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Topic: Clarithromycin

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  Clarithromycin - Wikipedia, the free encyclopedia
Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), skin and skin structure infections, and, in HIV and AIDS patients to prevent, and to treat, disseminated Mycobacterium avium complex or MAC.
Clarithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides.
Clarithromycin's and its metabolites' main routes of elimination are urinary and biliary excretion.
en.wikipedia.org /wiki/Clarithromycin   (429 words)

 Clarithromycin/Omeprazole Combo Approved for H pylori Ulcers   (Site not responding. Last check: 2007-10-26)
Clarithromycin, like erythromycin, is a macrolide antibiotic that inhibits bacterial protein synthesis, although it is more acid stable, better absorbed, and more active against H pylori than erythromycin.
Clarithromycin should not be used in pregnant women, and if pregnancy occurs during therapy, the woman should be advised of the potential hazard to the fetus.
Clarithromycin is rapidly absorbed orally; elimination half- life is 3-7 hours (depending on dose); and the majority of the dose is metabolized and excreted in the urine.
pharminfo.8media.org /pubs/msb/hpylori.html   (462 words)

 [No title]   (Site not responding. Last check: 2007-10-26)
Clarithromycin is useful therapy for infections of the upper respiratory tract in children and adults.
In general, clarithromycin is prepared by methylation of the 6-hydroxy group of erythromycin A. However, in the conversion process it is necessary to protect various groups, especially hydroxy groups at positions of erythromycin A, which are potentially reactive with alkylating agents, prior to alkylation of the 6-hydroxy group.
Actual dosage levels of clarithromycin Form IV in the pharmaceutical compositions of this invention may be varied so as to obtain an amount of the clarithromycin Form IV that is effective to achieve the desired therapeutic response for a particular patient, compositions, and mode of administration.
www.wipo.int /cgi-pct/guest/getbykey5?KEY=01/44262.010621&ELEMENT_SET=DECL   (5305 words)

 Clarithromycin   (Site not responding. Last check: 2007-10-26)
Clarithromycin differs from erythromycin in itís methyl substitution at the number six position of the macrolide ring.
Clarithromycin also has an active metabolite, 14-hydroxy clarithromycin which has been reported to be "synergistic" with the parent compound.
Like azithromycin, clarithromycin can be used safely down to age six months and is able to achieve tissue concentrations in excess of serum concentrations.
www.fhsu.edu /nursing/otitis/clarithromycin.html   (130 words)

 Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients -- Fish and ...
the absorption and pharmacokinetics of a clarithromycin suspension
that the absorption of a clarithromycin suspension is adequate
Simultaneous determination of clarithromycin and 14-R-hydroxyclarithromycin in plasma and urine using high-performance liquid chromatography with electrochemical detection.
aac.asm.org /cgi/content/full/43/5/1277   (1800 words)

 MedlinePlus Drug Information: Clarithromycin (Systemic)   (Site not responding. Last check: 2007-10-26)
Clarithromycin (kla-RITH-roe-mye-sin) is used to treat bacterial infections in many different parts of the body.
Clarithromycin also may be used for other problems as determined by your doctor.
Clarithromycin may be taken with meals or milk or on an empty stomach, extended release tablets should be taken with food.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/202667.html   (1439 words)

 Ranbaxy Is Granted FDA Approval for Clarithromycin Tablets USP
Clarithromycin Tablets, USP are indicated for the treatment of mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions as follows: Pharyngitis/Tonsillitis, Acute maxillary sinusitis, Acute bacterial exacerbation of chronic bronchitis, Community-Acquired Pneumonia, Uncomplicated skin and skin structure infections, and disseminated mycobacterial infections.
Clarithromycin Tablets in combination with Amoxicillin and Lansoprazole or Omeprazole Delayed-Release Capsules, as triple therapy, are indicated for the treatment of patients with H.
Clarithromycin Tablets in combination with Omeprazole capsules or Ranitidine bismuth citrate tablets are also indicated for the treatment of patients with an active duodenal ulcer associated with H. pylori infection.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/09-27-2004/0002259413&EDATE=   (544 words)

 Patient Education - Drugs - clarithromycin
Clarithromycin, like all antibiotics, works best when there is a constant amount of drug in the blood.
Clarithromycin is ranked C. Always consult your physician before taking any drug during or when planning pregnancy.
Clarithromycin is now used in combination with certain other drugs for a 14 day period to cure the stomach bacteria infection called Helicobacter pylori.
www.endowsec.com /pated/clarithromycin.htm   (792 words)

 Epharma - Clinical Pharmacokinetics Of Clarithromycin
Clarithromycin is acid stable rapidly and completely absorbed per orally to the extent of 100% and absolute bioavailability is 55% and is unaffected by food.
Clarithromycin inhibits the isoenzyme of Cyt P 450 viz., CYP3A family and thereby increase the concentrations of several drugs administered concurrently resulting in serious clinically significant drug interactions.
Significant quantities of clarithromycin and its metabolites are excreted in breast milk of nursing mothers.
www.medindia.net /doctors/Epharma/september3.asp   (361 words)

