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Topic: Cisplatin

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	Cisplatin (PIM 132)
		Intact cisplatin and its metabolites are excreted principally in urine.
		Cisplatin induces nephrotoxicity with hypomagnesaemia, hypocalcaemia and hypokalaemia as manifestations.
		The hypothesis is that this regimen dilutes the cisplatin metabolite concentrations in the kidney and lessens the incidence of toxicity to the cells.
	www.inchem.org /documents/pims/pharm/cisplat.htm (7650 words)

	Cisplatin Information on Healthline (Site not responding. Last check: )
		Cisplatin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
		Cisplatin is used to treat various types of cancer including metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer.
		Cisplatin is in the FDA pregnancy category D. This means that cisplatin is known to be harmful to an unborn baby.
	www.healthline.com /multumcontent/cisplatin (671 words)

	Cisplatin 1mg/ml Injection BP (Wockhardt UK Ltd) , SPC from the eMC
		The cisplatin dosage depends on the primary disease, the expected reaction, and on whether cisplatin is used for monotherapy or as a component of a combination chemotherapy.
		Neurotoxicity caused by cisplatin is characterised by peripheral neuropathy (typically bilateral and sensory), and rarely by the loss of taste or tactile function, or by retrobulbar neuritis with loss of sight and cerebral dysfunction (confusion, slurred speech, individual cases of cortical blindness, loss of memory, paralysis).
		Following cisplatin doses of 20 to 120 mg/m², the concentrations of platinum are highest in liver, prostate and kidney, somewhat lower in bladder, muscles, testicle, pancreas and spleen and lowest in bowel, adrenal, heart, lung, cerebrum and cerebellum.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=10742 (3431 words)

	Cisplatin and DNA repair in cancer chemotherapy
		Cisplatin and its analogs are heavy metal complexes containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position.
		Cisplatin is soluble in water or saline at 1mg/ml and in diethylformamide at 24 mg/ml.
		Cisplatin is a very successful anticancer agent and its success has led to the discovery of additional generations of platinum drugs.
	bioweb.wku.edu /courses/Biol588/Bishopl.html (997 words)

	Cisplatin : Cancerbackup
		Cisplatin is a chemotherapy drug that is given as a treatment for some types of cancer.
		Cisplatin is given as a drip (infusion) through a fine tube (cannula) inserted into the vein.
		Numbness or tingling in hands or feet This is due to the effect of cisplatin on nerves and is known as peripheral neuropathy.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Cisplatin (1480 words)

	Platinol Online, Description, Chemistry, Ingredients - Cisplatin - RxList Monographs
		PLATINOL®-AQ (cisplatin injection) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
		The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula PtCl2H6N2, and a molecular weight of 300.1.
		Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position.
	www.rxlist.com /cgi/generic3/cisplatin.htm (320 words)

	Chemical & Engineering News: Top Pharmaceuticals: Cisplatin
		For cisplatin, the "penicillin of cancer drugs" is perhaps a proper moniker because it has been one of the most widely prescribed as well as a first and effective treatment for many cancer diagnoses.
		Cisplatin is used to treat many types of cancer, but it is most widely prescribed for testicular, ovarian, bladder, lung, and stomach cancers.
		Although the mechanism has not yet been fully elucidated, cisplatin is generally believed to kill cancer cells by binding to DNA and interfering with the cell's repair mechanism, which eventually leads to cell death.
	pubs.acs.org /cen/coverstory/83/8325/8325cisplatin.html (785 words)

	Cisplatin
		(Cisplatin is what is called an “ototoxic” drug.) In humans, a cisplatin-associated neuropathy has been described (involving a sensory nerve interference).
		Cisplatin concentrates in the liver, intestines and kidneys and is still present in the body six months after treatment but 80% eliminated in urine after 48 hours.
		Cisplatin cannot be used in patients with renal disease or bone marrow suppression.
	www.marvistavet.com /html/body_cisplatin.html (423 words)

	Cisplatin
		Cisplatin is a neurotoxic chemotherapeutic agent known to cause sensory peripheral neuropathy or ototoxicity.
		Cisplatin is a widely used chemotherapeutic agent implicated in a range of adverse effects affecting the nervous system.
		This case adds further to the clinical diversity of cisplatin toxicity and, in view of the similarity to a recently defined disorder of posterior leukoencephalopathy, suggests regional endovascular injury rather than a direct cerebral toxicity as the initial event in the evolution of encephalopathy.
	www.whale.to /a/cisplatin.html (996 words)

