| | The Hyphal-Specific Gene ALS7 is a Member of a Candida albicans Gene Family Encoding Agglutinin-like Cell-surface ... (Site not responding. Last check: 2007-10-30) |
 | | Molecular & Cell Biology, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK Candida albicans can undergo a reversible morphological transition from a budding yeast to a hyphal form which contributes to the virulence of this pathogenic fungus [1]. |
 | | Since C. albicans is diploid and asexual, one approach towards the elucidation of the molecular mechanisms which control morphogenesis has been the identification of genes which are regulated in response to this transition. |
 | | Interestingly, ALS7 over-expression in S. cerevisiae induces cell clumping, and constitutive over-expression of ALS7 in C. albicans generates slightly elongated yeast cells, suggesting that Als7p might influence cell shape and adhesion. |
| www.yeastgenome.org /community/meetings/yeast98/abshtml/490.html (289 words) |