 Epharma - Clinical Efficacy Of Clarithromycin
Clarithromycin is an ideal choice in case of pneumoccal pneumonia, H.influenzae and Legionellae pneumonia.
Clarithromycin is one of the single agent in the long term prophylaxis against opportunistic MAC infection in AIDS patients.
Clarithromycin acts slowly and exhibit synergy with omeprazole and Lansoprazole and enhance H pylori eradication rapidly and moreover clarithromycin with Omeprazole show beneficial interaction for rapid synergistic efficacy.
www.medindia.net /doctors/Epharma/september4.asp   (953 words)

Clarithromycin is also used to fight opportunistic infections in people with HIV.
Clarithromycin is used for mild or moderate bacterial infections.
Clarithromycin is available in tablets of 250 or 500 milligrams (mg.) It is also available in granules to prepare a liquid form.
www.aids.org /factSheets/532-Clarithromycin-Biaxin.html   (653 words)

 amoxicillin, clarithromycin, and lansoprazole - [Medication]
The combination, amoxicillin, clarithromycin, and lansoprazole, is used to decrease the amount of acid in the stomach and to treat Helicobacter pylori, a bacterial infection involved in causing stomach ulcers.
Amoxicillin, clarithromycin, and lansoprazole is in the FDA pregnancy category C. This means that it is not known whether amoxicillin, clarithromycin, and lansoprazole will harm an unborn baby.
Symptoms of an amoxicillin, clarithromycin, and lansoprazole overdose are not known but might include nausea, vomiting, diarrhea, abdominal discomfort, muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, and agitation.
www.peacehealth.org /kbase/multum/d04272a1.htm   (1191 words)

 HIVInfo.us - clarithromycin - Biaxin information
Clarithromycin (Biaxin) is an antibiotic that is used to treat and prevent certain infections.
Clarithromycin is such an excellent and safe drug there may be tendency for it to be overused.
Clarithromycin may be given by pill or liquid at a variety of doses to treat infections: the usual range is 500 mg twice a day depending on the type of infection.
www.hivinfo.us /clarithromycin.html   (637 words)

Clarithromycin is an anti-infective drug (antibiotic) that is used to prevent or treat Mycobacterium avium complex (MAC) infection.
Clarithromycin may also be used to treat other types of infections such as bacterial pneumonia, toxoplasmosis, and stomach / intestinal ulcers due to an organism called H.pylori.
Clarithromycin should NOT be taken if you are pregnant, unless your doctor believes the benefits outweigh the risks.  The safety of clarithromycin has not been established during breastfeeding.  Please discuss this with your doctor or pharmacist if this is a concern.
www.tthhivclinic.com /FactSheets/html/CLARITHROMYCIN.html   (603 words)

 Biaxin Indications, Dosage, Storage, Stability - Clarithromycin - RxList Monographs
Clarithromycin may be administered without dosage adjustment in the presence of hepatic impairment if there is normal renal function.
No studies of clarithromycin for MAC prophylaxis have been performed in pediatric populations and the doses recommended for prophylaxis are derived from MAC treatment studies in children.
Clarithromycin should be used in combination with other antimycobacterial drugs that have shown in vitro activity against MAC or clinical benefit in MAC treatment.
www.rxlist.com /cgi/generic/clarith_ids.htm   (1381 words)

 ADAP drugs: clarithromycin   (Site not responding. Last check: 2007-10-26)
Clarithromycin is an antibiotic approved for treatment of common bacterial infections in non-immunocompromised individuals.
Clarithromycin is used orally for the treatment of upper and lower respiratory tract and skin and skin structure infections.
Multiple-drug treatment of MAC with clarithromycin at 500 mg to 2 g daily, ethambutol, and/or ciprofolxacin, clofazimine, amikacin or rifabutin is for at least 6 weeks.
www.atdn.org /access/drugs/clar.html   (391 words)

 Cefaclor AF vs Clarithromycin in Acute Exacerbation of Chronic Bronchitis   (Site not responding. Last check: 2007-10-26)
Eight patients of the cefaclor group and 14 patients of clarithromycin group, did not complete the study protocol and thus the evaluable patients were 136 and 142 in the cefaclor and clarithromycin groups respectively making a total of 278 evaluable patients.
In the cefaclor group, 108 patients were exposed to smoke (51 to cigarette, 31 to hukka/cigar and 26 to wood/charcoal) where as 106 patients were exposed to smoke in the clarithromycin group (54 to cigarette, 25 to hukka/cigar and 27 to wood/ charcoal).
The clinical efficacy of both the drugs was comparable and the bacteriological response was comparable to the clinical response with an eradication rate of 76% for cefaclor and 70% for the clarithromycin group although the bacteriological response was observed to be slightly less as compared to the clinical response.
jpma.org.pk /JPMA/8Aug03/fulltext6.htm   (3486 words)

 clarithromycin Drug Information
Clarithromycin is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, sinusitis, tonsillitis, skin infections, and stomach ulcers caused by bacteria.
Clarithromycin is in the FDA pregnancy category C. This means that it is not known whether clarithromycin will harm an unborn baby.
Clarithromycin is usually taken two times a day with the doses about 12 hours apart.
www.drugs.com /MTM/clarithromycin.html   (1124 words)