	Cisplatin
		Since cisplatin is administered as an aqeuous solution, it is therefore, essential that ligand substitution be minimised before it reaches the tumour.
		Before cisplatin binds to such nucleophiles, it is usually converted to the active form by aquation.
		A further feature of treatment with cisplatin is the marked synergy shown in combination with a wide variety of other chemotherapeutic agents, such as 5-fluorouracil, cytarabine and bleomycin, which, on a practical level, allows for greater flexibility in the design of drug regimens.
	www.ch.ic.ac.uk /local/projects/s_liu/Html/Cisplatin.html (986 words)

	Cisplatin 1 mg/ml Sterile Concentrate, SPC from the eMC
		Cisplatin is indicated in metastatic, non-seminomatous germ cell carcinoma, advanced stage and refractory ovarian carcinoma, advanced stages and refractory bladder carcinoma and squamous cell carcinoma of head and neck.
		Cisplatin has been shown to be cumulatively ototoxic and should not be given to patients with hearing impairment.
		Cisplatin should not be used during pregnancy unless the clinician considers the risk in an individual patient to be clinically justified.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=623 (2602 words)

	Cisplatin - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: )
		Cisplatin interferes with the growth of rapidly dividing cells, like cancer cells, and eventually causes these cells to die.
		Cisplatin may be used alone or with other chemotherapy agents or radiation therapy.
		Cisplatin is for injection or infusion into a vein.
	www.drugdigest.org /DD/DVH/Uses/0,3915,153\|Cisplatin,00.html (983 words)

	Cisplatin : by Ray Sahelian, M.D.
		Cisplatin : by Ray Sahelian, M.D. Cisplatin by Ray Sahelian, M.D. Cisplatin is a drug that is used widely to treat different cancers including testicular, germ cell, head and neck, bladder and lung cancer.
		Cisplatin is one of the most active cytotoxic agents in the treatment of a wide range of solid tumors.
		Cisplatin ototoxicity and nephrotoxicity seem to result from the inhibition of cochlear antioxidant defences, causing an increase in the amount of reactive oxygen species.
	www.raysahelian.com /cisplatin.html (1706 words)

	MedlinePlus Drug Information: Cisplatin
		Cisplatin can cause a decrease in the number of blood cells in your bone marrow.
		Cisplatin is in a class of drugs known as platinum-containing compounds; it slows or stops the growth of cancer cells in your body.
		Cisplatin also is used to treat certain types of head and neck cancer, cervical carcinoma, lung cancer, neurologic cancers, and a wide variety of other cancers.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a684036.html (630 words)

	cisplatin medical facts from Drugs.com
		Cisplatin is used to treat various types of cancer including metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer.
		Cisplatin is in the FDA pregnancy category D. This means that cisplatin is known to be harmful to an unborn baby.
		Cisplatin may decrease the effects of medicines used to control seizures and a dosage adjustment may be required.
	www.drugs.com /mtm/cisplatin.html (1037 words)

	Cisplatin Information on Healthline (Site not responding. Last check: )
		Cisplatin is a member of the group of chemotherapy drugs known as heavy metal alkylating-like agents.
		A cisplatin dose can be determined using a mathematical calculation that measures body surface area (BSA), which depends on a person's overall size.
		Before receiving cisplatin large volumes of intravenous fluids are given to keep the kidneys flushed with water.
	www.healthline.com /galecontent/cisplatin (620 words)

	Mesothelioma Chemotherapy Drugs - Cisplatin
		A member of the family of chemotherapy drugs known as platinum containing compounds or alkylating agents, Cisplatin has been in use for many years and was the first member in its class of drugs.
		Cisplatin’s side effects can be more severe than its more recent counterparts, as is usually the case with drugs that have been on the market for several decades.
		Cisplatin is administered intravenously or through a central line inserted for the purpose of prolonged chemotherapy.
	www.mesotheliomasos.com /treatmentCisplatin.php (421 words)

	Cisplatin (Site not responding. Last check: )
		Cisplatin is a chemotherapy drug used to treat some forms of cancer.
		High-dose cisplatin therapy is associated with kidney toxicity and damage, which may be reduced by glutathione administration.
		Cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin.
	www.kroger.com /hn/Drug/Cisplatin.htm (3419 words)

