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Topic: Classical complement pathway


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In the News (Thu 23 May 19)

  
  Classical complement pathway - Wikipedia, the free encyclopedia
The classical pathway of activation of the complement system is a group of blood proteins that mediate the specific antibody response.
It is the binding of a specific part of the antibody molecule to the C1 component that initiates this pathway.
Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins (specifically IgM and IgG), the controlling action of C1-In is overcome and C1q effects activation of C1r2s2.
en.wikipedia.org /wiki/Classical_complement_pathway   (294 words)

  
 eMedicine - Complement Deficiency : Article by Ruchir Agrawal, MD   (Site not responding. Last check: 2007-10-06)
This pathway is activated by the combination of factor B, factor D, and properdin with microbial polysaccharides and cell walls with the formation of alternate pathway C3 convertase (C3bBb).
Classical pathway deficiencies (C1, C4, C2) are inherited in the autosomal recessive pattern.
Ratnoff WD: Inherited deficiencies of complement in rheumatic diseases.
www.emedicine.com /PED/topic447.htm   (3824 words)

  
 Complement
Both classical and alternative pathways lead to the activation of C5 convertase and result in the production of C5b which is essential for the activation of the membrane attack pathway.
Classical pathway (Figure 1) normally requires a suitable Ab bound to antigen (Ag), complement components 1, 4, 2 and 3 and Ca and Mg cations.
This pathway is initiated by three proteins: a mannan -binding lectin (MBL), also known as mannan-binding protein (MBP) which interacts with two mannan-binding lectin-associated serine proteases (MASP and MADSP2), analogous to C1r and C1s.
pathmicro.med.sc.edu /ghaffar/complement.htm   (1474 words)

  
 Classical Complement Pathway [Definition]
The classical pathway of activation of the complement system is a group of blood proteins that mediate the specific antibody An antibody is a protein complex used by the immune system to identify and neutralize foreign objects like bacteria and viruses.
Alternate complement pathway The alternative pathway of the complement system is a humoral component of the immune system's natural defence against infections which can operate without antibody participation.
The alternative pathway convertase consists of the activated B and D factors, forming an unstable...
www.wikimirror.com /Classical_complement_pathway   (836 words)

  
 JGV Direct - Review: Virus complement evasion strategies (H. W. Favoreel and others)
Complement evasion is of particular importance for viruses, since complement activation is a crucial component of innate immunity (alternative and mannan-binding lectin activation pathway) as well as of adaptive immunity (classical, antibody-dependent complement activation).
Activation of the complement cascade via the classical (A), lectin (B) or alternative (C) pathway results in the initiation of the terminal complement pathway (D), leading to the formation of membrane attack complexes.
The classical activation pathway of complement involves binding of complement protein C1q either to antibody–antigen complexes or, occasionally, directly to the surface of certain pathogens.
www.socgenmicrobiol.org.uk /JGVDirect/18709/18709ft.htm   (8800 words)

  
 Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis -- Celik et ...
pathway ( 32) and thereby underlines that MASP-2 is the effector
Combined deficiency of the classical, lectin, and alternative pathways of complement activation is lethal in an experimental model of polymicrobial peritonitis and sepsis.
Distinct pathways of mannan-binding lectin (MBL)- and C1 complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.
iai.asm.org /cgi/content/full/69/12/7304   (3824 words)

  
 Complement Protein C3 Binding to Mycobacterium tuberculosis Is Initiated by the Classical Pathway in Human ...
Complement Protein C3 Binding to Mycobacterium tuberculosis Is Initiated by the Classical Pathway in Human Bronchoalveolar Lavage Fluid -- Ferguson et al.
Involvement of antilipoarabinomannan antibodies in classical complement activation in tuberculosis.
Activation of the lectin complement pathway by H-ficolin (Hakata antigen).
iai.asm.org /cgi/content/full/72/5/2564   (6021 words)

  
 Inhibition of Activation of the Classical Pathway of Complement by Human Neutrophil Defensins -- van den Berg et al. 92 ...
Inhibition of Activation of the Classical Pathway of Complement by Human Neutrophil Defensins -- van den Berg et al.
fluid phase and inhibits the classical complement pathway.
Mayer MM: Complement and complement fixation, in Kabat EA, Mayer MM (eds): Experimental Immunochemistry.
www.bloodjournal.org /cgi/content/full/92/10/3898   (4174 words)

  
 How Complement Works
The classical pathway of the complement system is a major effector of the humoral branch of the human immune response.
The trigger for the classical pathway is either IgG or IgM antibody bound to antigen.
The lysis of cells via the complement pathways is thus critical for both innate and specific immunity.
www.brown.edu /Courses/Bio_160/Projects1999/ies/how.html   (1415 words)

