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Topic: Cisternal progression

	Cisternal progression - Wikipedia, the free encyclopedia
		Cisternal progression is a theory of protein transport through the Golgi apparatus inside a cell, as opposed to the bulk flow model.
		In cisternal progression, instead of vesicles continually budding and fusing to static cisternae carrying cargo molecules, the cisternae themselves would move towards the cell surface.
		This is basically where the idea of cisternal progression came from, the study if algal sclaes and collagen transport.
	en.wikipedia.org /wiki/Cisternal_progression (375 words)

	Cisternal progression -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-18)
		Cisternal progression is a theory of protein transport through the (A net-like structure in the cytoplasm of animal cells (especially in those cells that produce secretions)) Golgi apparatus inside a cell, as opposed to the bulk flow model.
		In cisternal progression, instead of (A small anatomically normal sac or bladderlike structure (especially one containing fluid)) vesicles continually budding and fusing to static (additional info and facts about cisternae) cisternae carrying cargo ((physics and chemistry) the simplest structural unit of an element or compound) molecules, the cisternae themselves would move towards the cell surface.
		Those favoring cisternal progression use this fact to explain their (A tentative theory about the natural world; a concept that is not yet verified but that if true would explain certain facts or phenomena) hypothesis.
	www.absoluteastronomy.com /encyclopedia/c/ci/cisternal_progression.htm (451 words)

	CISTERNAL PROGRESSION
		Cisternal progression is one theory of protein transport through the Golgi.
		Both models of transport are considered to hold true (cisternal progression vs. bulk flow).
		This is basically where cisternal progression came from, the study if algal sclaes and collagen transport.
	www.websters-online-dictionary.org /definition/CISTERNAL+PROGRESSION (336 words)

	Exclusion of Golgi Residents from Transport Vesicles Budding from Golgi Cisternae in Intact Cells -- Orci et al. 150 ...
		the significance of cisternal progression for anterograde transport,
		A, The immunogold particles are predominantly associated with the cisternal profiles of the Golgi complex.
		The comparable orientation of the Golgi stacks in cryosections A and B shows that Man II staining is present on medial cisternae, but is absent from vesicles lateral to the cisternal tips (A), whereas COPI-labeling has the reverse distribution, being localized to the vesicles lateral to the Golgi stack (B).
	www.jcb.org /cgi/content/full/150/6/1263 (3522 words)

	Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments - Nature Cell Biology (Site not responding. Last check: 2007-10-18)
		Throughout progression, cisternae overlapped tightly—even in zones containing procollagen-I aggregates—and images of procollagen-I distensions protruding laterally from cisternae, or suggestive of either a budding or a fusing process taking place between cisternae and distensions, were not seen (Fig.
		Their main function might be to act as conduits for enzymes to flow retrogradely during cisternal progression, as they have the correct topology and abundance to do so.
		During progression, the Golgi enzymes diffuse through the intercisternal continuities, and thereby explore the Golgi space, partitioning according to their physico-chemical properties into those cisternae that have their most favourable compositions.
	nature.com /ncb/journal/v6/n11/full/ncb1180.html;jsessionid=FB7CE91B... (7072 words)

	Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta ...
		Cisternal bypass in the Golgi of glucose-stimulated islet beta cells.
		In E and F, the lateral continuities at the periphery of the upper stack can be followed; the arrowhead in F highlights the connection between cisternae at different levels (blue) through a fenestration or hole in the adjacent (green) cisterna.
		Cisternal bypass at the stack periphery where the Golgi ribbon is unbranched.
	www.pnas.org /cgi/content/full/101/15/5565 (3402 words)

	Figure - Nature Cell Biology
		20 min: the stack returns to a quiescent state, with a reduction in cisternal number and surface area, and the disappearance of intercisternal connections.
		The Golgi enzymes (E) (trans enzyme, circle; medial, triangle; cis, square) can diffuse freely through the stack by means of the connections, but reside preferentially in the cisternae offering the most favourable environment (represented here by the match between membrane thickness and length of the enzyme transmembrane domains).
		Thus, the arrival of intermediate compartment membranes at the cis pole (accompanied by consumption at the trans) causes both enzyme backflow and cisternal progression (above), resulting in the synchronization of these two events, in cisternal maturation and progression.
	www.nature.com /ncb/journal/v6/n11/fig_tab/ncb1180_F6.html (441 words)

	Functional evaluation of the cisternal architecture of Golgi stacks in Pichia yeast and plant cells visualized ...
		Functional evaluation of the cisternal architecture of Golgi stacks in Pichia yeast and plant cells visualized by dual-axis EM tomography.
		Recently, the cisternal progression/maturation model has regained favor over the vesicle shuttle model, but the mechanisms of cisternal assembly and maturation, as well as cisternal fragmentation have yet to be elucidated.
		Taken together, the progressive changes in cisternal morphology and the apparent release of the fragmenting trans-most cisternae into the cytosol are consistent with the cisternal progression/maturation model for Golgi trafficking.
	abstracts.aspb.org /pb2002/public/P38/0142.html (298 words)

	C2006 (Site not responding. Last check: 2007-10-18)
		Best answer is stationary cisternal model; vesicle is moving toward the trans side, and enzyme will never enter a vesicle again.
		In the stationary model, new protein is transported from sac to sac in a cis to trans direction using the vesicles.
		The answers that fit this scenario are: cisternal progression model; the vesicle is moving towards the cis side, and enzyme is in a retrograde vesicle.
	www.columbia.edu /cu/biology/courses/c2006/exams05/k-exam2-05.html (3363 words)