	Cisplatin page
		Anticancer activity is due to aquated cisplatin binding to DNA in the major groove and preventing replication.
		Cisplatin has been described as one of the worst drugs to be given to man. One of the main reasons for cisplatin's notoriety is the extreme nausea and vomiting that go hand in hand with chemotherapy treatment.
		Another main side effect of cisplatin is renal toxicity, this is where cells of the kidney are damaged resulting in poor filtration of the blood.
	faculty.gvsu.edu /carlsont/chemo/SSD/cisplatinpage2.html (1050 words)

	Platinol advanced consumer information \| Drugs.com
		Cisplatin is to be administered only by or under the immediate supervision of your doctor.
		Cisplatin causes toxic or harmful effects in the fetus in humans and birth defects in mice.
		Cisplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.drugs.com /cons/Platinol.html (2131 words)

	ACS :: Cancer Drug Guide: cisplatin
		Cisplatin is a platinum compound chemotherapy drug that acts like an alkylating agent.
		Cisplatin stops the growth of cancer cells, causing the cell to die.
		Cisplatin is given by an injection into the vein over at least 1 hour.
	www.cancer.org /docroot/CDG/content/CDG_cisplatin.asp (707 words)

	Cisplatin
		Cisplatin is an intravenous (IV) medication usually given in a dose that is based on body surface area.
		Cisplatin is a heavy metal that kills cells by interfering with the multiplication of cancer cells.
		Cisplatin is administered only under the supervision of a medical oncologist.
	www.webmd.com /hw/cancer/tv6626.asp (353 words)

	Cisplatin, Platinol AQ, CDDP - Chemotherapy Drugs, Chemo Drug Side Effects
		Before and/or after the Cisplatin infusion, extra IV fluids are given, care is taken to ensure adequate hydration before, during and after Cisplatin, to protect your kidney function.
		Cisplatin side effects are often predictable in terms of their onset and duration.
		Cisplatin may be inadvisable if you have a history of severe allergic reaction to Cisplatin, carboplatin, other platinum-containing formulations or mannitol.
	www.chemocare.com /bio/cisplatin.asp (1622 words)

	Cisplatin - Family factsheets - GOSH and ICH
		This fact sheet explains what Cisplatin is, how it is given and some of the possible side effects.
		Cisplatin is a chemotherapy drug used to treat certain types of cancer.
		Nausea and vomiting: Cisplatin is one of the drugs which causes severe nausea and vomiting.
	www.ich.ucl.ac.uk /factsheets/families/F990241 (736 words)

	BioMed Central \| Full text \| Identification of genes associated with cisplatin resistance in human oral squamous cell ...
		Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma.
		The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells.
		Cisplatin is one of the most potent chemotherapeutic agents currently in use, exerting its cytotoxic action through the formation of intra-strand DNA crosslink adducts [3].
	www.biomedcentral.com /1471-2407/6/224 (4730 words)

	Cisplatin
		Gastrointestinal: Cisplatin is one of the most emetogenic agents used in cancer chemotherapy; nausea and vomiting occur in 76% to 100% of patients and is dose related.
		Damage to the proximal tubules by unbound cisplatin is suspected to cause the toxicity.
		Pretreatment hydration with 1-2 L of fluid is recommended prior to cisplatin administration; adequate hydration and urinary output (>100 mL/hour) should be maintained for 24 hours after administration.
	www.umm.edu /altmed/drugs/cisplatin-029300.htm (2334 words)

	[No title]
		All patients should receive adequate hydration prior to and for 24 hours after cisplatin administration, with or without mannitol and/or furosemide, to ensure good urine output and decrease the chance of nephrotoxicity; reduce dosage in renal impairment.
		Dermatologic: Mild alopecia Gastrointestinal: Cisplatin is one of the most emetogenic agents used in cancer chemotherapy; nausea and vomiting occur in 76% to 100% of patients and is dose-related.
		Damage to the proximal tubules by unbound cisplatin is suspected to cause the toxicity.
	www.musc.edu /pharmacyservices/Drugs/C/Cisplatin.doc (477 words)

	ChemCases: Cisplatin - 13. Recent Developments
		Carboplatin and cisplatin have been shown to form an identical type of adduct with DNA and have similar activities against ovarian and lung tumors; however, carboplatin is less toxic to the peripheral nervous system and the kidneys.
		The lower toxicity of carboplatin compared to cisplatin is believed to be due to the structure of carboplatin.
		Cisplatin has been shown to bind DNA and cause the DNA duplex to bend and unwind.
	science.kennesaw.edu /~mhermes/cisplat/cisplat13.htm (1142 words)

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