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Topic: Clobazam

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	Data Sheet
		Age and sex influence the metabolism of clobazam in that the total clearance of clobazam is significantly lower in the elderly male and elimination half life is extended in both the elderly male and female which leads to the accumulation of the parent compound and its active metabolite.
		Clobazam must not be used in children between the ages of 6 months and 3 years, other than in exceptional cases for anticonvulsant treatment where there is a compelling indication.
		Clobazam is extensively metabolised, probably by the liver and excreted with its metabolites primarily by the kidney.
	www.medsafe.govt.nz /profs/Datasheet/f/Frisiumtab.htm (1760 words)

	Introduction to clobazam (Intermediate) : Epilepsy.com
		Clobazam is a seizure medicine and is available in many countries outside the United States.
		Clobazam is not sold in the United States.
		Clobazam tablets should be swallowed whole, followed by at least a half a glass of water.
	www.epilepsy.com /medications/i_clobazam_intro.html (413 words)

	Phase II Data Shows Ovation's Novel Compound Clobazam To Be Well Tolerated In Patients With Catastrophic Epilepsy
		Results from the first study in the United States designed to evaluate the safety and efficacy of clobazam as adjunctive therapy in patients with Lennox-Gastaut syndrome (LGS), one of the most severe forms of childhood epilepsy, demonstrated that clobazam is well tolerated.
		In the trial, clobazam was shown to be effective in significantly reducing drop (or atonic) seizures, the most debilitating of the LGS seizure types, which can result in severe trauma to the brain and body, by 85.3 percent compared to baseline (in the high dose group versus 12 percent in the low dose group; P=.0001).
		Currently, clobazam is widely available worldwide with approvals in more than 100 countries for various uses in both children and adults, including the treatment of epilepsy and anxiety.
	www.pharma-lexicon.com /medicalnews.php?newsid=58108 (1101 words)

	Clobazam
		Clobazam acts on receptors in the brain (GABA receptors) to increase the release of GABA.
		As clobazam prevents fitting, it may be used (in conjunction with another anti-epileptic medicine) for the treatment of epilepsy.
		Clobazam may also be used to relieve anxiety in serious or disabling anxiety related conditions.
	www2.netdoctor.co.uk /medicines/100000534.html (709 words)

	Clobazam - Wikipedia, the free encyclopedia
		Clobazam is a drug which is a benzodiazepine derivative.
		Clobazam has two major metabolites: N-desmethyl-clobazam and 4'-hydroxyclobazam, the former of which is active.
		In addition to epilepsy and severe anxiety, clobazam is also approved as an adjunctive agent in schizophrenia and other psychotic disorders.
	en.wikipedia.org /wiki/Clobazam (1227 words)

	Clobazam And Anxiety (Site not responding. Last check: 2007-10-11)
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	Frisium Tablets 10 mg , SPC from the eMC
		In patients with impairment of renal or hepatic function, responsiveness to clobazam and susceptibility to adverse effects are increased, and a dose reduction may be necessary.
		Especially when clobazam is administered at higher doses, an enhancement of the central depressive effect may occur in cases of concomitant use with antipsychotics (neuroleptics), hypnotics, anxiolytics/sedatives, antidepressant agents, narcotic analgesics, anticonvulsant drugs, anaesthetics and sedative antihistamines.
		Clobazam may cause sedation, leading to fatigue and sleepiness, especially at the beginning of treatment and when higher doses are used.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=8298 (1971 words)

	What are the most common side effects of clobazam? (Intermediate) : Epilepsy.com
		The side effects of clobazam are generally mild and usually disappear if the dose is reduced.
		Clobazam and other benzodiazepines are the medicines that are most likely to cause psychological dependence.
		In many of these cases, very gradual reduction of the benzodiazepine (often over many months or years) can lead to a dramatic improvement in attention, concentration, memory, and mood without worsening the seizures, insomnia, or anxiety for which the medication was originally prescribed.
	www.epilepsy.com /medications/i_clobazam_sideeffects.html (393 words)

