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Topic: Cimetidine

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	MedlinePlus Drug Information: Cimetidine
		Cimetidine is used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome.
		Over-the-counter cimetidine is used to prevent and treat symptoms of heartburn associated with acid indigestion and sour stomach.
		Cimetidine is also used sometimes to treat stress ulcers, hives and itching, and viral warts, and to prevent aspiration pneumonia during anesthesia.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682256.html (733 words)

	cimetidine
		Cimetidine is used to treat and prevent ulcers in the stomach and intestines.
		Cimetidine is also used to treat conditions in which the stomach produces too much acid and conditions in which acid comes up into the esophagus and causes heartburn, such as gastroesophageal reflux disease (GERD).
		Cimetidine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
	hw.healthdialog.com /kbase/multum/d00140a1.htm (1164 words)

	[No title]
		Cimetidine, famotidine and ranitidine are competitive, reversible inhibitors of the action of histamine at the H2-receptors, including receptors on the gastric cells.(1-5) This results in the inhibition of acid secretion and volume of gastric secretion.
		The possibility that intestinal cimetidine transport may be mediated by an intestinal carrier for cysteamine is of special interest as this agent is given orally to treat cystinosis.
		Failure of cysteine to inhibit initial cimetidine uptake may be consistent with the fact that it is not a substrate for the cysteamine lysosomal carrier.
	www.lycos.com /info/cimetidine--miscellaneous.html (433 words)

	Cimetidine Information on Healthline
		Cimetidine is used to treat and prevent certain types of ulcer, and to treat conditions that cause the stomach to produce too much acid.
		Cimetidine is also used to treat gastroesophageal reflux disease (GERD), when stomach acid backs up into the esophagus and causes heartburn.
		Cimetidine is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	www.healthline.com /multumcontent/cimetidine (915 words)

	Cimetidine (Site not responding. Last check: 2007-11-01)
		Over-the-counter cimetidine is used toprevent and treat symptoms of heartburn associated with acidindigestion and sour stomach.
		Cimetidine is in a class of medicationscalled H2 blockers.
		Cimetidine is used to treat gastric andduodenal ulcers.
	pharmacycom.net /product_cimetidine-p13751.html (463 words)

	Le Magazine, July 2002 - Cover Story: Cimetidine (Tagamet) For Cancer Treatment
		It was then discovered that cimetidine inhibits the expression of E-selectin (ELAM-1) which is one of the molecules in blood vessels that cancer cells adhere to using their own cell surface ligands, Lewis X and Lewis A.4 These are carbohydrate groups on the surface on certain cancer cells that allow them to bind to E-selectin.
		Since cimetidine inhibits the expression of E-selectin in blood vessels, cancer cells that are in the bloodstream can't bind to the blood vessels and establish a metastatic tumor.
		Since cimetidine inhibits the expression of E-selectin in blood vessels, cancer cells that are in the bloodstream can't bind to the blood vessels and establish a metastatic tumor and are eventually eliminated.
	www.lef.org /magazine/mag2002/jul2002_cover_cimetidine_01.html (2597 words)

	[No title]
		Cimetidine administration did not lead to malabsorption of unbound cobalamin but caused malabsorption of protein-bound cobalamin.
		The effects of cimetidine and ciprofloxacin on the renal clearance of theophylline and on the formation clearance to theophylline metabolites are summarized in table 4.
		In the young male, elderly male and elderly female subjects, after treatment with cimetidine and ciprofloxacin, the renal clearance of theophylline tended to be lower than the base-line values, although the difference did not reach statistical significance.
	lycos.cs.cmu.edu /info/cimetidine--treatments.html (536 words)

	Cimetidine HCl (Tagamet®)
		Cimetidine is available over the counter but should not be administered unless under the supervision and guidance of a veterinarian.
		Cimetidine is used in the treatment and prevention of stomach and intestinal ulcers.
		Cimetidine should not be used in animals with known hypersensitivity or allergy to the drug.
	www.petplace.com /drug-library/cimetidine-hcl-tagamet/page1.aspx (625 words)

