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Topic: Clozaril

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	NAMI \| About Medication
		Clozaril is approved for the treatment of schizophrenia that has not responded to other treatments.
		Clozaril is also being studied for the treatment of bipolar disorder that has not responded to other treatments.
		Clozaril has virtually no incidence of extrapyramidal symptoms such as muscle spasms, cramps, or posturing movements common to other antipsychotic medications, and a low incidence of side effects such as restlessness, muscle rigidity, and tremor.
	www.nami.org /helpline/clozapine.htm (1784 words)

	WhatMeds.com - Clozaril (Site not responding. Last check: 2007-10-14)
		Clozaril is an atypical antipsychotic drug that helps to correct an imbalance of nerve impulses that causes schizophrenic thought disorders.
		Clozaril is used to treat schizophrenia and false perceptions such as hallucinations or delusions.
		Clozaril is often prescribed for people whose negative or positive symptoms have not improved after treatment with at least two other antipsychotic drugs, or who encountered unusually severe side effects from taking other antipsychotic medications.
	www.whatmeds.com /meds/clozaril.html (405 words)

	Clozaril Indications, Dosage, Storage, Stability - Clozapine - RxList Monographs
		The superiority of CLOZARIL to chlorpromazine was documented in statistical analyses employing both categorical and continuous measures of treatment effect.
		CLOZARIL is indicated for reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for reexperiencing suicidal behavior, based on history and recent clinical state.
		The InterSePT study demonstrated the efficacy of CLOZARIL in treatment of patients with schizophrenia or schizoaffective disorder at risk for recurrent suicidal behavior where the mean daily dose was about 300 mg (range 12.5 to 900 mg).
	www.rxlist.com /cgi/generic3/clozapine_ids.htm (1464 words)

	FDA Approves Clozaril (Clozapine) To Reduce The Risk Of Suicidal Behavior
		Clozaril is still also indicated for the treatment of severely ill schizophrenic patients who fail to respond adequately to standard antipsychotic drug therapies.
		Clozaril use is associated with a substantial risk of seizure affecting 1% to 2% of patients at low doses (below 300 mg/day), 3% to 4% at moderate doses (300 mg/day to 600 mg/day), and 5% at high doses (600 mg/day to 900 mg/day).
		Analysis of post-marketing safety databases suggest that Clozaril is associated with an increased risk of fatal myocarditis, especially during, but not limited to, the first month of therapy.
	www.docguide.com /dg.nsf/PrintPrint/A936DE6A769702CD85256C9400510F3B (914 words)

	Clozaril (Clozapine) Reduces Risk Of Suicidal Behavior Among Patients With Schizophrenia, Schizoaffective Disorder (Site not responding. Last check: 2007-10-14)
		The InterSePT trial, a multi-center, randomized study was initiated in 1998 to compare the efficacy of two antipsychotic compounds, Clozaril (clozapine) and Zyprexa®* (olanzapine) in reducing the risk of suicide and self-destructive behavior among patients with schizophrenia or schizoaffective disorder.
		In addition, patients treated with Clozaril made fewer suicide attempts (p=0.03); required fewer rescue interventions to prevent suicide (p=0.01); experienced fewer hospitalizations to prevent suicide (p=0.05); and needed fewer concomitant medications such as antidepressants (p=0.02) and anxiolytics/soporifics (p=0.03).
		In particular, Clozaril is recognized for a unique binding profile which is associated with a particularly low propensity for movement disorders (extrapyramidal side effects) seen with the typical antipsychotic medications.
	www.pslgroup.com /dg/2273A2.htm (1564 words)

	Clozaril Reduces the Rate of Suicide in People With Schizophrenia
		Data demonstrate the advantage of Clozaril therapy to current users was not attributable to a transient increase in suicide risk immediately upon discontinuation of therapy.
		Introduced in the U.S. in February 1990, Clozaril has proven to be highly effective and is indicated for the management of people with treatment-resistant schizophrenia -- approximately 10 to 15 percent of the schizophrenia population.
		Clozaril should only be used in patients who have failed to respond adequately to treatment with appropriate courses of two standard antipsychotic drugs.
	www.docguide.com /dg.nsf/PrintPrint/C32DE67F01A82E7D8525653D005EB71A (744 words)

