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Topic: Coagulation of human blood

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	Coagulation - Wikipedia, the free encyclopedia
		Coagulation is similar in all mammals, but as most is known about the system in humans, this article focuses on human blood coagulation.
		Coagulation factors are generally indicated by Roman numerals, with a lowercase a appended to indicate an active form, ultimately resulting in cross-linked fibrin.
		If a coagulation factor is part of the contact or tissue factor pathway, a deficiency of that factor will affect only one of the tests: thus hemophilia A, a deficiency of factor VIII, which is part of the contact factor pathway, results in an abnormally prolonged aPTT test but a normal PT test.
	en.wikipedia.org /wiki/Coagulation (2130 words)

	F10 - Coagulation factor X precursor (Site not responding. Last check: 2007-11-07)
		Human factor XSanto Domingo is a form of coagulation factor X in which a mutation within the signal peptide region of the precursor protein has been correlated genetically with a severe deficiency of factor X in the affected individual.
		Human blood coagulation factor X has two N-linked oligosaccharides at Asn39 and Asn49 residues and two O-linked oligosaccharides at Thr17 and Thr29 residues in the region of the factor X activation peptide (XAP) which is cleaved off during its activation by factor IXa.
		Human monocyte-macrophages were incubated for 24 h in Ham's F-10 medium with human low-density lipoprotein (LDL) in the presence or absence of beta-carotene, canthaxanthin or zeaxanthin, at final concentrations of 2.5, 12.5 and 25 mg/l.
	www.pdg.cnb.uam.es /UniPub/iHOP/gi/88111.html (6450 words)

	Coagulation Books 1900-1979 (Site not responding. Last check: 2007-11-07)
		The blood and its third anatomical element; application of the microzymian theory of the living organization to the study of the anatomical and chemical constitution of the blood and to that of the anatomical and physiological causes of the phenomena of its coagulation and of its other spontaneous changes.
		The physiological inhibitors of blood coagulation and fibrinolysis : proceedings of a round-table conference held at the University of Leuven, Belgium, July 22-23, 1978.
		Godal, H. The effect of EDTA on human fibrinogen and its significance for the coagulation of fibrinogen with thrombin.
	www.medlina.com /coagulation_books_1900-1979.htm (3282 words)

	Results of the search
		Blood coagulation in pregnancy: proconvertin and prothrombin, and the hypercoagulable state.
		Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting.
		A new inherited coagulation disorder caused by an abnormal fibrinogen ('fibrinogen Baltimore').
	invention.swmed.edu /trite/abstracts/user-1015797314/results.shtml (2204 words)

	Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX -- Ameri et al. 101 (5): 1871 -- ...
		Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX -- Ameri et al.
		Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX
		Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans.
	www.bloodjournal.org /cgi/content/full/101/5/1871 (2089 words)

	Blood Coagulation
		However, equally significant is the role of activated platelet surface phospholipids in the activation of the coagulation cascade.
		-antitrypsin is the primary serine protease inhibitor of human plasma.
		In response to injury, the heparin is released and inhibits coagulation.
	www.med.unibs.it /~marchesi/blood.html (3486 words)

	HUMAN BLOOD AND BLOOD COMPONENTS (Site not responding. Last check: 2007-11-07)
		Blood cultures are obtained, and the patient is treated for septicemia with antibiotics, IV fluids, vasopressors, and steroids.
		Whole blood cannot be considered a source of viable platelets or white cells or of therapeutic levels of labile coagulation factors V and VIII.
		Red blood cells (or whole blood) may be modified by centrifugation, filtration, addition of sedimenting agents or a combination of these procedures to remove the leukocytes.
	www.csufresno.edu /nursing/n140/studassign/blood.htm (4107 words)

	Coagulation (disambiguation) - Wikipedia, the free encyclopedia
		Coagulation is the process by which a liquid changes to a thickened, curdlike, insoluble state by some kind of chemical reaction, rather than by evaporation.
		Curd, or the coagulation of milk by rennet or acid
		This is a disambiguation page — a list of pages that otherwise might share the same title.
	en.wikipedia.org /wiki/Coagulation_(disambiguation) (101 words)