	Parkinsn's List Drug DataBase cimetidine / Tagamet
		Cimetidine does not appear to alter gastric motility, gastric emptying, esophageal pressure, or the secretion rate of the gallbladder or pancreas.
		Studies have shown that cimetidine's ability to interfere with this metabolic step is a function of its structure and not of its ability to block HA-receptors since other HA-blockers do not appear to inhibit this metabolic pathway to the same degree as cimetidine.
		Cimetidine may also interfere with the clearance of paroxetine, however, additional data is needed to better describe this interaction.
	www.parkinsons-information-exchange-network-online.com /drugdb/032.html (1690 words)

	VitaminShoppe.com - Health Guide - Cimetidine
		Cimetidine is a member of the H-2 blocker (histamine blocker) family of drugs that prevents the release of acid into the stomach.
		Cimetidine is available as a prescription drug and as a nonprescription over-the-counter product for relief of heartburn.
		Cimetidine may decrease the clearance of caffeine from the body, causing increased caffeine blood levels and unwanted actions.
	www.vitaminshoppe.com /learning/healthguide/healthguide_content.jhtml?Category=Drug&title=Cimetidine&relativePath=/content/healthnotes/Drug/Cimetidine.htm (871 words)

	Le Magazine, July 2002 - Abstracts: Curcumin, Theanine, Arginine, Cimetidine, Regenerative Medicine
		Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.
		According to our previous observations that cimetidine blocked the expression of E-selectin on vascular endothelium and inhibited the adhesion of cancer cells to the endothelium, we have further stratified the patients according to the expression levels of sialyl Lewis antigens X (sL(x)) and A (sL(a)).
		The effect of cimetidine on survival was investigated in 181 patients with gastric cancer.
	www.lef.org /magazine/mag2002/jul2002_abs_03.html (1097 words)

	cimetidine (Tagamet) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		PRESCRIBED FOR: Cimetidine is used for the treatment of duodenal ulcers, active gastric ulcers, gastroesophageal reflux disease (GERD), pathological hypersecretory conditions (e.g., Zollinger Ellison syndrome), heartburn and the prevention of gastrointestinal bleeding.
		Cimetidine also may increase the blood levels phenytoin, theophylline, lidocaine, amiodarone, metronidazole, loratadine, calcium channel blockers (e.g., diltiazem, felodipine, nifedipine), bupropion, carbamazepine and fluvastatin.
		Because cimetidine reduces stomach acid, it may reduce the absorption of drugs (e.g., ketoconazole) that are best absorbed in acidic conditions.
	www.medicinenet.com /cimetidine/article.htm (627 words)

	Cimetidine HCl (Tagamet®) - PetPlace.com (Site not responding. Last check: 2007-11-01)
		Cimetidine is used in the treatment and prevention of stomach and intestinal ulcers.
		Cimetidine may be useful in the treatment of stomach inflammation caused by kidney failure.
		Cimetidine should be used with caution in animals with liver or kidney disease.
	petplace.netscape.com /articles/artShow.asp?artID=1514 (522 words)

	Data Sheet
		Cimetidine is partially metabolised in the liver to the sulphoxide and to hydroxymethylcimetidine but most (70%) is excreted by the kidneys unchanged.
		Cimetidine is contraindicated in patients with a known hypersensitivity to the medication.
		Cimetidine should be avoided in pregnancy unless the benefits outweigh the potential risk to the foetus.
	www.medsafe.govt.nz /profs/datasheet/a/apocimetidinetab.htm (1542 words)

	Cimetidine (Site not responding. Last check: 2007-11-01)
		Cimetidine was tested for carcinogenicity by oral administration in single studies in mice, rats and dogs.
		Cimetidine did not induce single-strand breaks in DNA from rats treated in vivo, nor did it methylate DNA in a variety of tissues of rats in vivo.
		Cimetidine in combination with sodium nitrite did not induce DNA damage in vivo or methylate DNA in a variety of tissues of rats in vivo.
	monographs.iarc.fr /htdocs/monographs/vol50/11-cimetidine.htm (642 words)

