy (a side effect of some chemotherapy drugs that causes numbness of fingertips and feet) by 50%.
		The group of patients receiving chronotherapy also had significantly fewer bouts with other side effects of the treatment, including inflammation of the mouth (six times less), severe diarrhea (two times less), and moderate hair loss (seen in 5% of the constant-rate group, none of the chronotherapy group).
		The results in the chronotherapy group of patients were so significant that the researchers, on advice from their policy board, stopped the trial early.
	www.personalmd.com /news/a1997090503.shtml (677 words)

	A Time to Heal: Chronotherapy Tunes In to Body's Rhythms
		Chronotherapy for asthma is aimed at getting maximal effect from bronchodilator medications during the early morning hours.
		Chronotherapy for all forms of arthritis uses standard treatment, nonsteroidal anti-inflammatory drugs and corticosteroids; however, the dosages are timed to ensure that the highest blood levels of the drug coincide with peak pain.
		But chronotherapy has a way to go, considering that only 5 percent of the doctors surveyed said they were "very familiar" with the subject.
	www.fda.gov /fdac/features/1997/397_chrono.html (1419 words)

	ABC News: Chronotherapy: For Some Treatments, It's About Time (Site not responding. Last check: 2007-10-08)
		"Chronotherapy is the key to [asthma] management," says Dr. Richard Martin, an asthma specialist at National Jewish Center for Immunology and Respiratory Medicine in Denver, in the April 15, 1996 edition of Hospital Practice.
		Chronotherapy has also been used to lower the amount of side effects from chemotherapy drugs.
		Chronotherapy may be a fairly new concept, but it is certainly not an outlandish one.
	abcnews.go.com /Health/Healthology/story?id=1078801&... (1009 words)

	Evolving Concepts in Chronotherapy with CCBs: Implications for Pharmacists
		Chronotherapy is a method of optimizing safe and effective pharmacotherapy by proportioning drug concentration throughout the 24-hour time period in synchrony with biologic rhythms of disease processes.
		A chronotherapeutic approach may be chosen when the threat of dangerous medical events or the intensity and symptoms of a disease are known to vary predictably during the 24-hour time period.
		In the cardiovascular patient, the focus of chronotherapy would be to optimally deliver the antihypertensive and/or antianginal agent in higher concentrations during the time of greatest need (ie, the early morning postawakening hours) and lower concentrations when the need is less (ie, the middle of the sleep cycle).
	www.pharmacytimes.com /article.cfm?ID=2113 (3902 words)

	Delayed Sleep Phase Syndrome - Treatment - Sleepchannel.com (Site not responding. Last check: 2007-10-08)
		Chronotherapy was first used to treat DSPS in 1981 and was first suggested by C.A. eisler.
		In chronotherapy, the patient progressively goes to bed and wakes up 3 hours later than the previous night, until he or she moves around the clock and can consistently sleep earlier.
		Chronotherapy can interfere with prescription medications and indications associated with other disorders.
	www.sleepdisorderchannel.net /dsps/treatment.shtml (1176 words)

	Steve Parker - Articles/Others/Su-Laine (Site not responding. Last check: 2007-10-08)
		Chronotherapy is difficult, although for people with DSPS it is often much easier than just trying to wake up at 7 am from the first day.
		During chronotherapy, patients often can fall asleep very quickly as soon as they get into bed, which helps their confidence.
		Be sure to check with your doctor if you have another condition that chronotherapy could interfere with, such as if you're taking insulin or other regular medication.
	steve-parker.org /articles/others/su-laine/chronotherapy.shtml (492 words)

	Chemotherapy Given In Biological Rhythms Gives Better Results (Site not responding. Last check: 2007-10-08)
		Chronotherapy reduced the rate of severe adverse effects on the lining of the gastrointestinal tract (eg, sloughing and inflammation) five-fold and halved the rate of functional impairment from peripheral nerve damage, such as loss of sensitivity of fingertips or feet.
		Median time to treatment failure was 6.4 months for those on chronotherapy and 4.9 months for those on constant infusion, which is a significant difference.
		The investigators conclude that chronotherapy was significantly less toxic and more effective than flat infusion and that the concept of circadian selectivity of cancer chemotherapy is well founded.
	www.docguide.com /dg.nsf/PrintPrint/9FA5756D6243507785256509004E419C (399 words)

