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Topic: Chylomicron


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In the News (Fri 13 Nov 09)

  
  LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in ...
Uptake of asialofetuin and chylomicron remnants by the perfused liver.
Uptake of chylomicron remnants and asialofetuin in wild-type (WT) livers.
Clustering of chylomicron remnants is mediated by the LRP.
www.jci.org /cgi/content/full/107/11/1387   (4744 words)

  
 Encyclopedia: Chylomicron
Chylomicrons are large lipoprotein particles (having a diameter of 75 to 1,200nm) that are created by the absorptive cells of the small intestine.
Chylomicrons transport lipids to adipose tissue where they are broken down by lipoprotein lipase.
Chylomicrons are the largest and least dense lipoprotein particles and are mostly responsible for the transport of dietary fat (triglycerides) from the intestine.
www.nationmaster.com /encyclopedia/Chylomicron   (520 words)

  
 Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants. A QUANTITATIVE ...
ApoE is essential for the hepatic removal of chylomicron remnants, as evidently demonstrated by the fact that apoE-deficient humans (10, 11) and mice (12, 13) develop severe plasma retention of chylomicron remnants.
H]retinyl ester in chylomicron to LDL is negligible in mice.
We speculate that the injected chylomicron remnants might be removed from the circulation by a mechanism that is distinct either from the LDLR or from the non-LDLR pathway as defined in the experiment of Fig.
www.jbc.org /cgi/content/full/271/37/22422   (5366 words)

  
 A new method for the study of chylomicron kinetics in vivo -- Park et al. 279 (6): 1258 -- AJP - Endocrinology and ...
To estimate the extent of VLDL contamination of the chylomicron fraction, the relative proportions of apolipoprotein (apo)B-100
The former represent chylomicrons derived from the labeled test drink and the latter the labeled infused lipid emulsion.
from chylomicrons and VLDL in the specimens was estimated to be
ajpendo.physiology.org /cgi/content/full/279/6/E1258   (3875 words)

  
 Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes ...
Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes -- Zeng et al.
Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes
Chylomicron remnant uptake is regulated by the expression and
www.jlr.org /cgi/content/full/39/4/845   (6824 words)

  
 Differential Effects of Low-Density Lipoprotein and Chylomicron Remnants on Lipid Accumulation in Human Macrophages -- ...
Chylomicron remnant-induced foam cell formation and cytotoxicity: a possible mechanism of cell death in atherosclerosis.
Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low density lipoprotein, high density lipoprotein and albumin.
Chylomicron remnant–like particles inhibit receptor-mediated endothelium-dependent vaso-relaxation in porcine coronary arteries.
www.ebmonline.org /cgi/content/full/229/6/528   (6050 words)

  
 Metabolism of Chylomicron Cholesterol Is Delayed by Estrogen. An In Vivo Study in the Rat -- Bravo et al. 226 (2): 112 ...
the hepatic uptake of chylomicron cholesterol and its excretion
Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.
The influence of dietary saturated and unsaturated fat on hepatic cholesterol metabolism and the biliary excretion of chylomicron cholesterol in the rat.
www.ebmonline.org /cgi/content/full/226/2/112   (4910 words)

  
 LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in ...
LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice -- Yu et al.
LDL receptor–related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice
Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase
www.jci.org /cgi/content/abstract/107/11/1387   (549 words)

  
 Online Canadian Pharmacy - Discount Canadian Drugs - Medical Dictionary - Chylomicron   (Site not responding. Last check: 2007-10-08)
Chylomicrons are found in the blood and lymphatic fluid where they serve to transport fat from its port of entry in the intestine to the liver and to adipose (fat) tissue.
After a fatty meal, the blood is so full of chylomicrons that it looks milky.
The chylomicrons are synthesized (made) in the mucosa (the lining) of the intestine.
www.canadian-drugs.com /dictionary/c/Cf-Cj/Chylomicron.html   (108 words)

  
 Markers of Triglyceride-rich Lipoprotein Remnant Metabolism in Visceral Obesity -- Chan et al. 48 (2): 278 -- Clinical ...
The catabolism of chylomicron remnants was measured by intravenous
Postprandial chylomicron response may be predicted by a single measurement of plasma apolipoprotein B-48 in the fasting state.
Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice.
www.clinchem.org /cgi/content/full/48/2/278   (2908 words)

  
 Vitamin E deficiency due to chylomicron retention disease in Marinesco-Sjogren syndrome.   (Site not responding. Last check: 2007-10-08)
Vitamin E deficiency due to chylomicron retention disease in Marinesco-Sjogren syndrome.
Vitamin E deficiency due to chylomicron retention disease in Marinesco-Sjogren syndrome.The electron microscopy of the intestinal mucosa was consistent with a chylomicron retention disease.
We speculate that both chylomicron retention disease and Marinesco-Sjogren syndrome are related to defects in a gene crucial for the assembly or secretion of the chylomicron particles, leading to very low serum levels of vitamin E.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/2097604.html   (113 words)