	Howstuffworks "Cimetidine: A Profile of an Ulcer and Stomach Acid Drug"
		When obtained by prescription, cimetidine is used for the treatment of duodenal and gastric ulcers, for the long-term treatment of excessive stomach acid secretion, and for the prevention of recurrent ulcers.
		The absorption of ketoconazole and itraconazole is decreased by cimetidine.
		Cimetidine appears to be safe during pregnancy; however, extensive testing has not been conducted.
	health.howstuffworks.com /define-cimetidine.htm (829 words)

	Cimetidine Is Not Effective in the Treatment of Multiple Warts
		You are seeing a teenager with multiple warts that have been refractory to standard topical therapy, and she is looking for an effective alternative.
		Cimetidine is an H2-receptor antagonist known to have immunomodulatory effects including enhancement of T-cell-dependent responses.
		Ten studies of cimetidine treatment for warts have been done; only three were double-blind, placebo-controlled; the remainder were either open-label studies, comparison with standard therapy, or case reports.
	www.med.umich.edu /pediatrics/ebm/cats/cimetidine.htm (416 words)

	Canadian Pharmacy, Canada Drugs, Online Pharmacy Prescriptions
		Cimetidine is belongs to the group of Histamine H2-receptor antagonist and Urticaria therapy adjunct drug, commonly used for the prevention and treatment of the symptoms of ulcers and prevent their return.
		Cimetidine is useful for the treatment of the Healing and prevention of peptic ulcers in the stomach or duodenum.
		Cimetidine is belongs to the group of medicines known as Histamine H2-receptor antagonist and Urticaria therapy adjunct drug, commonly used for the prevention and treatment of the symptoms of ulcers and prevent their return.
	www.abconlinepharmacy.com /ns/customer/product2408-c-p1 (949 words)

	Cimetidine, Tagamet, Tagamet HB
		Cimetidine is a member of the H-2 blocker (histamine blocker) family of drugs that prevents the release of acid into the stomach.
		In healthy volunteers, a magnesium hydroxide/aluminum hydroxide antacid, taken with cimetidine, decreased cimetidine absorption by 20 to 25%.
		Cimetidine may decrease the clearance of caffeine from the body, causing increased caffeine blood levels and unwanted actions.
	www.truestarhealth.com /Notes/1108009.html (677 words)

	The Cancer Files: Is cimetidine a better cure for cancer?
		It demonstrated very convincingly the benefit of cimetidine taken for seven days before surgery to reduce the immunosuppressive effects of the surgery: at the three year follow-up, ninety-three percent of patients in the cimetidine group were alive compared with only fifty-nine percent in the control group.
		In a Danish pilot study of cimetidine at 400 mg per day or placebo in colorectal cancer a total of 192 patients who had undergone surgery for cancers of the colon or rectum were studied for forty months.
		Cimetidine is probably the easiest drug to obtain and is suggested as the drug of first choice when cancer is suspected.
	www.second-opinions.co.uk /cimetidine.html (2605 words)

	Patient Education - Drugs - cimetidine
		The location of cimetidine's action within the cell is the histamine 2 site so this and other drugs like it are called histamine 2 receptor antagonists or H2RA for short.
		Cimetidine is metabolized at a certain place in the liver where many other drugs are also broken down.
		Cimetidine is ranked B. Always consult your physician before taking any drug during or when planning pregnancy.
	www.endowsec.com /pated/cimetidine.htm (901 words)

	Patient Education - Drugs - cimetidine
		Cimetidine was the very first drug specifically designed to block the acid producing cell in the stomach.
		It ranks drugs from A, where medical studies show no evidence for danger to the fetus or mother, to B, C, D and X, where the medical evidence indicates that the risk to the fetus outweighs any benefit to the mother.
		Cimetidine may cause breast swelling in males, loss of libido and impotence.
	www.gicare.com /pated/cimetidine.htm (919 words)