	American Journal of Chinese Medicine: Chronotherapy in Traditional Chinese Medicine
		This last form of treatment is known as "acupuncture", whose purpose is to re-establish the normal circulation of Qi within the meridian, and, subsequently, the affected organ.
		Chronotherapy in TCM encompasses the recognition of the diurnal variation in the flow of Qi throughout the internal organs and the treatment of imbalance, by acupuncture, at specific times.
		One of the classic and most important works written on TCM is "The Yellow Emperor's Classic of Medicine", thought to have been written by the emperor Huang Di, who reigned during the middle of the third millenium BCE (Ni, 1995).
	findarticles.com /p/articles/mi_m0HKP/is_2000_Summer-Fall/ai_69540134 (1351 words)

	Chronotherapy - Tunes In to Body's Rhythms - Arthritis and arthritic conditions, medications, and treatment on ...
		One example is the bronchodilator Uniphyl, a long-acting theophylline preparation manufactured by Purdue Frederick Co. of Norwalk, Conn., and approved by FDA in 1989.
		I have found that unless treatment improves nighttime asthma, it is hard to improve its daytime manifestations." For people with severe asthma who wake up several times a night gasping for breath, a good night's sleep can be a dream come true.
		For osteoarthritis sufferers, the optimal time for a nonsteroidal anti-inflammatory drug such as ibuprofen would be around noon or mid-afternoon.
	www.medicinenet.com /script/main/art.asp?articlekey=551 (925 words)

	Cancer Decisions - Free Newsletter - May 30, 2003
		In a study of patients with metastatic renal cell cancer, patients were given their drugs in either a traditional or a chronotherapy approach.
		Finally, it was shown that selection of the Melodie brand infusion pump to deliver the chronotherapy resulted in "a further 18 percent reduction of overall costs and made it possible for patients to enjoy increased autonomy and improved quality of life" (Focan 2002).
		Chronotherapy seems like another in a long line of good treatment ideas that remains underdeveloped because it does not augment the short-term financial interests of those who provide, or reimburse for, cancer treatment.
	www.cancerdecisions.com /053003_page.html (4034 words)

	Feature (Site not responding. Last check: 2007-10-08)
		Chronotherapy coordinates drug delivery with human biological rhythms and holds huge promise in areas of pain management and treatment of asthma, heart disease and cancer.
		Langer points out that while controlling the technology and ensuring stability are some challenges in chronotherapy, there are vast applications in treatment of cancer and heart diseases that have shown benefits from such pulsatile delivery.
		As this field gains importance, regulatory aspects in clinical trials should change to accommodate new factors such as time of the day the drug is administered, time-related biological factors and patients’ normal routines.
	www.pharmaquality.com /Feature7a.htm (1443 words)

	Chronotherapy - Wikipedia, the free encyclopedia
		Also, there is a period of about three weeks while the clocks are being reset, during which one is rising at very peculiar times, and one cannot report to a regular job during this time.
		Here's an example of how Chronotherapy could work over a week's course of treatment, with the patient going to sleep three hours later every day until the desired sleep and waketime is reached.
		This page was last modified 08:53, 7 July 2005.
	en.wikipedia.org /wiki/Chronotherapy (178 words)

	Block Center for Integrative Cancer Care
		Through this revolutionary approach, chemotherapy is administered to patients based on circadian timing to optimize effectiveness while reducing toxic side effects.
		Chronotherapy is based on the scientific fact that our biochemistry behaves differently at different times of the day.
		Chronotherapy seeks to exploit this fact by calibrating the dosing of chemotherapy agents to these circadian rhythms.
	www.blockmd.com /unique/Chronotherapy.html (273 words)

	Postgraduate Medicine: Timing treatment to the rhythm of disease
		In selecting the most appropriate treatment for diseases that can be managed with chronotherapy, clinicians should understand that pharmacodynamic profiles of chronotherapeutic formulations are often different from those of traditional homeostatic formulations, even when the active drug itself is the same.
		Probably the most impressive results of chronotherapy were obtained in a clinical trial involving patients with colorectal cancer (20).
		Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer.
	www.postgradmed.com /issues/2001/08_01/elliott.htm (2563 words)

	CHRONOTHERAPY OF CANCER: (Site not responding. Last check: 2007-10-08)
		The first chronotherapy studies using doxorubicin, performed in 1977, revealed that the rate of tumor shrinkage following doxorubicin treatment of a transplanted plasmacytoma in rats is dependent upon the time of day that the drug is given.
		Clearly, our goal in chronotherapy protocols for each of these diseases was to reduce treatment-related toxicity and complication rates by optimal circadian drug timing, allowing high-doses of drug to be administered safely and most effectively.
		In a 5-day chronotherapy protocol, the infusion rates of FU, LV and I-OHP were automatically increased and decreased along the 24 hour scale using a multi-channel pump (Intelliject, Ivion Corp., Englewood, CO).
	www.rpi.edu /~hrushw/chroncancmajdrgdelchal.html (18045 words)