	Clobazam Anti-Anxiety Drugs Online Cheap
		Clobazam is a 1,5-benzodiazepine with antianxiety and anticonvulsant properties, advocated for the treatment of primary anxiety and that associated with organic or functional disorders.
		Therapeutic trials indicate that the antianxiety effect of clobazam 30 to 80 mg daily is comparable with that of half its dose of diazepam.
		Although subjective drowsiness has occurred with similar frequency with clobazam and diazepam in some studies, clobazam causes less objectively measured sedation or psychomotor impairment in experimental studies.
	www.druglisting.com /Clobazam.php (171 words)

	CLOBAZAM (Frisium®)
		Clobazam's interaction with other anti-epileptic drugs is variable.
		Clobazam use should be avoided during pregnancy if possible, especially during the first trimester.
		Clobazam passes into breastmilk and should be avoided by nursing mothers.
	www.epilepsytoronto.org /clobazam.html (489 words)

	Epilepsy Ontario :: Medications :: Clobazam
		Clobazam is currently used only in combination with another anticonvulsant medication.
		Clobazam is a useful addition to the anti-epileptic medications for people with refractory or difficult-to-control seizures.
		Common reactions to clobazam include drowsiness, dizziness, lack of coordination and fatigue (with a high dose at the beginning of treatment).
	epilepsyontario.org /client/eo/EOWeb.nsf/web/clobazam (301 words)

	Medbroadcast Drug Info
		The recommended adult dose of clobazam ranges from 5 mg to 80 mg daily, as directed by the doctor, taken in one or two doses with or without food.
		It should be used with caution by seniors, those who are debilitated, those with organic brain disorders such as dementia, and those with breathing problems such as asthma.
		Occupational hazards: Since clobazam causes drowsiness, undertaking potentially hazardous activities requiring mental alertness and physical coordination (such as driving or operating dangerous machinery) is not recommended until you determine how clobazem affects you.
	www.medbroadcast.com /drug_info_details_pf.asp?brand_name_id=360 (984 words)

	eMedicine - Antiepileptic Drugs: An Overview : Article by Juan G Ochoa, MD (Site not responding. Last check: 2007-10-11)
		Clobazam is metabolized by oxidation in the liver to norclobazam (N-desmethylclobazam).
		Clobazam is administered orally at a dose 10-20 mg/d, taken at night or twice daily.
		Clobazam is useful in intermittent treatments (eg, catamenial epilepsy) and as prophylaxis for some situations, such as traveling, celebrations, and other occasions.
	www.emedicine.com /neuro/topic692.htm (12315 words)

	Effect of a new benzodiazepine derivate, clobazam, in anxious patients with gastrointestinal disorders -- Laudano et ...
		Effect of a new benzodiazepine derivate, clobazam, in anxious patients with gastrointestinal disorders -- Laudano et al.
		Effect of a new benzodiazepine derivate, clobazam, in anxious patients with gastrointestinal disorders
		Anxiolytic treatment consisted of 30 mg/day clobazam (HR 376) or 15 mg/day diazepam, given in a randomized, double-blind manner.
	jcp.sagepub.com /cgi/content/abstract/17/7/441 (250 words)

	Pharmacy Choice - Pharmaceutical News - Significant Positive Results in OVATION's Phase II Clobazam Trial - December ...
		Clobazam has a unique chemical structure with associated properties when compared with other currently available benzodiazepines.
		Patients were randomized to two treatment groups with a low dose (target of 0.25 mg/kg/day) of clobazam or a high dose (target of 1.0 mg/kg/day) for a total treatment duration of up to 10 weeks.
		There was a significant difference between the treatment groups in the percent reduction in weekly drop seizures from baseline to maintenance period (p-value=0.0001).
	www.pharmacychoice.com /News/article.cfm?Article_ID=41451 (747 words)

	Ovation's epilepsy drug OK in phase 2
		SAN DIEGO, Dec. 4 (UPI) -- U.S. firm Ovation said Monday clobazam, a potential treatment for a severe form of childhood epilepsy, appeared safe and effective in a phase 2 study.
		Ovation is developing clobazam as a treatment for Lennox-Gastaut syndrome, a devastating type of the disease that is usually treated with anti-convulsants.
		In the phase 2 trial 68 LGS patients ranging from 2 to 26 years of age received low- or high-dose clobazam for up to 10 weeks.
	www.softcom.net /webnews/wed/cb/Uus-ovation-briefing.RX6I_GD4.html (169 words)

