| | Erythromycin inhibits Cl secretion across canine tracheal epithelial cells -- Tamaoki et al. 5 (2): 234 -- European ... (Site not responding. Last check: 2007-11-03) |
 | | The erythromycin-induced decrease in Isc was not altered by amiloride, but it was abolished by bumetanide, diphenylamine-2-carboxylate2, and substitution of Cl in the bathing medium with gluconate (p less than 0.001, in each case). |
 | | The effect of erythromycin on epithelial Isc was attenuated by pretreatment of cells with indomethacin but not with AA-861 a lipoxygenase inhibitor. |
 | | These results indicate that erythromycin may selectively inhibit Cl secretion across airway epithelium through the inhibition of prostaglandin synthesis and suggest that this action possibly reflects its clinical efficacy in the treatment of airway hypersecretion. |
| erj.ersjournals.com /cgi/content/abstract/5/2/234 (770 words) |