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Topic: Clomipramine

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	Clomipramine - Wikipedia, the free encyclopedia
		Clomipramine is widely used for the treatment of disturbed behaviour of dogs, cats, and horses.
		Clomipramine shows a number of clinical significant interactions, either due to central depressant or stimulant activity of the other drug or due to interference of the other drug with the metabolization and elimination of Clomipramine or vice versa.
		Clomipramine is not able to increase the mood of non-depressive persons and that any unindicated use may be dangerous.
	en.wikipedia.org /wiki/Clomipramine (1587 words)

	Clomipramine (Anaframil) Anti-Depressant (Site not responding. Last check: 2007-11-02)
		Clomipramine is the most specific of all the tricyclic antidepressants with regard to its ability to inhibit serotonin reuptake versus norepinephrine reuptake.
		Although clomipramine is used clinically to treat obsessive-compulsive disorder, it is occasionally used for major depressionº.
		Clomipramine may cross the placenta and is distributed into breast milk.
	www.rockford.uic.edu /jc/clomipr2.htm (394 words)

	Clomipramine
		Clomipramine inhibits the removal of serotonin in the brain so that the serotonin present is present for a longer time.
		Clomipramine is thus classified a “selective serotonin re-uptake inhibitor” or “SSRI.” These are terms with which one may be familiar from discussions of human anti-anxiety medications.
		Clomipramine should not be used in patients with seizure disorders as it may facilitate seizures.
	www.marvistavet.com /html/body_clomipramine.html (464 words)

	University of Portsmouth \| clomipramine trial
		Clomipramine was the tricyclic drug that appeared to do so to the greatest extent.
		Clomipramine not only crossed the blood brain barrier, but also is sequestered in large quantities in the brain and lungs.
		Since we know that Clomipramine is metabolised to varying extents in different people we intended to assess the potential effect of that on patient outcome.
	www.port.ac.uk /research/ibbs/neuro-oncology/research/clomipraminetrial (348 words)

	Clomipramine (Clomicalm®) - PetPlace.com (Site not responding. Last check: 2007-11-02)
		Clomipramine is one of these drugs, and one of the very few specifically approved for use in dogs.
		Clomipramine is approved for the treatment of canine behavioral disorders classified as separation anxiety.
		Clomipramine is available in 20 mg, 25 mg, 40 mg, 50 mg, 75 mg and 80 mg tablets or capsules.
	www.petplace.com /drug-library/clomipramine-clomicalm/page1.aspx (501 words)

	clomipramine Drug Information
		While you are taking clomipramine you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed.
		Clomipramine is used to relieve symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions.
		Clomipramine is in the FDA pregnancy category C. This means that it is not known whether clomipramine will harm an unborn baby.
	www.drugs.com /MTM/clomipramine.html (1483 words)

	Clomipramine 75mg Cap Generic to Clomicalm Sold Per Pill (Site not responding. Last check: 2007-11-02)
		Clomipramine (Clomicalm) is a tricyclic antidepressant FDA approved for veterinary use in dogs for the treatment of separation anxiety.
		Clomipramine (Anafranil), FDA approved for human use, is sometimes used in veterinary medicine to treat aggression and obsessive-compulsive disorders such as tail chasing.
		Clomipramine may also be useful in cats, but cats tend to be more sensitive to tricyclic antidepressant drugs.
	www.vetscriptions.com /index.asp?PageAction=VIEWPROD&ProdID=59 (483 words)

	Clomipramine
		Clomipramine may potentiate the cardiovascular effects of noradrenaline or adrenaline, amphetamine, as well as nasal drops and local anesthetics containing sympathomimetics.
		Clomipramine should not be administered for a period of at least 14 days after the discontinuation of treatment with MAO-inhibitors due to the potential for severe interactions (see Contraindications).
		Clomipramine should be discontinued prior to elective surgery, for as long as clinically feasible, since little is known about the interaction between clomipramine and general anesthetics.
	www.twilightbridge.com /psychiatryproper/drugbulletin/clomipramine/clomipramineDruginteractions.htm (267 words)

	Anafranil, Clomipramine Pharmacology - HealthyPlace.com
		Clomipramine is contraindicated in patients with existing liver or kidney damage and should not be administered to patients with a history of blood dyscrasias.
		Clomipramine is contraindicated in patients with glaucoma, as the condition may be aggravated due to the atropine-like effects of the drug.
		Therefore, clomipramine should be administered with extreme caution to patients with a history of cardiovascular disease, especially those who have a history of conduction disorders, those with circulatory lability and elderly patients.
	www.healthyplace.com /medications/anafranil.htm (3035 words)

	APO-CLOMIPRAMINE 10; APO-CLOMIPRAMINE 25; APO-CLOMIPRAMINE 50
		Clomipramine should not be administered for a period of at least 14 days after the discontinuation of treatment with MAO-inhibitors due to the potential for severe interactions: severe hypertensive reactions, hyperpyretic crises, convulsions and fatalities have been reported.
		Clomipramine hydrochloride should be administered with caution in patients with urinary retention, prostatic hypertrophy or constipation or in patients with increased intraocular pressure due to its anticholinergic properties.
		Clomipramine should be discontinued prior to elective surgery for as long as clinically feasible, since little is known about the interaction between clomipramine and general anaesthetics.
	home.intekom.com /pharm/apotex/ap-clomp.html (1319 words)