	Clobazam
		Clobazam is a barbiturate used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain.
		Clobazam binds at a distinct binding site associated with a Cl ionopore at the GABA-A receptor, increasing the duration of time for which the Cl ionopore is open.
		Results from the first study in the United States designed to evaluate the safety and efficacy of clobazam as adjunctive therapy in patients with Lennox...
	www.mongabay.com /health/medications/Clobazam.html (512 words)

	clobazam Buy Phentermine Xanax Hydrocodone Online (via CobWeb/3.1 planetlab2.tamu.edu) (Site not responding. Last check: 2007-10-11)
		Benzodiazepines clobazam Buy Phentermine Xanax Hydrocodone Online may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses.
		Before clobazam Buy Phentermine Xanax Hydrocodone Online is given to children for long periods of time, you should discuss its use with your child's doctor.
		If you are taking clobazam Buy Phentermine Xanax Hydrocodone Online regularly (for example, every day as for epilepsy) and you miss a dose, take it right away if you remember within an hour or so of the missed dose.
	clobazam.creativelifecoaching.com.cob-web.org:8888 (5362 words)

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		Before clobazam clobazam Online Pharmacy Huge Discounts is given to children for long periods of time, you should discuss its use with your child's doctor.
		If you are taking clobazam clobazam Online Pharmacy Huge Discounts regularly (for example, every day as for epilepsy) and you miss a dose, take it right away if you remember within an hour or so of the missed dose.
		Stopping clobazam clobazam Online Pharmacy Huge Discounts suddenly is most likely to cause seizures if you have been taking it for epilepsy or another seizure disorder.
	clobazam.iravetv.com.cob-web.org:8888 (5487 words)

	clobazam Fioricet ( Brand Name Butabitial ) Buy Fioricet Online (via CobWeb/3.1 planetlab2.tamu.edu) (Site not responding. Last check: 2007-10-11)
		Benzodiazepines clobazam Fioricet (Brand Name Butabitial) Buy Fioricet Online may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses.
		Before clobazam Fioricet (Brand Name Butabitial) Buy Fioricet Online is given to children for long periods of time, you should discuss its use with your child's doctor.
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	clobazam.annexsoft.com.cob-web.org:8888 (5539 words)

	Farmaci antiepilettici - Interazioni (benzodiazepine) / Antiepileptic drugs - Interactions (benzodiazepines) (Site not responding. Last check: 2007-10-11)
		Clobazam: a review of its pharmacological properties and therapeutic use in anxiety.
		Clobazam in therapy-resistant patients with partial epilepsy: a double-blind placebo-controlled crossover study.
		The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.
	www.neuro.unibo.it /epil/bdzint97.htm (471 words)

	Kava & Anxiety
		There is one study comparing the benzodiazepine clobazam with kava to which we can look for some guidance.
		Synthetic kavain was compared to clobazam in a placebo-controlled, double blind study in 15 healthy volunteers.
		Subjects received placebo, various doses of kavain (200,400, and 600mg), or 30mg clobazam.
	www.hinckleydrug.com /Kava.htm (851 words)

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		Before clobazam clobazam Fioricet - Butalbital Online Butalbital Fioricet is given to children for long periods of time, you should discuss its use with your child's doctor.
		If you are taking clobazam clobazam Fioricet - Butalbital Online Butalbital Fioricet regularly (for example, every day as for epilepsy) and you miss a dose, take it right away if you remember within an hour or so of the missed dose.
		Stopping clobazam clobazam Fioricet - Butalbital Online Butalbital Fioricet suddenly is most likely to cause seizures if you have been taking it for epilepsy or another seizure disorder.
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	CLOBAZAM: buy clobazam, discount clobazam, side effects clobazam - Swiftrx (Site not responding. Last check: 2007-10-11)
		Clobazam passes into breast milk and may have undesirable effects on a nursing infant.
		Tell your doctor of all prescription and nonprescription medication you may use, especially: medication for depression, narcotic pain relievers, sleeping pills, tranquilizers, antihistamines, other seizure medications.
		FDA's general position: The FDA, due to the current state of their regulations, has taken the position that virtually all shipments of prescription drugs imported from a Canadian pharmacy by a U.S. consumer will violate the law.
	www.meds4u.com /quick_search.jsp?criteria=CLOBAZAM (688 words)