 Clarithromycin against Mycobacterium avium complex infections
A relapse of bacteremia occurred in 14 of 56 patients, and in 9 of 14 the isolates became resistant to clarithromycin.
Emergence of resistance of the MAC isolates to clarithromycin (minimum inhibitory concentration ([MIC] > 32 µg/ml) was registered in 46% of 152 patients, and was always associated with recrudescence of symptoms and relapse of bacteremia.
Comparison of the activity of various agents including clarithromycin in the beige mouse model has shown that amikacin was almost as active as clarithromycin, while rifampin and rifabutin were totally inactive, and ethambutol and spafflokacin exhibited a limited inhibitory effect.
alan.kennedy.name /crohns/research/chemo/heifet96.htm   (5644 words)

 N101 | Clarithromycin   (Site not responding. Last check: 2007-10-26)
Clarithromycin is a macrolide antibiotic used to treat a variety of bacterial infections.
Clarithromycin can increase the serum level of digitalis glycosides, increasing the therapeutic effects as well as the risk of side effects.
Clarithromycin may be taken with or without food and may be taken with milk.
www.n101.com /HealthNotes/HNs/Drug/Clarithromycin.htm   (1052 words)

 MedlinePlus Drug Information: Clarithromycin
Clarithromycin is used to treat certain infections caused by bacteria, such as pneumonia, bronchitis, and infections of the ears, lungs, sinuses, skin, and throat.
Clarithromycin comes as a tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth.
Clarithromycin also is used sometimes to treat Lyme disease and toxoplasmosis.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a692005.html   (756 words)

 clarithromycin - Medical and health information on the common cold and flu
PRESCRIBED FOR: Clarithromycin is effective against susceptible bacteria causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, and skin infections.
Clarithromycin can significantly increase blood levels of the active metabolite of terfenadine (Seldane) when these two medications are co-administered.
Treatment with clarithromycin and other antibiotics can alter normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria responsible for pseudomembranous colitis.
www.medicinenet.com /clarithromycin/article.htm   (560 words)

 Clarithromycin against Mycobacterium avium complex infections   (Site not responding. Last check: 2007-10-26)
Monotherapy with clarithromycin resulted in elimination of bacteremia in almost all patients with disseminated infection, which is inevitably followed by a relapse of bacteremia in patients who survived long enough to reach this event.
Cross-resistance between clarithromycin and azithromycin was confirmed with laboratory mutants and clinical isolates.
The remaining major problem in the therapy of the M. avium infections is a selection of companion drugs to be used in combination with clarithromycin (or azithromycin) to prevent the emergence of the macrolide-resistance.
www.crohns.org /articles/1996_02_19-26_tld.htm   (316 words)

 CATIE Fact Sheet : Clarithromycin (Biaxin)
Clarithromycin is an oral antibiotic approved for use in the treatment of
Clarithromycin is used in combination with other drugs to treat MAC.
HIV-positive participants in clinical trials of clarithromycin reported generally mild to moderate side effects which were dose-related, that is, the higher the dose, the greater the side effect.
www.catie.ca /facts.nsf/a86faa4a32f0108285256f5f0050a2e0/650c266c1d9f5108852566b900057498?OpenDocument   (668 words)

 Effects of Clarithromycin and Rifabutin Alone and in Combination on Intracellular and Extracellular Replication of ...
In conclusion, clarithromycin played the major role in the antimicrobial activity of the tested combination, while rifabutin may have enhanced this effect during a prolonged exposure of the intracellular bacteria to these two agents.
The aim of the present study was to evaluate the activity of Clarithromycin in combination with rifabutin against M avium in a cell-free culture medium and human monocyte-derived macrophages.
2); combination of clarithromycin at 1.5 µg/ml with rifabutin 0.15 µg/ml was less effective than clarithromycin at 3.0 µg/ml alone, and the addition of 0.3 µg of rifabutin per ml to 3.0 µg/ml of clarithromycin per ml did not enhance the effect of 3.0 µg clarithromycin per ml alone.
alan.kennedy.name /crohns/research/chemo/heifet94.htm   (3058 words)

 Patient Information Sheet: Clarithromycin (marketed as Biaxin)
In a study done in Denmark using clarithromycin in patients with heart disease, clarithromycin use was associated with a higher chance of death from heart problems.
Clarithromycin is in a class of medicines called macrolide antibiotics.
Do not take clarithromycin if you are allergic to clarithromycin or any of the other macrolide antibiotics such as erythromycin or azithromycin.
www.fda.gov /cder/drug/InfoSheets/patient/clarithromycinPIS.htm   (435 words)

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