	Pharmacy Times CE: Evolving Concepts in Chronotherapy with CCBs: Implications for Pharmacists
		MWC Office of Continuing Professional Education is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
		In pharmacy school, we are trained to focus on what specific therapeutic agent to recommend-what are its particular side effects, drug interactions, and contraindications; who exclusively should receive therapy; and how specifically should the therapy be monitored.
		Moreover, the MS group was associated with stroke events independent of 24-hour BP, nocturnal BP dipping status, and baseline prevalence of silent infarcts (P = 0.008).
	secure.pharmacytimes.com /lessons/200503-03.asp (4942 words)

	Chronotherapy Helps Lung Cancer Patient on the Road to Recovery
		Though Olszowka was told she had months to live, she decided she was going to fight the disease, and ultimately found her way to cancer specialist, Keith Block, MD, where she received chronotherapy as part of her treatment plan.
		She wants the world to know about the role chronotherapy played in her survival in the hopes of helping other cancer patients.
		Chronotherapy is being widely researched around the world: There are over 62,000 references in PubMed (the National Institute of Health’s archive of biomedical and life sciences journal articles) about chronobiology (how biology is affected by timing) and over 500 scientific articles specifically about chronotherapy.
	www.prweb.com /releases/2005/11/inktomi307888.php (956 words)

	Timing Your Medical Treatments for Better Health: The New Science of Chronotherapy
		An emerging science known as chronotherapy (or medical chronobiology) uses this fundamental knowledge to determine the best time to administer various medical treatments.
		Chronotherapy researchers have made significant strides in recent years.
		For more on chronotherapy, see his Web site at www.rpi.edu/Ëhrushw.
	www.bottomlinesecrets.com /blpnet/article.html?article_id=27623 (1041 words)

	Sleep - Open Encyclopedia (Site not responding. Last check: 2007-10-08)
		A majority of sleep disorders which originate within the body (for example, insomnia, Delayed Sleep Phase Syndrome, or Advanced Sleep Phase Syndrome) result from errors in synchronization of sleep with the body clock.
		Only a fraction of sleep problems are organic and cannot be resolved with chronotherapy.
		One of the simplest solutions towards getting good sleep is free-running sleep.
	open-encyclopedia.com /Sleeping (958 words)

	QOL & Chronotherapy
		The first centered on the stability of QoL during a 6mon treatment period in patients undergoing chronotherapy.
		The second centered on research of the biological and clinical determinants of QoL involving features of the circadian activity rhythm and patient survival and the relationship between QoL and patient performance status, response to therapy, and psychosocial variables as well as drug-induced toxicity.
		The third centered on the clinical effectiveness of psychological intervention on patients undergoing chronotherapy to improve psychosocial status during treatment.
	www.annieappleseedproject.org /qolchron.html (251 words)

	ASCO - Browse by Meeting - Clinical experiences with irinotecan and chronotherapy in integrative care of advanced colon ... (Site not responding. Last check: 2007-10-08)
		Beginning in 1999 a regimen of irinotecan, 5FU and leucovorin was administered, using a Melodie chronotherapy pump to deliver drugs at optimal times, e.g.
		Patients whose adult diets were vegetarian or who changed to vegetarian diets after diagnosis with early stage disease appeared to have extended survival.
		Chronotherapy and integrative care may allow effective treatment with irinotecan, 5FU and leucovorin without the severe gastrointestinal side effects that have been the subject of recent publications.
	www.asco.org /ac/1,1003,_12-002702-00_18-0016-00_19-002382,00.asp (788 words)

	CBS News \| Timely Prescriptions \| June 20, 2003 18:49:31
		It may be hard for people to remember to take their prescription in mid-afternoon, in the middle of the workday or when they are busy with their children.
		Marshall says the concept of chronotherapy is not new, but there haven't been many American studies on it.
		European research shows when chronotherapy is followed, patients can better tolerate higher doses of the medications given to them, and they have fewer side effects.
	www.cbsnews.com /stories/2003/06/20/earlyshow/saturday/main559727.shtml (509 words)