	clobazam Buy Diazepam - Valium - Online (via CobWeb/3.1 planetlab2.tamu.edu) (Site not responding. Last check: 2007-10-11)
		It is possible that using clonazepam for long periods of time may cause unwanted effects on physical and mental growth in children.
		If you must wake up before this, you may continue to feel drowsy and may experience memory problems, because the effects of the medicine have not had time to wear off.
		The number of capsules or tablets, or the amount of solution that you take, or the number of injections you receive, depends on the strength of the medicine.
	clobazam.akunin.biz.cob-web.org:8888 (5167 words)

	PharmaLive: Phase II Data Shows Ovation's Novel Compound Clobazam to Be Well Tolerated in Patients With Catastrophic ...
		PharmaLive: Phase II Data Shows Ovation's Novel Compound Clobazam to Be Well Tolerated in Patients With Catastrophic Epilepsy
		SAN DIEGO, December 04, 2006 /PRNewswire/ -- Results from the first study in the United States designed to evaluate the safety and efficacy of clobazam as adjunctive therapy in patients with Lennox-Gastaut syndrome (LGS), one of the most severe forms of childhood epilepsy, demonstrated that clobazam is well tolerated.
		InfoPass gives you access to an array of integrated information services – information that is critical to your success and the success of your organization.
	www.engelpub.com /News/Index.cfm?articleid=396435 (1128 words)

	Clobazam
		Hypersensitivity to clobazam or any component of the formulation (cross-sensitivity with other benzodiazepines may exist); myasthenia gravis; narrow-angle glaucoma; severe hepatic or respiratory disease; sleep apnea; history of substance abuse; use in pregnancy (particularly 1st trimester) and breast-feeding contraindicated per manufacturer
		Anticonvulsants (carbamazepine, phenytoin, valproate, phenobarbital): Clinically-significant interactions are rare, but reports of clobazam increasing levels of carbamazepine, phenytoin, valproate, and phenobarbital exist.
		CNS depressants: Sedative effects and/or respiratory depression may be additive with CNS depressants.
	www.musc.edu /pharmacyservices/Drugs/C/Clobazam.htm (565 words)

	Lennox-Gastaut Syndrome - Ovation reports positive results in phase 2 trial ...
		The phase 2 multicenter, randomized, double-blind dose-finding study performed in the United States involved 68 patients (2 to 26 years of age) with LGS.
		Data from the phase 2 clobazam clinical trial showed both clinically relevant and statistically significant results.
		There was a significant difference between the treatment groups in the percent of reduction in weekly drop seizures from baseline to maintenance period (p=.0001).
	www.newsrx.com /health-articles/403467.html (572 words)

	Drug Information: Benzodiazepines (Systemic) (Print Version)
		Alprazolam and clonazepam are used in the treatment of panic disorder.
		Clobazam, clonazepam, clorazepate, diazepam, and lorazepam are used in the treatment of certain convulsive (seizure) disorders, such as epilepsy.
		The benzodiazepines may also be used for other conditions as determined by your doctor.
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/202084.html (4937 words)

	Atlas: Revisited effects on Psychomotor functions of Clobazam and Diazepam, ANOVA vs. survival analysis study by Rita ... (Site not responding. Last check: 2007-10-11)
		Data was collected from nine healthy females, who undertook a double-blind study to compare the effects of single doses of 20mg of clobazam, 10mg of diazepam and placebo.
		The results suggests that 3 hours after the intake of dosages similar of those used in clinical grounds diazepam decreases the CNS arousal and clobazam interferes on perceptual skills.
		The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # cath-85.
	atlas-conferences.com /cgi-bin/abstract/cath-85 (286 words)

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