  
 Classical pathway
The classical pathway of complement activation is a mediator of the specific antibody response.
C5b is critical in initiating the lytic sequence of reactions, and plays an important role in directing the association of further late-acting components of the complement system which interact to produce a lesion in the bacterial surface leading to bacterial death (20).
Thus, under most conditions the concentration of the C4bp greatly exceeds the small amounts of C4b generated by the activation of the classical pathway and C4b is therefore inactivated.
www-micro.msb.le.ac.uk /mbchb/Merralls/Classical.html   (1137 words)

  
 The Classical Activation Pathway of the Human Complement System Is Specifically Inhibited by Calreticulin from ...
Complement activation was assessed using a phosphatase-conjugated chicken anti-human C4 Ab to detect deposition of activated C4.
Complement component C1 and the collectins: first-line defense molecules in innate and acquired immunity.
Carroll, M. The role of complement and complement receptors in induction and regulation of immunity.
www.jimmunol.org /cgi/content/full/172/5/3042   (6335 words)

  
 The Innate Immune System: The Complement System - The Classical Complement Pathway   (Site not responding. Last check: 2007-10-06)
There are 3 complement pathways that make up the complement system: the classical complement pathway, the lectin pathway, and the alternative complement pathway.
Although at least 21 different serum proteins have thus far been identified as part of the classical complement pathway, one can look at it as a pathway that is primarily activated by either IgG or IgM binding to an antigen (def) and involves 11 major serum protein components.
Typically to activate the classical complement pathway, IgG or IgM is made in response to an antigen.
www.cat.cc.md.us /courses/bio141/lecguide/unit2/innate/classical.html   (1235 words)

  
 The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae ...   (Site not responding. Last check: 2007-10-06)
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice -- Brown et al.
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
that the classical pathway is the dominant complement pathway
www.pnas.org /cgi/content/full/99/26/16969   (4268 words)

  
 Laozi
Focusing on rhyme patterns, Liu Xiaogan (1994 and 1997) concludes that the poetic structure of the Laozi is closer to that of the Shijing (Classic of Poetry) than that of the later Chuci (“Songs of the South”; David Hawkes, trans.
The Daodejing is also referred to as the Daode zhenjing (True Classic of the Way and Virtue), the Taishang xuanyuan Daodejing (Classic of the Way and Virtue of the Highest Primordial Mystery), and less formally the “five-thousand character” text, on account of its approximate length.
This complements the paradigm of the feminine (e.g., chs.
plato.stanford.edu /entries/laozi   (13445 words)

  
 Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis -- Celik et ...
Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis -- Celik et al.
Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis
The complement system and the natural antibody repertoire provide a critical first-line defense against infection.
iai.asm.org /cgi/content/abstract/69/12/7304   (425 words)

  
 Spontaneous Classical Pathway Activation and Deficiency of Membrane Regulators Render Human Neurons Susceptible to ...
Complement activation and opsonization on human fetal neurons cultured in the presence of NHS.
Complement activation and attack in the absence of anti-myelin antibodies.
Vanguri P, Koski CL, Silverman B, Shin ML: Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies.
ajp.amjpathol.org /cgi/content/full/157/3/905   (6938 words)

  
 Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic ...
To determine the ability of C1 INH to block the classical complement pathway, we used an erythrocyte hemolytic assay.
Hattori R, Hamilton KK, Mcever RP and Sims PJ (1989) Complement protein C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface.
Shandelya SML, Kuppusamy P, Herskowitz A, Weisfeldt ML and Zweier JL (1993) Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart.
www.jpet.org /cgi/content/full/286/1/429   (6501 words)

  
 Energy, Entropy, Economics, and Ecology
By definition, solar emergy is only conserved along a pathway of transformations until the ability to do work of the final energy remaining from its sources is used up (usually in interactive feedbacks).
It can be argued that it was from classical mechanics that economists derived the attitude that economic processes are fully controllable once they have been fully described.
The functions are a network of nutrient pathways (a food web), the topology of which is determined by ecological strategies of the species, and is an essentially fixed evolutionary feature on the time scale of ecosystem processes.
www.dieoff.com /page17.htm   (9324 words)

  
 Role for the Alternative Complement Pathway in Ischemia/Reperfusion Injury -- Stahl et al. 162 (2): 449 -- American ...
pathway and is important in the clearance and recognition of
Fearon DT, Austen KF: Activation of the alternative complement pathway due to resistance of zymosan-bound.
Volanakis JE, Macon KJ: Isolation of complement protein D from urine of patients with Fanconi’s syndrome.
ajp.amjpathol.org /cgi/content/full/162/2/449   (3548 words)

  
 Complement in Ischemia Reperfusion Injury -- Riedemann and Ward 162 (2): 363 -- American Journal of Pathology
Stein SH, Osgood RW, Barnes JL, Reineck HJ, Pinckard RN, McManus LM: The role of complement in the pathogenesis of postischemic acute renal failure.
Buerke M, Prufer D, Dahm M, Oelert H, Meyer J, Darius H: Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury.
Jiang H, Wagner E, Zhang H, Frank MM: Complement 1 inhibitor is a regulator of the alternative complement pathway.
ajp.amjpathol.org /cgi/content/full/162/2/363   (3619 words)