	Be aware of clomipramine effects on thyroid function, study says - "Evaluation of the Effects of Clomipramine on Canine ...
		Clomipramine is a TCA that has been used to treat various psychiatric conditions in humans, and was recently approved for the treatment of separation anxiety in dogs.
		The clinical importance of the decrease in T4 and fT4 with prolonged administration of clomipramine lies in the interference with a diagnosis of hypothyroidism, the potential for the induction of hypothyroidism, and the possible effects on the therapeutic response to clomipramine.
		Clomipramine should be added to the list of drugs that alter thyroid function, along with anti-convulsants, potentiated sulfonamides and glucocorticoids.
	www.dvmnewsmagazine.com /dvm/article/articleDetail.jsp?id=94463 (1120 words)

	Clomipramine (Site not responding. Last check: 2007-11-02)
		Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties.
		Clomipramine is presumed to influence depression and obsessive and compulsive behaviour through its effects on serotonergic neurotransmission.
		Clomipramine appears to have a mild sedative effect which may be helpful in alleviating the anxiety component often accompanying depression.
	www.twilightbridge.com /psychiatryproper/drugbulletin/clomipramine/clomipraminepharma.htm (171 words)

	Clomipramine
		Clomipramine was Better than Citalopram or Paroxetine or Moclobemide: Malene Grubbe Hildebrandt, Odense University Hospital in Denmark, Three DB 292 inpatients with major depression.
		Clomipramine was compared with citalopram, paroxetine, or moclobemide-during 5-week treatment periods.
		Clomipramine vs desipramine crossover trial in body dysmorphic disorder: selective efficacy of a serotonin reuptake inhibitor in imagined ugliness.
	www.modern-psychiatry.com /clomipramine.htm (874 words)

	Clomipramine
		Clomipramine may also be used in the treatment of obsessive disorders such as obsessive-compulsive disorder and phobia disorders.
		It is not fully understood how clomipramine works in these conditions but it is thought to be related to the increased effect of serotonin and noradrenaline in the brain.
		Clomipramine is thought to be of use in this condition by increasing the stimulating effect of the chemical noradrenaline in the brain.
	www.tiscali.co.uk /lifestyle/healthfitness/health_advice/netdoctor/archive/100000538.html (891 words)

	Clomipramine - Patient UK
		Clomipramine is used to treat depression, especially when the patient is experiencing difficulty sleeping and a loss of appetite.
		Clomipramine can also be used to treat phobias (fears) and obsessions, and cataplexy, which is collapsing associated with narcolepsy (extreme sleepiness).
		Clomipramine can cause some people to become more sensitive to sunlight than they usually are.
	www.patient.co.uk /showdoc/30002913 (908 words)

	Neurology Journal Club Aricle #1 (Site not responding. Last check: 2007-11-02)
		Clomipramine has been recommended,3,7 but, to the authors' knowledge, there are no reports of rigorous clinical studies on the use of clomipramine for treatment of a variety of canine compulsive behaviors.
		Clomipramine appeared to be associated with sedation, decreased appetite, and frequency of defecation, and increased water consumption and frequency of urination (Table 1).
		Clomipramine in dogs has a short elimination half-life and marked inter-dog variability.22 Inter-subject variability is a characteristic of clomipramine in human beings,27 and monitoring of drug concentration in patients is recommended.26 Such monitoring is impractical in dogs, but the dose rate for individual dogs could be established empirically.
	neuro.vetmed.ufl.edu /neuro/Journal_Club/Articles/clorimip_Art.htm (4452 words)

	Clomipramine More Effective Than Desipramine For Body Dysmorphic Disorder (Site not responding. Last check: 2007-11-02)
		LOS ANGELES, CA -- October 26, 1999 -- The drug clomipramine is more effective than desipramine in the treatment of body dysmorphic disorder (BDD), a disorder in which a person is preoccupied with an imagined or slight defect in their appearance.
		The researchers found that clomipramine, a serotonin reuptake inhibitor, was significantly more effective than desipramine, a norepinephrine reuptake inhibitor, in reducing the patient’s obsessive preoccupation with perceived body defects and their repetitive behaviors in response to this preoccupation as well as reducing overall BDD symptom severity.
		Clomipramine is a serotonin reuptake inhibitor and desipramine is a selective norepinephrine reuptake inhibitor.
	www.pslgroup.com /dg/13ea96.htm (708 words)