	Woman Receives Chemotherapy While Rollerblading on Lakefront : ArriveNet Press Releases : Health (Site not responding. Last check: 2007-10-08)
		Chronotherapy is medicine that takes the body"s natural rhythms into account.
		"With chronotherapy, instead of receiving the chemo infused in one hour and having your body take all of the toxicity in that hour, they instead used an infusion pump.
		A review of the progress of chronotherapy research was published in May 2001 in the respected medical journal Lancet Oncology.
	press.arrivenet.com /health/article.php/669084.html (1638 words)

	Circadian Cancer Chronotherapy: The Necessity for Complementary Preclinical Investigation (Site not responding. Last check: 2007-10-08)
		Circadian Cancer Chronotherapy: The Necessity for Complementary Preclinical Investigation
		A series of studies in mice and rats followed which led to the circadian optimization of the doxorubicin/cisplatin combination.
		In order to assure that the optimum circadian patterns are tested in human beings with cancer, funding must be provided for adequate preclinical studies prior to the design of clinical infusional 5-FU chronotherapy studies.
	www.rpi.edu /~hrushw/ccctncpi.html (1364 words)

	Doctors are Finding Chronotherapy More Effective in Treating a Wide-range of Diseases
		We have found that often patients receiving chronotherapy reduce what would have been recurring side effects of nausea, vomiting, diarrhea, and fatigue.
		After working with Dr. Block and undergoing chronotherapy, Lopez, now 42, is cancer free.
		He will attend the September 30th national meeting of the Colon Cancer Alliance (CCA) in New York where Dr. Block will address the CCA and explain how even though time was not on Randy's side, timing was literally the key to his successful recovery.
	www.emediawire.com /releases/2005/9/emw288015.htm (884 words)

	Chronotherapy and Chronotoxicity of the Cyclooxygenase-2 Inhibitor, Celecoxib, in Athymic Mice Bearing Human Breast ...
		Chronotherapy and Chronotoxicity of the Cyclooxygenase-2 Inhibitor, Celecoxib, in Athymic Mice Bearing Human Breast Cancer Xenografts -- Blumenthal et al.
		Chronotherapy and Chronotoxicity of the Cyclooxygenase-2 Inhibitor, Celecoxib, in Athymic Mice Bearing Human Breast Cancer Xenografts
		either the chronotherapy or the chronotoxicity results obtained.
	clincancerres.aacrjournals.org /cgi/content/abstract/7/10/3178 (493 words)

	NEL, Season’s Appreciations 2000 ... pii: NEL22012001X001
		It was hence the more important that a meeting on chronoastrobiology and chronotherapy could be held a few months later.
		A chronotherapy for pre-habilitation may save much of the cost and may overcome the limitations to rehabilitation (e.g., after a massive stroke) that may be much more difficult to implement in extraterrestrial space.
		Toward this aim, physiological monitoring can contribute to a timely chronotherapy with now available drugs [103, 116] and thus to the maintenance of mobility and independence for everybody, for the elderly in particular, as well as for those on extraterrestrial missions.
	www.nel.edu /22_1/NEL22012001X001_Halberg.htm (12012 words)

	ASCO - Browse by Meeting - Age-independent benefit of chronotherapy with 5-fluorouracil, leucovorin and oxaliplatin in ... (Site not responding. Last check: 2007-10-08)
		Age-independent benefit of chronotherapy with 5-fluorouracil, leucovorin and oxaliplatin in patients with metastatic colorectal cancer within multicenter randomized phase III trials
		The magnitude of the efficacy benefit from chronotherapy was similar in the elderly subgroup and in the < 65y population (no independent prognostic value of age in multivariate analyses).
		Circadian 3-drug chronotherapy achieved otherwise similar tolerability and efficacy benefits in MCC patients irrespective of age and can be administered in elderly cancer patients.
	www.asco.org /ac/1,1003,_12-002702-00_18-0016-00_19-001431,00.asp (865 words)

	Experimental Chronotherapy of Mouse Mammary Adenocarcinoma MA13/C with Docetaxel and Doxorubicin as Single Agents and ...
		Experimental Chronotherapy of Mouse Mammary Adenocarcinoma MA13/C with Docetaxel and Doxorubicin as Single Agents and in Combination -- Granda et al.
		Levi F., Zidani R., Misset J. L., for the International Organization for Cancer Chronotherapy Randomized multicentre trial of chronotherapy with oxaliplatin, fluorouracil and folinic acid in metastatic colorectal cancer.
		Biology and therapeutic response of a mouse mammary adenocarcinoma (16/C) and its potential as a model for surgical adjuvant chemotherapy.
	cancerres.aacrjournals.org /cgi/content/full/61/5/1996 (4335 words)

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