  
 Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic ...
Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic Myocardium from Reperfusion Injury -- Buerke et al.
Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic Myocardium from Reperfusion Injury
pathway by deposition of C1q on cardiac myocytes and cardiac vessels.
www.jpet.org /cgi/content/abstract/286/1/429   (814 words)

  
 BIOL 230 Lecture Guide - The Classical Complement Pathway: Formation of C1   (Site not responding. Last check: 2007-10-06)
BIOL 230 Lecture Guide - The Classical Complement Pathway: Formation of C1 Assembly of C1 during the Classical Complement Pathway
The Fab of IgG or IgM bind to epitopes on an antigen.
C1q, C1r, and C1s then assembles on the Fc portion of the antibodies to form C1, the first enzyme of the classical complement pathway.
www.cat.cc.md.us /courses/bio141/lecguide/unit2/innate/c1act.html   (76 words)

  
 Formation of High Affinity C5 Convertase of the Classical Pathway of Complement -- Rawal and Pangburn 278 (40): 38476 ...
Formation of High Affinity C5 Convertase of the Classical Pathway of Complement -- Rawal and Pangburn 278 (40): 38476 -- Journal of Biological Chemistry
Articles by Rawal, N. Articles by Pangburn, M. Formation of High Affinity C5 Convertase of the Classical Pathway of Complement
the classical pathway C5 convertase may compensate for the fewer
www.jbc.org /cgi/content/abstract/278/40/38476   (381 words)

  
 Genetic Evidence for Involvement of Classical Complement Pathway in Induction of Experimental Autoimmune Myasthenia ...
Genetic Evidence for Involvement of Classical Complement Pathway in Induction of Experimental Autoimmune Myasthenia Gravis -- Tüzün et al.
Abs to acetylcholine receptor (AChR) and complement are the
complement pathway in the induction of EAMG induced by AChR
www.jimmunol.org /cgi/content/abstract/171/7/3847   (404 words)

  
 Complement   (Site not responding. Last check: 2007-10-06)
Microbiology @ Leicester : Infection and Immunity : Complement
THE ROLE OF COMPLEMENT IN THE ELIMINATION OF MICROORGANISMS
The Interaction of Micro-organisms with the Complement System:
www-micro.msb.le.ac.uk /MBChB/Merralls/Merralls.html   (26 words)

  
 [No title]
To determine whether interference with complement functions may contribute to the immunomodulatory activity of beta-glycyrrhetinic acid, its effects on the classical and alternative activation pathways of human complement were investigated.
We found that beta-glycyrrhetinic acid is a potent inhibitor of the classical complement pathway (IC50 = 35 microM), whereas no inhibitory activity was observed towards the alternative pathway (IC50 > 2500 microM).
In: Basic Life Sci (1993) 61:65-74 ISSN: 0090-5542 Extracellular interception of mutagens by excreted enzymes or by chemical agents that react with or bind to formed mutagens provides an important means of defense against chemical mutagens/carcinogens.
www.swsbm.com /Abstracts/Glycyrrhiza-AB.txt   (6516 words)

  
 Ariadne Genomics: Tools for Systems Biology
develops user-friendly software tools for biologists in the areas of pathway analysis, sequence data management and automated scientific text processing.
PathwayStudio Central™ : client-server software for visualization and analysis of biological pathways.
Seqware DataCenter™ allows you to store, organize and compare your sequences, together with the GenBank, on a regular PC.
www.ariadnegenomics.com   (180 words)

  
 Yoga Journal : 200 Key Sanskrit Yoga Terms
Gheranda-Samhita ("[Sage] Gheranda's Compendium"): one of three major manuals of classical hatha yoga, composed in the seventeenth century; cf.
Granthi ("knot"): any one of three common blockages in the central pathway (sushumna-nadi) preventing the full ascent of the serpent power (kundalini-shakti) ; the three knots are known as brahma-granthi (at the lowest psychoenergetic center of the subtle body), the vishnu-granthi (at the heart), and the rudra-granthi (at the eyebrow center)
Hatha-Yoga-Pradipika ("Light on Hatha Yoga"): one of three classical manuals on hatha yoga, authored by Svatmarama Yogendra in the fourteenth century
www.yogajournal.com /newtoyoga/159_1.cfm   (3811 words)

  
 A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells In Vivo -- Taylor et ...
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells In Vivo -- Taylor et al.
pathway complement proteins in vivo in the clearance of apoptotic
Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors CR1 and CR2
www.jem.org /cgi/content/abstract/192/3/359   (1895 words)

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