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Blood Coagulation |
 | | The platelets stimulate local activation of plasma coagulation factors, leading to generation of a fibrin clot that reinforces the platelet aggregate. |
 | | In this manner, 11 plasma coagulation factors were discovered: 6 in the "intrinsic" pathway (factors VIII, IX, XI, XII, prekallikrein, and high-molecular weight kininogen), 1 in the "extrinsic" pathway (factor VII), and 4 in the common pathway (factors II, V, X, and fibrinogen). |
 | | The structures of the protease zymogens involved in coagulation (i.e., factors II (prothrombin), VII, IX, X, XI, XII, and kallikrein) are shown in Fig. |
| tollefsen.wustl.edu /projects/coagulation/coagulation.html (2316 words) |
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