	FACTS ABOUT ANTIPSYCHOTIC MEDICATIONS (Site not responding. Last check: 2007-10-14)
		Clozaril does not appear to cause TD and may even improve the condition in some clients.
		Clozaril (clozapine) is a unique antipsychotic drug that has been available in the United States for about 10 years (it has been used in Europe for more than twenty years).
		One important side effect of Clozaril that occurs in a small percentage of people is a reduction in number of white blood cells (a condition called agranulocytosis).
	www.npi.ucla.edu /ssg/antipsychotic.htm (1554 words)

	FDA Approves Clozaril (Site not responding. Last check: 2007-10-14)
		Although generic versions of Clozaril are available, FDA regulations provide Novartis with exclusive rights to market the new indication for a period of 36 months.
		Clozaril reduced the risk of suicide attempts and hospitalizations to prevent suicide by about 25% compared to Zyprexa®.
		The safety profile observed in the study was consistent with the well-known characteristics of Clozaril®.
	namissw.org /default/news/clorazil.htm (294 words)

	Clozaril Diabetes Lawsuit Side Effects Lawyer (Site not responding. Last check: 2007-10-14)
		Clozaril (generic name: clozapine) and Zyprexa (generic name: olanzapine) have been linked with diabetes, hyperglycemia and pancreatitis.
		Clozaril and Zyprexa are atypical antipsychotic drugs used to treat schizophrenia.
		Zyprexa and Symbyax from Eli Lilly, Risperdal from Johnson & Johnson, Seroquel from AstraZeneca, Abilify from Bristol-Myers Squibb, Clozaril from Novartis and Geodon from Pfizer are all affected by the warning.
	www.yourlawyer.com /practice/overview.htm?topic=Clozaril (821 words)

	Clozaril Management (Site not responding. Last check: 2007-10-14)
		Clozaril is an antipsychotic medication used to treat patient with schizophrenia.
		Clozaril Therapy can cause a severe decrease in a patient's WBC (White Blood Cell) count called agranulocytosis.
		The Clozaril National Registry was established to protect patient's safety by creating a database to support physicians and pharmacists in tracking WBC counts.
	madison.neighborcare.com /Services/SpecialServices/Clozaril%20Management/ClozarilManagement.htm (195 words)

	Clozaril - Resources from Educational and Academic Institutions (Site not responding. Last check: 2007-10-14)
		: Clozaril (or cloazapine) is one of the first new drugs useful for schizophrenia that has been introduced in over 20 years.
		Recovery from psychosis: There is some emerging data that Clozaril given early in adolescence may reduce or perhaps just retard the development of the disorder.
		We are part of the system which administers Clozaril, and have participated in drug trials, both inpatient and outpatient.
	drugs.mongabay.com /Clozaril.html (1340 words)

	Clozaril approved to reduce risk of suicidal behavior in schizophrenics (Site not responding. Last check: 2007-10-14)
		Clozaril (clozapine-Novartis) was approved in 1989 for treatment of schizophrenia in patients who do not respond to other available therapies.
		Patients who may benefit from Clozaril are those judged to be at chronic risk for re-experiencing suicidal behavior, based on history of attempted suicide, hospitalization, or thoughts of suicide with or without hallucinations.
		It is recommended that Clozaril treatment for the risk of recurrent suicidal behavior be continued for at least 2 years.
	www.pharmacist.com /articles/h_ts_0178.cfm (176 words)

	Clozaril (clozapine) (Site not responding. Last check: 2007-10-14)
		Patients for whom Clozaril treatment may be useful are those who are judged to be at chronic risk for re-experiencing suicidal behavior, based on history of attempted suicide, hospitalization, or suicidal ideation (thoughts of suicide) with or without hallucinations.
		It is recommended that Clozaril treatment to reduce the risk of recurrent suicidal behavior should be continued for at least two years.
		FDA is advising the health care community that a majority of patients in both the Clozaril arm and the olanzapine arm of the trial received other treatments to reduce the suicide risk, including antidepressants and other medications, hospitalization and psychotherapy.
	www.stjhs.org /Library/FDADrugApprovals/Clozaril.htm (314 words)

	Clozaril
		Clozaril is given to help people with severe schizophrenia who have failed to respond to standard treatments.
		Clozaril is not a cure, but it can help some people return to more normal lives.
		Clozaril is considered a somewhat risky medication because of its potential to cause agranulocytosis and seizures.
	www.healthsquare.com /newrx/CLO1089.HTM (1496 words)