	[No title]
		We will discuss Golgi apparatus structure and function, the concept of cisternal progression, and the vesicle pathways that move Golgi enzymes from older layers back (retrograde transport) to younger layers of Golgi membranes.
		This series of electron micrographs shows: (A) unstained Golgi, (B) stained with osmium, which is reduced in the cis layer and associated vesicles, (C) activity stain for nucleoside diphosphatase, found in the trans-Golgi cisternal layer, and (D) activity stain for acid phosphatase, found in the trans-Golgi network of vesicles.
		Before this acceptance, the interpretation of this experiment was that VSVG was incorporated into forward moving transport vesicles thought to move from one Golgi layer to the next carrying protein cargo.
	web.uconn.edu /mcb380/lecture08.html (1449 words)

	Golgi enzymes are enriched in perforated zones of golgi cisternae but are depleted in COPI vesicles
		In the most widely accepted version of the cisternal maturation/progression model of intra-Golgi transport, the polarity of the Golgi complex is maintained by retrograde transport of Golgi enzymes in COPI-coated vesicles.
		Instead, we find that Golgi enzymes are concentrated in the perforated zones of cisternal rims both in vivo and in a cell-free system.
		The exclusion of Golgi enzymes from COPI vesicles and their transport-dependent accumulation in perforated zones argues against the current vesicle-mediated version of the cisternal maturation/progression model.
	www.3dem-noe.org /publications/publ_006.html (229 words)

	A synthetic model of intra-Golgi traffic -- Mironov et al. 12 (2): 249 -- The FASEB Journal
		When the cisternal progression mechanism was rejected long ago,
		The cistern maturation and lateral diffusion models are not
		cisterns functioning as plates, lateral diffusion of cargo as
	www.fasebj.org /cgi/content/full/12/2/249 (2488 words)

	Variations on the Intracellular Transport Theme: Maturing Cisternae and Trafficking Tubules -- Mironov et al. 138 (3): ...
		The model of transport by cisternal progression has been largely based on morphological observations of scale-covered green
		and appear to be transported by the progression of Golgi cisternae
		maturation of the cisternae, with the consequence that cargo progresses
	www.jcb.org /cgi/content/full/138/3/481 (3136 words)

	cisternal - OneLook Dictionary Search
		Tip: Click on the first link on a line below to go directly to a page where "cisternal" is defined.
		cisternal : Dorland's Illustrated Medical Dictionary [home, info]
		Phrases that include cisternal: cisternal puncture, cisternal progression
	www.onelook.com /?w=cisternal&ls=all (115 words)

	Keystone Symposia \| Scientific Conferences on Biomedical and Life Science Topics
		The resulting diversity of experimental data has continued to fuel debate about how cargo molecules move through the Golgi, how the different cisternal elements maintain their identities despite the constant flux of components, and how and where cargo molecules are sorted and packaged into transport carriers.
		The central goal of this symposium is to bring together a broad group of researchers interested in the secretory pathway, with an emphasis on events that occur during transport to, through, and from the Golgi apparatus.
		The central challenge for this meeting will be to identify the current frontiers in secretory pathway research, and to stimulate new avenues of investigation by integrating insights from a wide range of experimental systems.
	keystonesymposia.org /Meetings/viewPastMeetings.cfm?MeetingID=677&... (961 words)

	Golgi Enzymes Are Enriched in Perforated Zones of Golgi Cisternae but Are Depleted in COPI Vesicles -- Kweon et al. 15 ...
		of the cisternae, with the consequence that cargo progresses
		In J–M, perforated zones analyzed by serial cryosections; a substantial proportion of the round profiles (arrowheads) located in the vicinity to cisternal rims seen as cross sections of tangential tubules or perforated zones of cisternae (arrows).
		STF-HRP is absent in 50- to 60-nm round profiles and cisternal buds.
	www.molbiolcell.org /cgi/content/full/15/10/4710 (8083 words)

	[No title] (Site not responding. Last check: 2007-10-18)
		This is, obviously, an important question, because without specificity all the compartments could just fuse into one large compartment with a resulting loss of the identity of the cell.
		Vesicle Budding While there are other potential means of transport (such as cisternal progression in the Golgi) the main mode of transport of proteins in eukaryotic cells is undoubtedly vesicular transport.
		Vesicular transport likely involves concentration of cargo proteins, curving of the membrane, budding off of the vesicle, finding its way specifically to the next target, docking, fusing, and releasing its contents into the compartment.
	fulcrum.physbio.mssm.edu /courses/CORE_II/2002CORE/l23.doc (5667 words)

	C-Terminal Truncation of {alpha}-COP Affects Functioning of Secretory Organelles and Calcium Homeostasis in Hansenula ...
		The Golgi apparatus is composed of distinct cisternal regions,
		Progression of the tightly stacked Golgi cisternae of
		Progress in the study of the COPI coat, based initially
	ec.asm.org /cgi/content/full/3/1/52 (5326 words)

	Reevaluation of the Effects of Brefeldin A on Plant Cells Using Tobacco Bright Yellow 2 Cells Expressing Golgi-Targeted ...
		The stack has a clear cis-to-trans polarity indicated by the differences in membrane staining and cisternal morphology.
		The first effect of the toxin we have visualized with our tools is the loss of COPI coats from the Golgi.
		This is followed by a loss of the oldest, trans-most (trans-Golgi network) cisterna and the simultaneous maturation of the younger cisternae, consistent with the cisternal progression/maturation model of intra-Golgi trafficking.
	www.plantcell.org /cgi/content/full/14/1/237 (10094 words)

	MBC -- About the Cover (Apr 2001, 12, (4))
		Such alternative pathways include cisternal progression and direct transport
		Note in the 3-D reconstruction made by Alvar
		Trucco that cisternal distensions containing procollagen aggregates (red) are
	www.molbiolcell.org /content/vol12/issue4/cover.shtml (248 words)

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