	Biophysical Journal: Structure of dynamics of zymogen human blood coagulation factor X (Site not responding. Last check: 2007-11-07)
		ABSTRACT The solution structure and dynamics of the human coagulation factor X (FX) have been investigated to understand the key structural elements in the zymogenic form that participates in the activation process.
		Human coagulation factor X (FX), a vitamin K (VKD)-- dependent plasma zymogen, plays a central role in the blood coagulation cascade (Davie et al., 1991).
		The sequence of human FX is highly homologous to other VKDblood coagulation factors such as VII, IX, and protein C and shares similar structure-function relationships with the same family of enzymes (Greer, 1981; Furie et al., 1982).
	www.findarticles.com /p/articles/mi_qa3938/is_200203/ai_n9083652 (1103 words)

	Coagulation - free-definition (Site not responding. Last check: 2007-11-07)
		The coagulation of human blood is a fairly complex process by which liquid blood becomes solid clots.
		It is an important part of hemostasis where a damaged blood vessel is ultimately covered by a fibrin clot to stop hemorrhage.
		If a coagulation factor is part of the intrinsic or extrinsic pathway, a deficiency of that factor will affect only one of the tests: thus hemophilia A, a deficiency of factor VIII, which is part of the intrinsic pathway, results in an abnormally prolonged PT test but a normal PTT test.
	www.free-definition.com /Coagulation.html (1067 words)

	Human Annexin V Binds to Sulfatide: Contribution to Regulation of Blood Coagulation -- Ida et al. 135 (5): 583 -- ...
		Human Annexin V Binds to Sulfatide: Contribution to Regulation of Blood Coagulation -- Ida et al.
		Human Annexin V Binds to Sulfatide: Contribution to Regulation of Blood Coagulation
		V binds to sulfatide and affects the coagulant activity of sulfatide.
	jb.oxfordjournals.org /cgi/content/abstract/135/5/583 (213 words)

	Maybe you can get blood from a turnip after all
		Pacific Northwest researchers have produced two blood factors that are used to treat most patients with blood clotting disorders.
		Using plants to produce human blood proteins eliminates the possibility of transmitting disease along with lifesaving treatments.
		Pacific Northwest researchers have produced coagulation factor VIII, which is critical to hemophilia therapies, as well as factor XIII and a substance called thrombin which are clotting enzymes that aid in healing wounds and offer an alternative to sutures and other surgical sealants.
	www.eurekalert.org /pub_releases/1999-07/PNNL-Mycg-120799.php (455 words)

	Structure and Dynamics of Zymogen Human Blood Coagulation Factor X -- Venkateswarlu et al. 82 (3): 1190 -- Biophysical ...
		FIGURE 1 Schematic representation of the primary amino acid sequence of the two-chain human factor X. The tripeptide of Arg140-Lys141-Arg142 that connects the light chain to the activation peptide is not shown because the form that lacks the tripeptide is predominant in circulating blood plasma.
		Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X: the role of the carbohydrate moieties in the activation of factor X. Eur.
		Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C. Biochemistry.
	www.biophysj.org /cgi/content/full/82/3/1190 (8073 words)

	Analysis of the coagulation of human blood cells on diamond surfaces by atomic force microscopy
		Atomic force microscopy (AFM) was used to study the morphology and coagulation of human blood cells in contact with solid surfaces.
		Blood was extracted from the veins of healthy adult donors and the samples were used immediately after extraction, deposited either on borosilicate glass or diamond substrates.
		The coagulation results suggest that blood clotting on diamond produces a less rough surface than blood clotting on glass.
	stacks.iop.org /0957-4484/15/1661 (321 words)