	Clozaril Side Effects, FDA Warning (Site not responding. Last check: 2007-10-14)
		Novartis with the FDA added a "Black Box" warning to the label of Clozaril, that states that post-marketing data from four countries revealed 82 reports of an inflammation of the heart lining known as myocarditis in patients using the drug.
		Clozaril patients experiencing unexplained fatigue, fever or malaise should consult their doctor immediately.
		Please note that you are not considered a client until you have signed a retainer agreement and we have accepted your case.
	www.clozaril-side-effects.com (224 words)

	FDA Consumer: Clozaril approved - antipsychotic drug (Site not responding. Last check: 2007-10-14)
		FDA has approved an antipsychotic drug, Clozaril (clozapine), for patients with severe schizophrenia who do not improve with standard drug treatments.
		Clozaril can cause seizures as well as a potentially fatal blood disorder called agranulocytosis.
		Because of the serious risk, Clozaril's manufacturer, Sandoz Pharmaceutical Corp., has devised a special delivery system in which a home health-care company will deliver a week's worth of medication and collect a blood sample from the patient.
	www.findarticles.com /p/articles/mi_m1370/is_n10_v23/ai_8309999 (341 words)

	Clozaril (Brand) vs. clozapine (Generic)
		Of these products, clozapine (Clozaril, Novartis) stands unique; it has been found useful in treating refractory patients who have shown little improvement with traditional neuroleptics and have been institutionalized for years as a result.
		Early reports casting doubts on the product's equivalence to branded Clozaril were proven unfounded, and since its introduction, 21,000 patients have been successfully switched from the branded product.
		Zenith/Goldline had developed a protocol for transferring all the information about patients already on Clozaril into their data system, and had a satisfactory method for monitoring blood work and alerting physicians of any significant abnormal data.
	www.omh.state.ny.us /omhweb/omhq/q0302/ClozarilvsClozapine.htm (596 words)

	HON - News : Clozaril Treats Suicidal Behavior (Site not responding. Last check: 2007-10-14)
		The approval follows two years of clinical trials that compared patients on Clozaril with those on a drug from the same family, olanzapine.
		Among the 980 participants, those on Clozaril made fewer suicide attempts and required fewer hospitalizations for suicidal tendencies.
		Clozaril does have a dangerous side effect -- it puts those who take it at risk of a dangerous blood disorder called agranulocytosis.
	www.hon.ch /News/HSN/510970.html (406 words)

	Clozaril Online, Description, Chemistry, Ingredients - Clozapine - RxList Monographs
		CLOZARIL is available in pale yellow tablets of 25 mg and 100 mg for oral administration.
		Active Ingredient: clozapine is a yellow, crystalline powder, very slightly soluble in water.
		For information on ordering Clozaril Online, please click the "online pharmacy" link on the blue horizontal navigation bar at the top of every page or click the "Get a Price Quote" Badge on the right side of pages like this one for a more direct route to a specific product.
	www.rxlist.com /cgi/generic3/clozapine.htm (276 words)

	Bipolar Meds - III
		Weight gain: A 1999 study by Allison et al found that Clozaril resulted in a mean weight gain of 9.8 pounds in ten weeks, 9.1 for Zyprexa, 6.4 for Risperdal, and negligible for Geodon.
		The labeling advises that women who are pregnant or intend to get pregnant notify their physician, further advising to stay on the med only if the benefit outweighs the risks.
		Clozaril (clozapine) - Clozaril is the first of the atypicals, but because weekly blood work is required due to risk of damage to white blood cells (agranulocytosis), the drug is regarded as a last treatment option.
	www.mcmanweb.com /article-178.htm (5123 words)

	briefs3
		The evidence establishes that he recognizes the need to do so, that he has consistently done so for several years without objection, and that there is no reason to believe that he will not continue to do so.
		The administration of Clozaril would be closely monitored, while the weekly blood work would continue to be done at the hospital proper.
		This position notwithstanding, Respondent's counsel specifically did not at hearing and does not now argue for the purposes of the instant proceeding that Respondent, if found to meet the criteria for commitment, may not be committed to such a program.
	www.mass.gov /cpcs/mhp/briefs3.html (1887 words)