  
 Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over ...
Postchallenge plasma lipoprotein retinoids: chylomicron remnants in endogenous hypertriglyceridemia.
Berr F, Eckel RH, Kern F. Plasma decay of chylomicron remnants is not affected by heparin-stimulated plasma lipolytic activity in normal fasting man. J Lipid Res 1985;26:852-9.
The metabolism of chylomicron cholesterol ester in the rat.
www.bmj.com /cgi/content/full/312/7036/935   (3500 words)

  
 Modulation of lipid chylomicron-synthesizing enzymes in rats by the dietary (n-6):(n-3) fatty acid ratio.   (Site not responding. Last check: 2007-10-08)
Modulation of lipid chylomicron-synthesizing enzymes in rats by the dietary (n-6):(n-3) fatty acid ratio.We suggest that (n-3) PUFA ingestion leads to an enhanced velocity of chylomicron synthesis in rats.
Results showed that after a 4-wk feeding period, ACAT, ACLAT and DGAT basal activities were significantly enhanced by the dietary fatty acids of the (n-3) series, whereas MGAT activity was not affected.
The effect of diets with various (n-6):(n-3) polyunsaturated fatty acid (PUFA) ratios and a constant polyunsaturated: saturated fatty acid ratio on the basal activity of chylomicron lipid synthesizing enzymes was investigated in rat intestinal microsomes.
www.ihop-net.org /UniPub/iHOP/gp/6894036.html   (189 words)

  
 Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester.
Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester.Little is known about physiologic factors important to this uptake.
We hypothesized that lipoprotein lipase (LpL) contributes to extrahepatic clearance of chylomicron vitamin A.
To investigate this, [3H]retinyl ester-containing rat mesenteric chylomicrons were injected intravenously into induced mutant mice and nutritionally manipulated rats.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/1783915.html   (197 words)

  
 Chylomicron beta -Carotene and Retinyl Palmitate Responses Are Dramatically Diminished When Men Ingest beta -Carotene ...   (Site not responding. Last check: 2007-10-08)
Chylomicron beta -Carotene and Retinyl Palmitate Responses Are Dramatically Diminished When Men Ingest beta -Carotene with Medium-Chain Rather than Long-Chain Triglycerides -- Borel et al.
The ratios of chylomicron retinyl palmitate to chylomicron
The fact that no chylomicron triglycerides were detected during the postprandial period after consumption of the MCT meal
nutrition.org /cgi/content/full/128/8/1361   (3620 words)

  
 Intestinal lipoprotein assembly in apobec-1-/- mice reveals subtle alterations in triglyceride secretion coupled with a ...
Serum chylomicrons (density <1.006) were isolated from pooled samples taken 4 h after an oral triglyceride bolus and were subjected to negative stain electron microscopy (E–H).
Increased dietary triacylglycerol markedly enhances the ability of isolated rabbit enterocytes to secrete chylomicrons: an effect related to dietary fatty acid composition.
Superior role of apolipoprotein B48 over apolipoprotein B100 in chylomicron assembly and fat absorption: an investigation of apobec-1 knockout and wild-type mice.
ajpgi.physiology.org /cgi/content/full/285/4/G735   (5568 words)

  
 IngentaConnect Postprandial chylomicron and plasma vitamin E responses in health...   (Site not responding. Last check: 2007-10-08)
Postprandial chylomicron and plasma vitamin E responses in healthy older subjects compared with younger ones
The effect of ageing on vitamin E bioavailability in humans was assessed by comparing chylomicron and plasma alpha-tocopherol postprandial concentrations after a dose of vitamin E (432 or 937 IU as dl-alpha-tocopherol acetate), in eight young (20-30 years old) and eight healthy elderly men (64-72 years old).
In both groups, the plasma and chylomicron alpha-tocopherol postprandial concentrations were significantly, approximately twofold, higher after the 937-IU meal than after the 432-IU meal.
www.ingentaconnect.com /content/bsc/ejci/1997/00000027/00000010/art00196   (383 words)

  
 Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice.   (Site not responding. Last check: 2007-10-08)
A mouse model of chylomicron deficiency was recently developed; these mice express a human apolipoprotein (apo) B transgene in the liver but do not synthesize any apoB in the intestine.
The fractional contribution from plasma NEFA to hepatic TG was greatly elevated in the chylomicron-deficient animals (62% compared with 23%).
Accordingly, 73% of hepatic TG was neither from DNL nor from plasma NEFA in controls, presumably reflecting prior contribution from chylomicron remnants, compared with only 26% in the chylomicron-deficient group.
www.arclab.org /medlineupdates/abstract_10510316.html   (317 words)