	Coping With Depression - Clomipramine (Clomipramine Hydrochloride) (Site not responding. Last check: 2007-11-02)
		Clomipramine capsules contain either 10, 25 or 50 mg of Clomipramine Hydrochloride.
		Clomipramine belongs to a group of drugs called tricyclic antidepressants.
		Clomipramine capsules are used to treat depression, phobias and obsessive states.
	www.huddersfield1.co.uk /depression/clomipramine.htm (1041 words)

	clomipramine (Site not responding. Last check: 2007-11-02)
		She was treated as an out-patient, with clomipramine 100 mg per 24 hours.
		However, the patient was particularly ambivalent about continuing the medication, because he had noted a frequent intense urge to yawn without tiredness and that on many occasions when he yawned, he experienced orgasm, with ejaculation.
		The patient subsequently reported that he had stopped taking clomipramine after seven days because he had noted that every time he yawned he experienced such as intense sense of exhaustion and weakness, that he had to lie down for 10 to 15 minutes after each yawn, until the sensation subsided.
	webperso.easyconnect.fr /baillement/clomipramine.html (1110 words)

	RemedyFind: patient ratings of Anafranil for Generalized Anxiety Disorder
		Clomipramine was one in a number of meds.
		This study of 227 OCD patients found that fluvoxamine and clomipramine were both clinically effective, however, those treated with clomipramine had more anticholinergic side effects (dry mouth, constipation and tremor) and premature withdrawals due to adverse events.
		Clomipramine has been proven effective, however, side effects caused by this agent would suggest that an SSRI is a better choice.
	www.remedyfind.com /rem.asp?ID=4285 (576 words)

	Truehope Research Library - Tourette's Syndrome
		An adverse event is described which appeared when the macrolide antibiotic erythromycin was added to a regimen of risperidone 0.5 mg bid and clomipramine 50 mg tid in a 15-year-old male being treated for Tourette's, obsessive-compulsive, and attention-deficit hyperactivity disorders.
		Clomipramine metabolism is dependent upon the isoenzymes CYP2D6 and CYP1A2, and risperidone is a substrate for CYP2D6.
		In the absence of clomipramine, risperidone clearance would not be affected by erythromycin.
	www.truehope.com /research/tourettes/tourettes_3_03.asp (314 words)

	Healthopedia.com - Clomipramine (Oral) (Anafranil) - Drugs Information, Side Effects, & Interactions
		You should not use clomipramine if you have ever had an allergic reaction to clomipramine or to related medicine such as Elavil® or nortriptyline.
		Clomipramine should not be used if you have had a recent heart attack or are taking an MAO inhibitor (such as Nardil® or Parnate®).
		It may be 2 to 3 weeks after you start clomipramine before you notice an improvement in your symptoms.
	www.healthopedia.com /drugs/quick/clomipramine (557 words)

	Chronic Clomipramine and Triiodothyronine Increase Serotonin Levels in Rat Frontal Cortex In Vivo: Relationship to ...
		Clomipramine is chemically a member of the TCA group of drugs but is characterized by a very high affinity for the 5-HT uptake
		The half-life of clomipramine is 4.4 h in the rat (Fujita et al., 1991
		Davidson C and Stamford JA (1995) The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT-1a and 5-HT-1b/d receptor antagonists.
	jpet.aspetjournals.org /cgi/content/full/288/1/81 (5697 words)

	Anafranil Online, Description, Chemistry, Ingredients - Clomipramine Hcl - RxList Monographs
		Anyone considering the use of clomipramine hydrochloride or any other antidepressant in a child or adolescent must balance this risk with the clinical need.
		, (clomipramine hydrochloride capsules, USP), is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants.
		Clomipramine hydrochloride is a white to off-white crystalline powder.
	www.rxlist.com /cgi/generic/clomipr.htm (279 words)

	Clomipramine (Clomicalm, Anafranil) - VeterinaryPartner.com - a VIN company!
		Clomipramine is thus classified a selective serotonin re-uptake inhibitor or SSRI.
		This means that clomipramine inhibits the involuntary functions mediated by the neurotransmitter acetylcholine.
		This means clomipramine may not be used in conjunction with anti-tick collars containing amitraz (the Preventic® collar).
	www.veterinarypartner.com /Content.plx?P=A&A=1537&S=1&SourceID=52 (642 words)

	A Fatality Involving Clothiapine and Clomipramine
		A fatality resulting from the suicidal ingestion of clothiapine, clomipramine and biperiden is reported.
		Clomipramine, its metabolite N-desmethylclomipramine and clothiapine were quantified in blood, liver, kidney and gastric contents by HPLC and GC.
		Concentrations of clomipramine and N-desmethylclomipramine ranged from 0.48 to 1.61 mg/L and 0.26 to 1.32 mg/L, respectively, and clothiapine from 0.50 to 2.15 mg/L. This phenomenon may reflect a postmortem drug redistribution.
	www.astm.org /JOURNALS/FORENSIC/PAGES/2409.htm (164 words)

	Anafranil - Drugs & Vitamins - Drug Library - DrugDigest
		Clomipramine can help patients with an obsessive compulsive disorder.
		Clomipramine may cause dry eyes and blurred vision.
		Clomipramine may make your skin more sensitive to the sun.
	www.drugdigest.org /DD/DVH/Uses/0,3915,162\|Anafranil,00.html (1010 words)

	MedlinePlus Drug Information: Clomipramine
		Clomipramine is used to treat patients with obsessive-compulsive disorder.
		Do not stop taking clomipramine without talking to your doctor, especially if you have taken large doses for a long time.
		If you take clomipramine several times a day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a697002.html (920 words)

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