	Cimetidine -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-11-01)
		Metiamide was an effective agent, however it was associated with unacceptable (Click link for more info and facts about nephrotoxicity) nephrotoxicity and (An acute blood disorder (often caused by radiation or drug therapy) characterized by severe reduction in granulocytes) agranulocytosis.
		It was proposed that the toxicity arose from the (Click link for more info and facts about thiourea) thiourea group, and similar guanidine-analogues were investigated until the ultimate discovery of cimetidine.
		For example, cimetidine may decrease metabolism of some drugs, such as (A contraceptive in the form of a pill containing estrogen and progestin to inhibit ovulation and so prevent conception) oral contraceptives.
	www.absoluteastronomy.com /encyclopedia/c/ci/cimetidine.htm (701 words)

	CIMETIDINE (TAGAMET) AS IMMUNOMODULATOR, ANTITUMOR TREATMENT?
		Cimetidine (Tagamet), commonly used to treat stomach ulcers and one of the most widely prescribed drugs in the U.S., has shown immune enhancing and antitumor activity in recent studies.
		Cimetidine has also been shown to be useful for controlling herpes simplex and herpes zoster outbreaks, as well as chronic Epstein-Barr infection.
		She points out that cimetidine is relatively a very safe drug and is available now to people with HIV and their physicians.
	www.aids.org /atn/a-080-04.html (828 words)

	Cimetidine: A review of the recent developments and reports in cutaneous medicine
		Cimetidine has a valuable role in treating of PFAPA syndrome.[47] In one study, it was as an effective first-line therapy for PFAPA at 20 mg/kg/day, curing 49 of 83 patients.[48] Alternatively, other authorities state that glucocorticoids are the most highly effective in controlling symptoms.
		Cimetidine has been suggested as a treatment for acute intermittent porphyria.[51] Its role seems to be as a second-line treatment to intravenous hemin, which is expensive but appears to be more effective than increased carbohydrate intake.
		In rats, cimetidine has been shown to be more effective than ranitidine or famotidine in the reversible inhibition of the toxic metabolic pathway which produces dapsone's hydroxylamine metabolite.[57] Cimetidine also did not appear to inhibit the detoxification pathways of dapsone or cytosolic acetylation because of its greater affinity for cytochrome P-450.
	dermatology.cdlib.org /92/reviews/cimetidine/scheinfeld.html (2283 words)

	Treatments: Cimetidine - WrongDiagnosis.com
		Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor.
		Cimetidine : histamine congener; competitively inhibits histamine binding to H2 receptors, inhibits gastric acid secretion, pepsin, and gastrin output, and blocks the activity of cytochrome P-450.
		Count: Cimetidine is listed as a: treatment for 4 conditions; alternative treatment for 4 conditions; preventive treatment for 0 conditions; research treatment for 0 conditions.
	www.wrongdiagnosis.com /treat/cimetidine.htm (292 words)

	[No title]
		Cimetidine was the first H2-antagonist to receive approval from the Food and Drug Administration (FDA) in 1977.
		The influence of secretory transporters on intestinal permeability characteristics of the H2 receptor antagonists ranitidine and cimetidine was studied in Caco-2 monolayers and rat intestinal mucosa mounted in Ussing chambers.
		Similarly, the uptake of radiolabeled cimetidine from capillaries into proximal tubule cells was inhibited by tetraethylammonium and probenecid, compounds known to interact with organic cation and organic anion transporters, respectively (27, 28).
	www.lycos.com /info/cimetidine.html (722 words)

	Cimetidine Transport in Brush-Border Membrane Vesicles from Rat Small Intestine -- Piyapolrungroj et al. 289 (1): 346 ...
		cimetidine uptake is osmolality-sensitive and corresponds to intravesicular
		Concentration of cimetidine was 50 µM. Data are the mean ± S.E.M. of triplicate uptake samples measured in three separate membrane preparations, except at intravesicular pH 6.5, where data were obtained from triplicate uptake measurement of one membrane preparation.
		Cimetidine uptake studies were performed by incubating vesicles for 30 s at room temperature and 4°C in a medium containing 75 mM HEPES, 50 mM Tris, and 200 mM mannitol (pH 7.5).
	jpet.aspetjournals.org /cgi/content/full/289/1/346 (4835 words)

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