  
 Mobilisation of enterocyte fat stores by oral glucose in humans -- Robertson et al. 52 (6): 834 -- Gut   (Site not responding. Last check: 2007-10-08)
Large numbers of chylomicron sized lipid droplets (L) are present in the apical cytoplasm identified by the presence of microvilli (MV).
Formation and transport of chylomicrons by enterocytes to the lymphatics.
Chylomicron synthesis by intestinal cells in vitro and in vivo.
gut.bmjjournals.com /cgi/content/full/52/6/834   (3724 words)

  
 COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport ...
Golgi complex on its way to exit the cell as a chylomicron.
The released chylomicron fraction was isolated by centrifugation
(B) After the fusion reaction, the Golgi was separated from PCTV on a sucrose gradient and incubated with or without carbonate (100 mM, pH 11) as indicated to release the chylomicrons.
jcs.biologists.org /cgi/content/full/116/2/415   (7644 words)

  
 Canine hyperlipidemia
A diagnosis can be confirmed by doing a simple blood test on a dog that has fasted for 12 hours.
A test called the Chylomicron test is performed.
Hyperlipidemia can sometimes be managed through a low fat diet and sometimes by medications.
www.weir.net /~lglass/canine-hyperlipidemia.htm   (2189 words)

  
 Chylomicron   (Site not responding. Last check: 2007-10-08)
Chylomicrons es las partículas grandes de la lipoproteína que son creadas por las células absorbentes del intestino pequeño.
Lípidos del transporte de Chylomicrons al tejido fino adiposo.
English version: Chylomicron Next: Isla De Akimiski Up
www.yotor.net /wiki/es/ch/Chylomicron.htm   (78 words)

  
 Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism -- Weintraub ...
Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism -- Weintraub et al.
in the chylomicron remnant fraction was reduced significantly
Total plasma RP and chylomicron RP remained unchanged.
jcem.endojournals.org /cgi/content/abstract/84/7/2532   (361 words)

  
 Baptist Northeast : Health Illustrated Encyclopedia
Apolipoprotein CII (apoCII) is in found in chylomicrons (large lipoprotein particles absorbed from the gastrointestinal tract) and VLDL (large lipoproteins that are broken down to eventually form LDL).
ApoCII activates the enzyme that breaks down chylomicron and VLDL molecules.
This test is usually performed to help determine the cause of hyperlipidemia (elevated blood lipid levels).
healthcontent.baptistnortheast.com /adamcontent/ency/article/003505.asp   (608 words)

  
 In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector -- Hara et al. ...
In the blood circulation, chylomicrons are remodeled to
chylomicron remnants by hydrolysis of the core triglycerides by
chylomicron is only one type of lipoprotein that transports lipids
www.pnas.org /cgi/content/full/94/26/14547   (5219 words)

  
 Lipoprotein lipase and uptake of chylomicron triglyceride by skeletal muscle of rats -- Linder et al. 231 (3): 860 -- ...
Lipoprotein lipase and uptake of chylomicron triglyceride by skeletal muscle of rats -- Linder et al.
Lipoprotein lipase and uptake of chylomicron triglyceride by skeletal muscle of rats
Uptake of chylomicron triglyceride and lipoprotein lipase was studied in red and white skeletal muscles, heart, and adipose tissue of rats.
ajplegacy.physiology.org /cgi/content/abstract/231/3/860   (376 words)

  
 Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism -- Weintraub ...
is essential for the degradation of chylomicrons (35), was shown
1996 Clearance of chylomicron remnants in normolipidemic patients with coronary artery disease: a case-control study over three years.
1991 Independent regulation of chylomicron lipolysis and particle removal rates: effect of insulin and thyroid hormones on the metabolism of artificial chylomicrons.
jcem.endojournals.org /cgi/content/full/84/7/2532   (2659 words)

  
 Lipid-dependent Bidirectional Traffic of Apolipoprotein B in Polarized Enterocytes -- Morel et al. 15 (1): 132 -- ...
Cartwright, I.J., and Higgins, J.A. Direct evidence for a two-step assembly of ApoB48-containing lipoproteins in the lumen of the smooth endoplasmic reticulum of rabbit enterocytes.
Glickman, R.M., Kilgore, A., and Khorana, J. Chylomicron apoprotein localization within rat intestinal epithelium: studies of normal and impaired lipid absorption.
Hussain, M.M., Kedees, M.H., Singh, K., Athar, H., and Jamali, N.Z. Signposts in the assembly of chylomicrons.
www.molbiolcell.org /cgi/content/full/15/1/132   (7927 words)

  
 Postprandial Chylomicron Clearance Rate in Late Teenagers with Diabetes Mellitus Type 1 -- VAN WAARDE et al. 50 (5): ...   (Site not responding. Last check: 2007-10-08)
Postprandial Chylomicron Clearance Rate in Late Teenagers with Diabetes Mellitus Type 1 -- VAN WAARDE et al.
Postprandial Chylomicron Clearance Rate in Late Teenagers with Diabetes Mellitus Type 1
A delayed chylomicron (CM) clearance rate, a known risk factor
www.pedresearch.org /cgi/content/abstract/50/5/611   (289 words)

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