	Clozaril - references in online news media (Site not responding. Last check: 2007-10-14)
		April 8, 2004 — Clozapine (Clozaril) is associated with a risk of hyperglycemia and diabetes, according to an alert released yesterday by MedWatch, the US...
		With the possible exception of clozapine (Clozaril), for which divergent findings have been collected with respect to memory, studies investigating the...
		The panel found that clozapine (brand name Clozaril) and olanzapine (Zyprexa) appear to produce the greatest weight gain and are associated with the greatest...
	www.linkmorgue.org /DRUGS/nov03-nov04/Clozaril.html (1203 words)

	FDA APPROVES CLOZARIL TO REDUCE THE RISK OF SUICIDAL BEHAVIOR IN PATIENTS WITH SCHIZOPHRENIA OR SCHIZOAFFECTIVE DISORDER (Site not responding. Last check: 2007-10-14)
		Clozaril was approved in 1989 for treatment of schizophrenia in patients who do not respond to other available therapies.
		Patients for whom Clozaril treatment may be useful are those who are judged to be at chronic risk for reexperiencing suicidal behavior, based on history of attempted suicide, hospitalization, or suicidal ideation (thoughts of suicide) with or without hallucinations.
		Clozaril tablets are manufactured and marketed by Novartis of East Hanover, N.J. Media Contacts
	www.fda.gov /bbs/topics/ANSWERS/2002/ANS01184.html (416 words)

	Clozaril / Clozapine Lawsuit Overview - Find Trial Lawyers and Attorneys with Experience in Clozaril / Clozapine ...
		Clozaril and tardive dyskinesia have also been linked.
		A report published in the August 2003 issue of the medical journal Pharmacotherapy linked Clozaril use to the development of pancreatitis.
		In April 2004, FDA and Novartis notified healthcare professionals of revision to the WARNINGS section of Clozaril labeling, describing the increased risk of hyperglycemia and diabetes in patients taking Clozaril.
	www.injuryboard.com /view.cfm/TOPIC=739 (504 words)

	Prescriber Notification
		You or a nurse working with you should contact the pharmacy prior to September 1, 2004, with a new prescription order.
		Any patient who is admitted to the hospital where generic clozapine is used will be expected to remain on generic clozapine after discharge, unless it is clinically demonstrated that the person had a therapeutic failure, or an adverse or allergic reaction to generic clozapine.
		Although this is unnecessary for most patients, Medicaid will pay for these serum levels, if you believe they are clinically appropriate.
	www.dhfs.state.wi.us /medicaid4/pharmacy/clozaril/genericprsrbrltr.htm (1238 words)

	Historical Context
		Clozaril was then a new and expensive antipsychotic medication.
		When clozaril was approved for use, the field lacked an inexpensive, easy-to-use, comprehensive QoL assessment tool for use in busy mental health settings.
		Our primary objective was to develop an inexpensive, easy-to-use, self-report and self-administered instrument that would reflect consumer values and goals for improvement with treatment.
	wqli.fmhi.usf.edu /historic.htm (299 words)

	[No title]
		ZGP’s clozapine is the generic version of Novartis AG’s (formerly Sandoz’s) brand name drug, Clozaril, used for the management of severely ill schizophrenic patients who either fail to respond to or are unable to take other standard antipsychotic treatments.
		The Food and Drug Administration (FDA) approved Clozaril® in 1989; a new formulation for Clozaril was subsequently approved in 1997.
		In the case of the study conducted in Texas, it was found that the study was not actually designed to evaluate whether patients responded to the generic version as well as they did to Clozaril, nor could the reported results be interpreted to provide a basis for FDA regulatory action.
	www.fda.gov /cder/drug/infopage/clozapine/clozapine.htm (452 words)

	[No title]
		According to its manufacturer, patients taking Clozaril, an antipsychotic medication, must have ongoing blood tests to monitor for the development of a fatal blood disorder that can occur during treatment.
		The U.S. pharmacy that declined our order indicated that Clozaril should not have been offered for sale on its Web site, and the Canadian pharmacy indicated that more stringent prescription requirements prevented it from dispensing the drug to patients outside of Canada.
		These included pharmacies that accepted payment but did not provide the drugs ordered, shipments of drugs with questionable return addresses, pharmacies that obscured details about the drugs sold, and pharmacies that were under investigation by regulatory agencies.
	www.gao.gov /atext/d04820.txt (8314 words)

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