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| | CITALOPRAM |
 | | Citalopram is widely distributed throughout the body with an apparent volume of distribution of 15 L/kg (Kragh-Sorensen et al, 1981; Milne and Goa, 1991; Sweetman, 2000). |
 | | Citalopram is metabolized in the liver primarily via N-demethylation, deamination, and N-oxidation to less lipophilic compounds which are more readily excreted by the kidney (Milne and Goa, 1991; Sweetman, 2000). |
 | | Approximately 12% to 13% of a dose of citalopram is excreted as unchanged drug in the urine (Oyehaug and Ostensen, 1984; Milne and Goa, 1991; Sweetman, 2000). |
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