	Human blood coagulation factor XIII (Site not responding. Last check: 2007-11-07)
		These large proteins are intimately involved in formation of skin and hair, in blood coagulation, in fertilization events, and in several disease states as well.
		The human zymogen is synthesized by the yeast, Saccharomyces cerevesiae.
		Current efforts are directed to the study of site specific mutant forms of the protein, to crystallization studies of the thrombin activated enzyme, and to study of inhibited forms of the enzyme and zymogen activated by high calcium ion concentrations.
	www.bmsc.washington.edu /projects/fxiii.html (366 words)

	UM Human Genetics - Kurachi (Site not responding. Last check: 2007-11-07)
		Our research interests are centered around: (1) molecular mechanisms responsible for developmental and age regulation of the blood coagulation system; (2) development of gene therapies for hemophilias and thrombotic disorders; and (3) biological function of hepsin, a membrane protease, in cell growth and development.
		The molecular mechanisms responsible for age-associated regulation (homeostasis) of blood coagulation are poorly understood.
		We are now extending our comprehensive studies to other key factors involved in blood coagulation as well as fibrinolysis.
	www.med.umich.edu /hg/RESEARCH/FACULTY/Kurachi/Kurachi.htm (528 words)

	Blood Coagulation
		The function of vWF is to act as a bridge between a specific glycoprotein on the surface of platelets (GPIb/IX) and collagen fibrils.
		Treatment of hemophilia A is accomplished by infusion of factor VIII concentrates prepared from either human plasma or by recombinant DNA technology.
		The prevalence of hemophilia B is approximately one-tenth that of hemophilia A. All patients with hemophilia B have prolonged coagulation time and decreased factor IX clotting activity.
	web.indstate.edu /thcme/mwking/blood-coagulation.html (3732 words)

	The Gene Letter by GeneSage - News (Site not responding. Last check: 2007-11-07)
		They then injected mice with a plasmid containing a transposon that contained a gene for human blood coagulation factor IX, along with a plasmid encoding transposase, in the tail vein of a mouse model of human hemophilia B. Injecting the plasmids in the tail vein targets them to the liver, the authors note.
		After 60 days, levels of the coagulation factor were undetectable in mice injected with a mutant transposase, but rose to between 77 and 105 ng/mL in mice receiving wild-type transposase.
		At day 102, bleeding times were reduced from more than 30 minutes in mice receiving mutant transposase to 4 to 7 minutes in mice receiving wild-type transposase.
	www.genesage.com /professionals/geneletter/news/pr051100b.html (481 words)

	Identification of Distinct Sequences in Human Blood Coagulation Factor Xa and Prothrombin Essential for Substrate and ...
		Identification of Distinct Sequences in Human Blood Coagulation Factor Xa and Prothrombin Essential for Substrate and Cofactor Recognition in the Prothrombinase Complex -- Yegneswaran et al.
		Sequence alignment was performed with the Genetics Computer Group Sequence Analysis software program GAP (23) using published sequences derived from the cDNA of Protein C (16), fX (24), and fII (25).
		Residual fXa activity was determined in fXa-1 stage coagulation assays in the presence of 500 µ
	www.jbc.org /cgi/content/full/278/35/33312 (4588 words)

	Lalith Perera's Publications
		Venkateswarlu, R. Duke, L. Perera, T. Darden, and L. Pedersen, (2003) An all-atom solution-equilibrated model for human extrinsic blood coagulation complex (sTF-VIIa-Xa): a protein-protein docking and molecular dynamics refinement study.
		(1999) Probing the Structural Changes in the Light Chain of Human Coagulation Factor VII due to Tissue Factor Association.
		"Solution Structure of the Light Chain of Human Coagulation Factor VII: A Molecular Dynamic Simulation," FASEB Summer Research Conference, Saxtons River, August 1997.
	www.unc.edu /~perera/Publications.html (1160 words)

	COMP 169 - Solution structural model for human extrinsic blood coagulation complex (TF.VIIa.X): Protein-protein docking ... (Site not responding. Last check: 2007-11-07)
		Tissue factor (TF) bound activated VII (VIIa) plays critical role in activating factor X to Xa, an event that rapidly results in blood coagulation.
		In an attempt to further the current knowledge of TF/VIIa mediated FX activation, we built a structural model for human form of TF.VIIa.FX ternary complex based on homology modeling, protein-protein docking and molecular dynamics (MD) simulations.
		The current model may serve as reasonable structural template to design new mutagenesis studies and further characterize the exosites in enzyme and substrate involved in the extrinsic pathway of blood coagulation cascade.
	membership.acs.org /C/COMP/pastprograms/spr03/P582028.HTM (438 words)

	[No title] (Site not responding. Last check: 2007-11-07)
		Our focus is to test newly developed drugs in the immunologic and coagulation field.
		Jilma B, Marsik C, Kovar F, Wagner OF, Jilma-Stohlawetz P, Endler G: The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia.
		Derhaschnig U, Reiter R, Knöbl P, Baumgartner M, Keen P, Jilma B: Recombinant human activated protein C (rhAPC, drotrecogin alfa activated) has minimal effect on markers of coagulation, fibrinolysis and inflammation in acute human endotoxemia.
	www.akh-wien.ac.at /klpharm/htm/page6.html (227 words)

	The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe ...
		The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B -- Shapiro et al.
		Prepublished online as a Blood First Edition Paper on September 21, 2004; DOI 10.1182/blood-2004-06-2283.
		The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B
	www.bloodjournal.org /cgi/content/abstract/105/2/518 (256 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #800139 - Structural basis for chemical inhibition of human blood coagulation factor Xa Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		For a journal article, please see the Resource Relation field.
		Structural basis for chemical inhibition of human blood coagulation factor Xa
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=800139 (138 words)

	EC 3.4.21.6 (Site not responding. Last check: 2007-11-07)
		Jesty, J. and Nemerson, Y. The activation of bovine coagulation factor X. Methods Enzymol.
		Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade.
		Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
	www.chem.qmw.ac.uk /iubmb/enzyme/EC3/4/21/6.html (168 words)

	ClinicalTrials.gov - Information on Clinical Trials and Human Research Studies: Browse: Blood Coagulation Disorders
		Study of Abnormal Blood Clotting in Children with Stroke
		Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow
		Conditions: Bone Marrow Transplantation; Blood Disease; Hematopoietic Stem Cell Transplantation; Leukemia; Multiple Myeloma; Myelodysplastic Syndromes;...
	clinicaltrials.gov /ct/gui/action/FindCondition?ui=D001778&... (793 words)

	Structural basis for chemical inhibition of human blood coagulation factor Xa -- Kamata et al. 95 (12): 6630 -- ...
		Structural basis for chemical inhibition of human blood coagulation factor Xa -- Kamata et al.
		The N-terminal Epidermal Growth Factor-like Domain of Coagulation Factor IX.
		Structure of human factor VIIa and its implications for the triggering of blood coagulation
	www.pnas.org /cgi/content/abstract/95/12/6630 (552 words)

	Best Book Buys - Blood coagulation disorders Books (Site not responding. Last check: 2007-11-07)
		Books > Browse > Subject Category > Medical > Hematology > Blood coagulation disorders
		Subject Category > Medical > Hematology > Blood coagulation disorders
		Immunological Mechanisms in Blood Coagulation, Thrombosis and Hemostasis: New Developments in Antithrombotic Therapy Transactions of the Conference Held under the Auspices of the International Committee on Haemostasis and Thrombosis and the International Society on Thrombosis and Haemostasis, Montreux, Switzerland, July 28 to
	www.bestwebbuys.com /Hematology-N_10022711-books.html (203 words)

	Best Book Buys - Blood - Coagulation Books (Site not responding. Last check: 2007-11-07)
		Best Book Buys - Blood - Coagulation Books
		Mechanisms in Blood Coagulation Fibrinolysis and the Complement System
		Handbook of Synthetic Substrates: For the Coagulation and Fibrinolytic System
	www.bestwebbuys.com /Hematology-N_10022703-books.html (136 words)

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